Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 282, Issue 1 45-1, 2002, Pages

  Anna Diehl, M A E ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Innate immunity; Leptin; Steatohepatitis

Indexed keywords

ALCOHOL; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 6; LEPTIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROSTAGLANDIN E2; PROSTANOID; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CHOLESTASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; FATTY LIVER; HEPATITIS; IMMUNITY; KUPFFER CELL; LIVER CELL; LIVER DISEASE; LIVER FATTY DEGENERATION; LYMPHOCYTE; MACROPHAGE FUNCTION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT STRAIN;

EID: 0036083787     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00384.2001     Document Type: Article

References (40)

1. IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: Evidence for differential receptor subunit utilization associated with stimulation or inhibition
2. Obesity induces expression of uncoupling protein- 2 in hepatocytes and promotes liver ATP depletion
3. Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis
4. Bacterial lipopolysaccharide induces uncoupling protein-2 in hepatocytes via a tumor necrosis alpha-dependent mechanism
5. Kupffer cell sensitization by alcohol involves increased permeabilityy to gut-derived endotoxin
6. Leptin deficiency enhances sensitivity to endotoxin-induced lethality
7. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18
8. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+T cells
9. Altered hepatic lymphocyte subpopulations in obesity-related fatty livers
10. Weight-reducing effects of the protein encoded by the obese gene
11. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
12. Reversible defects in natural killer and memory CD8 T cell lineage in interleukin 15-deficient mice
13. High concentration of leptin stimulates myeloid diferentiation from human bone marrow CD34+ progenitors: Potential involvement in leukocytosis of obese subjects
14. Kupffer cells are a dominant type of uncoupling protein- 2 expression in rat liver
15. Functional heterogeneity of liver and lung macrophages
16. Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL- 18
17. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
18. The emerging role of IL-15 in NK-cell development
19. Leptin regulates proinflammatory immune responses
20. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
21. Liver pathology and the metabolic syndrome X in severe obesity
22. Association of nonalcoholic fatty liver disease with insulin resistance
23. Propionibacterium acnes treatment diminishes CD4+NK1.1+ T cells but induces type 1 T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells
24. Pathobiology of lipopolysaccharide
25. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
26. Inhibition of concanavalin A-induced hepatic injury of mice by bacterial lipopolysaccharide via the induction of IL-6 and the subsequent reduction of IL-4: The cytokine milieu of concanvalin A hepatitis
27. Effects of the obese gene product on body weight regulation in ob/ob mice
28. Leptin receptor missense mutation in the fatty Zucker rat
29. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
30. Transgenic mice lacking white fat: Models for understanding human lipoatrophic diabetes
31. Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine
32. Human leptin enhances activation and proliferation of human circulating T lymphocytes
33. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors
34. The liver as a crucial orgain in the first line of host defense: The role of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells and T helper 1 immune responses
35. Kupffer cell-derived cyclooxygenases-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats
36. Concanavalin A-induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice
37. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells
38. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
39. Hepatocellular oxidative DNA injury induced by macrophage-derived nitric oxide
40. Obesity increases sensitivity to endotoxin liver injury: Implications for pathogenesis of steatohepatitis