Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease

Journal of Hepatology

Volumn 41, Issue 6, 2004, Pages 943-949

  Angulo, Paul ^a   Alba, Laura M ^a   Petrovic, Lydia M ^a   Adams, Leon A ^a   Lindor, Keith D ^a   Jensen, Michael D ^a  

^a Mayo Clinic   (United States)

Author keywords

Insulin resistance; Leptin; Liver fibrosis; Nonalcoholic fatty liver disease; Steatohepatitis

Indexed keywords

LEPTIN;

ADULT; AGE DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FEMALE; HUMAN; INSULIN RESISTANCE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; SEX RATIO;

ADULT; AGED; AGING; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; LEPTIN; LIVER; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 9644265298     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2004.08.020     Document Type: Conference Paper

References (29)

1. P. Angulo Nonalcoholic fatty liver disease N Engl J Med 346 2002 1221 1231
2. G. Fantuzzi, and R. Faggioni Leptin in the regulation of immunity, inflammation, and hematopoiesis J Leukoc Biol 68 2000 437 446
3. B. Cohen, D. Novick, and M. Rubinstein Modulation of insulin activities by leptin Science 274 1996 1185 1188
4. G. Pagano, G. Pacini, G. Musso, R. Gambino, F. Mecca, and N. Depetris Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association Hepatology 35 2002 367 372
5. S. Chitturi, S. Abeygunasekera, G.C. Farrell, J. Holmes-Walker, J.M. Hui, and C. Fung NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome Hepatology 35 2002 373 379
6. C. Otte, J.M. Otte, D. Strodthoff, S.R. Bornstein, U.R. Folsch, and H. Monig Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis Exp Clin Endocrinol Diabetes 112 2004 10 17
7. J.J. Potter, L. Womack, E. Mezey, and F.A. Anania Transdifferentiation of rat hepatic stellate cells results in leptin expression Biochem Biophys Res Commun 244 1998 178 182
8. N.K. Saxena, K. Ikeda, D.C. Rockey, S.S.T. Friedman, and F.A. Anania Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice Hepatology 35 2002 762 771
9. N.K. Saxena, G. Saliba, J.J. Floyd, and F.A. Anania Leptin induces increased α2(I) collagen gene expression in cultured rat hepatic stellate cells J Cell Biochem 89 2003 311 320
10. H. Honda, K. Ikejima, M. Hirose, M. Yoshikawa, T. Lang, and N. Enomoto Leptin is required for fibrogenic responses indiced by thioacetamide in the murin liver Hepatology 36 2002 12 21
11. K. Ikejima, Y. Takei, H. Honda, M. Hirose, M. Yoshikawa, and Y.J. Zhang Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat Gastroenterology 122 2002 1399 1410
12. A. Koteish, and A.M. Diehl Animal models of steatosis Semin Liver Dis 21 2001 89 104
13. J. Laurin, K.D. Lindor, J.S. Crippin, A. Gossard, G.J. Gores, and J. Ludwig Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study Hepatology 23 1996 1464 1467
14. K.D. Lindor, K.V. Kowdley, E.J. Heathcote, M.E. Harrison, R. Jorgensen, and P. Angulo Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial Hepatology 39 2004 770 778
15. American Diabetes Association American Diabetes Association Diabetes Care 23 2000
16. A. Katz, S.S. Nambi, K. Mather, D.A. Baron, D.A. Follman, and F. Sullivan Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 2000 2402 2410
17. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostatic model assessment: insulin resistance and beta-cell function from fasting glucose and insulin concentrations in man Diabetologia 28 1985 412 419
18. E.M. Brunt, C.G. Janney, A.M. Di Bisceglie, B.A. Neuschwander-Tetri, and B.R. Bacon Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions Am J Gastroenterol 94 1999 2467 2474
19. R.V. Considine, M.K. Sinha, M.L. Heiman, A. Kriauciunas, T.W. Stephens, and M.R. Nyce Serum immunoreactive-leptin concentrations in normal-weight and obese humans N Engl J Med 334 1995 192 295
20. M. Maffei, J. Halaas, E. Ravussin, R.E. Pratley, G.H. Lee, and Y. Zhang Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight reduced subjects Nat Med 1 1995 1155 1161
21. H. Li, M. Matheny, M. Nicolson, N. Tumer, and P.J. Scarpace Leptin gene expression increases with age independent of increasing adiposity in rats Diabetes 46 1997 2035 2039
22. H. Li, M. Matheny, N. Tumer, and P.J. Scarpace Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression Am J Physiol 275 1998 E404 E411
23. A. Nogalska, and J. Swierczynski The age-related differences in obese and fatty acid synthase gene expression in white adipose tissue of rat Biochem Biophys Acta 1533 2001 73 80
24. A. Nogalska, A. Pankiewicz, E. Goyke, and J. Swierczynski The age-related inverse relationship between ob and lipogenic enzymes genes expression in rat white adipose tissue Exp Gerontol 38 2003 415 422
25. R.L. Bradley, and B. Cheatham Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes Diabetes 48 1999 272 278
26. I.A. Leclercq, G.C. Farrell, R. Schriemer, and G.R. Robertson Leptin is essential for hepatic fibrogenic response to chronic liver injury J Hepatol 37 2002 206 213
27. C.P. Day, and O.F. James Steatohepatitis: a tale of two 'hits'? Gastroenterology 114 1998 842 845
28. E. Bugianesi, P. Manzini, S. D'Antico, E. Vanni, F. Longo, and N. Leone Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver Hepatology 39 2004 179 187
29. W.A. Haque, I. Shimomura, Y. Matsuzawa, and A. Garg Serum adiponectin and leptin levels in patients with lipodystrophies J Clin Endocrinol Metab 887 2002 2395 2398