CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex

PLoS Pathogens

Volumn 8, Issue 4, 2012, Pages

  Lu, Rongze ^a,b   Pan, Hao ^a,c   Shively, John E ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b GENENTECH INC   (United States)

^c Nexelcom Bioscience LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CATHEPSIN B; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; CARCINOEMBRYONIC ANTIGEN; CEACAM1 PROTEIN, MOUSE; MULTIPROTEIN COMPLEX; PROTEIN TYROSINE KINASE; PTPN6 PROTEIN, MOUSE; SIGNAL PEPTIDE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL DAMAGE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; LYSOSOME; MOUSE; NEISSERIA; NEUTROPHIL; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; RNA INTERFERENCE; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE ACTIVATION; MACROPHAGE; METABOLISM; MOUSE MUTANT; NEISSERIACEAE INFECTION; PATHOLOGY; PHOSPHORYLATION;

NEGIBACTERIA; NEISSERIA;

ANIMALS; CARCINOEMBRYONIC ANTIGEN; CASPASE 1; ENZYME ACTIVATION; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; LYSOSOMES; MACROPHAGES; MICE; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NEISSERIA; NEISSERIACEAE INFECTIONS; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 4;

EID: 84861204618     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002597     Document Type: Article

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