TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism

Endocrinology

Volumn 153, Issue 12, 2012, Pages 5821-5833

  Gan, Lixia ^a,b   Guo, Kaiying ^a   Cremona, Maria Laura ^a   McGraw, Timothy E ^c   Leibel, Rudolph L ^a   Zhang, Yiying ^a  

^a College of Physicians and Surgeons ^*  (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 O METHYLPHORBOL 13 ACETATE 12 MYRISTATE; BREFELDIN A; CADHERIN; LEPTIN RECEPTOR; PROTEIN KINASE C; STAT3 PROTEIN; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; UPREGULATION;

ANIMALS; CADHERINS; CELL LINE; CELL MEMBRANE; ENZYME INHIBITORS; GOLGI APPARATUS; HOMEOSTASIS; HUMANS; INDOLES; MALEIMIDES; MICE; NEURONS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN TRANSPORT; RECEPTORS, LEPTIN; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84870172217     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1510     Document Type: Article

References (59)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Leibel RL 2008 Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond) 32:S98-S108
3. Myers Jr MG, Leibel RL, Seeley RJ, Schwartz MW 2010 Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab 21:643-651
4. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI 1998 Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897-901
5. Guo X, Roberts MR, Becker SM, Podd B, Zhang Y, Chua SC Jr, Myers MG Jr, Duggal P, Houpt ER, Petri Jr WA 2011 Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica. Mucosal Immunol 4:294-303
6. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS 1997 Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 138:3859-3863
7. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G 2005 Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-520
8. Takahashi N, Waelput W, Guisez Y 1999 Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 189:207-212
9. Tschöp J, Nogueiras R, Haas-Lockie S, Kasten KR, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S Jr, Farooqi IS, O'Rahilly S, Caldwell CC, Tschöp MH 2010 CNS leptin action modulates immune response and survival in sepsis. J Neurosci 30:6036-6047
10. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
11. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
12. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
13. Chua Jr SC, Koutras IK, Han L, Liu SM, Kay J, Young SJ, Chung WK, Leibel RL 1997 Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts. Genomics 45:264-270
14. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers Jr MG 2003 STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-859
15. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG 1996 Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106
16. de Luca C, Kowalski TJ, Zhang Y, Elmquist JK, Lee C, Kilimann MW, Ludwig T, Liu SM, Chua Jr SC 2005 Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 115:3484-3493
17. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J 2001 Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 283:982-988
18. Huang L, Wang Z, Li C 2001 Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 276:6343-6349
19. Yang G, Ge H, Boucher A, Yu X, Li C 2004 Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol 18:1354-1362
20. Zastrow O, Seidel B, Kiess W, Thiery J, Keller E, Böttner A, Kratzsch J 2003 The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord 27:1472-1478
21. Tu H, Kastin AJ, Hsuchou H, Pan W 2008 Soluble receptor inhibits leptin transport. J Cell Physiol 214:301-305
22. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, Ross RJ 2001 Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 142:4389-4393
23. Ge H, Huang L, Pourbahrami T, Li C 2002 Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 277:45898-45903
24. Belouzard S, Delcroix D, Rouillé Y 2004 Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway. J Biol Chem 279:28499-28508
25. Barr VA, Lane K, Taylor SI 1999 Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem 274:21416-21424
26. Baskin DG, Schwartz MW, Seeley RJ, Woods SC, Porte D Jr, Breininger JF, Jonak Z, Schaefer J, Krouse M, Burghardt C, Campfield LA, Burn P, Kochan JP 1999 Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 47:353-362
27. Diano S, Kalra SP, Horvath TL 1998 Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells. J Neuroendocrinol 10:647-650
28. Lundin A, Rondahl H, Walum E, Wilcke M 2000 Expression and intracellular localization of leptin receptor long isoform-GFP chimera. Biochim Biophys Acta 1499:130-138
29. Uotani S, Bjørbaek C, Tornøe J, Flier JS 1999 Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48:279-286
30. Wilcke M, Walum E 2000 Characterization of leptin intracellular trafficking. Eur J Histochem 44:325-334
31. Séron K, Couturier C, Belouzard S, Bacart J, Monté D, Corset L, Bocquet O, Dam J, Vauthier V, Lecoeur C, Bailleul B, Hoflack B, Froguel P, Jockers R, Rouillé Y 2011 Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway. J Biol Chem 286:17968-17981
32. Sethi G, Sung B, Aggarwal BB 2008 TNF: a master switch for inflammation to cancer. Front Biosci 13:5094-5107
33. Moller DE 2000 Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11:212-217
34. Orbak Z, Ertekin V, Akçay F, Ozkan B, Ors R 2003 Serum leptin levels in neonatal bacterial septicemia. J Pediatr Endocrinol Metab 16:727-731
35. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM 1998 Leptin regulates proinflammatory immune responses. FASEB J 12:57-65
36. Voegeling S, Fantuzzi G 2001 Regulation of free and bound leptin and soluble leptin receptors during inflammation in mice. Cytokine 14:97-103
37. Schulze PC, Kratzsch J, Linke A, Schoene N, Adams V, Gielen S, Erbs S, Moebius-Winkler S, Schuler G 2003 Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Heart Fail 5:33-40
38. McGraw TE, Greenfield L, Maxfield FR 1987 Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor. J Cell Biol 105:207-214
39. Duffy AM, O'Doherty AM, O'Brien T, Strappe PM 2005 Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques. Gene Ther 12 Suppl 1:S62-S72
40. Zhang M, Guller S, Huang Y 2007 Method to enhance transfection efficiency of cell lines and placental fibroblasts. Placenta 28:779-782
41. Guo K, McMinn JE, Ludwig T, Yu YH, Yang G, Chen L, Loh D, Li C, Chua S Jr, Zhang Y 2007 Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology 148:3987-3997
42. Haniu M, Arakawa T, Bures EJ, Young Y, Hui JO, Rohde MF, Welcher AA, Horan T 1998 Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain. J Biol Chem 273:28691-28699
43. Kamikubo Y, Dellas C, Loskutoff DJ, Quigley JP, Ruggeri ZM 2008 Contribution of leptin receptor N-linked glycans to leptin binding. Biochem J 410:595-604
44. Cohen P, Yang G, Yu X, Soukas AA, Wolfish CS, Friedman JM, Li C 2005 Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem 280:10034-10039
45. Campfield LA, Smith FJ, Burn P 1996 The OB protein (leptin) pathway: a link between adipose tissue mass and central neural networks. Horm Metab Res 28:619-632
46. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H 1998 Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17:2596-2606
47. Zhang HH, Halbleib M, Ahmad F, Manganiello VC, Greenberg AS 2002 Tumor necrosis factor-α stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes 51:2929-2935
48. Clarke CJ, Guthrie JM, Hannun YA 2008 Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-α involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol 74:1022-1032
49. Olszanecka-Glinianowicz M, Zahorska-Markiewicz B, Janowska J, Zurakowski A 2004 Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-α and TNF soluble receptors in women with overweight and obesity. Metabolism 53:1268-1273
50. Winkler G, Lakatos P, Salamon F, Nagy Z, Speer G, Kovács M, Harmos G, Dworak O, Cseh K 1999 Elevated serum TNF-α level as a link between endothelial dysfunction and insulin resistance in normotensive obese patients. Diabet Med 16:207-211
51. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW 2003 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
52. Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante AW, Jr 2010 C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 59:916-925.
53. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW 2012 Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153-162
54. Damas P, Reuter A, Gysen P, Demonty J, Lamy M, Franchimont P 1989 Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 17:975-978
55. Calandra T, Baumgartner JD, Grau GE, Wu MM, Lambert PH, Schellekens J, Verhoef J, Glauser MP 1990 Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. Swiss-Dutch J5 Immunoglobulin Study Group. J Infect Dis 161:982-987
56. Sun Q, Cornelis MC, Kraft P, Qi L, vanDam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Mantzoros CS, Hu FB 2010 Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet 19:1846-1855
57. Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR 2007 High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282:23672-23678
58. Lehmann W, Edgar CM, Wang K, Cho TJ, Barnes GL, Kakar S, Graves DT, Rueger JM, Gerstenfeld LC, Einhorn TA 2005 Tumor necrosis factor α (TNF-α) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing. Bone 36:300-310
59. Bzowska M, Jura N, Lassak A, Black RA, Bereta J 2004 Tumour necrosis factor-α stimulates expression of TNF-α converting enzyme in endothelial cells. Eur J Biochem 271:2808-2820