메뉴 건너뛰기




Volumn 16, Issue 5, 2002, Pages 663-678

Pathogenesis of steatohepatitis

Author keywords

Cytokines; Fatty acids; Insulin resistance; Lipid peroxidation; Mitochondria; Obesity; Reactive oxygen species; Steatohepatitis; Steatosis; Type 2 diabetes; Uncoupling proteins

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ACYL COENZYME A; APOLIPOPROTEIN E; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 4A; CYTOKINE; FATTY ACID; GAMMA INTERFERON; HFE PROTEIN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 8; IRON; MANGANESE SUPEROXIDE DISMUTASE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2;

EID: 0036780582     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2002.0333     Document Type: Article
Times cited : (389)

References (87)
  • 1
    • 16044363694 scopus 로고    scopus 로고
    • Profile of an urban hospital-based practice
    • Byron D Minuk G Y Profile of an urban hospital-based practice Hepatology 24 1996 813-815
    • (1996) Hepatology , vol.24 , pp. 813-815
    • Byron, D.1    Minuk, G.Y.2
  • 2
    • 0034862590 scopus 로고    scopus 로고
    • Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology
    • Skelly M M James P D Ryder S D Findings on liver biopsy to investigate abnormal liver function tests in the absence of diagnostic serology Journal of Hepatology 35 2001 195-199
    • (2001) Journal of Hepatology , vol.35 , pp. 195-199
    • Skelly, M.M.1    James, P.D.2    Ryder, S.D.3
  • 3
    • 0032171686 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH): A disease of emerging identity and importance
    • James O FW Day C P Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance Journal of Hepatology 29 1998 495-501
    • (1998) Journal of Hepatology , vol.29 , pp. 495-501
    • James, O.F.W.1    Day, C.P.2
  • 4
    • 0033038672 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • Matteoni C A Younossi Z M Gramlich T et al. Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity Gastroenterology 116 1999 1413-1419
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramlich, T.3
  • 5
    • 0033019013 scopus 로고    scopus 로고
    • Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease
    • Caldwell S H Oelsner D H Lezzoni J C et al. Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease Hepatology 29 1999 664-670
    • (1999) Hepatology , vol.29 , pp. 664-670
    • Caldwell, S.H.1    Oelsner, D.H.2    Lezzoni, J.C.3
  • 6
    • 0033797838 scopus 로고    scopus 로고
    • Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case-control study
    • Poonwala A Nair S Thuluvath P J Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: a case-control study Hepatology 32 2000 689-692
    • (2000) Hepatology , vol.32 , pp. 689-692
    • Poonwala, A.1    Nair, S.2    Thuluvath, P.J.3
  • 7
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day C P James OFW Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.W.2
  • 8
    • 0035084699 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal A J Campbell-Sargent C Mirshahi F et al. Non-alcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183-1192
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 9
    • 0035431018 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease. A feature of the metabolic syndrome
    • Marchesini G Brizi M Bianchi G et al. Non-alcoholic fatty liver disease. A feature of the metabolic syndrome Diabetes 50 2001 1844-1850
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 10
    • 0031799747 scopus 로고    scopus 로고
    • Hepatic steatosis: Innocent bystander or guilty party?
    • Day C P James O FW Hepatic steatosis: innocent bystander or guilty party? Hepatology 27 1998 1463-1465
    • (1998) Hepatology , vol.27 , pp. 1463-1465
    • Day, C.P.1    James, O.F.W.2
  • 11
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless I R Lentz J S Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors Hepatology 12 1990 1106-1110
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 12
    • 0033767987 scopus 로고    scopus 로고
    • Characterization of pathogenic and prognostic factors of non-alcoholic statohepatitis associated with obesity
    • Garcia-Monzon C Martin-Perez E Lo Iacono O et al. Characterization of pathogenic and prognostic factors of non-alcoholic statohepatitis associated with obesity Journal of Hepatology 33 2000 716-724
    • (2000) Journal of Hepatology , vol.33 , pp. 716-724
    • Garcia-Monzon, C.1    Martin-Perez, E.2    Lo Iacono, O.3
  • 13
    • 0021173477 scopus 로고
    • Prospective evaluation of alcohol abuse and alcohol liver injury in men as predictors of development of cirrhosis
    • Sorenson T I A Orholm M Bentsen K D et al. Prospective evaluation of alcohol abuse and alcohol liver injury in men as predictors of development of cirrhosis Lancet ii 1984 241-244
    • (1984) Lancet , vol.2 , pp. 241-244
    • Sorenson, T.I.A.1    Orholm, M.2    Bentsen, K.D.3
  • 14
    • 0029165057 scopus 로고
    • Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver
    • Teli M R Day C P Burt A D et al. Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver Lancet 246 1995 987-990
    • (1995) Lancet , vol.246 , pp. 987-990
    • Teli, M.R.1    Day, C.P.2    Burt, A.D.3
  • 15
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi L E Gambardella M Andreana A et al. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity Hepatology 33 2001 1358-1364
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3
  • 16
    • 0030296956 scopus 로고    scopus 로고
    • Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis
    • Reeves H L Burt A D Wood S Day C P Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis Journal of Hepatology 25 1996 677-683
    • (1996) Journal of Hepatology , vol.25 , pp. 677-683
    • Reeves, H.L.1    Burt, A.D.2    Wood, S.3    Day, C.P.4
  • 18
    • 0034847310 scopus 로고    scopus 로고
    • Alcoholic liver disease: New insights into mechanisms and preventative strategies
    • Stewart S F Jones D EJ Day C P Alcoholic liver disease: new insights into mechanisms and preventative strategies Trends in Molecular Medicine 7 2001 408-413
    • (2001) Trends in Molecular Medicine , vol.7 , pp. 408-413
    • Stewart, S.F.1    Jones, D.E.2    Day, C.P.3
  • 19
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis
    • Leclerq I A Farrell G C Field J et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine non-alcoholic steatohepatitis Journal of Clinical Investigation 105 2000 1067-1075
    • (2000) Journal of Clinical Investigation , vol.105 , pp. 1067-1075
    • Leclerq, I.A.1    Farrell, G.C.2    Field, J.3
  • 20
    • 0342716457 scopus 로고    scopus 로고
    • Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice
    • Letteron P Fromenty B Terris B et al. Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice Journal of Hepatology 24 1996 200-208
    • (1996) Journal of Hepatology , vol.24 , pp. 200-208
    • Letteron, P.1    Fromenty, B.2    Terris, B.3
  • 22
    • 0038619851 scopus 로고    scopus 로고
    • Oxidative stress in alcoholic and non-alcoholic liver disease
    • U Leuschner, O FW James, & H Dancygier (eds.), Dordrecht: Kluwer Academic Publishers
    • Cortez-Pinto H Oxidative stress in alcoholic and non-alcoholic liver disease In Leuschner U James OFW Dancygier H (eds) Steatohepatitis (NASH and ASH) 2001 54-61 Kluwer Academic Publishers Dordrecht
    • (2001) Steatohepatitis (NASH and ASH) , pp. 54-61
    • Cortez-Pinto, H.1
  • 23
    • 0024542475 scopus 로고
    • Inhibition of target cell mitochondrial electron transfer by tumour necrosis factor
    • Lancaster J R Laster S M Gooding L R Inhibition of target cell mitochondrial electron transfer by tumour necrosis factor FEBS Letters 248 1989 169-174
    • (1989) FEBS Letters , vol.248 , pp. 169-174
    • Lancaster, J.R.1    Laster, S.M.2    Gooding, L.R.3
  • 24
  • 27
    • 0028788763 scopus 로고
    • Role of oxidative stress generated from mitochondrial electron transport chain and mitochondrial electron status in loss of mitochondrial function and activation of transcription factor nuclear factor-κB: Studies with isolated mitochondria and rat hepatocytes
    • Garcia-Ruiz C Collel A Morales A et al. Role of oxidative stress generated from mitochondrial electron transport chain and mitochondrial electron status in loss of mitochondrial function and activation of transcription factor nuclear factor-κB: studies with isolated mitochondria and rat hepatocytes Molecular Pharmacology 48 1995 8250-8345
    • (1995) Molecular Pharmacology , vol.48 , pp. 8250-8345
    • Garcia-Ruiz, C.1    Collel, A.2    Morales, A.3
  • 28
    • 0031962151 scopus 로고    scopus 로고
    • Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis
    • Weltman M D Farrell G C Hall P et al. Hepatic cytochrome P450 2E1 is increased in patients with non-alcoholic steatohepatitis Hepatology 27 1998 128-133
    • (1998) Hepatology , vol.27 , pp. 128-133
    • Weltman, M.D.1    Farrell, G.C.2    Hall, P.3
  • 29
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George D K Goldwurm S Macdonald G A et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis Gastroenterology 114 1998 311-318
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.K.1    Goldwurm, S.2    Macdonald, G.A.3
  • 30
    • 0032881292 scopus 로고    scopus 로고
    • Hepatic iron and non-alcoholic fatty liver disease
    • Younossi Z M Gramlich T Bacon B R et al. Hepatic iron and non-alcoholic fatty liver disease Hepatology 30 1999 847-850
    • (1999) Hepatology , vol.30 , pp. 847-850
    • Younossi, Z.M.1    Gramlich, T.2    Bacon, B.R.3
  • 31
    • 0033198978 scopus 로고    scopus 로고
    • Mitochondrial abnormalities in non-alcoholic steatohepatitis
    • Caldwell S H Swerdlow R H Khan E M et al. Mitochondrial abnormalities in non-alcoholic steatohepatitis Journal of Hepatology 31 1999 430-434
    • (1999) Journal of Hepatology , vol.31 , pp. 430-434
    • Caldwell, S.H.1    Swerdlow, R.H.2    Khan, E.M.3
  • 32
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis. A pilot study
    • Cortez-Pinto H Chatham J Chacko V P et al. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis. A pilot study Journal of the American Medical Association 282 1999 1659-1664
    • (1999) Journal of the American Medical Association , vol.282 , pp. 1659-1664
    • Cortez-Pinto, H.1    Chatham, J.2    Chacko, V.P.3
  • 33
  • 34
    • 0020065283 scopus 로고
    • Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole irrespective of protein-calorie malnutrition
    • Drenick E J Fisler J Johnson D Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole irrespective of protein-calorie malnutrition Gastroenterology 83 1982 534-548
    • (1982) Gastroenterology , vol.83 , pp. 534-548
    • Drenick, E.J.1    Fisler, J.2    Johnson, D.3
  • 35
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang S Q Lin H Z Lane M D et al. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis Proceedings of the National Academy of Science of the USA 94 1997 2557-2562
    • (1997) Proceedings of the National Academy of Science of the USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3
  • 36
    • 0034005303 scopus 로고    scopus 로고
    • Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitisation to liver damage
    • Guebre-Xabier M Yang S Lin H Z et al. Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitisation to liver damage Hepatology 31 2000 633-640
    • (2000) Hepatology , vol.31 , pp. 633-640
    • Guebre-Xabier, M.1    Yang, S.2    Lin, H.Z.3
  • 37
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumour necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J Cayon A Fernandez-Gil P et al. Gene expression of tumour necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients Hepatology 34 2001 1158-1163
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3
  • 38
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss and relationship to lipoprotein lipase
    • Kern P A Saghizadeh M Ong J M et al. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss and relationship to lipoprotein lipase Journal of Clinical Investigation 95 1995 2111-2119
    • (1995) Journal of Clinical Investigation , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3
  • 39
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg A J Roberts-Thomson I C Dymock R B et al. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis Gut 48 2001 206-211
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3
  • 40
    • 0034950652 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: Predictors of non-alcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon J B Bhathal P S O'Brien P E Non-alcoholic fatty liver disease: predictors of non-alcoholic steatohepatitis and liver fibrosis in the severely obese Gastroenterology 121 2001 91-100
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 41
    • 0034925462 scopus 로고    scopus 로고
    • Alcohol, obesity, and TNFα
    • Poullis A Mendall M A Alcohol, obesity, and TNFα Gut 49 2001 313
    • (2001) Gut , vol.49 , pp. 313
    • Poullis, A.1    Mendall, M.A.2
  • 42
    • 0033605261 scopus 로고    scopus 로고
    • Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
    • Chavin K D Yang S Q Lin H Z et al. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion Journal of Biological Chemistry 274 1999 5692-5700
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 5692-5700
    • Chavin, K.D.1    Yang, S.Q.2    Lin, H.Z.3
  • 43
    • 18244379331 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling proteins
    • Echtay K S Roussel D St-Pierre J et al. Superoxide activates mitochondrial uncoupling proteins Nature 415 2002 96-99
    • (2002) Nature , vol.415 , pp. 96-99
    • Echtay, K.S.1    Roussel, D.2    St-Pierre, J.3
  • 44
    • 0027944505 scopus 로고
    • Liver injury following normothermic ischemia in steatotic rat liver
    • Hui A M Kawasaki S Makuuchi M et al. Liver injury following normothermic ischemia in steatotic rat liver Hepatology 20 1994 1287-1293
    • (1994) Hepatology , vol.20 , pp. 1287-1293
    • Hui, A.M.1    Kawasaki, S.2    Makuuchi, M.3
  • 45
    • 0034812914 scopus 로고    scopus 로고
    • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology
    • Yang S Q Lin H Z Mandal A K et al. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology Hepatology 34 2001 694-706
    • (2001) Hepatology , vol.34 , pp. 694-706
    • Yang, S.Q.1    Lin, H.Z.2    Mandal, A.K.3
  • 49
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, metabolic syndrome: Further evidence for an etiologic association
    • Pagano G Pacinin G Musso G et al. Nonalcoholic steatohepatitis, insulin resistance, metabolic syndrome: further evidence for an etiologic association Hepatology 35 2002 367-372
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1    Pacinin, G.2    Musso, G.3
  • 50
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S Abeygunasekera S Farrell G C et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome Hepatology 35 2002 373-379
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 51
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with non-alcoholic steatohepatitis
    • Angulo P Keach J C Batts K P et al. Independent predictors of liver fibrosis in patients with non-alcoholic steatohepatitis Hepatology 30 1999 1356-1362
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3
  • 52
    • 0034116558 scopus 로고    scopus 로고
    • Liver fibrosis in overweight patients
    • Ratziu V Giral P Charlotte F et al. Liver fibrosis in overweight patients Gastroenterology 118 2000 1117-2113
    • (2000) Gastroenterology , vol.118 , pp. 1117-2113
    • Ratziu, V.1    Giral, P.2    Charlott, F.3
  • 55
    • 0024602053 scopus 로고
    • Influence of body fat distribution on free fatty acid metabolism in obesity
    • Jensen M D Haymond M W Rizza R A et al. Influence of body fat distribution on free fatty acid metabolism in obesity Journal of Clinical Investigation 83 1989 1168-1173
    • (1989) Journal of Clinical Investigation , vol.83 , pp. 1168-1173
    • Jensen, M.D.1    Haymond, M.W.2    Rizza, R.A.3
  • 56
    • 0032474246 scopus 로고    scopus 로고
    • Not all fat is alike
    • Arner P Not all fat is alike Lancet 351 1998 1301-1302
    • (1998) Lancet , vol.351 , pp. 1301-1302
    • Arner, P.1
  • 57
    • 0037022005 scopus 로고    scopus 로고
    • Resistin, central obesity, and type 2 diabetes
    • McTernan C L McTernan P G Harte A L et al. Resistin, central obesity, and type 2 diabetes Lancet 359 2002 46-47
    • (2002) Lancet , vol.359 , pp. 46-47
    • McTernan, C.L.1    McTernan, P.G.2    Harte, A.L.3
  • 58
    • 0030936556 scopus 로고    scopus 로고
    • Does central obesity reflect "Cushing's disease of the omentum"?
    • Bujalska I J Kumar S Stewart P M Does central obesity reflect "Cushing's disease of the omentum"? Lancet 349 1997 1210-1213
    • (1997) Lancet , vol.349 , pp. 1210-1213
    • Bujalska, I.J.1    Kumar, S.2    Stewart, P.M.3
  • 59
    • 0032936343 scopus 로고    scopus 로고
    • Glucocorticoids and insulin resistance: Old hormones, new targets
    • Andrews R C Walker B R Glucocorticoids and insulin resistance: old hormones, new targets Clinical Science 966 1999 513-523
    • (1999) Clinical Science , vol.966 , pp. 513-523
    • Andrews, R.C.1    Walker, B.R.2
  • 60
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal K T Wiesbrock S M Marino M W Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function Nature 389 1997 610-614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3
  • 61
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ
    • Yuan M Konstantopoulos N Lee J et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKKβ Science 293 2001 1673-1677
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3
  • 64
    • 0034791616 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription
    • Clarke S D Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription American Journal of Physiology: Gastrointestinal and Liver Physiology 281 2001 G865-G869
    • (2001) American Journal of Physiology: Gastrointestinal and Liver Physiology , vol.281
    • Clarke, S.D.1
  • 66
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman G I Cellular mechanisms of insulin resistance Journal of Clinical Investigation 106 2000 171-176
    • (2000) Journal of Clinical Investigation , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 67
    • 0024452665 scopus 로고
    • Steatohepatitis associated with limb lipodystrophy
    • Powell E E Searle J Mortimer R Steatohepatitis associated with limb lipodystrophy Gastroenterology 97 1989 1022-1024
    • (1989) Gastroenterology , vol.97 , pp. 1022-1024
    • Powell, E.E.1    Searle, J.2    Mortimer, R.3
  • 68
    • 0345983627 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and familial partial lipodystrophy - A strong association
    • (abstract)
    • Martinelli A C Viana C F Montenegro R M et al. Nonalcoholic fatty liver disease and familial partial lipodystrophy - a strong association Hepatology 34 2001 461 (abstract)
    • (2001) Hepatology , vol.34 , pp. 461
    • Martinelli, A.C.1    Viana, C.F.2    Montenegro, R.M.3
  • 69
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity: The antisteatotic role of hyperleptinemia
    • Lee Y Wang M Y Kakuma T et al. Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia Journal of Biological Chemistry 276 2001 5629-5635
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 5629-5635
    • Lee, Y.1    Wang, M.Y.2    Kakuma, T.3
  • 70
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty acid oxidation by activating AMP-activated protein kinase
    • Minokoshi Y Kim Y-B Peroni O D et al. Leptin stimulates fatty acid oxidation by activating AMP-activated protein kinase Nature 415 2002 339-343
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.-B.2    Peroni, O.D.3
  • 71
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in the mechanism of metformin action
    • Zhou G Myers R Li Y et al. Role of AMP-activated protein kinase in the mechanism of metformin action Journal of Clinical Investigation 108 2001 1167-1174
    • (2001) Journal of Clinical Investigation , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 72
    • 0030956006 scopus 로고    scopus 로고
    • Glucocorticoids inhibit mitochondrial matrix acyl-coenzyme A dehydrogenases and fatty acid β-oxidation
    • Letteron P Brahimi-Bourouni N Robin M A et al. Glucocorticoids inhibit mitochondrial matrix acyl-coenzyme A dehydrogenases and fatty acid β-oxidation American Journal of Physiology 272 1997 G1141-G1150
    • (1997) American Journal of Physiology , vol.272
    • Letteron, P.1    Brahimi-Bourouni, N.2    Robin, M.A.3
  • 73
    • 0036156736 scopus 로고    scopus 로고
    • Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression
    • Woodcroft K J Hafner M S Novak R Insulin signaling in the transcriptional and posttranscriptional regulation of CYP2E1 expression Hepatology 35 2002 263-273
    • (2002) Hepatology , vol.35 , pp. 263-273
    • Woodcroft, K.J.1    Hafner, M.S.2    Novak, R.3
  • 74
    • 0035658444 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis III. Peroxisomal β-peroxidation, PPARα, and steatohepatitis
    • Reddy J K Nonalcoholic steatosis and steatohepatitis III. Peroxisomal β-peroxidation, PPARα, and steatohepatitis American Journal of Physiology 281 2001 G1333-G1339
    • (2001) American Journal of Physiology , vol.281
    • Reddy, J.K.1
  • 75
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumours in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    • Fan C-Y Usuda N Yeldandi A V et al. Steatohepatitis, spontaneous peroxisome proliferation and liver tumours in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism Journal of Biological Chemistry 273 1998 15639-15645
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 15639-15645
    • Fan, C.-Y.1    Usuda, N.2    Yeldandi, A.V.3
  • 76
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinaemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V Perlemuter G Bonvoust F et al. High glucose and hyperinsulinaemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis Hepatology 34 2001 738-744
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3
  • 77
    • 33645183446 scopus 로고    scopus 로고
    • Leptin is required for fibrogenic responses in the murine liver induced by thioacetamide
    • (in press)
    • Honda, H, Ikejima, K, Hirose, M, et al. Leptin is required for fibrogenic responses in the murine liver induced by thioacetamide, Hepatology (in press)
    • Hepatology
    • Honda, H.1    Ikejima, K.2    Hirose, M.3
  • 78
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena N K Ikeda K Rockey D C Friedman S L Anania F A Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice Hepatology 35 2002 762-771
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 79
    • 0033983645 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol and cholestatic disease
    • Zein N N Abdulkarim A S Wiesner R H et al. Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol and cholestatic disease Journal of Hepatology 32 2000 209-217
    • (2000) Journal of Hepatology , vol.32 , pp. 209-217
    • Zein, N.N.1    Abdulkarim, A.S.2    Wiesner, R.H.3
  • 80
    • 0033759783 scopus 로고    scopus 로고
    • Prevalence of abnormal serum alanine aminotransferase levels in obese patients and patients with type 2 diabetes
    • Erbey J R Silberman C Lydick E Prevalence of abnormal serum alanine aminotransferase levels in obese patients and patients with type 2 diabetes American Journal of Medicine 109 2000 588-589
    • (2000) American Journal of Medicine , vol.109 , pp. 588-589
    • Erbey, J.R.1    Silberman, C.2    Lydick, E.3
  • 82
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with nonalcoholic steatohepatitis: Insulin resistance, familial tendency, and severity of disease
    • Willner I R Waters B Patil S R et al. Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease American Journal of Gastroenterology 96 2001 2957-2961
    • (2001) American Journal of Gastroenterology , vol.96 , pp. 2957-2961
    • Willner, I.R.1    Waters, B.2    Patil, S.R.3
  • 83
    • 0006168517 scopus 로고    scopus 로고
    • The genetic basis for non-alcoholic and alcoholic steatohepatitis
    • U Leuschner, OFW James, & H Dancygier (eds.), Dordrecht: Kluwer Academic Publishers
    • Day C P Daly A K The genetic basis for non-alcoholic and alcoholic steatohepatitis In Leuschner U James OFW Dancygier H (eds.) Steatohepatitis (NASH and ASH) 2001 43-53 Kluwer Academic Publishers Dordrecht
    • (2001) Steatohepatitis (NASH and ASH) , pp. 43-53
    • Day, C.P.1    Daly, A.K.2
  • 84
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in non-alcoholic steatohepatitis
    • Marchesini G Brizi M Bianchi G et al. Metformin in non-alcoholic steatohepatitis Lancet 358 2001 893-894
    • (2001) Lancet , vol.358 , pp. 893-894
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 85
    • 0035824440 scopus 로고    scopus 로고
    • A transgenic model of visceral obesity and the metabolic syndrome
    • Masuzaki H Paterson J Shinyama H et al. A transgenic model of visceral obesity and the metabolic syndrome Science 294 2001 2166-2170
    • (2001) Science , vol.294 , pp. 2166-2170
    • Masuzaki, H.1    Paterson, J.2    Shinyama, H.3
  • 86
    • 0033846558 scopus 로고    scopus 로고
    • Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes
    • Bernard S Touzet S Personne I et al. Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes Diabetologia 43 2000 995-999
    • (2000) Diabetologia , vol.43 , pp. 995-999
    • Bernard, S.1    Touzet, S.2    Personne, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.