Role of mitochondria in non-alcoholic fatty liver disease

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue SUPPL. 1, 2007, Pages

  Pessayre, Dominique ^a  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Diabetes; Mitochondria; Obesity; Steatohepatitis; Steatosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOKINE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXYNITRITE; POLYPEPTIDE; PROTEIN KINASE C THETA; REACTIVE OXYGEN METABOLITE; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 2;

BIOGENESIS; CELL MEMBRANE; CELL STRESS; CONFERENCE PAPER; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA POLYMORPHISM; ELECTRON; ENZYME ACTIVATION; EXERCISE; FATTY LIVER; FOOD INTAKE; GENE MUTATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; LIPID PEROXIDATION; LIPOGENESIS; LIVER CELL; LIVER INJURY; METABOLIC DISORDER; MITOCHONDRION; MUSCLE; MUSCLE CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY CHAIN;

EID: 34249792393     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04640.x     Document Type: Conference Paper

References (77)

1. Pessayre D, Berson A, Fromenty B, Mansouri A. Mitochondria in steatohepatitis. Semin. Liver Dis. 2001 21 : 57 69.
2. Pessayre D, Mansouri A, Fromenty B. Mitochondrial dysfunction in steatohepatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 2002 282 : G193 9.
3. Pessayre D, Fromenty B, Mansouri A. Mitochondrial injury in steatohepatitis. Eur. J. Gastroenterol. Hepatol. 2004 16 : 1095 105.
4. Pessayre D, Fromenty B. NASH: a mitochondrial disease. J. Hepatol. 2005 42 : 928 40.
5. Yang D, Oyaizu Y, Oyaizu H, Olsen GJ, Woese CR. Mitochondrial origins. Proc. Natl Acad. Sci. USA 1985 82 : 4443 7.
6. Mourier T, Hansen AJ, Willerslev E, Arctander P. The human genome projects reveals a continuous transfer of large mitochondrial fragments to the nucleus. Mol. Biol. Evol. 2001 18 : 1833 7.
7. Taanman JW. The mitochondrial genome: structure, transcription, translation and replication. Biochim. Biophys. Acta 1999 1410 : 103 23.
8. Fromenty B, Pessayre D. Inhibition of mitochondrial β-oxidation as a mechanism of hepatotoxicity. Pharmacol. Ther. 1995 67 : 101 54.
9. Frøsig C, Jørgensen SB, Hardie DG, Richter EA, Wojtaszewski JFP. 5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 2004 286 : E411 17.
10. Wu H, Kanatous SB, Thurmond FA et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 2002 296 : 349 52.
11. Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in the transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 2000 20 : 1868 76.
12. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 2000 106 : 847 56.
13. Wis I, Øff U, Najjar SM et al. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science 2005 307 : 418 20.
14. Shepherd PR, Kahn BB. Glucose transporters and insulin action. Implications for insulin resistance and diabetes mellitus. N. Engl. J. Med. 1999 341 : 248 57.
15. Mootha VK, Lindgren CM, Eriksson KF et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately down-regulated in human diabetes. Nat. Genet. 2003 34 : 267 73.
16. Patti ME, Butte AJ, Crunkhorn S et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl Acad. Sci. USA 2003 100 : 8466 71.
17. Colberg SR, Simoneau JA, Thaete FL, Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J. Clin. Invest. 1995 95 : 1846 53.
18. Simoneau JA, Veerkamp JH, Turcotte LP, Kelley DE. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J. 1999 13 : 2051 60.
19. Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002 51 : 2944 50.
20. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 2004 350 : 664 71.
21. Rimbert V, Boirie Y, Bedu M, Hocquette JF, Ritz P, Morio B. Muscle oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB J. 2004 18 : 737 9.
22. Sparks LM, Xie H, Koza RA et al. High-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005 54 : 1926 33.
23. Muller YL, Bogardus C, Pedersen O, Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor γ coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima indians. Diabetes 2003 52 : 895 8.
24. Ek J, Andersen G, Urhammer SA et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 2001 44 : 2220 6.
25. Hara K, Tobe K, Okada T et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 2003 45 : 740 3.
26. Petersen KF, Befroy D, Dufour S et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003 300 : 1140 2.
27. Wang Y, Michikawa Y, Mallidis C et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc. Natl Acad. Sci. USA 2001 98 : 4022 7.
28. Perseghin G, Scifo P, De Cobelli F et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans. A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999 48 : 1600 6.
29. Kim JK, Filmore JJ, Sunshine MJ et al. PKC-θ knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 2004 114 : 823 7.
30. Hirosumi J, Tuncman G, Chang L et al. A central role for JNK in obesity and insulin resistance. Nature 2002 420 : 353 6.
31. Özcan U, Cao Q, Yilmaz E et al. Endoplasmic reticulum stress links obesity, insulin action and type 2 diabetes. Science 2004 306 : 457 61.
32. Polonsky KS, Sturis J, Bell GI. Non-insulin-dependent diabetes mellitus: a genetically programmed failure of beta cell to compensate for insulin resistance. N. Engl. J. Med. 1996 334 : 777 83.
33. Maechler P, Wollheim CB. Mitochondrial function in normal and diabetic β-cells. Nature 2001 414 : 807 12.
34. Anello M, Lupi R, Spampinato D et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 2005 48 : 282 9.
35. Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 2001 50 : 802 9.
36. Krauss S, Zhang CY, Scorrano L et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β-cell dysfunction. J. Clin. Invest. 2003 112 : 1831 42.
37. Joseph JW, Koshkin V, Saleh MC et al. Free fatty acid-induced β-cell defects are dependent on uncoupling protein-2 expression. J. Biol. Chem. 2004 279 : 51049 56.
38. Sasahara M, Nishi M, Kawashima H et al. Uncoupling protein 2 promoter polymorphism - 866G/A affects its expression in β-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 2004 53 : 482 5.
39. Sesti G, Gardellini M, Marini MA et al. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 2003 52 : 1280 3.
40. Esterbauer H, Schneitler C, Oberkofler H et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nature Genet 2001 28 : 178 83.
41. Van den Ouweland JMW, Lemkes HHPJ, Ruitenbeek W et al. Mutation in mitochondrial tRNALeu (UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet 1992 1 : 368 71.
42. Ballinger SW, Shoffner JM, Hedaya et al. Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nat. Genet 1992 1 : 11 15.
43. El-Assaad W, Buteau J, Peyot ML et al. Saturated fatty acids synergize with elevated glucose to cause pancreatic β-cell death. Endocrinology 2003 144 : 4154 63.
44. Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger RH. Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 1982 31 : 694 700.
45. Gorden ES. Non-esterified fatty acids in blood of obese and lean subjects. Am. J. Clin. Nutr. 1960 8 : 740 7.
46. Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004 114 : 147 52.
47. Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 1999 274 : 30 28 32.
48. Yamashita H, Takenoshita M, Sakurai M et al. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc. Natl Acad. Sci. USA 2001 98 : 9116 21.
49. Lizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc. Natl Acad. Sci. USA 2004 101 : 7281 6.
50. Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am. J. Physiol. Endocrinol. Metab. 2002 282 : E46 51.
51. Cook GA, Gamble MS. Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA. J. Biol. Chem. 1987 262 : 2050 5.
52. Brady LJ, Brady PS, Romsos DR, Hoppel CL. Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese (ob/ob) mice. Biochem. J. 1985 231 : 439 44.
53. Cortez-Pinto H, Lin HZ, Yang SQ, Da Costa SOD, Diehl AM. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. Gastroenterology 1999 116 : 1184 93.
54. Sanyal AJ, Campbell-Sargent C, Mirshahi F et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001 120 : 1183 92.
55. Chalasani N, Gorki JC, Asghar MS et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology 2003 37 : 544 50.
56. Miele L, Grieco A, Armuzzi A et al. Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test. Am. J. Gastroenterol. 2003 98 : 2335 6.
57. Adiels M, Boren J, Caslake MJ et al. Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia. Arterioscler. Thromb. Vasc. Biol. 2005 25 : 16 67 703.
58. Charlton M, Sreekumar R, Rasmussen D, Lindor K, Nair S. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 2002 35 : 898 904.
59. Sparks JD, Sparks CE. Obese Zucker (fa/fa) rats are resistant to insulin's inhibitory effects on hepatic apo B secretion. Biochem. Biophys. Res. Commun. 1994 205 : 417 22.
60. Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis. A pilot study. J. Am. Med. Assoc. 1999 282 : 1659 64.
61. Caldwell SH, Swerdlow RH, Khan EM et al. Mitochondrial abnormalities in nonalcoholic steatohepatitis. J. Hepatol. 1999 31 : 430 4.
62. Pérez-Carreras M, Del Hoyo P, Martin MA et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology 2003 38 : 999 1007.
63. Haque M, Mirshahi F, Campbell-Sargent C et al. Nonalcoholic steatohepatitis (NASH) is associated with hepatocyte mitochondrial DNA depletion. Hepatology 2002 36 : 403A.
64. Yang S, Zhu H, Li Y et al. Mitochondrial adaptations to obesity-related oxidant stress. Arch. Biochem. Biophys. 2000 378 : 259 68.
65. Hensley K, Kotake Y, Sang H et al. Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria. Carcinogenesis 2000 21 : 983 9.
66. Gao D, Wei C, Chen L, Huang J, Yang S, Diehl AM. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 2004 287 : G1070 7.
67. Chen J, Schenker S, Frosto TA, Henderson GI. Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE). Role of HNE adduct formation with the enzyme catalytic site. Biochem. Biophys. Acta 1998 1380 : 336 44.
68. Chen J, Petersen DR, Schenker S, Henderson GI. Formation of malondialdehyde adducts in livers of rats exposed to ethanol: role of ethanol-mediated inhibition of cytochrome c oxidase. Alcohol. Clin. Exp. Res. 2000 24 : 544 52.
69. Feldstein AE, Canbay A, Angulo P et al. Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003 125 : 437 43.
70. Canbay A, Taimr P, Torok N, Higuchi H, Friedman S, Gores GJ. Apoptotic body engulfment by a human stellate cell line is profibrogenic. Lab. Invest. 2003 83 : 655 63.
71. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J. Clin. Invest. 1998 101 : 890 8.
72. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998 395 : 763 70.
73. Leonarduzzi G, Scavazza A, Biasi F et al. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. FASEB J. 1997 11 : 851 7.
74. Parola M, Pinzani M, Casini A et al. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen α1 (I) gene expression in human liver fat-storing cells. Biochem. Biophys. Res. Commun. 1993 194 : 1044 50.
75. Ikejima K, Takei Y, Honda H et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002 122 : 1399 40.
76. Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002 35 : 762 71.
77. Fukuda K, Kojiro M, Chiu JF. Induction of apoptosis by transforming growth factor-β1 in the rat hepatoma cell line McA-RH7777: a possible association with tissue transglutaminase expression. Hepatology 1993 18 : 945 53.