메뉴 건너뛰기




Volumn 4, Issue 12, 2013, Pages

TOR-centric view on insulin resistance and diabetic complications: Perspective for endocrinologists and gerontologists

Author keywords

aging; diseases; rapalogs; rapamycin; senescence

Indexed keywords

INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

EID: 84891785508     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.506     Document Type: Review
Times cited : (104)

References (175)
  • 1
    • 33745851096 scopus 로고    scopus 로고
    • Insulin resistance and pancreatic beta cell failure
    • Kasuga M. Insulin resistance and pancreatic beta cell failure. J Clin Invest 2006; 116: 1756-1760
    • (2006) J Clin Invest , vol.116 , pp. 1756-1760
    • Kasuga, M.1
  • 2
    • 33745476017 scopus 로고    scopus 로고
    • Diabetic microvascular complications-can the presence of one predict the development of another
    • Girach A, Vignati L. Diabetic microvascular complications-can the presence of one predict the development of another. J Diabetes Complications 2006; 20: 228-237
    • (2006) J Diabetes Complications , vol.20 , pp. 228-237
    • Girach, A.1    Vignati, L.2
  • 3
    • 11944263528 scopus 로고
    • Onset of niddm occurs at least 4-7yr before clinical diagnosis
    • Harris MI, Klein R, Welborn TA, Knuiman MW. Onset of NIDDM occurs at least 4-7yr before clinical diagnosis. Diabetes Care 1992; 15: 815-819
    • (1992) Diabetes Care , vol.15 , pp. 815-819
    • Harris, M.I.1    Klein, R.2    Welborn, T.A.3    Knuiman, M.W.4
  • 4
    • 79951711413 scopus 로고    scopus 로고
    • Glycemic thresholds for diabetes-specific retinopathy: Implications for diagnostic criteria for diabetes
    • Colagiuri S, Lee CM, Wong TY, Balkau B, Shaw JE, Borch-Johnsen K. Glycemic thresholds for diabetes-specific retinopathy: Implications for diagnostic criteria for diabetes. Diabetes Care 2011; 34: 145-150
    • (2011) Diabetes Care , vol.34 , pp. 145-150
    • Colagiuri, S.1    Lee, C.M.2    Wong, T.Y.3    Balkau, B.4    Shaw, J.E.5    Borch-Johnsen, K.6
  • 5
    • 80052120069 scopus 로고    scopus 로고
    • Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: A cross-sectional study
    • Ellis JD, Zvandasara T, Leese G, McAlpine R, Macewen CJ, Baines PS et al. Clues to duration of undiagnosed disease from retinopathy and maculopathy at diagnosis in type 2 diabetes: A cross-sectional study. Br J Ophthalmol 2011; 95: 1229-1233
    • (2011) Br J Ophthalmol , vol.95 , pp. 1229-1233
    • Ellis, J.D.1    Zvandasara, T.2    Leese, G.3    McAlpine, R.4    Macewen, C.J.5    Baines, P.S.6
  • 6
    • 0031972613 scopus 로고    scopus 로고
    • Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (niddm
    • Cohen JA, Jeffers BW, Faldut D, Marcoux M, Schrier RW. Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM). Muscle Nerve 1998; 21: 72-80
    • (1998) Muscle Nerve , vol.21 , pp. 72-80
    • Cohen, J.A.1    Jeffers, B.W.2    Faldut, D.3    Marcoux, M.4    Schrier, R.W.5
  • 7
    • 33646269278 scopus 로고    scopus 로고
    • Therapy insight: Neurological complications of prediabetes
    • Singleton JR, Smith AG. Therapy insight: Neurological complications of prediabetes. Nat Clin Pract Neurol 2006; 2: 276-282
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 276-282
    • Singleton, J.R.1    Smith, A.G.2
  • 8
    • 37349105692 scopus 로고    scopus 로고
    • Neuropathy associated with prediabetes: What is new in 2007
    • Singleton JR, Smith AG. Neuropathy associated with prediabetes: What is new in 2007? Curr Diab Rep 2007; 7: 420-424
    • (2007) Curr Diab Rep , vol.7 , pp. 420-424
    • Singleton, J.R.1    Smith, A.G.2
  • 9
    • 0036598583 scopus 로고    scopus 로고
    • Longitudinal association of glycemia and microalbuminuria: The framingham offspring study
    • Meigs JB, D'Agostino RBS, Nathan DM, Rifai N, Wilson PW. Longitudinal association of glycemia and microalbuminuria: The Framingham Offspring Study. Diabetes Care 2002; 25: 977-983
    • (2002) Diabetes Care , vol.25 , pp. 977-983
    • Meigs, J.B.1    D'Agostino, R.B.S.2    Nathan, D.M.3    Rifai, N.4    Wilson, P.W.5
  • 10
    • 33750596002 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes
    • Groop PH, Forsblom C, Thomas MC. Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab 2005; 1: 100-110
    • (2005) Nat Clin Pract Endocrinol Metab , vol.1 , pp. 100-110
    • Groop, P.H.1    Forsblom, C.2    Thomas, M.C.3
  • 11
    • 33846626478 scopus 로고    scopus 로고
    • The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the diabetes prevention program
    • Diabetes prevention program research group
    • Diabetes Prevention Program Research Group. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program. Diabet Med 2007; 24: 137-144
    • (2007) Diabet Med , vol.24 , pp. 137-144
  • 12
    • 33644652509 scopus 로고    scopus 로고
    • Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes
    • Wong TY, Mohamed Q, Klein R, Couper DJ. Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes? Br J Ophthalmol 2006; 90: 301-303
    • (2006) Br J Ophthalmol , vol.90 , pp. 301-303
    • Wong, T.Y.1    Mohamed, Q.2    Klein, R.3    Couper, D.J.4
  • 13
  • 14
    • 0036276294 scopus 로고    scopus 로고
    • Obesity, diabetes, and risk of cardiovascular disease in the elderly
    • Wilson PW, Kannel WB. Obesity, diabetes, and risk of cardiovascular disease in the elderly. Am J Geriatr Cardiol 2002; 11: 119-123
    • (2002) Am J Geriatr Cardiol , vol.11 , pp. 119-123
    • Wilson, P.W.1    Kannel, W.B.2
  • 16
    • 70450159843 scopus 로고    scopus 로고
    • Downregulation of serum IGF-1 for treatment of early worsening of diabetic retinopathy: A long-Term follow-up of two cases
    • Chantelau E, Meyer-Schwickerath R, Klabe K. Downregulation of serum IGF-1 for treatment of early worsening of diabetic retinopathy: A long-Term follow-up of two cases. Ophthalmologica 2010; 224: 243-246
    • (2010) Ophthalmologica , vol.224 , pp. 243-246
    • Chantelau, E.1    Meyer-Schwickerath, R.2    Klabe, K.3
  • 17
    • 0026985137 scopus 로고
    • Irreversible progression of severe retinopathy in young type I insulin-dependent diabetes mellitus patients after improved metabolic control
    • Agardh CD, Eckert B, Agardh E. Irreversible progression of severe retinopathy in young type I insulin-dependent diabetes mellitus patients after improved metabolic control. J Diabetes Complications 1992; 6: 96-100
    • (1992) J Diabetes Complications , vol.6 , pp. 96-100
    • Agardh, C.D.1    Eckert, B.2    Agardh, E.3
  • 18
    • 0033364506 scopus 로고    scopus 로고
    • Progression of retinopathy after improved metabolic control in type 2 diabetic patients relation to igf-1 and hemostatic variables
    • Henricsson M, Berntorp K, Berntorp E, Fernlund P, Sundkvist G. Progression of retinopathy after improved metabolic control in type 2 diabetic patients. Relation to IGF-1 and hemostatic variables. Diabetes Care 1999; 22: 1944-1949
    • (1999) Diabetes Care , vol.22 , pp. 1944-1949
    • Henricsson, M.1    Berntorp, K.2    Berntorp, E.3    Fernlund, P.4    Sundkvist, G.5
  • 19
    • 0028865515 scopus 로고
    • Progression of retinopathy after change of treatment from oral antihyperglycemic agents to insulin in patients with NIDDM
    • Henricsson M, Janzon L, Groop L. Progression of retinopathy after change of treatment from oral antihyperglycemic agents to insulin in patients with NIDDM. Diabetes Care 1995; 18: 1571-1576
    • (1995) Diabetes Care , vol.18 , pp. 1571-1576
    • Henricsson, M.1    Janzon, L.2    Groop, L.3
  • 20
    • 0026469208 scopus 로고
    • Effect of rapid glycemic control on progression of diabetic retinopathy
    • Funatsu H, Yamashita H, Ohashi Y, Ishigaki T. Effect of rapid glycemic control on progression of diabetic retinopathy. Jpn J Ophthalmol 1992; 36: 356-367
    • (1992) Jpn J Ophthalmol , vol.36 , pp. 356-367
    • Funatsu, H.1    Yamashita, H.2    Ohashi, Y.3    Ishigaki, T.4
  • 21
    • 77951730299 scopus 로고    scopus 로고
    • Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy
    • Gibbons CH, Freeman R. Treatment-induced diabetic neuropathy: A reversible painful autonomic neuropathy. Ann Neurol 2010; 67: 534-541
    • (2010) Ann Neurol , vol.67 , pp. 534-541
    • Gibbons, C.H.1    Freeman, R.2
  • 22
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mtor/p70 s6 kinase pathway a negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 2001; 276: 38052-38060
    • (2001) J Biol Chem , vol.276 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 23
    • 77953577017 scopus 로고    scopus 로고
    • Mtor's role in ageing: Protein synthesis or autophagy
    • Hands SL, Proud CG, Wyttenbach A. mTOR's role in ageing: Protein synthesis or autophagy? Aging (Albany NY) 2009; 1: 586-597
    • (2009) Aging (Albany NY , vol.1 , pp. 586-597
    • Hands, S.L.1    Proud, C.G.2    Wyttenbach, A.3
  • 25
    • 78650510609 scopus 로고    scopus 로고
    • Mtor: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 26
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: A common molecular mechanism. Aging 2009; 1: 357-362
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 27
    • 84874807522 scopus 로고    scopus 로고
    • Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
    • Leontieva OV, Geraldine M, Paszkiewicz GM, Blagosklonny MV. Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging (Albany NY) 2012; 4: 899-891
    • (2012) Aging (Albany NY , vol.4 , pp. 899-891
    • Leontieva, O.V.1    Geraldine, M.2    Paszkiewicz, G.M.3    Blagosklonny, M.V.4
  • 28
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7: 3355-3361
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 31
    • 79958248002 scopus 로고    scopus 로고
    • Be quiet and yoúll keep young: Does mTOR underlie p53 action in protecting against senescence by favoring quiescence
    • Dulic V. Be quiet and yoúll keep young: Does mTOR underlie p53 action in protecting against senescence by favoring quiescence? Aging (Albany NY) 2011; 3: 3-4
    • (2011) Aging (Albany NY , vol.3 , pp. 3-4
    • Dulic, V.1
  • 32
    • 79952116991 scopus 로고    scopus 로고
    • Tp53 and mtor crosstalk to regulate cellular senescence
    • Galluzzi L, Kepp O, Kroemer G. TP53 and MTOR crosstalk to regulate cellular senescence. Aging (Albany NY) 2010; 2: 535-537
    • (2010) Aging (Albany NY , vol.2 , pp. 535-537
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 33
    • 84871503188 scopus 로고    scopus 로고
    • Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells
    • Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle 2012; 11: 4642-4649
    • (2012) Cell Cycle , vol.11 , pp. 4642-4649
    • Leontieva, O.V.1    Lenzo, F.2    Demidenko, Z.N.3    Blagosklonny, M.V.4
  • 35
    • 84868302065 scopus 로고    scopus 로고
    • Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
    • Hinojosa CA, Mgbemena V, Van Roekel S, Austad SN, Miller RA, Bose S et al. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol 2012; 47: 958-965
    • (2012) Exp Gerontol , vol.47 , pp. 958-965
    • Hinojosa, C.A.1    Mgbemena, V.2    Van Roekel, S.3    Austad, S.N.4    Miller, R.A.5    Bose, S.6
  • 36
    • 84874925174 scopus 로고    scopus 로고
    • Potential anti-Aging agents suppress the level of constitutive mtor-And dna damage-signaling
    • Halicka HD, Zhao H, Li J, Lee YS, Hsieh TC, Wu JM et al. Potential anti-Aging agents suppress the level of constitutive mTOR-And DNA damage-signaling. Aging (Albany NY) 2012; 4: 952-965
    • (2012) Aging (Albany NY , vol.4 , pp. 952-965
    • Halicka, H.D.1    Zhao, H.2    Li, J.3    Lee, Y.S.4    Hsieh, T.C.5    Wu, J.M.6
  • 37
    • 84870692721 scopus 로고    scopus 로고
    • Exploiting the mTOR paradox for disease prevention
    • Iglesias-Bartolome R, Gutkind SJ. Exploiting the mTOR paradox for disease prevention. Oncotarget 2012; 3: 1061-1063
    • (2012) Oncotarget , vol.3 , pp. 1061-1063
    • Iglesias-Bartolome, R.1    Gutkind, S.J.2
  • 39
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities
    • Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities. J Clin Invest 2013; 123: 966-972
    • (2013) J Clin Invest , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 40
    • 84891713034 scopus 로고    scopus 로고
    • Senescenceassociated secretory phenotypes reveal cell-nonautonomous functions of oncogenic ras and the p53 tumor suppressor
    • CoppŽ JP, Patil CK, Rodier F, Sun Y, Mu-oz DP, Goldstein J et al. Senescenceassociated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 2008; 6: 2853-2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • CoppŽ, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Mu-oz, D.P.5    Goldstein, J.6
  • 41
    • 84862891914 scopus 로고    scopus 로고
    • Cell cycle arrest is not yet senescence which is not just cell cycle arrest: Terminology for tor-driven aging
    • Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: Terminology for TOR-driven aging. Aging (Albany NY) 2012; 4: 159-165
    • (2012) Aging (Albany NY , vol.4 , pp. 159-165
    • Blagosklonny, M.V.1
  • 42
    • 84878357576 scopus 로고    scopus 로고
    • Senescence-Associated secretory phenotype favors the emergence of cancer stem-like cells
    • Cahu J, Bustany S, Sola B. Senescence-Associated secretory phenotype favors the emergence of cancer stem-like cells. Cell Death Dis 2012; 3: E446
    • (2012) Cell Death Dis , vol.3
    • Cahu, J.1    Bustany, S.2    Sola, B.3
  • 44
    • 84874801912 scopus 로고    scopus 로고
    • Answering the ultimate question 'what is the proximal cause of aging?
    • Blagosklonny MV. Answering the ultimate question 'what is the proximal cause of aging?'. Aging (Albany NY) 2012; 4: 861-877
    • (2012) Aging (Albany NY , vol.4 , pp. 861-877
    • Blagosklonny, M.V.1
  • 45
    • 77955739991 scopus 로고    scopus 로고
    • Why men age faster but reproduce longer than women: MTOR and evolutionary perspectives
    • Blagosklonny MV. Why men age faster but reproduce longer than women: MTOR and evolutionary perspectives. Aging (Albany NY) 2010; 2: 265-273
    • (2010) Aging (Albany NY , vol.2 , pp. 265-273
    • Blagosklonny, M.V.1
  • 46
    • 84866494334 scopus 로고    scopus 로고
    • Prospective treatment of age-related diseases by slowing down aging
    • Blagosklonny MV. Prospective treatment of age-related diseases by slowing down aging. Am J Pathol 2012; 181: 1142-1146
    • (2012) Am J Pathol , vol.181 , pp. 1142-1146
    • Blagosklonny, M.V.1
  • 47
    • 84868027889 scopus 로고    scopus 로고
    • How to save Medicare: The anti-Aging remedy
    • Blagosklonny MV. How to save Medicare: The anti-Aging remedy. Aging (Albany NY) 2012; 4: 547-552
    • (2012) Aging (Albany NY , vol.4 , pp. 547-552
    • Blagosklonny, M.V.1
  • 48
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: Quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle 2006; 5: 2087-2102
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 49
    • 33847226657 scopus 로고    scopus 로고
    • An anti-Aging drug today: From senescence-promoting genes to antiaging pill
    • Blagosklonny MV. An anti-Aging drug today: From senescence-promoting genes to antiaging pill. Drug Disc Today 2007; 12: 218-224
    • (2007) Drug Disc Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1
  • 50
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mtor) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today 2007; 12: 112-124
    • (2007) Drug Disc Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 51
    • 84872527628 scopus 로고    scopus 로고
    • Mtor is a key modulator of ageing and age-related disease
    • Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013; 493: 338-345
    • (2013) Nature , vol.493 , pp. 338-345
    • Johnson, S.C.1    Rabinovitch, P.S.2    Kaeberlein, M.3
  • 52
    • 84861917512 scopus 로고    scopus 로고
    • Autophagy and cardiovascular aging: Lesson learned from rapamycin
    • Nair S, Ren J. Autophagy and cardiovascular aging: Lesson learned from rapamycin. Cell Cycle 2012; 11: 2092-2099
    • (2012) Cell Cycle , vol.11 , pp. 2092-2099
    • Nair, S.1    Ren, J.2
  • 53
    • 79959539851 scopus 로고    scopus 로고
    • Normalizing a hyperactive mtor initiates muscle growth during obesity
    • Williamson DL. Normalizing a hyperactive mTOR initiates muscle growth during obesity. Aging (Albany NY) 2011; 3: 83-84
    • (2011) Aging (Albany NY , vol.3 , pp. 83-84
    • Williamson, D.L.1
  • 54
    • 84884941853 scopus 로고    scopus 로고
    • Rapamycin extends life-And health span because it slows aging
    • Blagosklonny MV. Rapamycin extends life-And health span because it slows aging. Aging (Albany NY) 2013; 5: 592-598
    • (2013) Aging (Albany NY , vol.5 , pp. 592-598
    • Blagosklonny, M.V.1
  • 55
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogenous mice
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K et al. Rapamycin fed late in life extends lifespan in genetically heterogenous mice. Nature 2009; 460: 392-396
    • (2009) Nature , vol.460 , pp. 392-396
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 56
    • 80051606004 scopus 로고    scopus 로고
    • Potential of mtor inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex
    • Major P. Potential of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas in tuberous sclerosis complex. Aging (Albany NY) 2011; 3: 189-191
    • (2011) Aging (Albany NY , vol.3 , pp. 189-191
    • Major, P.1
  • 61
    • 84872787640 scopus 로고    scopus 로고
    • The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson disease pathway
    • Levine AJ, Harris CR, Puzio-Kuter AM. The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson disease pathway. Oncotarget 2012; 3: 1301-1307
    • (2012) Oncotarget , vol.3 , pp. 1301-1307
    • Levine, A.J.1    Harris, C.R.2    Puzio-Kuter, A.M.3
  • 62
    • 84872561715 scopus 로고    scopus 로고
    • Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
    • Donehower LA. Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency. Aging (Albany NY) 2012; 4: 660-661
    • (2012) Aging (Albany NY , vol.4 , pp. 660-661
    • Donehower, L.A.1
  • 63
    • 84865525400 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and noncognitive components of behavior throughout lifespan in mice
    • Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB et al. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and noncognitive components of behavior throughout lifespan in mice. Neuroscience 2012; 223: 102-113
    • (2012) Neuroscience , vol.223 , pp. 102-113
    • Halloran, J.1    Hussong, S.A.2    Burbank, R.3    Podlutskaya, N.4    Fischer, K.E.5    Sloane, L.B.6
  • 66
    • 77955747346 scopus 로고    scopus 로고
    • With tor less is more: A key role for the conserved nutrient-sensing tor pathway in aging
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL et al. With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab 2010; 11: 453-465
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6
  • 67
    • 83755206860 scopus 로고    scopus 로고
    • Rapamycin: Killing two birds with one stone
    • Khanna A, Kapahi P. Rapamycin: Killing two birds with one stone. Aging (Albany NY) 2011; 3: 1043-1044
    • (2011) Aging (Albany NY , vol.3 , pp. 1043-1044
    • Khanna, A.1    Kapahi, P.2
  • 68
    • 83755186591 scopus 로고    scopus 로고
    • Intermittent supplementation with rapamycin as a dietary restriction mimetic
    • Longo VD, Fontana L. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY) 2011; 3: 1039-1040
    • (2011) Aging (Albany NY , vol.3 , pp. 1039-1040
    • Longo, V.D.1    Fontana, L.2
  • 69
    • 84881102986 scopus 로고    scopus 로고
    • Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
    • Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG et al. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging (Albany NY) 2013; 5: 539-550
    • (2013) Aging (Albany NY , vol.5 , pp. 539-550
    • Ye, L.1    Widlund, A.L.2    Sims, C.A.3    Lamming, D.W.4    Guan, Y.5    Davis, J.G.6
  • 71
    • 16844370268 scopus 로고    scopus 로고
    • Regulation of insulin signalling by hyperinsulinaemia: Role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
    • Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM et al. Regulation of insulin signalling by hyperinsulinaemia: Role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Diabetologia 2005; 48: 506-518
    • (2005) Diabetologia , vol.48 , pp. 506-518
    • Ueno, M.1    Carvalheira, J.B.2    Tambascia, R.C.3    Bezerra, R.M.4    Amaral, M.E.5    Carneiro, E.M.6
  • 72
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the tsc/rheb/mtor/s6k cassette induces irs1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004; 14: 1650-1656
    • (2004) Curr Biol , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 73
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 2006; 26: 63-76
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 74
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance. Endocrinology 2005; 146: 1473-1481
    • (2005) Endocrinology , vol.146 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 75
    • 35348832340 scopus 로고    scopus 로고
    • Identification of irs-1 ser-1101 as a target of s6k1 in nutrient-And obesity-induced insulin resistance
    • Tremblay F, BržlŽ S, Hee UmS, Li Y, Masuda K, Roden M et al. Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient-And obesity-induced insulin resistance. Proc Natl Acad Sci USA 2007; 104: 14056-14061
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14056-14061
    • Tremblay, F.1    Bržlž, S.2    Hee, U.M.S.3    Li, Y.4    Masuda, K.5    Roden, M.6
  • 76
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 2005; 54: 2674-2684
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3    Brehm, A.4    Bernroider, E.5    Roth, E.6
  • 77
    • 80055115885 scopus 로고    scopus 로고
    • Insulin resistance due to nutrient excess: Is it a consequence of ampk downregulation
    • Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: Is it a consequence of AMPK downregulatioñ Cell Cycle 2011; 10: 3447-3451
    • (2011) Cell Cycle , vol.10 , pp. 3447-3451
    • Saha, A.K.1    Xu, X.J.2    Balon, T.W.3    Brandon, A.4    Kraegen, E.W.5    Ruderman, N.B.6
  • 78
    • 79955664598 scopus 로고    scopus 로고
    • Chronically increased s6k1 is associated with impaired irs1 signaling in skeletal muscle of gdm women with impaired glucose tolerance postpartum
    • Barbour LA, McCurdy CE, Hernandez TL, Friedman JE. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. J Clin Endocrinol Metab 2011; 96: 1431-1441
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1431-1441
    • Barbour, L.A.1    McCurdy, C.E.2    Hernandez, T.L.3    Friedman, J.E.4
  • 79
    • 79958696694 scopus 로고    scopus 로고
    • The mtor-regulated phosphoproteome reveals a mechanism of mtorc1-mediated inhibition of growth factor signaling
    • Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 2011; 332: 1317-1322
    • (2011) Science , vol.332 , pp. 1317-1322
    • Hsu, P.P.1    Kang, S.A.2    Rameseder, J.3    Zhang, Y.4    Ottina, K.A.5    Lim, D.6
  • 80
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villen J et al. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011; 332: 1322-1326
    • (2011) Science , vol.332 , pp. 1322-1326
    • Yu, Y.1    Yoon, S.O.2    Poulogiannis, G.3    Yang, Q.4    Ma, X.M.5    Villen, J.6
  • 81
    • 33750922694 scopus 로고    scopus 로고
    • Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
    • Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A et al. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006; 49: 3049-3057
    • (2006) Diabetologia , vol.49 , pp. 3049-3057
    • Korsheninnikova, E.1    Van Der Zon, G.C.2    Voshol, P.J.3    Janssen, G.M.4    Havekes, L.M.5    Grefhorst, A.6
  • 82
    • 34249679233 scopus 로고    scopus 로고
    • The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
    • Krebs M, Brunmair B, Brehm A, Artwohl M, Szendroedi J, Nowotny P et al. The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. Diabetes 2007; 56: 1600-1607
    • (2007) Diabetes , vol.56 , pp. 1600-1607
    • Krebs, M.1    Brunmair, B.2    Brehm, A.3    Artwohl, M.4    Szendroedi, J.5    Nowotny, P.6
  • 83
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/akt/mtor pathway mediates and pten antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 2001; 98: 4640-4645
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6
  • 84
    • 84863329778 scopus 로고    scopus 로고
    • Inflammaging: Disturbed interplay between autophagy and inflammasomes
    • Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: Disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) 2012; 4: 166-175
    • (2012) Aging (Albany NY , vol.4 , pp. 166-175
    • Salminen, A.1    Kaarniranta, K.2    Kauppinen, A.3
  • 85
    • 84863431784 scopus 로고    scopus 로고
    • Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB
    • Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging (Albany NY) 2012; 4: 98-115
    • (2012) Aging (Albany NY , vol.4 , pp. 98-115
    • Cai, D.1    Liu, T.2
  • 86
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans
    • Blagosklonny MV. Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans). Cell Cycle 2010; 9: 683-688
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 87
    • 39749190584 scopus 로고    scopus 로고
    • A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle
    • Glynn EL, Lujan HL, Kramer VJ, Drummond MJ, DiCarlo SE, Rasmussen BB. A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle. Appl Physiol Nutr Metab 2008; 33: 93-101
    • (2008) Appl Physiol Nutr Metab , vol.33 , pp. 93-101
    • Glynn, E.L.1    Lujan, H.L.2    Kramer, V.J.3    Drummond, M.J.4    DiCarlo, S.E.5    Rasmussen, B.B.6
  • 88
    • 0036196081 scopus 로고    scopus 로고
    • Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF
    • Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J et al. Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest 2002; 109: 805-815
    • (2002) J Clin Invest , vol.109 , pp. 805-815
    • Poulaki, V.1    Qin, W.2    Joussen, A.M.3    Hurlbut, P.4    Wiegand, S.J.5    Rudge, J.6
  • 89
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331: 1480-1487
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3    Keyt, B.A.4    Jampel, H.D.5    Shah, S.T.6
  • 90
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16: 4604-4613
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6
  • 91
    • 31944433624 scopus 로고    scopus 로고
    • Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development
    • Vinores SA, Xiao WH, Aslam S, Shen J, Oshima Y, Nambu H et al. Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development. J Cell Physiol 2006; 206: 749-758
    • (2006) J Cell Physiol , vol.206 , pp. 749-758
    • Vinores, S.A.1    Xiao, W.H.2    Aslam, S.3    Shen, J.4    Oshima, Y.5    Nambu, H.6
  • 93
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 2002; 277: 27975-27981
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 94
    • 3242875457 scopus 로고    scopus 로고
    • Igf-1-induced vegf and igfbp-3 secretion correlates with increased hif-1 alpha expression and activity in retinal pigment epithelial cell line d407
    • Slomiany MG, Rosenzweig SA. IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci 2004; 45: 2838-2847
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 2838-2847
    • Slomiany, M.G.1    Rosenzweig, S.A.2
  • 95
    • 79956014865 scopus 로고    scopus 로고
    • The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1alpha
    • Demidenko ZN, Blagosklonny MV. The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1alpha. Cell Cycle 2011; 10: 1557-1562
    • (2011) Cell Cycle , vol.10 , pp. 1557-1562
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 96
    • 0032758384 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor
    • Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med 1999; 5: 1390-1395
    • (1999) Nat Med , vol.5 , pp. 1390-1395
    • Smith, L.E.1    Shen, W.2    Perruzzi, C.3    Soker, S.4    Kinose, F.5    Xu, X.6
  • 98
    • 15944411740 scopus 로고    scopus 로고
    • Progression of diabetic retinopathy during improved metabolic control may be treated with reduced insulin dosage and/or somatostatin analogue administration-A case report
    • Chantelau E, Frystyk J. Progression of diabetic retinopathy during improved metabolic control may be treated with reduced insulin dosage and/or somatostatin analogue administration-A case report. Growth Horm IGF Res 2005; 15: 130-135
    • (2005) Growth Horm IGF Res , vol.15 , pp. 130-135
    • Chantelau, E.1    Frystyk, J.2
  • 102
    • 84865013696 scopus 로고    scopus 로고
    • Chemoprevention of age-related macular regeneration (AMD) with rapamycin
    • Zheng XF. Chemoprevention of age-related macular regeneration (AMD) with rapamycin. Aging (Albany NY) 2012; 4: 375-376
    • (2012) Aging (Albany NY , vol.4 , pp. 375-376
    • Zheng, X.F.1
  • 106
    • 34748880045 scopus 로고    scopus 로고
    • Rapamycin prevents early steps of the development of diabetic nephropathy in rats
    • Yang Y, Wang J, Qin L, Shou Z, Zhao J, Wang H et al. Rapamycin prevents early steps of the development of diabetic nephropathy in rats. Am J Nephrol 2007; 27: 495-502
    • (2007) Am J Nephrol , vol.27 , pp. 495-502
    • Yang, Y.1    Wang, J.2    Qin, L.3    Shou, Z.4    Zhao, J.5    Wang, H.6
  • 107
    • 12344323484 scopus 로고    scopus 로고
    • Type 2 diabetes-A matter of beta-cell life and death
    • Rhodes CJ. Type 2 diabetes-A matter of beta-cell life and death? Science 2005; 307: 380-384
    • (2005) Science , vol.307 , pp. 380-384
    • Rhodes, C.J.1
  • 109
    • 79958103103 scopus 로고    scopus 로고
    • Health and function of participants in the long life family study: A comparison with other cohorts
    • Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R et al. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) 2011; 3: 63-76
    • (2011) Aging (Albany NY , vol.3 , pp. 63-76
    • Newman, A.B.1    Glynn, N.W.2    Taylor, C.A.3    Sebastiani, P.4    Perls, T.T.5    Mayeux, R.6
  • 111
    • 79951938474 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency is associated with a major reduction in pro-Aging signaling, cancer, and diabetes in humans
    • 70ra13
    • Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW et al. Growth hormone receptor deficiency is associated with a major reduction in pro-Aging signaling, cancer, and diabetes in humans. Sci Transl Med 2011; 3: 70ra13
    • (2011) Sci Transl Med , vol.3
    • Guevara-Aguirre, J.1    Balasubramanian, P.2    Guevara-Aguirre, M.3    Wei, M.4    Madia, F.5    Cheng, C.W.6
  • 112
    • 80055115839 scopus 로고    scopus 로고
    • Type 2 diabetes and the aging pancreatic beta cell
    • Gunasekaran U, Gannon M. Type 2 diabetes and the aging pancreatic beta cell. Aging (Albany NY) 2011; 3: 565-575
    • (2011) Aging (Albany NY , vol.3 , pp. 565-575
    • Gunasekaran, U.1    Gannon, M.2
  • 113
    • 84859492402 scopus 로고    scopus 로고
    • Molecular links between cellular senescence, longevity and age-related diseases-A systems biology perspective
    • Tacutu R, Budovsky A, Yanai H, Fraifeld VE. Molecular links between cellular senescence, longevity and age-related diseases-A systems biology perspective. Aging (Albany NY) 2011; 3: 1178-1191
    • (2011) Aging (Albany NY , vol.3 , pp. 1178-1191
    • Tacutu, R.1    Budovsky, A.2    Yanai, H.3    Fraifeld, V.E.4
  • 114
    • 42349086872 scopus 로고    scopus 로고
    • Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
    • Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T et al. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol 2008; 28: 2971-2979
    • (2008) Mol Cell Biol , vol.28 , pp. 2971-2979
    • Shigeyama, Y.1    Kobayashi, T.2    Kido, Y.3    Hashimoto, N.4    Asahara, S.5    Matsuda, T.6
  • 115
    • 84878987312 scopus 로고    scopus 로고
    • Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
    • Leontieva OV, Paszkiewicz G, Demidenko ZN, Blagosklonny MV. Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet. Cell Death Dis 2013; 4: E472
    • (2013) Cell Death Dis , vol.4
    • Leontieva, O.V.1    Paszkiewicz, G.2    Demidenko, Z.N.3    Blagosklonny, M.V.4
  • 116
    • 84879664826 scopus 로고    scopus 로고
    • Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B
    • Chen J, Huang XF. Mechanism for the synergistic effect of rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B. Cell Death Dis 2013; 4: E680
    • (2013) Cell Death Dis , vol.4
    • Chen, J.1    Huang, X.F.2
  • 117
    • 12544252740 scopus 로고    scopus 로고
    • Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells
    • Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ. Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells. J Biol Chem 2005; 280: 2282-2293
    • (2005) J Biol Chem , vol.280 , pp. 2282-2293
    • Briaud, I.1    Dickson, L.M.2    Lingohr, M.K.3    McCuaig, J.F.4    Lawrence, J.C.5    Rhodes, C.J.6
  • 118
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002; 283: E413-E422
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • White, M.F.1
  • 119
    • 63349109171 scopus 로고    scopus 로고
    • Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1
    • Bachar E, Ariav Y, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1. PLoS One 2009; 4: E4954
    • (2009) PLoS One , vol.4
    • Bachar, E.1    Ariav, Y.2    Ketzinel-Gilad, M.3    Cerasi, E.4    Kaiser, N.5    Leibowitz, G.6
  • 120
    • 78651303018 scopus 로고    scopus 로고
    • Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis
    • Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Cell Death Differ 2011; 18: 328-337
    • (2011) Cell Death Differ , vol.18 , pp. 328-337
    • Allagnat, F.1    Cunha, D.2    Moore, F.3    Vanderwinden, J.M.4    Eizirik, D.L.5    Cardozo, A.K.6
  • 121
    • 84870988528 scopus 로고    scopus 로고
    • C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells
    • Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L et al. C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta-cells. Cell Death Differ 2012; 19: 1836-1846
    • (2012) Cell Death Differ , vol.19 , pp. 1836-1846
    • Allagnat, F.1    Fukaya, M.2    Nogueira, T.C.3    Delaroche, D.4    Welsh, N.5    Marselli, L.6
  • 122
    • 84862536825 scopus 로고    scopus 로고
    • Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
    • Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY et al. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl) 2011; 90: 575-585
    • (2011) J Mol Med (Berl , vol.90 , pp. 575-585
    • Yang, S.B.1    Lee, H.Y.2    Young, D.M.3    Tien, A.C.4    Rowson-Baldwin, A.5    Shu, Y.Y.6
  • 123
    • 80053395566 scopus 로고    scopus 로고
    • Activation of protein kinase C-zeta in pancreatic beta-cells in vivo improves glucose tolerance and induces beta-cell expansion via mTOR activation
    • Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC et al. Activation of protein kinase C-zeta in pancreatic beta-cells in vivo improves glucose tolerance and induces beta-cell expansion via mTOR activation. Diabetes 2011; 60: 2546-2559
    • (2011) Diabetes , vol.60 , pp. 2546-2559
    • Velazquez-Garcia, S.1    Valle, S.2    Rosa, T.C.3    Takane, K.K.4    Demirci, C.5    Alvarez-Perez, J.C.6
  • 124
    • 77957579650 scopus 로고    scopus 로고
    • Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells
    • Elghazi L, Balcazar N, Blandino-Rosano M, Cras-Meneur C, Fatrai S, Gould AP et al. Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells. Diabetes 2010; 59: 2390-2399
    • (2010) Diabetes , vol.59 , pp. 2390-2399
    • Elghazi, L.1    Balcazar, N.2    Blandino-Rosano, M.3    Cras-Meneur, C.4    Fatrai, S.5    Gould, A.P.6
  • 125
    • 84055190702 scopus 로고    scopus 로고
    • Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
    • Blagosklonny MV. Rapamycin-induced glucose intolerance: Hunger or starvation diabetes. Cell Cycle 2011; 10: 4217-4224
    • (2011) Cell Cycle , vol.10 , pp. 4217-4224
    • Blagosklonny, M.V.1
  • 126
    • 84867460485 scopus 로고    scopus 로고
    • Once again on rapamycin-induced insulin resistance and longevity: Despite of or owing to
    • Blagosklonny MV. Once again on rapamycin-induced insulin resistance and longevity: Despite of or owing to. Aging (Albany NY) 2012; 4: 350-358
    • (2012) Aging (Albany NY , vol.4 , pp. 350-358
    • Blagosklonny, M.V.1
  • 127
    • 0021961644 scopus 로고
    • Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes
    • Unger RH, Grundy S. Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes. Diabetologia 1985; 28: 119-121
    • (1985) Diabetologia , vol.28 , pp. 119-121
    • Unger, R.H.1    Grundy, S.2
  • 128
    • 0026636945 scopus 로고
    • Mechanisms of hyperglycemiainduced insulin resistance in whole body and skeletal muscle of type I diabetic patients
    • Vuorinen-Markkola H, Koivisto VA, Yki-Jarvinen H. Mechanisms of hyperglycemiainduced insulin resistance in whole body and skeletal muscle of type I diabetic patients. Diabetes 1992; 41: 571-580
    • (1992) Diabetes , vol.41 , pp. 571-580
    • Vuorinen-Markkola, H.1    Koivisto, V.A.2    Yki-Jarvinen, H.3
  • 129
    • 0030837470 scopus 로고    scopus 로고
    • Acute and chronic effects of hyperglycaemia on glucose metabolism: Implications for the development of new therapies
    • Yki-Jarvinen H. Acute and chronic effects of hyperglycaemia on glucose metabolism: Implications for the development of new therapies. Diabet Med 1997; 14(Suppl 3): S32-S37
    • (1997) Diabet Med , vol.14 , Issue.SUPPL. 3
    • Yki-Jarvinen, H.1
  • 130
    • 28844433563 scopus 로고    scopus 로고
    • Pilot study with an intensified oral sirolimus regimen for the prevention of in-stent restenosis in de novo lesions: A serial intravascular ultrasound study
    • Chaves AJ, Sousa AG, Mattos LA, Abizaid A, Feres F, Staico R et al. Pilot study with an intensified oral sirolimus regimen for the prevention of in-stent restenosis in de novo lesions: A serial intravascular ultrasound study. Catheter Cardiovasc Interv 2005; 66: 535-540
    • (2005) Catheter Cardiovasc Interv , vol.66 , pp. 535-540
    • Chaves, A.J.1    Sousa, A.G.2    Mattos, L.A.3    Abizaid, A.4    Feres, F.5    Staico, R.6
  • 131
    • 0142057462 scopus 로고    scopus 로고
    • Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina single-center study (orar trial
    • Rodriguez AE, Alemparte MR, Vigo CF, Pereira CF, Llaurado C, Russo M et al. Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial). J Invasive Cardiol 2003; 15: 581-584
    • (2003) J Invasive Cardiol , vol.15 , pp. 581-584
    • Rodriguez, A.E.1    Alemparte, M.R.2    Vigo, C.F.3    Pereira, C.F.4    Llaurado, C.5    Russo, M.6
  • 133
    • 84874671061 scopus 로고    scopus 로고
    • Common drugs and treatments for cancer and age-related diseases: Revitalizing answers to nci's provocative questions
    • Blagosklonny MV. Common drugs and treatments for cancer and age-related diseases: Revitalizing answers to NCI's provocative questions. Oncotarget 2012; 3: 1711-1724
    • (2012) Oncotarget , vol.3 , pp. 1711-1724
    • Blagosklonny, M.V.1
  • 134
    • 84863005397 scopus 로고    scopus 로고
    • NCI's provocative questions on cancer: Some answers to ignite discussion
    • Blagosklonny MV. NCI's provocative questions on cancer: Some answers to ignite discussion. Oncotarget 2011; 2: 1352-1367
    • (2011) Oncotarget , vol.2 , pp. 1352-1367
    • Blagosklonny, M.V.1
  • 135
    • 84862646284 scopus 로고    scopus 로고
    • Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-Aging drug
    • Mercier I, Camacho J, Titchen K, Gonzales DM, Quann K, Bryant KG et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-Aging drug. Am J Pathol 2012; 181: 278-293
    • (2012) Am J Pathol , vol.181 , pp. 278-293
    • Mercier, I.1    Camacho, J.2    Titchen, K.3    Gonzales, D.M.4    Quann, K.5    Bryant, K.G.6
  • 136
    • 83755186554 scopus 로고    scopus 로고
    • Yeast-like chronological senescence in mammalian cells: Phenomenon, mechanism and pharmacological suppression
    • Leontieva OV, Blagosklonny MV. Yeast-like chronological senescence in mammalian cells: Phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) 2011; 3: 1078-1091
    • (2011) Aging (Albany NY , vol.3 , pp. 1078-1091
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 138
    • 84864541430 scopus 로고    scopus 로고
    • Metformin in obesity, cancer and aging: Addressing controversies
    • Berstein LM. Metformin in obesity, cancer and aging: Addressing controversies. Aging (Albany NY) 2012; 4: 320-329
    • (2012) Aging (Albany NY , vol.4 , pp. 320-329
    • Berstein, L.M.1
  • 140
    • 78649816080 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
    • Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Mammalian target of rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes. Endocr Relat Cancer 2010; 17: 941-951
    • (2010) Endocr Relat Cancer , vol.17 , pp. 941-951
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    LeRoith, D.5
  • 142
    • 84859360525 scopus 로고    scopus 로고
    • Therapeutic metformin/ampk activation blocked lymphoma cell growth via inhibition of mtor pathway and induction of autophagy
    • Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX et al. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis 2012; 3: E275
    • (2012) Cell Death Dis , vol.3
    • Shi, W.Y.1    Xiao, D.2    Wang, L.3    Dong, L.H.4    Yan, Z.X.5    Shen, Z.X.6
  • 143
    • 84874960161 scopus 로고    scopus 로고
    • Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development
    • Liu Y, Huang Y, Wang Z, Li X, Louie A, Wei G et al. Temporal mTOR inhibition protects Fbxw7-deficient mice from radiation-induced tumor development. Aging (Albany NY) 2013; 5: 111-119
    • (2013) Aging (Albany NY , vol.5 , pp. 111-119
    • Liu, Y.1    Huang, Y.2    Wang, Z.3    Li, X.4    Louie, A.5    Wei, G.6
  • 147
    • 84874724239 scopus 로고    scopus 로고
    • The promise of dual targeting aktmtor signaling in lethal prostate cancer
    • Floc'h N, Abate-Shen C. The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer. Oncotarget 2012; 3: 1483-1484
    • (2012) Oncotarget , vol.3 , pp. 1483-1484
    • Floc'h, N.1    Abate-Shen, C.2
  • 148
    • 84859876030 scopus 로고    scopus 로고
    • Will PI3K pathway inhibitors be effective as single agents in patients with cancer
    • Garrett JT, Chakrabarty A, Arteaga CL. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget 2011; 2: 1314-1321
    • (2011) Oncotarget , vol.2 , pp. 1314-1321
    • Garrett, J.T.1    Chakrabarty, A.2    Arteaga, C.L.3
  • 150
    • 84859489680 scopus 로고    scopus 로고
    • Molecular damage in cancer: An argument for mTOR-driven aging
    • Blagosklonny MV. Molecular damage in cancer: An argument for mTOR-driven aging. Aging (Albany NY) 2011; 3: 1130-1141
    • (2011) Aging (Albany NY , vol.3 , pp. 1130-1141
    • Blagosklonny, M.V.1
  • 151
    • 84868101237 scopus 로고    scopus 로고
    • Tumor suppression by p53 without apoptosis and senescence: Conundrum or rapalog-like gerosuppression
    • Blagosklonny MV. Tumor suppression by p53 without apoptosis and senescence: Conundrum or rapalog-like gerosuppressioñ Aging (Albany NY) 2012; 4: 450-455
    • (2012) Aging (Albany NY , vol.4 , pp. 450-455
    • Blagosklonny, M.V.1
  • 152
    • 84870666200 scopus 로고    scopus 로고
    • Rapalogs in cancer prevention: Anti-Aging or anticancer
    • Blagosklonny MV. Rapalogs in cancer prevention: Anti-Aging or anticancer? Cancer Biol Ther 2012; 13: 1349-1354
    • (2012) Cancer Biol Ther , vol.13 , pp. 1349-1354
    • Blagosklonny, M.V.1
  • 153
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310: 1642-1646
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3    Koo, S.H.4    Bardeesy, N.5    Depinho, R.A.6
  • 154
    • 32944461233 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity
    • He G, Sung YM, Digiovanni J, Fischer SM. Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity. Cancer Res 2006; 66: 1873-1878
    • (2006) Cancer Res , vol.66 , pp. 1873-1878
    • He, G.1    Sung, Y.M.2    Digiovanni, J.3    Fischer, S.M.4
  • 155
    • 84880436096 scopus 로고    scopus 로고
    • Prolonged rapamycin treatment led to beneficial metabolic switch
    • Fang Y, Bartke A. Prolonged rapamycin treatment led to beneficial metabolic switch. Aging (Albany NY) 2013; 5: 328-329
    • (2013) Aging (Albany NY , vol.5 , pp. 328-329
    • Fang, Y.1    Bartke, A.2
  • 157
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • Houde VP, Brule S, Festuccia WT, Blanchard PG, Bellmann K, Deshaies Y et al. Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. Diabetes 2010; 59: 1338-1348
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3    Blanchard, P.G.4    Bellmann, K.5    Deshaies, Y.6
  • 158
    • 84862536825 scopus 로고    scopus 로고
    • Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
    • Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY et al. Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med (Berl) 2012; 90: 575-585
    • (2012) J Mol Med (Berl , vol.90 , pp. 575-585
    • Yang, S.B.1    Lee, H.Y.2    Young, D.M.3    Tien, A.C.4    Rowson-Baldwin, A.5    Shu, Y.Y.6
  • 159
    • 68949215897 scopus 로고    scopus 로고
    • Long-Term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice
    • Chang GR, Wu YY, Chiu YS, Chen WY, Liao JW, Hsu HM et al. Long-Term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice. Basic Clin Pharmacol Toxicol 2009; 105: 188-198
    • (2009) Basic Clin Pharmacol Toxicol , vol.105 , pp. 188-198
    • Chang, G.R.1    Wu, Y.Y.2    Chiu, Y.S.3    Chen, W.Y.4    Liao, J.W.5    Hsu, H.M.6
  • 160
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012; 335: 1638-1643
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 161
    • 84880507764 scopus 로고    scopus 로고
    • Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
    • Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell 2013; 12: 712-718
    • (2013) Aging Cell , vol.12 , pp. 712-718
    • Lamming, D.W.1    Ye, L.2    Astle, C.M.3    Baur, J.A.4    Sabatini, D.M.5    Harrison, D.E.6
  • 162
    • 77953624320 scopus 로고    scopus 로고
    • Linking calorie restriction to longevity through sirtuins and autophagy: Any role for tor
    • Blagosklonny MV. Linking calorie restriction to longevity through sirtuins and autophagy: Any role for TOR. Cell Death Dis 2010; 1: E12
    • (2010) Cell Death Dis , vol.1
    • Blagosklonny, M.V.1
  • 163
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444: 840-846
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 164
    • 34548092167 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
    • Mordier S, Iynedjian PB. Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes. Biochem Biophys Res Commun 2007; 362: 206-211
    • (2007) Biochem Biophys Res Commun , vol.362 , pp. 206-211
    • Mordier, S.1    Iynedjian, P.B.2
  • 165
    • 0022091775 scopus 로고
    • Diabetic nephropathy and proliferative retinopathy with normal glucose tolerance
    • Chan JY, Cole E, Hanna AK. Diabetic nephropathy and proliferative retinopathy with normal glucose tolerance. Diabetes Care 1985; 8: 385-390
    • (1985) Diabetes Care , vol.8 , pp. 385-390
    • Chan, J.Y.1    Cole, E.2    Hanna, A.K.3
  • 166
    • 23044481147 scopus 로고    scopus 로고
    • Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the finndiane study
    • Thorn LM, Forsblom C, Fagerudd J, Thomas MC, Pettersson-Fernholm K, Saraheimo M et al. Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study). Diabetes Care 2005; 28: 2019-2024
    • (2005) Diabetes Care , vol.28 , pp. 2019-2024
    • Thorn, L.M.1    Forsblom, C.2    Fagerudd, J.3    Thomas, M.C.4    Pettersson-Fernholm, K.5    Saraheimo, M.6
  • 168
    • 34548632281 scopus 로고    scopus 로고
    • The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients
    • Ozaki KS, Camara NO, Nogueira E, Pereira MG, Granato C, Melaragno C et al. The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients. Clin Transplant 2007; 21: 675-680
    • (2007) Clin Transplant , vol.21 , pp. 675-680
    • Ozaki, K.S.1    Camara, N.O.2    Nogueira, E.3    Pereira, M.G.4    Granato, C.5    Melaragno, C.6
  • 170
    • 58149385408 scopus 로고    scopus 로고
    • Glycemic control in patients with insulinoma treated with everolimus
    • Kulke MH, Bergsland EK, Yao JC. Glycemic control in patients with insulinoma treated with everolimus. N Engl J Med 2009; 360: 195-197
    • (2009) N Engl J Med , vol.360 , pp. 195-197
    • Kulke, M.H.1    Bergsland, E.K.2    Yao, J.C.3
  • 171
    • 69949100179 scopus 로고    scopus 로고
    • Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
    • Bourcier ME, Sherrod A, DiGuardo M, Vinik AI. Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. J Clin Endocrinol Metab 2009; 94: 3157-3162
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3157-3162
    • Bourcier, M.E.1    Sherrod, A.2    DiGuardo, M.3    Vinik, A.I.4
  • 172
    • 71749087934 scopus 로고    scopus 로고
    • Sirolimus therapy for patients with adult polycystic kidney disease: A pilot study
    • Soliman AR, Ismail E, Zamil S, Lotfy A. Sirolimus therapy for patients with adult polycystic kidney disease: A pilot study. Transplant Proc 2009; 41: 3639-3641
    • (2009) Transplant Proc , vol.41 , pp. 3639-3641
    • Soliman, A.R.1    Ismail, E.2    Zamil, S.3    Lotfy, A.4
  • 173
    • 73249139173 scopus 로고    scopus 로고
    • Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study
    • Su TI, Khanna D, Furst DE, Danovitch G, Burger C, Maranian P et al. Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single-blind pilot study. Arthritis Rheum 2009; 60: 3821-3830
    • (2009) Arthritis Rheum , vol.60 , pp. 3821-3830
    • Su, T.I.1    Khanna, D.2    Furst, D.E.3    Danovitch, G.4    Burger, C.5    Maranian, P.6
  • 174
    • 84879513284 scopus 로고    scopus 로고
    • Alternative perspectives on aging in C elegans: Reactive oxygen species or hyperfunction
    • Gems DH, de la Guardia YI. Alternative perspectives on aging in C. elegans: Reactive oxygen species or hyperfunctioñ Antioxid Redox Signal 2013; 19: 321-329
    • (2013) Antioxid Redox Signal , vol.19 , pp. 321-329
    • Gems, D.H.1    De La Guardia, Y.I.2
  • 175
    • 84873633910 scopus 로고    scopus 로고
    • Genetics of longevity in model organisms: Debates and paradigm shifts
    • Gems D, Partridge L. Genetics of longevity in model organisms: Debates and paradigm shifts. Annu Rev Physiol 2013; 75: 621-644
    • (2013) Annu Rev Physiol , vol.75 , pp. 621-644
    • Gems, D.1    Partridge, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.