A chronic increase in physical activity inhibits fedstate mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle

Applied Physiology, Nutrition and Metabolism

Volumn 33, Issue 1, 2008, Pages 93-101

  Glynn, Erin L ^a   Lujan, Heidi L ^b   Kramer, Victoria J ^b   Drummond, Micah J ^a   DiCarlo, Stephen E ^b   Rasmussen, Blake B ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin resistance; IRS 1; mTOR; Physical activity; S6K1; Skeletal muscle

Indexed keywords

CITRATE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE; S6 KINASE; S6K1 PROTEIN, RAT; SERINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; CITRATE (SI)-SYNTHASE; INSULIN; INSULIN RESISTANCE; LACTIC ACID; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES; SERINE; STAT1 TRANSCRIPTION FACTOR;

EID: 39749190584     PISSN: 17155312     EISSN: None     Source Type: Journal    
DOI: 10.1139/H07-149     Document Type: Article

References (43)