Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells

Journal of Biological Chemistry

Volumn 280, Issue 3, 2005, Pages 2282-2293

  Briaud, Isabelle ^a   Dickson, Lorna M ^a   Lingohr, Melissa K ^a   McCuaig, Jill F ^a   Lawrence, John C ^b   Rhodes, Christopher J ^a,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIODEGRADATION; BIOLOGICAL ORGANS; GENETIC ENGINEERING; GLUCOSE; INSULIN; PHOSPHORS; SUBSTRATES;

CHRONIC ACTIVATION ANALYSIS; INSULIN RECEPTORS; PANCREATIC CELLS;

CELLS;

ADENOVIRUS VECTOR; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; LACTACYSTIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; RAPAMYCIN; SOMATOMEDIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; ENZYME REPRESSION; HYPERGLYCEMIA; NEGATIVE FEEDBACK; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PANCREAS ISLET BETA CELL; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE; HYDROLYSIS; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MAMMALS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 12544252740     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412179200     Document Type: Article

References (59)

1. Lingohr, M. K., Buettner, R., and Rhodes, C. J. (2002) Trends Mol. Med. 8, 375-384
2. Rhodes, C. J., and White, M. F. (2002) Eur. J. Clin. Investig. 32, Suppl. 3, 3-13
3. Cai, D., Dhe-Paganon, S., Melendez, P. A., Lee, J., and Shoelson, S. E. (2003) J. Biol. Chem. 278, 25323-25330
4. Withers, D. J., Gutierrez, J. S., Towery, H., Burks, D. J., Ren, J. M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., Bonner-Weir, S., and White, M. F. (1998) Nature 391, 900-904
5. Withers, D. J., Burks, D. J., Towery, H. H., Altamuro, S. L., Flint, C. L., and White, M. F. (1999) Nat. Genet. 23, 32-40
6. Hennige, A. M., Burks, D. J., Ozcan, U., Kulkarni, R. N., Ye, J., Park, S., Schubert, M., Fisher, T. L., Dow, M. A., Leshan, R., Zakaria, M., Mossa-Basha, M., and White, M. F. (2003) J. Clin. Investig. 112, 1521-1532
7. Lingohr, M. K., Dickson, L. M., McCuaig, J. F., Hugl, S. R., Twardzik, D. R., and Rhodes, C. J. (2002) Diabetes 51, 966-976
8. Lingohr, M. K., Dickson, L. M., Wrede, C. E., McCuaig, J. F., Myers, M. G., and Rhodes, C. J. (2003) Mol. Cell. Endocrinol. 204, 85-99
9. Lingohr, M. K., Dickson, L. M., Wrede, C. E., Briaud, I., McCuaig, J. F., Myers, M. G., Jr., and Rhodes, C. J. (2003) Mol. Cell. Endocrinol. 209, 17-31
10. Dickson, L. M., and Rhodes, C. J. (2004) Am. J. Physiol. 287, E192-E198
11. Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler, P. C. (2003) Diabetes 52, 102-110
12. Kloppel, G., Lohr, M., Habich, K., Oberholzer, M., and Heitz, P. U. (1985) Surv. Synth. Pathol. Res. 4, 110-125
13. Pick, A., Clark, J., Kubstrup, C., Levisetti, M., Pugh, W., Bonner-Weir, S., and Polonsky, K. S. (1998) Diabetes 47, 358-364
14. Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Suzuki, R., Tsubamoto, Y., Komeda, K., Nakano, R., Miki, H., Satoh, S., Sekihara, H., Sciacchitano, S., Lesniak, M., Aizawa, S., Nagai, R., Kimura, S., Akanuma, Y., Taylor, S. I., and Kadowaki, T. (2000) Diabetes 49, 1880-1889
15. Poitout, V., and Robertson, R. P. (2002) Endocrinology 143, 339-342
16. Unger, R. H., and Orci, L. (2001) FASEB J. 15, 312-321
17. Donath, M. Y., Gross, D. J., Cerasi, E., and Kaiser, N. (1999) Diabetes 48, 738-744
18. Efanova, I. B., Zaitsev, S. V., Zhivotovsky, B., Kohler, M., Efendic, S., Orrenius, S., and Berggren, P. O. (1998) J. Biol. Chem. 273, 33501-33507
19. Maedler, K., Spinas, G. A., Lehmann, R., Sergeev, P., Weber, M., Fontana, A., Kaiser, N., and Donath, M. Y. (2001) Diabetes 50, 1683-1690
20. Maedler, K., Oberholzer, J., Bucher, P., Spinas, G. A., and Donath, M. Y. (2003) Diabetes 52, 726-733
21. Cnop, M., Hannaert, J. C., Hoorens, A., Eizirik, D. L., and Pipeleers, D. G. (2001) Diabetes 50, 1771-1777
22. Wrede, C. E., Dickson, L. M., Lingohr, M. K., Briaud, I., and Rhodes, C. J. (2002) J. Biol. Chem. 277, 49676-49684
23. Cousin, S. P., Hugl, S. R., Wrede, C. E., Kajio, H., Myers, M. G., and Rhodes, C. J. (2001) Endocrinology 142, 229-240
24. Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., and Shulman, G. I. (1999) Diabetes 48, 1270-1274
25. Ikeda, Y., Olsen, G. S., Ziv, E., Hansen, L. L., Busch, A. K., Hansen, B. F., Shafrir, E., and Mosthaf-Seedorf, L. (2001) Diabetes 50, 584-592
26. Zick, Y. (2001) Trends Cell Biol. 11, 437-441
27. Pederson, T. M., Kramer, D. L., and Rondinone, C. M. (2001) Diabetes 50, 24-31
28. Haruta, T., Uno, T., Kawahara, J., Takano, A., Egawa, K., Sharma, P. M., Olefsky, J. M., and Kobayashi, M. (2000) Mol. Endocrinol. 14, 783-794
29. Dickson, L. M., Lingohr, M. K., McCuaig, J., Hugl, S. R., Snow, L., Kahn, B. B., Myers, M. G., Jr., and Rhodes, C. J. (2001) J. Biol. Chem. 276, 21110-21120
30. Briaud, I., Lingohr, M. K., Dickson, L. M., Wrede, C. E., and Rhodes, C. J. (2003) Diabetes 52, 974-983
31. Gomez, E., Pritchard, C., and Herbert, T. P. (2002) J. Biol. Chem. 277, 48146-48151
32. McDaniel, M. L., Marshall, C. A., Pappan, K. L., and Kwon, G. (2002) Diabetes 51, 2877-2885
33. Xu, G., Kwon, G., Cruz, W. S., Marshall, C. A., and McDaniel, M. L. (2001) Diabetes 50, 353-360
34. Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V., Burcelin, R., Le Marchand-Brustel, Y., Klumperman, J., Thorens, B., and Thomas, G. (2000) Nature 408, 994-997
35. Thomas, G., and Hall, M. N. (1997) Curr. Opin. Cell Biol. 9, 782-787
36. Sun, X. J., Goldberg, J. L., Qiao, L. Y., and Mitchell, J. J. (1999) Diabetes 48, 1359-1364
37. Pirola, L., Bonnafous, S., Johnston, A. M., Chaussade, C., Portis, F., and Van Obberghen, E. (2003) J. Biol. Chem. 278, 15641-15651
38. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., and Wollheim, C. B. (1992) Endocrinology 130, 167-178
39. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B., and Schreiber, S. L. (1995) Nature 377, 441-446
40. Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr., and Abraham, R. T. (1997) Science 277, 99-101
41. Sekulic, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M., and Abraham, R. T. (2000) Cancer Res. 60, 3504-3513
42. Brunn, G. J., Fadden, P., Haystead, T. A., and Lawrence, J. C., Jr. (1997) J. Biol. Chem. 272, 32547-32550
43. McMahon, L. P., Choi, K. M., Lin, T. A., Abraham, R. T., and Lawrence, J. C., Jr. (2002) Mol. Cell. Biol. 22, 7428-7438
44. He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2509-2514
45. Rui, L., Fisher, T. L., Thomas, J., and White, M. F. (2001) J. Biol. Chem. 276, 40362-40367
46. Rui, L., Yuan, M., Frantz, D., Shoelson, S., and White, M. F. (2002) J. Biol. Chem. 277, 42394-42398
47. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
48. White, M. F. (2002) Am. J. Physiol. 283, E413-E422
49. Li, J., DeFea, K., and Roth, R. A. (1999) J. Biol. Chem. 274, 9351-9356
50. Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., and Zick, Y. (1997) J. Biol. Chem. 272, 29911-29918
51. Aguirre, V., Uchida, T., Yenush, L., Davis, R., and White, M. F. (2000) J. Biol. Chem. 275, 9047-9054
52. Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., and Kobayashi, M. (2001) Mol. Cell. Biol. 21, 5050-5062
53. Paz, K., Liu, Y. F., Shorer, H., Hemi, R., LeRoith, D., Quan, M., Kanety, H., Seger, R., and Zick, Y. (1999) J. Biol. Chem. 274, 28816-28822
54. De Fea, K., and Roth, R. A. (1997) J. Biol. Chem. 272, 31400-31406
55. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
56. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Cell 110, 177-189
57. Harris, T. E., and Lawrence, J. C., Jr. (2003) Science's STKE http://stke.sciencemag.org/cgi/content/fullsigtrans;2003/re15
58. Hugl, S. R., White, M. F., and Rhodes, C. J. (1998) J. Biol. Chem. 273, 17771-17779
59. Shapiro, A. M., Lakey, J. R., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., and Rajotte, R. V. (2000) N. Engl. J. Med. 343, 230-238