Genetics of longevity in model organisms: Debates and paradigm shifts

Annual Review of Physiology

Volumn 75, Issue , 2013, Pages 621-644

  Gems, David ^a   Partridge, Linda ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

Aging; Dietary restriction; Disposable soma; Evolution; Hyperfunction; Insulin IGF 1 signaling; Oxidative damage; Target of rapamycin (TOR)

Indexed keywords

FREE RADICAL; INSULIN; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; SUPEROXIDE DISMUTASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FOXO; XENOBIOTIC AGENT;

AGING; CANCER RISK; CELL AGING; CELL DAMAGE; CELL METABOLISM; DIET RESTRICTION; DISEASE ACTIVITY; GENE MUTATION; GENETICS; GERONTOLOGY; HOMEOSTASIS; HUMAN; INTRACELLULAR SIGNALING; LIFESPAN; LONGEVITY; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITIONAL STATUS; OXIDATIVE STRESS; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; STOCHASTIC MODEL; STRESS; XENOBIOTIC METABOLISM;

AGING; ANIMALS; BIOLOGICAL EVOLUTION; FOOD; LONGEVITY; MODELS, ANIMAL; SIGNAL TRANSDUCTION;

EID: 84873633910     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-030212-183712     Document Type: Review

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