Decreased IRS signaling impairs β-cell cycle progression and survival in transgenic mice overexpressing S6K in β-cells

Diabetes

Volumn 59, Issue 10, 2010, Pages 2390-2399

  Elghazi, Lynda ^a   Balcazar, Norman ^a   Blandino Rosano, Manuel ^a   Cras Méneur, Corentin ^a   Fatrai, Szabolcs ^a   Gould, Aaron P ^a   Chi, Maggie M ^b   Moley, Kelle H ^b   Bernal Mizrachi, Ernesto ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; GLUCOSE; INSULIN RECEPTOR SUBSTRATE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; PROTEIN P16; PROTEIN P27; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL FUNCTION; CELL SIZE; CELL SURVIVAL; IMMUNOFLUORESCENCE TEST; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; RAT; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL SIZE; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS, GENETIC; RATS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 77957579650     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0851     Document Type: Article

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