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Volumn 3, Issue 11, 2012, Pages 1301-1307

The interfaces between signal transduction pathways: IGF-1/mtor, p53 and the parkinson disease pathway

Author keywords

IGF 1; MTOR; P53; Parkinson disease; RHEB

Indexed keywords

DJ 1 PROTEIN; GLUCOSE; LEUCINE RICH REPEAT KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; PARKIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C;

EID: 84872787640     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.759     Document Type: Article
Times cited : (21)

References (52)
  • 1
    • 77954310492 scopus 로고    scopus 로고
    • The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
    • Feng Z, Levine AJ. (2010) The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein. Trends Cell Biol. 2010; 20: 427-34.
    • (2010) Trends Cell Biol. 2010 , vol.20 , pp. 427-434
    • Feng, Z.1    Levine, A.J.2
  • 2
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter A. (2010) The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science. 2010; 330: 1340-44.
    • (2010) Science. 2010 , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.2
  • 3
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: a role for the DNA damage response?
    • Meek DW. (2009) Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer. 2009; 9: 714-723.
    • (2009) Nat Rev Cancer. 2009 , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 4
    • 84872776313 scopus 로고    scopus 로고
    • The Regulation of Multiple p53 Stress Responses are Mediated Through MDM-2
    • Hu W, Feng Z, Levine A.J. (2012) The Regulation of Multiple p53 Stress Responses are Mediated Through MDM-2. Genes Cancer. 2012; 3: 199-208.
    • (2012) Genes Cancer. 2012 , vol.3 , pp. 199-208
    • Hu, W.1    Feng, Z.2    Levine, A.J.3
  • 5
    • 84864926277 scopus 로고    scopus 로고
    • New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy
    • Mirzayans R, Andrais B, ScottA, and Murray D. (2012) New Insights into p53 Signaling and Cancer Cell Response to DNA Damage: Implications for Cancer Therapy. J Biomed Biotechnol. 2012;2012:170325.
    • (2012) J Biomed Biotechnol. 2012 , vol.2012 , pp. 170325
    • Mirzayans, R.1    Andrais, B.2    Scott, A.3    Murray, D.4
  • 6
    • 0035884191 scopus 로고    scopus 로고
    • APAF-1 Is a Transcriptional Target of p53 in DNA Damage-induced Apoptosis
    • Robles AI, Bemmels NA, Foraker AB, Harris CC. (2001) APAF-1 Is a Transcriptional Target of p53 in DNA Damage-induced Apoptosis. Cancer Res. 2001; 61: 6660-4.
    • (2001) Cancer Res. 2001 , vol.61 , pp. 6660-6664
    • Robles, A.I.1    Bemmels, N.A.2    Foraker, A.B.3    Harris, C.C.4
  • 7
    • 33646373219 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
    • Li J, Lee B, Lee AS. (2006) Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. J Biol Chem. 2006; 281: 7260-70.
    • (2006) J Biol Chem. 2006 , vol.281 , pp. 7260-7270
    • Li, J.1    Lee, B.2    Lee, A.S.3
  • 9
    • 17044393948 scopus 로고    scopus 로고
    • Regulation of Akt/PKB Ser473 phosphorylation
    • Bayascas JR, Alessi DR. Regulation of Akt/PKB Ser473 phosphorylation. (2005) Mol Cell. 2005;18:143-145.
    • (2005) Mol Cell. 2005 , vol.18 , pp. 143-145
    • Bayascas, J.R.1    Alessi, D.R.2
  • 10
  • 11
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase
    • Scheid MP, Marignani PA, Woodgett JR. (2006) Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol. 2002;22:6247-6260.
    • (2006) B. Mol Cell Biol. 2002 , vol.22 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 12
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 2002;4:648-657.
    • Nat Cell Biol. 2002 , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 14
    • 27744569843 scopus 로고    scopus 로고
    • mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz MK, Ballif BA, Gygi SP, Blenis J. (2005) mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005 a;123:569-580.
    • (2005) Cell. 2005 , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 15
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz MK, Blenis J. (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem. 2005 b;280:26089-26093.
    • (2005) J Biol Chem. 2005 , vol.280 , pp. 26089-26093
    • Holz, M.K.1    Blenis, J.2
  • 17
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. (1956) On the origin of cancer cells. Science. 1956; 123: 309.
    • (1956) Science. 1956 , vol.123 , pp. 309
    • Warburg, O.1
  • 19
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer. 2003;3:721-732.
    • Nat Rev Cancer. 2003 , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 21
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: there is more to growth than just surviving
    • Plas DR, Thompson CB. (2005) Akt-dependent transformation: there is more to growth than just surviving. Oncogene. 2005;24:7435-7442.
    • (2005) Oncogene. 2005 , vol.24 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 22
  • 23
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ. (2007) The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 2007;67:3043-3053.
    • (2007) Cancer Res. 2007 , vol.67 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    de Stanchina, E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6    Levine, A.J.7
  • 25
    • 84855878565 scopus 로고    scopus 로고
    • p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2
    • Contractor T, Harris C (2012). p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2. Cancer Res. 2012; 72:560-7.
    • (2012) Cancer Res. 2012 , vol.72 , pp. 560-567
    • Contractor, T.1    Harris, C.2
  • 27
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. (2010) Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA. 2010; 107:7455-60.
    • (2010) Proc Natl Acad Sci USA. 2010 , vol.107 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3    Sun, Y.4    Levine, A.5    Feng, Z.6
  • 28
  • 29
    • 84859855907 scopus 로고    scopus 로고
    • Redox regulation of p53, redox effectors regulated by p53: a subtle balance
    • Maillet A, Pervaiz S. (2012) Redox regulation of p53, redox effectors regulated by p53: a subtle balance. Antioxid Redox Signal. 2012; 16: 1285-94.
    • (2012) Antioxid Redox Signal. 2012 , vol.16 , pp. 1285-1294
    • Maillet, A.1    Pervaiz, S.2
  • 30
    • 79961176457 scopus 로고    scopus 로고
    • Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling
    • Budanov AV. (2011) Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. Antioxid Redox Signal. 2011; 15:1679-90.
    • (2011) Antioxid Redox Signal. 2011 , vol.15 , pp. 1679-1690
    • Budanov, A.V.1
  • 35
    • 36248985106 scopus 로고    scopus 로고
    • Update on the genetics of Parkinson's disease
    • Gasser T. (2007) Update on the genetics of Parkinson's disease. Mov Disord. 2007; 22: S343-50.
    • (2007) Mov Disord. 2007 , vol.22
    • Gasser, T.1
  • 36
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D., Tanaka A, Suen, D, Youle R. (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol. 183, 795-803.
    • (2008) J. Cell Biol. , vol.183 , pp. 795-803
    • Narendra, D..1    Tanaka, A.2    Suen, D.3    Youle, R.4
  • 37
    • 71849104427 scopus 로고    scopus 로고
    • Tickled PINK 2008; 1: Mitochondrial Homeostasis and Autophagy in Recessive Parkinsonism
    • Chu C. (2010) Tickled PINK 2008; 1: Mitochondrial Homeostasis and Autophagy in Recessive Parkinsonism. Biochem Biophys. Acta; 1802: 20-28.
    • (2010) Biochem Biophys. Acta , vol.1802 , pp. 20-28
    • Chu, C.1
  • 45
    • 84863348583 scopus 로고    scopus 로고
    • N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity
    • Sun L, Gu L, Wand S, Yuan J, Yang H, Shu J, Zhang H. (2012). N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS One, 2012; 7:e32503.
    • (2012) PLoS One, 2012 , vol.7
    • Sun, L.1    Gu, L.2    Wand, S.3    Yuan, J.4    Yang, H.5    Shu, J.6    Zhang, H.7
  • 49
    • 77953553525 scopus 로고    scopus 로고
    • The familial Parkinson disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E
    • Veeriah S, Morris L, Solit D, Chan TA. (2010). The familial Parkinson disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E. Cell Cycle. 2010; 9: 1451-2.
    • (2010) Cell Cycle. 2010 , vol.9 , pp. 1451-1452
    • Veeriah, S.1    Morris, L.2    Solit, D.3    Chan, T.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.