Nf90 coordinately represses the senescence-associated secretory phenotype

Aging

Volumn 4, Issue 10, 2012, Pages 695-708

  Tominaga Yamanaka, Kumiko ^a   Abdelmohsen, Kotb ^a   Martindale, Jennifer L ^a   Yang, Xiaoling ^a   Taub, Dennis D ^a   Gorospe, Myriam ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Mrna stability; Mrna translation; Post transcriptional gene regulation; Ribonucleoprotein complex; RNA binding protein; Senescence

Indexed keywords

EID: 84872512759     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100497     Document Type: Article

References (48)

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965; 37: 614-636.
2. Kuilman T, Michaloglou C, Mooi WJ, Peeper DS. The essence of senescence. Genes Dev. 2010; 24: 2463-2479.
3. Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescenceassociated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5: 99-118.
4. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008; 6: 2853-2868.
5. Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 2009; 9: 81-94.
6. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011; 192: 547-556.
7. Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007; 445: 656-660.
8. Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol. 2008; 73: 513-522.
9. Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. Senescence of activated stellate cells limits liver fibrosis. Cell 2008; 134: 657-667.
10. Freund A, Orjalo AV, Desprez PY, and Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010; 16: 238-246.
11. McElhaney JE, Effros RB. Immunosenescence: what does it mean to health outcomes in older adults? Curr Opin Immunol. 2009; 21: 418-424.
12. Hardy K, Mansfield L, Mackay A, Benvenuti S, Ismail S, Arora P, O'Hare MJ, Jat PS. Transcriptional networks and cellular senescence in human mammary fibroblasts. Mol Biol Cell 2005; 16: 943-953.
13. Acosta JC, O'loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008; 133: 1006-1018.
14. Kuilman T, Michaloglou C, Vredeveld LC, Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ, Peeper DS. Oncogeneinduced senescence relayed by an interleukin-dependent inflammatory network. Cell 2008; 133: 1019-1031.
15. Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J. Cell surface-bound IL-1a is an upstream regulator of the senescenceassociated IL-6/IL-8 cytokine network. Proc Natl Acad Sci USA 2009; 106: 17031-17036.
16. Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW. Control of the senescence-associated secretory phenotype by NF-?B promotes senescence and enhances chemosensitivity. Genes Dev. 2011; 25: 2125-2136.
17. Schieven GL The p38a kinase plays a central role in inflammation. Curr Top Med Chem. 2009; 9: 1038-1048.
18. Freund A, Patil CK, Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescenceassociated secretory phenotype. EMBO J. 2008; 30: 1536-1548.
19. Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-?B signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal. 2012; 24: 835-845.
20. Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G Transcriptional activation of the NF-?B p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 2003; 22:1313-1324.
21. Vermeulen L, Vanden Berghe W, Beck IME, De Bosscher K, Haegeman G. The versatile role of MSKs in transcriptional regulation. Trends Biochem Sci. 2009; 34: 311-318.
22. Kefaloyianni E, Gaitanaki C, Beis I. ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-?B transactivation during oxidative stress in skeletal myoblasts. Cell Signal. 2006; 18: 2238-2251.
23. Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT1 longevity factor suppresses NF-?B -driven immune responses: regulation of aging via NF-?B acetylation? Bioessays 2008; 29: 939-942.
24. Saccani S, Pantano S, Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 2002; 3: 69-75.
25. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL- 6 and IL-8. Aging 2009; 1: 402-411.
26. Lee EK, Gorospe M. Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systems. Endocrinology. 2010; 151: 1403-1408.
27. Schott J, Stoecklin G. Networks controlling mRNA decay in the immune system. Wiley Interdiscip Rev RNA. 2010; 1: 432-456.
28. Palanisamy V, Jakymiw A, Van Tubergen EA, D'Silva NJ, Kirkwood KL. Control of cytokine mRNA expression by RNAbinding proteins and microRNAs. J Dent Res. 2012; 91: 651-658.
29. Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Human antigen R contributes to hepatic stellate cell activation and liver fibrosis. Hepatology. 2012 doi: 10.1002/hep.25828. [Epub ahead of print]
30. Abdelmohsen K, Kuwano Y, Kim HH, Gorospe M. Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence. Biol Chem. 2008; 389: 243-255.
31. Abdelmohsen K, Gorospe M. RNA-binding protein nucleolin in disease. RNA Biol. 2012; 9 [Epub ahead of print].
32. Pont AR, Sadri N, Hsiao SJ, Smith S, Schneider RJ. mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol. Cell 2012; 47: 5-15.
33. Kuwano Y, Pullmann R Jr, Marasa BS, Abdelmohsen K, Lee EK, Yang X, Martindale JL, Zhan M, Gorospe M. NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res. 2010; 38: 225-238.
34. Reichman TW, Muñiz LC, Mathews MB. The RNA binding protein Nuclear Factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. Mol Cell Biol. 2002; 22: 343-356.
35. Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, Gorospe M. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev. 2009; 23: 1743-1748.
36. Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K, Shiekhattar R TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005; 436: 740-744.
37. Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN The role of PACT in the RNA silencing pathway. EMBO J. 2006; 25: 522-532.
38. Keene JD. RNA regulons: coordination of post-transcriptional events. Nat Rev Genet. 2007; 8: 533-543.
39. Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC. DRBP76, a doublestranded RNAbinding nuclear protein, is phosphorylated by the interferoninduced protein kinase, PKR. J Biol Chem. 1999; 274: 20432-20437.
40. Parrott AM, Walsh MR, Reichman TW, Mathews MB. RNA binding and phosphorylation determine the intracellular distribution of nuclear factors 90 and 110. J Mol Biol. 2005; 348: 281-293.
41. Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L. Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation. J Immunol. 2008; 180: 222-229.
42. Zhu P, Jiang W, Cao L, Yu W, Pei Y, Yang X, Wan B, Liu JO, Yi Q, Yu L. IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase Cß. J Immunol. 2010; 185: 5140-5149.
43. Kuwano Y, Kim HH, Abdelmohsen K, Pullmann R Jr, Martindale JL, Yang X, Gorospe M. MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol. 2008; 28: 4562-4575.
44. Kortlever RM, Higgins PJ, Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 2006; 8: 877-884.
45. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2008; 98: 12072-12077.
46. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008; 132: 363-374.
47. Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol. Cell Biol. 1989; 9: 3088-3092.
48. Tominaga K, Srikantan S, Lee EK, Subaran SS, Martindale JL, Abdelmohsen K, Gorospe M. Competitive regulation of nucleolin expression by HuR and miR-494. Mol Cell Biol. 2011; 31: 4219-4231.