Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

Science

Volumn 335, Issue 6076, 2012, Pages 1638-1643

  Lamming, Dudley W ^a,b   Ye, Lan ^c   Katajisto, Pekka ^a,b   Goncalves, Marcus D ^c   Saitoh, Maki ^a,b   Stevens, Deanna M ^a,b   Davis, James G ^c   Salmon, Adam B ^d   Richardson, Arlan ^d   Ahima, Rexford S ^c   Guertin, David A ^a,b,e   Sabatini, David M ^a,b   Baur, Joseph A ^c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; RAPAMYCIN; SERUM GLUCOCORTICOID INDUCED PROTEIN KINASE; UNCLASSIFIED DRUG;

FLY; GLUCOSE; HOMEOSTASIS; INHIBITION; LONGEVITY; PROTEIN; RODENT; YEAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HETEROZYGOTE; IMPAIRED GLUCOSE TOLERANCE; INDUCED RESISTANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESPAN; LONGEVITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

EID: 84859117806     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1215135     Document Type: Article

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