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Volumn 4, Issue 8, 2012, Pages 547-552

How to save medicare: The anti-aging remedy

Author keywords

Aging; Diseases; Health care; Rapamycin

Indexed keywords


EID: 84868027889     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100479     Document Type: Article
Times cited : (38)

References (61)
  • 1
    • 84874188612 scopus 로고    scopus 로고
    • The New Yourk Times
    • Pear R. Social Security and Financial Health Worsens. The New Yourk Times. 2012: http://www.nytimes.com/2012/2004/2024/us/politics/financial-outlook-dims-for-social-security.html.
    • (2012) Social Security and Financial Health Worsens
    • Pear, R.1
  • 2
    • 55849132493 scopus 로고    scopus 로고
    • Insulin and aging
    • Bartke A. Insulin and aging. Cell Cycle. 2008; 7: 3338-3343.
    • (2008) Cell Cycle , vol.7 , pp. 3338-3343
    • Bartke, A.1
  • 3
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care. 2006; 29: 254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 4
    • 28244481524 scopus 로고    scopus 로고
    • Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer
    • Hammarsten J, Hogstedt B. Hyperinsulinaemia: a prospective risk factor for lethal clinical prostate cancer. Eur J Cancer. 2005; 41: 2887-2895.
    • (2005) Eur J Cancer , vol.41 , pp. 2887-2895
    • Hammarsten, J.1    Hogstedt, B.2
  • 5
    • 78650316639 scopus 로고    scopus 로고
    • Metformin for aging and cancer prevention
    • Anisimov VN. Metformin for aging and cancer prevention. Aging. 2010; 2: 760-774.
    • (2010) Aging , vol.2 , pp. 760-774
    • Anisimov, V.N.1
  • 6
    • 79251527543 scopus 로고    scopus 로고
    • Tragedy and delight: the ethics of decelerated ageing
    • Gems D. Tragedy and delight: the ethics of decelerated ageing. Philos Trans R Soc Lond B Biol Sci. 2011; 366: 108-112.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 108-112
    • Gems, D.1
  • 7
    • 78049499910 scopus 로고    scopus 로고
    • Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis
    • Blagosklonny MV. Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis. Aging. 2010; 2: 177-182.
    • (2010) Aging , vol.2 , pp. 177-182
    • Blagosklonny, M.V.1
  • 8
    • 84859051249 scopus 로고    scopus 로고
    • Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    • Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT. Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol A Biol Sci Med Sci. 2012; 67: 395-405.
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 395-405
    • Andersen, S.L.1    Sebastiani, P.2    Dworkis, D.A.3    Feldman, L.4    Perls, T.T.5
  • 9
    • 0345540639 scopus 로고    scopus 로고
    • Centenarians: the older you get, the healthier you have been
    • Hitt R, Young-Xu Y, Silver M, Perls T. Centenarians: the older you get, the healthier you have been. Lancet. 1999; 354: 652.
    • (1999) Lancet , vol.354 , pp. 652
    • Hitt, R.1    Young-Xu, Y.2    Silver, M.3    Perls, T.4
  • 12
    • 0037338636 scopus 로고    scopus 로고
    • Morbidity profiles of centenarians: survivors, delayers, and escapers
    • Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003; 58: 232-237.
    • (2003) J Gerontol A Biol Sci Med Sci , vol.58 , pp. 232-237
    • Evert, J.1    Lawler, E.2    Bogan, H.3    Perls, T.4
  • 16
    • 64549083295 scopus 로고    scopus 로고
    • The scientific basis of caloric restriction leading to longer life
    • Fontana L. The scientific basis of caloric restriction leading to longer life. Curr Opin Gastroenterol. 2009; 25: 144-150.
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 144-150
    • Fontana, L.1
  • 17
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science. 2010; 328: 321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 18
    • 77953149043 scopus 로고    scopus 로고
    • Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans)
    • Blagosklonny MV. Calorie restriction: Decelerating mTORdriven aging from cells to organisms (including humans). Cell Cycle. 2010; 9: 683-688.
    • (2010) Cell Cycle , vol.9 , pp. 683-688
    • Blagosklonny, M.V.1
  • 20
    • 0034626747 scopus 로고    scopus 로고
    • Genetic pathways that regulate ageing in model organisms
    • Guarente L, Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature. 2000; 408: 255-262.
    • (2000) Nature , vol.408 , pp. 255-262
    • Guarente, L.1    Kenyon, C.2
  • 21
    • 33644755871 scopus 로고    scopus 로고
    • Unlocking the secrets of longevity genes
    • Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Sci Am. 2006; 294: 48-51.
    • (2006) Sci Am , vol.294 , pp. 48-51
    • Sinclair, D.A.1    Guarente, L.2
  • 23
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ. The genetics of ageing. Nature. 2010; 464: 504-512.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 25
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010; 11: 453-465.
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6    Kockel, L.7
  • 27
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: a common molecular mechanism
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging. 2009; 1: 357-362.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 28
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5: 2087-2102.
    • (2006) Cell Cycle , vol.5 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 29
    • 33847226657 scopus 로고    scopus 로고
    • An anti-aging drug today: from senescence-promoting genes to anti-aging pill
    • Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Disc Today. 2007; 12: 218-224.
    • (2007) Drug Disc Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1
  • 30
    • 84866494334 scopus 로고    scopus 로고
    • Prospective Treatment of Age-Related Diseases by Slowing Down Aging
    • Blagosklonny MV. Prospective Treatment of Age-Related Diseases by Slowing Down Aging. Am J Pathol. 2012.
    • Am J Pathol. 2012.
    • Blagosklonny, M.V.1
  • 31
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7: 3355-3361.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 32
    • 79959776029 scopus 로고    scopus 로고
    • Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
    • Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med. 2011; 3: 89ra58.
    • (2011) Sci Transl Med , vol.3
    • Cao, K.1    Graziotto, J.J.2    Blair, C.D.3    Mazzulli, J.R.4    Erdos, M.R.5    Krainc, D.6    Collins, F.S.7
  • 33
    • 84862881961 scopus 로고    scopus 로고
    • Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence
    • Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence. Cell Cycle. 2012; 11: 2391-2401.
    • (2012) Cell Cycle , vol.11 , pp. 2391-2401
    • Kolesnichenko, M.1    Hong, L.2    Liao, R.3    Vogt, P.K.4    Sun, P.5
  • 35
    • 84862891914 scopus 로고    scopus 로고
    • Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
    • Blagosklonny MV. Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging. 2012; 4: 159-165.
    • (2012) Aging , vol.4 , pp. 159-165
    • Blagosklonny, M.V.1
  • 36
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Leontieva OV, Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging. 2010; 2: 924-935.
    • (2010) Aging , vol.2 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 38
    • 75549090275 scopus 로고    scopus 로고
    • mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009; 2: ra75.
    • (2009) Sci Signal , vol.2
    • Chen, C.1    Liu, Y.2    Zheng, P.3
  • 39
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XFS. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Disc Today. 2007; 12: 112-124.
    • (2007) Drug Disc Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 40
    • 74549205329 scopus 로고    scopus 로고
    • Validation of anti-aging drugs by treating age-related diseases
    • Blagosklonny MV. Validation of anti-aging drugs by treating age-related diseases. Aging. 2009; 1: 281-288.
    • (2009) Aging , vol.1 , pp. 281-288
    • Blagosklonny, M.V.1
  • 42
    • 79953231709 scopus 로고    scopus 로고
    • A longer and healthier life with TOR down-regulation: genetics and drugs
    • Bjedov I, Partridge L. A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem Soc Trans. 2011; 39: 460-465.
    • (2011) Biochem Soc Trans , vol.39 , pp. 460-465
    • Bjedov, I.1    Partridge, L.2
  • 43
    • 84865013696 scopus 로고    scopus 로고
    • Chemoprevention of age-related macular regeneration (AMD) with rapamycin
    • Zheng XF. Chemoprevention of age-related macular regeneration (AMD) with rapamycin. Aging. 2012; 4: 375-376.
    • (2012) Aging , vol.4 , pp. 375-376
    • Zheng, X.F.1
  • 44
    • 4043142865 scopus 로고    scopus 로고
    • Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies
    • Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant. 2004; 18: 446-449.
    • (2004) Clin Transplant , vol.18 , pp. 446-449
    • Mathew, T.1    Kreis, H.2    Friend, P.3
  • 46
    • 50849110457 scopus 로고    scopus 로고
    • Prevention of cancer by inhibiting aging
    • Blagosklonny MV. Prevention of cancer by inhibiting aging. Cancer Biol Ther. 2008; 7: 1520-1524.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1520-1524
    • Blagosklonny, M.V.1
  • 50
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster
    • Moskalev AA, Shaposhnikov MV. Pharmacological Inhibition of Phosphoinositide 3 and TOR Kinases Improves Survival of Drosophila melanogaster. Rejuvenation Res. 2010; 13: 246-247.
    • (2010) Rejuvenation Res , vol.13 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 57
    • 84857926653 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice
    • Spong A, Bartke A. Rapamycin slows aging in mice. Cell Cycle. 2012; 11: 845.
    • (2012) Cell Cycle , vol.11 , pp. 845
    • Spong, A.1    Bartke, A.2
  • 58
    • 50549090486 scopus 로고    scopus 로고
    • Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
    • Blagosklonny MV. Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells. Rejuvenation Res. 2008; 11: 801-808.
    • (2008) Rejuvenation Res , vol.11 , pp. 801-808
    • Blagosklonny, M.V.1
  • 59
    • 84867460485 scopus 로고    scopus 로고
    • Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to
    • Blagosklonny MV. Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. Aging. 2012; 4: 350-358.
    • (2012) Aging , vol.4 , pp. 350-358
    • Blagosklonny, M.V.1
  • 60
    • 34247520866 scopus 로고    scopus 로고
    • Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors
    • Granville CA, Warfel N, Tsurutani J, Hollander MC, Robertson M, Fox SD, Veenstra TD, Issaq HJ, Linnoila RI, Dennis PA. Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors. Clin Cancer Res. 2007; 13: 2281-2289.
    • (2007) Clin Cancer Res , vol.13 , pp. 2281-2289
    • Granville, C.A.1    Warfel, N.2    Tsurutani, J.3    Hollander, M.C.4    Robertson, M.5    Fox, S.D.6    Veenstra, T.D.7    Issaq, H.J.8    Linnoila, R.I.9    Dennis, P.A.10
  • 61
    • 78650352864 scopus 로고    scopus 로고
    • Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal
    • Blagosklonny MV. Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal. Cell Cycle. 2010; 9: 4788-4794.
    • (2010) Cell Cycle , vol.9 , pp. 4788-4794
    • Blagosklonny, M.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.