Bronchial epithelium as a target for innovative treatments in asthma

Pharmacology and Therapeutics

Volumn 140, Issue 3, 2013, Pages 290-305

  Gras, Delphine ^a   Chanez, Pascal ^a,b   Vachier, Isabelle ^c   Petit, Aurélie ^c,d   Bourdin, Arnaud ^c,d  

^a INSERM   (France)

^b HÔPITAL NORD   (France)

^c MONTPELLIER UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY OF MONTPELLIER   (France)

Author keywords

Airways; Asthma; Epithelial cells; Structural changes; Treatment

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR; CORTICOSTEROID; DOCOSAHEXAENOIC ACID; ENDOTHELIN RECEPTOR; GLUCOCORTICOID; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5 ANTIBODY; INTERLEUKIN 8; INTERLEUKIN 9; LEBRIKIZUMAB; LIPOXIN; MEPOLIZUMAB; MUCIN; NICOTINIC RECEPTOR BETA2; OMALIZUMAB; RESIQUIMOD; TOLL LIKE RECEPTOR;

AIRWAY REMODELING; ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL DIFFERENTIATION; CELL STRUCTURE; DRUG MECHANISM; EPITHELIUM CELL; EXPERIMENTAL THERAPY; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ACH; AHR; AIRWAY HYPERRESPONSIVENESS; AIRWAY SMOOTH MUSCLE; AIRWAYS; ASM; ASTHMA; BAL; BEC; BRONCHIAL EPITHELIAL CELL; BRONCHOALVEOLAR LAVAGE; CF; CFTR; CHI3L1; CHITINASE 3 LIKE PROTEIN 1; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CIGARETTE SMOKE EXTRACT; COPD; COX; CSE; CYCLOOXYGENASE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DC; DELTA LIKE PROTEIN 1; DENDRITIC CELL; DHA; DLL-1; DOCOSAHEXAENOIC ACID; EGF; EGFR; EMTU; ENDOTHELIN; EPITHELIAL CELLS; EPITHELIAL GROWTH FACTOR; EPITHELIAL GROWTH FACTOR RECEPTOR; EPITHELIAL-MESENCHYMAL TROPHIC UNIT; ERK; ET; EXTRACELLULAR SIGNAL-REGULATED KINASE; G PROTEIN COUPLED RECEPTOR; GCS; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOIDS; GPCR; GR; HB-EGF; HEPARIN BINDING-EGF; ICS; IGA; IGE; IL; IL-R; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; INHALED CORTICOSTEROID; INTERLEUKIN; INTERLEUKIN RECEPTOR; LABA; LAMA; LEUKOTRIEN AGONIST; LIPOPOLYSACCHARIDE; LIPOXINS; LIPOXYGENASE; LO; LONG ACTING MUSCARINIC RECEPTOR; LONG ACTING Β2-AGONIST; LPS; LTRA; LXS; MATRIX METALLOPROTEINASE; MICRORNA; MIR; MMP; MUC; MUCIN; NF-KB; NITRIC OXIDE; NK2 HOMEOBOX 1; NKX2.1; NO; NUCLEAR FACTOR-KAPPAB; OVA; OVALBUMIN; PARTICULATE MATTER; PGE2; PHOSPHOKINASE C; PIGR; PKC; PM; POLYMERIC IMMUNOGLOBULIN RECEPTOR; PROSTAGLANDIN E2; SABA; SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR; SHORT ACTING Β2-AGONIST; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; SP; SPDEF; STAT; STRUCTURAL CHANGES; SURFACTANT PROTEIN; TACE; TGF; THYMIC STROMAL LYMPHOPOIETIN; TLR; TNF; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR; TREATMENT; TSLP; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME;

AIRWAY REMODELING; ANIMALS; ASTHMA; BRONCHI; HUMANS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 84885470108     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.07.008     Document Type: Review

References (312)

1. S. Abdelilah, K. Latifa, N. Esra, L. Cameron, L. Bouchaib, and N. Nicolaides Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release J Immunol 166 2001 2768 2774
2. I.M. Adcock, T. Gilbey, C.M. Gelder, K.F. Chung, and P.J. Barnes Glucocorticoid receptor localization in normal and asthmatic lung Am J Respir Crit Care Med 154 1996 771 782
3. A. Agusti, P.M. Calverley, B. Celli, H.O. Coxson, L.D. Edwards, and D.A. Lomas Characterisation of COPD heterogeneity in the eclipse cohort Respir Res 11 2010 122
4. S.P. Alexander, A. Mathie, and J.A. Peters Guide to receptors and channels, 1st edition Br J Pharmacol 141 Suppl. 1 2004 S1 S126
5. L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3 Nature 413 2001 732 738
6. F.R. Amble, S.O. Lindberg, T.V. McCaffrey, and T. Runer Mucociliary function and endothelins 1, 2, and 3 Otolaryngol Head Neck Surg 109 1993 634 645
7. G.P. Anderson Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease Lancet 372 2008 1107 1119
8. O. Andersson, L. Nordlund-Moller, H.J. Barnes, and J. Lund Heterologous expression of human uteroglobin/polychlorinated biphenyl-binding protein. Determination of ligand binding parameters and mechanism of phospholipase a2 inhibition in vitro J Biol Chem 269 1994 19081 19087
9. H. Arai, S. Hori, I. Aramori, H. Ohkubo, and S. Nakanishi Cloning and expression of a cDNA encoding an endothelin receptor Nature 348 1990 730 732
10. L. Armstrong, A.R. Medford, K.M. Uppington, J. Robertson, I.R. Witherden, and T.D. Tetley Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells Am J Respir Cell Mol Biol 31 2004 241 245
11. M. Baggiolini, A. Walz, and S.L. Kunkel Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils J Clin Invest 84 1989 1045 1049
12. N. Baiz, and I. Annesi-Maesano Is the asthma epidemic still ascending? Clin Chest Med 33 2012 419 429
13. J.L. Barlow, A. Bellosi, C.S. Hardman, L.F. Drynan, S.H. Wong, and J.P. Cruickshank Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity J Allergy Clin Immunol 129 191-198 2012 e191 194
14. P.J. Barnes New therapies for asthma: Is there any progress? Trends Pharmacol Sci 31 2010 335 343
15. P.J. Barnes Glucocorticosteroids: Current and future directions Br J Pharmacol 163 2011 29 43
16. E.D. Bateman, H.A. Boushey, J. Bousquet, W.W. Busse, T.J. Clark, and R.A. Pauwels Can guideline-defined asthma control be achieved? The gaining optimal asthma control study Am J Respir Crit Care Med 170 2004 836 844
17. E.D. Bateman, J. Bousquet, W.W. Busse, T.J. Clark, N. Gul, and M. Gibbs Stability of asthma control with regular treatment: an analysis of the gaining optimal asthma control (goal) study Allergy 63 2008 932 938
18. E. Battaglioli, C. Gotti, S. Terzano, A. Flora, F. Clementi, and D. Fornasari Expression and transcriptional regulation of the human alpha3 neuronal nicotinic receptor subunit in t lymphocyte cell lines J Neurochem 71 1998 1261 1270
19. E.H. Bel, A. Sousa, L. Fleming, A. Bush, K.F. Chung, and J. Versnel Compton CH: Diagnosis and definition of severe refractory asthma: An international consensus statement from the innovative medicine initiative (imi) Thorax 66 2011 910 917
20. K.E. Belmonte Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease Proc Am Thorac Soc 2 2005 297 304 (discussion 311-292)
21. M.A. Berry, B. Hargadon, M. Shelley, D. Parker, D.E. Shaw, and R.H. Green Evidence of a role of tumor necrosis factor alpha in refractory asthma N Engl J Med 354 2006 697 708
22. M. Biffen, H. Matsui, S. Edwards, A.J. Leishman, K. Eiho, and E. Holness Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity Br J Pharmacol 166 2012 573 586
23. M.R. Blanchet, A. Langlois, E. Israel-Assayag, M.J. Beaulieu, C. Ferland, and M. Laviolette Modulation of eosinophil activation in vitro by a nicotinic receptor agonist J Leukoc Biol 81 2007 1245 1251
24. S. Blanchet, K. Ramgolam, A. Baulig, F. Marano, and A. Baeza-Squiban Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells Am J Respir Cell Mol Biol 30 2004 421 427
25. S. Blouquit, A. Sari, A. Lombet, M. D'Herbomez, E. Naline, and R. Matran Effects of endothelin-1 on epithelial ion transport in human airways Am J Respir Cell Mol Biol 29 2003 245 251
26. B.S. Bochner, D.A. Klunk, S.A. Sterbinsky, R.L. Coffman, and R.P. Schleimer Il-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells J Immunol 154 1995 799 803
27. J.C. Bonner The epidermal growth factor receptor at the crossroads of airway remodeling Am J Physiol Lung Cell Mol Physiol 283 2002 L528 L530
28. I.S. Bos, R. Gosens, A.B. Zuidhof, D. Schaafsma, A.J. Halayko, and H. Meurs Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison Eur Respir J 30 2007 653 661
29. A. Bourdin, D. Neveu, I. Vachier, F. Paganin, P. Godard, and P. Chanez Specificity of basement membrane thickening in severe asthma J Allergy Clin Immunol 119 2007 1367 1374
30. A. Bourdin, M. Humbert, and P. Chanez Immunologic therapeutic interventions in asthma: Impact on natural history Clin Chest Med 33 2012 585 597
31. A.R. Brash, W.E. Boeglin, and M.S. Chang Discovery of a second 15 s-lipoxygenase in humans Proc Natl Acad Sci U S A 94 1997 6148 6152
32. O.E. Brodde, M. Brinkmann, R. Schemuth, N. O'Hara, and A. Daul Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen J Clin Invest 76 1985 1096 1101
33. G. Brunn, I. Wessler, and K. Racke Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea Br J Pharmacol 116 1995 1991 1998
34. P.R. Burgel, D. Montani, C. Danel, D.J. Dusser, and J.A. Nadel A morphometric study of mucins and small airway plugging in cystic fibrosis Thorax 62 2007 153 161
35. P.R. Burgel, and J.A. Nadel Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium Thorax 59 2004 992 996
36. P.R. Burgel, J.L. Paillasseur, D. Caillaud, I. Tillie-Leblond, P. Chanez, and R. Escamilla Clinical COPD phenotypes: a novel approach using principal component and cluster analyses Eur Respir J 36 2010 531 539
37. B. Button, L.H. Cai, C. Ehre, M. Kesimer, D.B. Hill, and J.K. Sheehan A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia Science 337 2012 937 941
38. P. Camateros, M. Tamaoka, M. Hassan, R. Marino, J. Moisan, and D. Marion Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand s28463 Am J Respir Crit Care Med 175 2007 1241 1249
39. A.M. Campbell, A.M. Vignola, P. Chanez, P. Godard, and J. Bousquet Low-affinity receptor for ige on human bronchial epithelial cells in asthma Immunology 82 1994 506 508
40. N. Carroll, J. Elliot, A. Morton, and A. James The structure of large and small airways in nonfatal and fatal asthma Am Rev Respir Dis 147 1993 405 410
41. P. Chanez, S.E. Wenzel, G.P. Anderson, J.M. Anto, E.H. Bel, and L.P. Boulet Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 119 2007 1337 1348
42. C. Chavis, P. Godard, A. Crastes de Paulet, and M. Damon Formation of lipoxins and leukotrienes by human alveolar macrophages incubated with 15(S)-HETE: a model for cellular cooperation between macrophages and airway epithelial cells Eicosanoids 5 1992 203 211
43. G. Chen, T.R. Korfhagen, Y. Xu, J. Kitzmiller, S.E. Wert, and Y. Maeda SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production J Clin Invest 119 2009 2914 2924
44. R. Chen, J.H. Lim, H. Jono, X.X. Gu, Y.S. Kim, and C.B. Basbaum Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF- kappaB signaling pathways Biochem Biophys Res Commun 324 2004 1087 1094
45. N. Chiang, M. Arita, and C.N. Serhan Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX Prostaglandins Leukot Essent Fatty Acids 73 2005 163 177
46. P. Chomarat, and J. Banchereau Interleukin-4 and interleukin-13: their similarities and discrepancies Int Rev Immunol 17 1998 1 52
47. L.K. Chong, R. Chess-Williams, and P.T. Peachell Pharmacological characterisation of the beta-adrenoceptor expressed by human lung mast cells Eur J Pharmacol 437 2002 1 7
48. L.K. Chong, D.E. Drury, J.F. Dummer, P. Ghahramani, R.P. Schleimer, and P.T. Peachell Protection by dexamethasone of the functional desensitization to beta 2-adrenoceptor-mediated responses in human lung mast cells Br J Pharmacol 121 1997 717 722
49. S.M. Clancy, M. Yeadon, J. Parry, M.S. Yeoman, E.C. Adam, and U. Schumacher Endothelin-1 inhibits mucin secretion from ovine airway epithelial goblet cells Am J Respir Cell Mol Biol 31 2004 663 671
50. L. Cosmi, F. Liotta, R. Angeli, B. Mazzinghi, V. Santarlasci, and R. Manetti Th2 cells are less susceptible than th1 cells to the suppressive activity of cd25+ regulatory thymocytes because of their responsiveness to different cytokines Blood 103 2004 3117 3121
51. W.I. de Boer, C.M. Hau, A. van Schadewijk, J. Stolk, J.H. van Krieken, and P.S. Hiemstra Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease Am J Clin Pathol 125 2006 184 192
52. W.J. de Jonge, and L. Ulloa The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation Br J Pharmacol 151 2007 915 929
53. J. de Kluijver, J.A. Schrumpf, C.E. Evertse, J.K. Sont, P.J. Roughley, and K.F. Rabe Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma Clin Exp Allergy 35 2005 1361 1369
54. Matsushita M. de Medeiros, L.F. da Silva, M.A. dos Santos, S. Fernezlian, J.A. Schrumpf, and P. Roughley Airway proteoglycans are differentially altered in fatal asthma J Pathol 207 2005 102 110
55. B.G. Dekkers, H. Maarsingh, H. Meurs, and R. Gosens Airway structural components drive airway smooth muscle remodeling in asthma Proc Am Thorac Soc 6 2009 683 692
56. D. Desai, and C. Brightling Cytokines and cytokine-specific therapy in asthma Adv Clin Chem 57 2012 57 97
57. S.S. Diebold, T. Kaisho, H. Hemmi, and S. Akira Reis e Sousa C: innate antiviral responses by means of tlr7-mediated recognition of single-stranded RNA Science 303 2004 1529 1531
58. G. Dorion, E. Israel-Assayag, M.J. Beaulieu, and Y. Cormier Effect of 1,1-dimethylphenyl 1,4-piperazinium on mouse tracheal smooth muscle responsiveness Am J Physiol Lung Cell Mol Physiol 288 2005 L1139 L1145
59. C. Druez, P. Coulie, C. Uyttenhove, and J. Van Snick Functional and biochemical characterization of mouse p40/IL-9 receptors J Immunol 145 1990 2494 2499
60. M.J. Duechs, C. Hahn, E. Benediktus, M. Werner-Klein, A. Braun, and H.G. Hoymann Tlr agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways Pulm Pharmacol Ther 24 2011 203 214
61. S.R. Durrani, R.K. Viswanathan, and W.W. Busse What effect does asthma treatment have on airway remodeling? Current perspectives J Allergy Clin Immunol 128 2011 439 448 quiz 449-450
62. T. Eiwegger, and C.A. Akdis Il-33 links tissue cells, dendritic cells and th2 cell development in a mouse model of asthma Eur J Immunol 41 2011 1535 1538
63. C. Emanueli, F. Ricciardolo, L. Vergnani, C. Bertrand, F. Ricci, and N. Manzoli Characterization of the endothelin receptor subtype mediating epithelium-derived relaxant nitric oxide release from guinea-pig trachea Br J Pharmacol 125 1998 963 968
64. K.J. Erb Helminths, allergic disorders and IgE-mediated immune responses: where do we stand? Eur J Immunol 37 2007 1170 1173
65. J.P. Fabisiak, E.S. Vesell, and D.E. Rannels Interactions of beta adrenergic antagonists with isolated rat alveolar type ii pneumocytes. Ii. Receptor-independent accumulation of beta adrenergic antagonists and other cationic amphiphilic drugs in lamellar bodies J Pharmacol Exp Ther 241 1987 728 735
66. K.A. Fagan, I.F. McMurtry, and D.M. Rodman Role of endothelin-1 in lung disease Respir Res 2 2001 90 101
67. J.V. Fahy, and B.F. Dickey Airway mucus function and dysfunction N Engl J Med 363 2010 2233 2247
68. C. Faisy, F. Pinto, C. Danel, E. Naline, P.A. Risse, and I. Leroy Beta2-adrenoceptor agonist modulates endothelin-1 receptors in human isolated bronchi Am J Respir Cell Mol Biol 34 2006 410 416
69. M. Faller, R. Kessler, R. Sapin, A. Chaouat, M. Ehrhart, and A. Ducolone Regulation of endothelin-1 at rest and during a short steady-state exercise in 21 COPD patients Pulm Pharmacol Ther 11 1998 151 157
70. C. Ferri, C. Bellini, C. De Angelis, L. De Siati, A. Perrone, and G. Properzi Circulating endothelin-1 concentrations in patients with chronic hypoxia J Clin Pathol 48 1995 519 524
71. I.M. Fierro, S.P. Colgan, G. Bernasconi, N.A. Petasis, C.B. Clish, and M. Arita Lipoxin a4 and aspirin-triggered 15-epi-lipoxin a4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells J Immunol 170 2003 2688 2694
72. F.D. Finkelman, T. Shea-Donohue, S.C. Morris, L. Gildea, R. Strait, and K.B. Madden Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites Immunol Rev 201 2004 139 155
73. P.A. Finney, L.E. Donnelly, M.G. Belvisi, T.T. Chuang, M. Birrell, and A. Harris Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of g(s alpha) Br J Pharmacol 132 2001 1261 1270
74. C.M. Fitzsimmons, R. McBeath, S. Joseph, F.M. Jones, K. Walter, and K.F. Hoffmann Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: molecular structure and patterns of in vivo exposure Int Arch Allergy Immunol 142 2007 40 50
75. P. Flood-Page, A. Menzies-Gow, S. Phipps, S. Ying, A. Wangoo, and M.S. Ludwig Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics J Clin Invest 112 2003 1029 1036
76. S.D. Freedman, P.G. Blanco, M.M. Zaman, J.C. Shea, M. Ollero, and I.K. Hopper Association of cystic fibrosis with abnormalities in fatty acid metabolism N Engl J Med 350 2004 560 569
77. R. Gagliardo, P. Chanez, A.M. Vignola, J. Bousquet, I. Vachier, and P. Godard Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma Am J Respir Crit Care Med 162 2000 7 13
78. R. Gagliardo, A.M. Vignola, and M. Mathieu Is there a role for glucocorticoid receptor beta in asthma? Respir Res 2 2001 1 4
79. S.P. Galant, and S.J. Allred Demonstration of beta-2 adrenergic receptors of high coupling efficiency in human neutrophil sonicates J Lab Clin Med 96 1980 15 23
80. A. Giangreco, S.D. Reynolds, and B.R. Stripp Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction Am J Pathol 161 2002 173 182
81. R.G. Goldie Endothelin receptor subtypes: distribution and function in the lung Pulm Pharmacol Ther 11 1998 89 95
82. R.G. Goldie, and P.J. Henry Endothelins and asthma Life Sci 65 1999 1 15
83. R.G. Goldie, P.J. Henry, P.G. Knott, G.J. Self, M.A. Luttmann, and D.W. Hay Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways Am J Respir Crit Care Med 152 1995 1653 1658
84. D.S. Goldstein Adrenaline and noradrenaline eLS 2010
85. R. Gosens, J. Zaagsma, H. Meurs, and A.J. Halayko Muscarinic receptor signaling in the pathophysiology of asthma and COPD Respir Res 7 2006 73
86. H.J. Gould, B.J. Sutton, A.J. Beavil, R.L. Beavil, N. McCloskey, and H.A. Coker The biology of ige and the basis of allergic disease Annu Rev Immunol 21 2003 579 628
87. D. Gras, A. Bourdin, I. Vachier, L. de Senneville, C. Bonnans, and P. Chanez An ex vivo model of severe asthma using reconstituted human bronchial epithelium J Allergy Clin Immunol 129 1259-1266 2012 e1251
88. R.K. Grencis, and A.J. Bancroft Interleukin-13: a key mediator in resistance to gastrointestinal-dwelling nematode parasites Clin Rev Allergy Immunol 26 2004 51 60
89. G. Grunig, M. Warnock, A.E. Wakil, R. Venkayya, F. Brombacher, and D.M. Rennick Requirement for IL-13 independently of IL-4 in experimental asthma Science 282 1998 2261 2263
90. S. Guimaraes, and D. Moura Vascular adrenoceptors: an update Pharmacol Rev 53 2001 319 356
91. R. Hajj, T. Baranek, R. Le Naour, P. Lesimple, E. Puchelle, and C. Coraux Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties Stem Cells 25 2007 139 148
92. P. Haldar, I.D. Pavord, D.E. Shaw, M.A. Berry, M. Thomas, and C.E. Brightling Cluster analysis and clinical asthma phenotypes Am J Respir Crit Care Med 178 2008 218 224
93. D.L. Hamilos, D.Y. Leung, S. Muro, A.M. Kahn, S.S. Hamilos, and S.E. Thawley GRbeta expression in nasal polyp inflammatory cells and its relationship to the anti-inflammatory effects of intranasal fluticasone J Allergy Clin Immunol 108 2001 59 68
94. L.M. Hamilton, C. Torres-Lozano, S.M. Puddicombe, A. Richter, I. Kimber, and R.J. Dearman The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma Clin Exp Allergy 33 2003 233 240
95. D.W. Hay Endothelin-1: an interesting peptide or an important mediator in pulmonary diseases? Pulm Pharmacol Ther 11 1998 141 146
96. D.W. Hay Putative mediator role of endothelin-1 in asthma and other lung diseases Clin Exp Pharmacol Physiol 26 1999 168 171
97. D.W. Hay, M.A. Luttmann, R.M. Muccitelli, and R.G. Goldie Endothelin receptors and calcium translocation pathways in human airways Naunyn Schmiedebergs Arch Pharmacol 359 1999 404 410
98. F. Hayashi, K.D. Smith, A. Ozinsky, T.R. Hawn, E.C. Yi, and D.R. Goodlett The innate immune response to bacterial flagellin is mediated by toll-like receptor 5 Nature 410 2001 1099 1103
99. F. Heil, H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, and S. Akira Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 303 2004 1526 1529
100. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, and H. Sanjo A toll-like receptor recognizes bacterial DNA Nature 408 2000 740 745
101. F. Henningsson, Z. Ding, J.S. Dahlin, M. Linkevicius, F. Carlsson, and K.O. Gronvik Ige-mediated enhancement of cd4+ t cell responses in mice requires antigen presentation by cd11c+cells and not by b cells PLoS One 6 2011 e21760
102. C. Hermans, and A. Bernard Lung epithelium-specific proteins: characteristics and potential applications as markers Am J Respir Crit Care Med 159 1999 646 678
103. G.K. Hershey Il-13 receptors and signaling pathways: an evolving web J Allergy Clin Immunol 111 2003 677 690 (quiz 691)
104. E.M. Hill, T. Eling, and P. Nettesheim Changes in expression of 15-lipoxygenase and prostaglandin-h synthase during differentiation of human tracheobronchial epithelial cells Am J Respir Cell Mol Biol 18 1998 662 669
105. S. Hill, E. Herlaar, A. Le Cardinal, G. van Heeke, and P. Nicklin Homologous human and murine antisense oligonucleotides targeting stat6. Functional effects on germline cepsilon transcript Am J Respir Cell Mol Biol 21 1999 728 737
106. D.J. Hilton, S.S. Watowich, L. Katz, and H.F. Lodish Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor J Biol Chem 271 1996 4699 4708
107. T. Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, and S. Doi Genome-wide association study identifies three new susceptibility loci for adult asthma in the japanese population Nat Genet 43 2011 893 896
108. T. Hirota, A. Takahashi, M. Kubo, T. Tsunoda, K. Tomita, and S. Doi Genome-wide association study identifies three new susceptibility loci for adult asthma in the japanese population Nat Genet 43 2011 893 896
109. S.J. Hirst, T.R. Walker, and E.R. Chilvers Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma Eur Respir J 16 2000 159 177
110. S.T. Holgate Epithelial damage and response Clin Exp Allergy 30 Suppl. 1 2000 37 41
111. S.T. Holgate The airway epithelium is central to the pathogenesis of asthma Allergol Int 57 2008 1 10
112. S.T. Holgate Pathophysiology of asthma: What has our current understanding taught us about new therapeutic approaches? J Allergy Clin Immunol 128 2011 495 505
113. T. Homma, A. Kato, N. Hashimoto, J. Batchelor, M. Yoshikawa, and S. Imai Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells Am J Respir Cell Mol Biol 31 2004 463 469
114. K.U. Hong, S.D. Reynolds, A. Giangreco, C.M. Hurley, and B.R. Stripp Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion Am J Respir Cell Mol Biol 24 2001 671 681
115. E. Houtmeyers, R. Gosselink, G. Gayan-Ramirez, and M. Decramer Regulation of mucociliary clearance in health and disease Eur Respir J 13 1999 1177 1188
116. Y.C. Huang, B. Leyko, and M. Frieri Effects of omalizumab and budesonide on markers of inflammation in human bronchial epithelial cells Ann Allergy Asthma Immunol 95 2005 443 451
117. J. Huang, R. Olivenstein, R. Taha, Q. Hamid, and M. Ludwig Enhanced proteoglycan deposition in the airway wall of atopic asthmatics Am J Respir Crit Care Med 160 1999 725 729
118. S.K. Huang, H.Q. Xiao, J. Kleine-Tebbe, G. Paciotti, D.G. Marsh, and L.M. Lichtenstein Il-13 expression at the sites of allergen challenge in patients with asthma J Immunol 155 1995 2688 2694
119. J.R. Hurst, J. Vestbo, A. Anzueto, N. Locantore, H. Mullerova, and R. Tal-Singer Susceptibility to exacerbation in chronic obstructive pulmonary disease N Engl J Med 363 2010 1128 1138
120. S. Iho, Y. Tanaka, R. Takauji, C. Kobayashi, I. Muramatsu, and H. Iwasaki Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB J Leukoc Biol 74 2003 942 951
121. A. James, T. Mauad, M. Abramson, and F. Green Airway smooth muscle hypertrophy and hyperplasia in asthma Am J Respir Crit Care Med 186 2012 568
122. M. Jinnin, H. Ihn, K. Yamane, and K. Tamaki Interleukin-13 stimulates the transcription of the human alpha2(i) collagen gene in human dermal fibroblasts J Biol Chem 279 2004 41783 41791
123. M. Johnson The beta-adrenoceptor Am J Respir Crit Care Med 158 1998 S146 S153
124. P.G. Jorens, P.D. Graf, I.F. Ueki, J. Olesch, and J.A. Nadel Interleukin-8 induces neutrophil accumulation in the trachea of allergic dogs Trans Assoc Am Physicians 105 1992 190 196
125. I.J. Juncadella, A. Kadl, A.K. Sharma, Y.M. Shim, A. Hochreiter-Hufford, and L. Borish Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation Nature 493 2013 547 551
126. K. Kalavantavanich, and C.M. Schramm Dexamethasone potentiates high-affinity beta-agonist binding and g(s)alpha protein expression in airway smooth muscle Am J Physiol Lung Cell Mol Physiol 278 2000 L1101 L1106
127. M.H. Kaplan, U. Schindler, S.T. Smiley, and M.J. Grusby Stat6 is required for mediating responses to IL-4 and for development of th2 cells Immunity 4 1996 313 319
128. S. Karne, C.K. Jayawickreme, and M.R. Lerner Cloning and characterization of an endothelin-3 specific receptor (etc receptor) from Xenopus laevis dermal melanophores J Biol Chem 268 1993 19126 19133
129. K. Kasuga, R. Yang, T.F. Porter, N. Agrawal, N.A. Petasis, and D. Irimia Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution J Immunol 181 2008 8677 8687
130. K. Kawakami, J. Taguchi, T. Murata, and R.K. Puri The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the stat6 pathway Blood 97 2001 2673 2679
131. K. Kawashima, and T. Fujii Extraneuronal cholinergic system in lymphocytes Pharmacol Ther 86 2000 29 48
132. J. Kearley, J.S. Erjefalt, C. Andersson, E. Benjamin, C.P. Jones, and A. Robichaud Il-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways Am J Respir Crit Care Med 183 2011 865 875
133. M. Kesimer, C. Ehre, K.A. Burns, C.W. Davis, J.K. Sheehan, and R.J. Pickles Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways Mucosal Immunol 6 2 2013 379 392
134. Y.M. Kim, M.M. Brinkmann, M.E. Paquet, and H.L. Ploegh Unc93b1 delivers nucleotide-sensing toll-like receptors to endolysosomes Nature 452 2008 234 238
135. S. Kim, C. Lewis, and J.A. Nadel Epidermal growth factor receptor reactivation induced by e-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (nci-h292) cells Exp Cell Res 317 2011 2650 2660
136. S. Kim, C. Lewis, and J.A. Nadel Ccl20/ccr6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (nci-h292) cells J Immunol 186 2011 3392 3400
137. H. Klapproth, T. Reinheimer, J. Metzen, M. Munch, F. Bittinger, and C.J. Kirkpatrick Non-neuronal acetylcholine, a signalling molecule synthesized by surface cells of rat and man Naunyn Schmiedebergs Arch Pharmacol 355 1997 515 523
138. K. Kohri, I.F. Ueki, J.J. Shim, P.R. Burgel, Y.M. Oh, and D.C. Tam Pseudomonas aeruginosa induces MUC5AC production via epidermal growth factor receptor Eur Respir J 20 2002 1263 1270
139. T.C. Kotsimbos, P. Ernst, and Q.A. Hamid Interleukin-13 and interleukin-4 are coexpressed in atopic asthma Proc Assoc Am Physicians 108 1996 368 373
140. S. Koyama, S.I. Rennard, and R.A. Robbins Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity Am J Physiol 262 1992 L466 L471
141. S. Koyama, E. Sato, H. Nomura, K. Kubo, S. Nagai, and T. Izumi Acetylcholine and substance p stimulate bronchial epithelial cells to release eosinophil chemotactic activity J Appl Physiol 84 1998 1528 1534
142. D.A. Kuperman, X. Huang, L.L. Koth, G.H. Chang, G.M. Dolganov, and Z. Zhu Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma Nat Med 8 2002 885 889
143. I. Kuwahara, E.P. Lillehoj, W. Lu, I.S. Singh, Y. Isohama, and T. Miyata Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line Am J Physiol Lung Cell Mol Physiol 291 2006 L407 L416
144. J. Lahmouzi, F. Simain-Sato, M.P. Defresne, M.C. De Pauw, E. Heinen, and T. Grisar Effect of nicotine on rat gingival fibroblasts in vitro Connect Tissue Res 41 2000 69 80
145. A. Laitinen, A. Altraja, M. Kampe, M. Linden, I. Virtanen, and L.A. Laitinen Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid Am J Respir Crit Care Med 156 1997 951 958
146. J. Laoukili, E. Perret, T. Willems, A. Minty, E. Parthoens, and O. Houcine Il-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells J Clin Invest 108 2001 1817 1824
147. I.R. Le Jeune, M. Shepherd, G. Van Heeke, M.D. Houslay, and I.P. Hall Cyclic amp-dependent transcriptional up-regulation of phosphodiesterase 4d5 in human airway smooth muscle cells. Identification and characterization of a novel pde4d5 promoter J Biol Chem 277 2002 35980 35989
148. Lefrancais, E., Roga, S., Gautier, V., Gonzalez-de-Peredo, A., Monsarrat, B., Girard, J.P., et al. Il-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin g. Proc Natl Acad Sci U S A, 109, 1673-1678.
149. S.Y. Leung, P. Eynott, P. Nath, and K.F. Chung Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features J Allergy Clin Immunol 115 2005 989 996
150. B.D. Levy, C. Bonnans, E.S. Silverman, L.J. Palmer, G. Marigowda, and E. Israel Diminished lipoxin biosynthesis in severe asthma Am J Respir Crit Care Med 172 2005 824 830
151. B.D. Levy, P. Kohli, K. Gotlinger, O. Haworth, S. Hong, and S. Kazani Protectin d1 is generated in asthma and dampens airway inflammation and hyperresponsiveness J Immunol 178 2007 496 502
152. B.D. Levy, I. Vachier, and C.N. Serhan Resolution of inflammation in asthma Clin Chest Med 33 2012 559 570
153. J.D. Li, A.F. Dohrman, M. Gallup, S. Miyata, J.R. Gum, and Y.S. Kim Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease Proc Natl Acad Sci U S A 94 1997 967 972
154. L. Li, Y. Xia, A. Nguyen, Y.H. Lai, L. Feng, and T.R. Mosmann Effects of th2 cytokines on chemokine expression in the lung: Il-13 potently induces eotaxin expression by airway epithelial cells J Immunol 162 1999 2477 2487
155. J.M. Liebler, Z. Borok, X. Li, B. Zhou, A.J. Sandoval, and K.J. Kim Alveolar epithelial type i cells express beta2-adrenergic receptors and g-protein receptor kinase 2 J Histochem Cytochem 52 2004 759 767
156. B.J. Lipworth Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern? Drug Saf 16 1997 295 308
157. Y.J. Liu Thymic stromal lymphopoietin and ox40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation J Allergy Clin Immunol 120 2007 238 244 (quiz 245-236)
158. P. Liu, M. Jamaluddin, K. Li, R.P. Garofalo, A. Casola, and A.R. Brasier Retinoic acid-inducible gene i mediates early antiviral response and toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells J Virol 81 2007 1401 1411
159. M. Longphre, D. Li, M. Gallup, E. Drori, C.L. Ordonez, and T. Redman Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells J Clin Invest 104 1999 1375 1382
160. J. Louahed, M. Toda, J. Jen, Q. Hamid, J.C. Renauld, and R.C. Levitt Interleukin-9 upregulates mucus expression in the airways Am J Respir Cell Mol Biol 22 2000 649 656
161. N.Z. Lu, and J.A. Cidlowski Glucocorticoid receptor isoforms generate transcription specificity Trends Cell Biol 16 2006 301 307
162. R. Lundgren, M. Soderberg, P. Horstedt, and R. Stenling Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids Eur Respir J 1 1988 883 889
163. Y. Maeda, G. Chen, Y. Xu, H.M. Haitchi, L. Du, and Keiser Airway epithelial transcription factor nk2 homeobox 1 inhibits mucous cell metaplasia and th2 inflammation Am J Respir Crit Care Med 184 2011 421 429
164. J.C. Mak, M. Nishikawa, and P.J. Barnes Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung Am J Physiol 268 1995 L41 L46
165. B. Marcet, B. Chevalier, G. Luxardi, C. Coraux, L.E. Zaragosi, and M. Cibois Control of vertebrate multiciliogenesis by mir-449 through direct repression of the delta/notch pathway Nat Cell Biol 13 2011 693 699
166. H. Matsui, S.H. Randell, S.W. Peretti, C.W. Davis, and R.C. Boucher Coordinated clearance of periciliary liquid and mucus from airway surfaces J Clin Invest 102 1998 1125 1131
167. S. Matsukura, C. Stellato, S.N. Georas, V. Casolaro, J.R. Plitt, and K. Miura Interleukin-13 upregulates eotaxin expression in airway epithelial cells by a stat6-dependent mechanism Am J Respir Cell Mol Biol 24 2001 755 761
168. S. Mattoli, M. Soloperto, M. Mezzetti, and A. Fasoli Mechanisms of calcium mobilization and phosphoinositide hydrolysis in human bronchial smooth muscle cells by endothelin 1 Am J Respir Cell Mol Biol 5 1991 424 430
169. A.D. Maus, E.F. Pereira, P.I. Karachunski, R.M. Horton, D. Navaneetham, and K. Macklin Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors Mol Pharmacol 54 1998 779 788
170. A.K. Mayer, M. Muehmer, J. Mages, K. Gueinzius, C. Hess, and K. Heeg Differential recognition of tlr-dependent microbial ligands in human bronchial epithelial cells J Immunol 178 2007 3134 3142
171. M.M. Mentink-Kane, and T.A. Wynn Opposing roles for IL-13 and IL-13
172. J. Metzen, F. Bittinger, C.J. Kirkpatrick, H. Kilbinger, and I. Wessler Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the m1-subtype Life Sci 72 2003 2075 2080
173. J.R. Michael, and B.A. Markewitz Endothelins and the lung Am J Respir Crit Care Med 154 1996 555 581
174. W.C. Moore, D.A. Meyers, S.E. Wenzel, W.G. Teague, H. Li, and X. Li Identification of asthma phenotypes using cluster analysis in the severe asthma research program Am J Respir Crit Care Med 181 2010 315 323
175. A. Muir, G. Soong, S. Sokol, B. Reddy, M.I. Gomez, and A. Van Heeckeren Toll-like receptors in normal and cystic fibrosis airway epithelial cells Am J Respir Cell Mol Biol 30 2004 777 783
176. J. Mullol, B.A. Chowdhury, M.V. White, K. Ohkubo, R.D. Rieves, and J. Baraniuk Endothelin in human nasal mucosa Am J Respir Cell Mol Biol 8 1993 393 402
177. T. Murata, N.I. Obiri, and R.K. Puri Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review) Int J Mol Med 1 1998 551 557
178. D.M. Murphy, and P.M. O'Byrne Recent advances in the pathophysiology of asthma Chest 137 2010 1417 1426
179. J.A. Nadel Protease actions on airway secretions. Relevance to cystic fibrosis Ann N Y Acad Sci 624 1991 286 296
180. J.A. Nadel Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease Curr Opin Allergy Clin Immunol 7 2007 57 62
181. H. Nakamura, K. Yoshimura, H.A. Jaffe, and R.G. Crystal Interleukin-8 gene expression in human bronchial epithelial cells J Biol Chem 266 1991 19611 19617
182. T. Nakanaga, J.A. Nadel, I.F. Ueki, J.L. Koff, and M.X. Shao Regulation of interleukin-8 via an airway epithelial signaling cascade Am J Physiol Lung Cell Mol Physiol 292 2007 L1289 L1296
183. E. Naline, C. Bertrand, K. Biyah, Y. Fujitani, T. Okada, and A. Bisson Modulation of et-1-induced contraction of human bronchi by airway epithelium-dependent nitric oxide release via et(a) receptor activation Br J Pharmacol 126 1999 529 535
184. T. Naseer, E.M. Minshall, D.Y. Leung, S. Laberge, P. Ernst, and R.J. Martin Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy Am J Respir Crit Care Med 155 1997 845 851
185. B. Naylor The shedding of the mucosa of the bronchial tree in asthma Thorax 17 1962 69 72
186. D.R. Neill, S.H. Wong, A. Bellosi, R.J. Flynn, M. Daly, and T.K. Langford Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity Nature 464 2010 1367 1370
187. K. Nelms, A.D. Keegan, J. Zamorano, J.J. Ryan, and W.E. Paul The IL-4 receptor: signaling mechanisms and biologic functions Annu Rev Immunol 17 1999 701 738
188. H.S. Nelson, S.T. Weiss, E.R. Bleecker, S.W. Yancey, and P.M. Dorinsky The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol Chest 129 2006 15 26
189. F.P. Nijkamp, F. Engels, P.A. Henricks, and A.J. Van Oosterhout Mechanisms of beta-adrenergic receptor regulation in lungs and its implications for physiological responses Physiol Rev 72 1992 323 367
190. H. Ninomiya, X.Y. Yu, Y. Uchida, S. Hasegawa, and E.W. Spannhake Specific binding of endothelin-1 to canine tracheal epithelial cells in culture Am J Physiol 268 1995 L424 L431
191. E.C. Nowak, C.T. Weaver, H. Turner, S. Begum-Haque, B. Becher, and B. Schreiner Il-9 as a mediator of th17-driven inflammatory disease J Exp Med 206 2009 1653 1660
192. N.I. Obiri, W. Debinski, W.J. Leonard, and R.K. Puri Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15 J Biol Chem 270 1995 8797 8804
193. K. Ochiai, B. Wang, A. Rieger, O. Kilgus, D. Maurer, and D. Fodinger A review on Fc epsilon RI on human epidermal langerhans cells Int Arch Allergy Immunol 104 Suppl. 1 1994 63 64
194. B.J. O'Connor, S.L. Aikman, and P.J. Barnes Tolerance to the nonbronchodilator effects of inhaled beta 2-agonists in asthma N Engl J Med 327 1992 1204 1208
195. R.A. O'Donnell, A. Richter, J. Ward, G. Angco, A. Mehta, and K. Rousseau Expression of erbb receptors and mucins in the airways of long term current smokers Thorax 59 2004 1032 1040
196. S. Ohta, N. Oda, T. Yokoe, A. Tanaka, Y. Yamamoto, and Y. Watanabe Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma Clin Exp Allergy 40 2010 1266 1275
197. A.L. Oldenburg, R.K. Chhetri, D.B. Hill, and B. Button Monitoring airway mucus flow and ciliary activity with optical coherence tomography Biomed Opt Express 3 2012 1978 1992
198. K.S. Park, T.R. Korfhagen, M.D. Bruno, J.A. Kitzmiller, H. Wan, and S.E. Wert Khurana Hershey GK, Chen G, Whitsett JA: Spdef regulates goblet cell hyperplasia in the airway epithelium J Clin Invest 117 2007 978 988
199. J.M. Parker, C.K. Oh, C. LaForce, S.D. Miller, D.S. Pearlman, and C. Le Safety profile and clinical activity of multiple subcutaneous doses of medi-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma BMC Pulm Med 11 2011 14
200. V.A. Pavlov, and K.J. Tracey The cholinergic anti-inflammatory pathway Brain Behav Immun 19 2005 493 499
201. J. Pawsey, A.B. Lansley, and M.I. Lethem Endothelin increases the ciliary beat frequency of ovine airway epithelium via its interaction with endothelin a receptors Pulm Pharmacol Ther 24 2011 602 609
202. S.P. Peters, S.J. Kunselman, N. Icitovic, W.C. Moore, R. Pascual, and B.T. Ameredes Tiotropium bromide step-up therapy for adults with uncontrolled asthma N Engl J Med 363 2010 1715 1726
203. L. Pini, Q. Hamid, J. Shannon, L. Lemelin, R. Olivenstein, and P. Ernst Differences in proteoglycan deposition in the airways of moderate and severe asthmatics Eur Respir J 29 2007 71 77
204. A. Planaguma, S. Kazani, G. Marigowda, O. Haworth, T.J. Mariani, and E. Israel Airway lipoxin a4 generation and lipoxin a4 receptor expression are decreased in severe asthma Am J Respir Crit Care Med 178 2008 574 582
205. J. Platz, C. Beisswenger, A. Dalpke, R. Koczulla, O. Pinkenburg, and C. Vogelmeier Microbial DNA induces a host defense reaction of human respiratory epithelial cells J Immunol 173 2004 1219 1223
206. R. Polosa, S.M. Puddicombe, M.T. Krishna, A.B. Tuck, P.H. Howarth, and S.T. Holgate Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects J Allergy Clin Immunol 109 2002 75 81
207. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, and X. Du Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
208. M. Profita, A. Bonanno, L. Siena, M. Ferraro, A.M. Montalbano, and F. Pompeo Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism Eur J Pharmacol 582 2008 145 153
209. B.J. Proskocil, H.S. Sekhon, Y. Jia, V. Savchenko, R.D. Blakely, and J. Lindstrom Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells Endocrinology 145 2004 2498 2506
210. D. Proud, and R. Leigh Epithelial cells and airway diseases Immunol Rev 242 2011 186 204
211. C. Prussin, and D.D. Metcalfe 5. Ige, mast cells, basophils, and eosinophils J Allergy Clin Immunol 117 2006 S450 S456
212. E. Puchelle, J.M. Zahm, J.M. Tournier, and C. Coraux Airway epithelial repair, regeneration, and remodeling after injury in chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2006 726 733
213. S.M. Puddicombe, R. Polosa, A. Richter, M.T. Krishna, P.H. Howarth, and S.T. Holgate Involvement of the epidermal growth factor receptor in epithelial repair in asthma FASEB J 14 2000 1362 1374
214. L. Pujols, J. Mullol, and C. Picado Alpha and beta glucocorticoid receptors: relevance in airway diseases Curr Allergy Asthma Rep 7 2007 93 99
215. L. Pujols, J. Mullol, J. Roca-Ferrer, A. Torrego, A. Xaubet, and J.A. Cidlowski Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues Am J Physiol Cell Physiol 283 2002 C1324 C1331
216. K. Racke, U.R. Juergens, and S. Matthiesen Control by cholinergic mechanisms Eur J Pharmacol 533 2006 57 68
217. K. Racke, and S. Matthiesen The airway cholinergic system: physiology and pharmacology Pulm Pharmacol Ther 17 2004 181 198
218. S.H. Randell Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease Proc Am Thorac Soc 3 2006 718 725
219. J.R. Reader, D.M. Hyde, E.S. Schelegle, M.C. Aldrich, A.M. Stoddard, and M.P. McLane Interleukin-9 induces mucous cell metaplasia independent of inflammation Am J Respir Cell Mol Biol 28 2003 664 672
220. A.J. Reefer, K.E. Hulse, A. Lannigan, M.D. Solga, P.W. Wright, and L.A. Kelly Flow cytometry imaging identifies rare t(h)2 cells expressing thymic stromal lymphopoietin receptor in a »Proallergic» Milieu J Allergy Clin Immunol 126 2010 1049 1058 1058 e1041-1010
221. J.C. Renauld, C. Druez, A. Kermouni, F. Houssiau, C. Uyttenhove, and E. Van Roost Expression cloning of the murine and human interleukin 9 receptor cDNAs Proc Natl Acad Sci U S A 89 1992 5690 5694
222. S.D. Reynolds, A. Giangreco, K.U. Hong, K.E. McGrath, L.A. Ortiz, and B.R. Stripp Airway injury in lung disease pathophysiology: Selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction Am J Physiol 287 2004 L1256 L1265
223. S.D. Reynolds, K.U. Hong, A. Giangreco, G.W. Mango, C. Guron, and Y. Morimoto Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells Am J Physiol 278 2000 L1256 L1263
224. A. Richter, R.A. O'Donnell, R.M. Powell, M.W. Sanders, S.T. Holgate, and R. Djukanovic Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke Am J Respir Cell Mol Biol 27 2002 85 90
225. M.E. Roberts, L. Magowan, I.P. Hall, and S.R. Johnson Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production Eur Respir J 37 2011 1482 1493
226. G.J. Rodrigo, H. Neffen, and J.A. Castro-Rodriguez Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review Chest 139 2011 28 35
227. M. Roland, A. Bhowmik, R.J. Sapsford, T.A. Seemungal, D.J. Jeffries, and T.D. Warner Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease Thorax 56 2001 30 35
228. B.M. Rollins, M. Burn, R.D. Coakley, L.A. Chambers, A.J. Hirsh, and M.T. Clunes A2b adenosine receptors regulate the mucus clearance component of the lung's innate defense system Am J Respir Cell Mol Biol 39 2008 190 197
229. M. Romagnoli, I. Vachier, A.M. Vignola, P. Godard, J. Bousquet, and P. Chanez Safety and cellular assessment of bronchial brushing in airway diseases Respir Med 93 1999 461 466
230. T. Runer, and S. Lindberg Ciliostimulatory effects mediated by nitric oxide Acta Otolaryngol 119 1999 821 825
231. S.M. Russell, J.A. Johnston, M. Noguchi, M. Kawamura, C.M. Bacon, and M. Friedmann Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID Science 266 1994 1042 1045
232. T. Sakurai, M. Yanagisawa, Y. Takuwa, H. Miyazaki, S. Kimura, and K. Goto Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor Nature 348 1990 732 735
233. E.J. Schenkelaars, and I.L. Bonta Beta 2-adrenoceptor agonists reverse the leukotriene c4-induced release response of macrophages Eur J Pharmacol 107 1984 65 70
234. J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy, and T.K. McClanahan Il-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein st2 and induces t helper type 2-associated cytokines Immunity 23 2005 479 490
235. R. Schwandner, R. Dziarski, H. Wesche, M. Rothe, and C.J. Kirschning Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2 J Biol Chem 274 1999 17406 17409
236. H.S. Sekhon, Y. Jia, R. Raab, A. Kuryatov, J.F. Pankow, and J.A. Whitsett Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys J Clin Invest 103 1999 637 647
237. C.N. Serhan, K. Gotlinger, S. Hong, Y. Lu, J. Siegelman, and T. Baer Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes J Immunol 176 2006 1848 1859
238. C.N. Serhan, S. Hong, K. Gronert, S.P. Colgan, P.R. Devchand, and G. Mirick Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals J Exp Med 196 2002 1025 1037
239. C.N. Serhan, and K.A. Sheppard Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene a4 by platelet 12-lipoxygenase in vitro J Clin Invest 85 1990 772 780
240. C.N. Serhan, R. Yang, K. Martinod, K. Kasuga, P.S. Pillai, and T.F. Porter Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions J Exp Med 206 2009 15 23
241. C.N. Serhan, G. Fredman, R. Yang, S. Karamnov, L.S. Belayev, and N.G. Bazan Novel proresolving aspirin-triggered DHA pathway Chem Biol 18 2011 976 987
242. J. Seybold, R. Newton, L. Wright, P.A. Finney, N. Suttorp, and P.J. Barnes Induction of phosphodiesterases 3b, 4a4, 4d1, 4d2, and 4d3 in jurkat t-cells and in human peripheral blood t-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization J Biol Chem 273 1998 20575 20588
243. Q. Sha, A.Q. Truong-Tran, J.R. Plitt, L.A. Beck, and R.P. Schleimer Activation of airway epithelial cells by toll-like receptor agonists Am J Respir Cell Mol Biol 31 2004 358 364
244. A. Shibaki, A. Ohkawara, S. Shimada, C. Ra, S. Aiba, and K.D. Cooper Expression, but lack of calcium mobilization by high-affinity ige fc epsilon receptor i on human epidermal and dermal langerhans cells Exp Dermatol 5 1996 272 278
245. S.A. Shore, and P.E. Moore Regulation of beta-adrenergic responses in airway smooth muscle Respir Physiol Neurobiol 137 2003 179 195
246. L. Uller, C.G. Persson, L. Kallstrom, and J.S. Erjefalt Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment Am J Respir Crit Care Med 164 2001 1948 1956
247. A. Tam, S. Wadsworth, D. Dorscheid, S.F. Man, and D.D. Sin The airway epithelium: More than just a structural barrier Ther Adv Respir Dis 5 2011 255 273
248. W. Xian, and F. McKeon Adult stem cells underlying lung regeneration Cell cycle 11 2012 887 894
249. C. Xiao, S.M. Puddicombe, S. Field, J. Haywood, V. Broughton-Head, and I. Puxeddu Defective epithelial barrier function in asthma J Allergy Clin Immunol 128 549-556 2011 e541 512
250. A. Woywodt, S. Lefrak, and E. Matteson Tainted eponyms in medicine: the "Clara" cell joins the list Eur Respir J 36 2010 706 708
251. A. Winkelmann, and T. Noack The clara cell: a "third reich eponym"? Eur Respir J 36 2010 722 727
252. J. Vestbo, L.D. Edwards, P.D. Scanlon, J.C. Yates, A. Agusti, and P. Bakke Changes in forced expiratory volume in 1 second over time in COPD N Engl J Med 365 2011 1184 1192
253. M.C. Siracusa, S.A. Saenz, D.A. Hill, B.S. Kim, M.B. Headley, and T.A. Doering TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation Nature 477 2011 229 233
254. B. Zhou, M.B. Headley, T. Aye, J. Tocker, M.R. Comeau, and S.F. Ziegler Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of th2 responses J Immunol 181 2008 6557 6562
255. B. Zhou, M.R. Comeau, T. De Smedt, H.D. Liggitt, M.E. Dahl, and D.B. Lewis Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice Nat Immunol 6 2005 1047 1053
256. S.F. Ziegler, and D. Artis Sensing the outside world: TSLP regulates barrier immunity Nat Immunol 11 2010 289 293
257. S.H. Wong, J.A. Walker, H.E. Jolin, L.F. Drynan, E. Hams, and A. Camelo Transcription factor RORalpha is critical for nuocyte development Nat Immunol 13 2012 229 236
258. E. Sigal, S. Dicharry, E. Highland, and W.E. Finkbeiner Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium Am J Physiol 262 1992 L392 L398
259. I. Vachier, C. Bonnans, C. Chavis, M. Farce, P. Godard, and J. Bousquet Severe asthma is associated with a loss of lx4, an endogenous anti-inflammatory compound J Allergy Clin Immunol 115 2005 55 60
260. I. Vachier, G. Chiappara, A.M. Vignola, R. Gagliardo, E. Altieri, and B. Terouanne Glucocorticoid receptors in bronchial epithelial cells in asthma Am J Respir Crit Care Med 158 1998 963 970
261. I. Strickland, K. Kisich, P.J. Hauk, A. Vottero, G.P. Chrousos, and D.J. Klemm High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids J Exp Med 193 2001 585 593
262. M. Surjit, K.P. Ganti, A. Mukherji, T. Ye, G. Hua, and D. Metzger Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor Cell 145 2011 224 241
263. M.S. Tsao, H. Zhu, and J. Viallet Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells Exp Cell Res 223 1996 268 273
264. K. Takeyama, B. Jung, J.J. Shim, P.R. Burgel, T. Dao-Pick, and I.F. Ueki Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke Am J Physiol Lung Cell Mol Physiol 280 2001 L165 L172
265. K. Takeyama, K. Dabbagh, H.M. Lee, C. Agusti, J.A. Lausier, and I.F. Ueki Epidermal growth factor system regulates mucin production in airways Proc Natl Acad Sci U S A 96 1999 3081 3086
266. M.C. Subauste, and D. Proud Effects of tumor necrosis factor-alpha, epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by, and human rhinovirus replication in, bronchial epithelial cells Int Immunopharmacol 1 2001 1229 1234
267. I. Wessler, and C.J. Kirkpatrick Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans Br J Pharmacol 154 2008 1558 1571
268. I.K. Wessler, and C.J. Kirkpatrick The non-neuronal cholinergic system: an emerging drug target in the airways Pulm Pharmacol Ther 14 2001 423 434
269. X. Su, J.W. Lee, Z.A. Matthay, G. Mednick, T. Uchida, and X. Fang Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats Am J Respir Cell Mol Biol 37 2007 186 192
270. P.S. Sudheer, J.E. Hall, R. Donev, G. Read, A. Rowbottom, and P.E. Williams Nicotinic acetylcholine receptors on basophils and mast cells Anaesthesia 61 2006 1170 1174
271. H. Wang, M. Yu, M. Ochani, C.A. Amella, M. Tanovic, and S. Susarla Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation Nature 421 2003 384 388
272. M. Takimoto, K. Oda, Y. Sasaki, and T. Okada Endothelin-a receptor-mediated prostanoid secretion via autocrine and deoxyribonucleic acid synthesis via paracrine signaling in human bronchial epithelial cells Endocrinology 137 1996 4542 4550
273. T. Wu, R.D. Rieves, P. Larivee, C. Logun, M.G. Lawrence, and J.H. Shelhamer Production of eicosanoids in response to endothelin-1 and identification of specific endothelin-1 binding sites in airway epithelial cells Am J Respir Cell Mol Biol 8 1993 282 290
274. M. Sofia, M. Mormile, S. Faraone, P. Carratu, M. Alifano, and G. Di Benedetto Increased 24-hour endothelin-1 urinary excretion in patients with chronic obstructive pulmonary disease Respiration 61 1994 263 268
275. J. Tamaoki, T. Kanemura, N. Sakai, K. Isono, K. Kobayashi, and T. Takizawa Endothelin stimulates ciliary beat frequency and chloride secretion in canine cultured tracheal epithelium Am J Respir Cell Mol Biol 4 1991 426 431
276. M. Wills-Karp Il-12/IL-13 axis in allergic asthma J Allergy Clin Immunol 107 2001 9 18
277. M. Wills-Karp, J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, and C.L. Karp Interleukin-13: central mediator of allergic asthma Science 282 1998 2258 2261
278. Z. Zhu, R.J. Homer, Z. Wang, Q. Chen, G.P. Geba, and J. Wang Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production J Clin Invest 103 1999 779 788
279. T.A. Wynn Il-13 effector functions Annu Rev Immunol 21 2003 425 456
280. N. Wood, M.J. Whitters, B.A. Jacobson, J. Witek, J.P. Sypek, and M. Kasaian Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2 J Exp Med 197 2003 703 709
281. M. Wills-Karp Interleukin-13 in asthma pathogenesis Immunol Rev 202 2004 175 190
282. N. Watanabe, F. Bruschi, and M. Korenaga IgE: a question of protective immunity in Trichinella spiralis infection Trends Parasitol 21 2005 175 178
283. D. von Bubnoff, N. Novak, S. Kraft, and T. Bieber The central role of FcepsilonRI in allergy Clin Exp Dermatol 28 2003 184 187
284. E. Untersmayr, G. Bises, P. Starkl, C.L. Bevins, O. Scheiner, and G. Boltz-Nitulescu The high affinity ige receptor fc epsilonri is expressed by human intestinal epithelial cells PLoS One 5 2010 e9023
285. U.A. Temann, G.P. Geba, J.A. Rankin, and R.A. Flavell Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness J Exp Med 188 1998 1307 1320
286. V. Steenwinckel, J. Louahed, M.M. Lemaire, C. Sommereyns, G. Warnier, and A. McKenzie Il-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa J Immunol 182 2009 4737 4743
287. V. Steenwinckel, J. Louahed, C. Orabona, F. Huaux, G. Warnier, and A. McKenzie Il-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells J Immunol 178 2007 3244 3251
288. U.A. Temann, Y. Laouar, E.E. Eynon, R. Homer, and R.A. Flavell Il9 leads to airway inflammation by inducing il13 expression in airway epithelial cells Int Immunol 19 2007 1 10
289. U.A. Temann, P. Ray, and R.A. Flavell Pulmonary overexpression of IL-9 induces th2 cytokine expression, leading to immune pathology J Clin Invest 109 2002 29 39
290. L. Whittaker, N. Niu, U.A. Temann, A. Stoddard, R.A. Flavell, and A. Ray Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by cd4 t cells and interleukin-9 Am J Respir Cell Mol Biol 27 2002 593 602
291. P.D. Vermeer, R. Harson, L.A. Einwalter, T. Moninger, and J. Zabner Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia Am J Respir Cell Mol Biol 28 2003 286 295
292. O. Takeuchi, T. Kawai, P.F. Muhlradt, M. Morr, J.D. Radolf, and A. Zychlinsky Discrimination of bacterial lipoproteins by toll-like receptor 6 Int Immunol 13 2001 933 940
293. O. Takeuchi, S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, and Z. Dong Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins J Immunol 169 2002 10 14
294. D. Zhang, G. Zhang, M.S. Hayden, M.B. Greenblatt, C. Bussey, and R.A. Flavell A toll-like receptor that prevents infection by uropathogenic bacteria Science 303 2004 1522 1526
295. F. Yarovinsky, D. Zhang, J.F. Andersen, G.L. Bannenberg, C.N. Serhan, and M.S. Hayden Tlr11 activation of dendritic cells by a protozoan profilin-like protein Science 308 2005 1626 1629
296. Q. Wang, D.R. Nagarkar, E.R. Bowman, D. Schneider, B. Gosangi, and J. Lei Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses J Immunol 183 2009 6989 6997
297. Z. Xing, R. Harper, J. Anunciacion, Z. Yang, W. Gao, and B. Qu Host immune and apoptotic responses to avian influenza virus h9n2 in human tracheobronchial epithelial cells Am J Respir Cell Mol Biol 44 2011 24 33
298. L. Zhu, P.K. Lee, W.M. Lee, Y. Zhao, D. Yu, and Y. Chen Rhinovirus-induced major airway mucin production involves a novel tlr3-egfr-dependent pathway Am J Respir Cell Mol Biol 40 2009 610 619
299. K. Ueno, T. Koga, K. Kato, D.T. Golenbock, S.J. Gendler, and H. Kai Muc1 mucin is a negative regulator of toll-like receptor signaling Am J Respir Cell Mol Biol 38 2008 263 268
300. T. Yukawa, D. Ukena, C. Kroegel, P. Chanez, G. Dent, and K.F. Chung Beta 2-adrenergic receptors on eosinophils. Binding and functional studies Am Rev Respir Dis 141 1990 1446 1452
301. D. Spina, P.J. Rigby, J.W. Paterson, and R.G. Goldie Autoradiographic localization of beta-adrenoceptors in asthmatic human lung Am Rev Respir Dis 140 1989 1410 1415
302. S. Zink, P. Rosen, B. Sackmann, and H. Lemoine Regulation of endothelial permeability by beta-adrenoceptor agonists: contribution of beta 1- and beta 2-adrenoceptors Biochim Biophys Acta 1178 1993 286 298
303. H. Zhong, Y. Wu, L. Belardinelli, and D. Zeng A2b adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase Am J Respir Cell Mol Biol 35 2006 587 592
304. P.G. Woodruff, B. Modrek, D.F. Choy, G. Jia, A.R. Abbas, and A. Ellwanger T-helper type 2-driven inflammation defines major subphenotypes of asthma Am J Respir Crit Care Med 180 2009 388 395
305. T.J. Torphy, H.L. Zhou, J.J. Foley, H.M. Sarau, C.D. Manning, and M.S. Barnette Salbutamol up-regulates pde4 activity and induces a heterologous desensitization of u937 cells to prostaglandin e2. Implications for the therapeutic use of beta-adrenoceptor agonists J Biol Chem 270 1995 23598 23604
306. Z. Zietkowski, R. Skiepko, M.M. Tomasiak-Lozowska, and A. Bodzenta-Lukaszyk Anti-ige therapy with omalizumab decreases endothelin-1 in exhaled breath condensate of patients with severe persistent allergic asthma Respiration 80 2010 534 542
307. M. Wills-Karp, and F.D. Finkelman Untangling the complex web of IL-4- and IL-13-mediated signaling pathways Sci Signal 1 2008 pe55
308. S.S. Sidhu, S. Yuan, A.L. Innes, S. Kerr, P.G. Woodruff, and L. Hou Roles of epithelial cell-derived periostin in tgf-beta activation, collagen production, and collagen gel elasticity in asthma Proc Natl Acad Sci U S A 107 2010 14170 14175
309. G. Takayama, K. Arima, T. Kanaji, S. Toda, H. Tanaka, and S. Shoji Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals J Allergy Clin Immunol 118 2006 98 104
310. D.E. Smith Il-33: A tissue derived cytokine pathway involved in allergic inflammation and asthma Clin Exp Allergy 40 2010 200 208
311. F. Zhang, G. Huang, B. Hu, Y. Song, and Y. Shi A soluble thymic stromal lymphopoietin (TSLP) antagonist, TSLPR-immunoglobulin, reduces the severity of allergic disease by regulating pulmonary dendritic cells Clin Exp Immunol 164 2011 256 264
312. K. Sugamura, N. Ishii, and A.D. Weinberg Therapeutic targeting of the effector t-cell co-stimulatory molecule ox40 Nat Rev Immunol 4 2004 420 431