Protection by dexamethasone of the functional desensitization to β2-adrenoceptor-mediated responses in human lung mast cells

British Journal of Pharmacology

Volumn 121, Issue 4, 1997, Pages 717-722

  Chong, Lee K ^a   Drury, Duncan E J ^a   Dummer, Jack F ^a   Ghahramani, Parviz ^a   Schleimer, Robert P ^b   Peachell, Peter T ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

2 adrenoceptors; Desensitization; Glucocorticoids; Mast cells

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DEXAMETHASONE; GLUCOCORTICOID; HISTAMINE; IMMUNOGLOBULIN E; ISOPRENALINE;

ARTICLE; ASTHMA; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DOSE TIME EFFECT RELATION; DRUG WITHDRAWAL; HISTAMINE RELEASE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MAST CELL; PRIORITY JOURNAL;

ADRENERGIC BETA-AGONISTS; ANTI-INFLAMMATORY AGENTS; DESENSITIZATION, IMMUNOLOGIC; DEXAMETHASONE; GLUCOCORTICOIDS; HUMANS; ISOPROTERENOL; LUNG; MAST CELLS; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0030958890     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701185     Document Type: Article

References (37)

1. ALI, H. & PEARCE, F.L. (1985). Isolation and properties of cardiac and other mast cells from the rat and guinea-pig. Agents Actions, 16, 138-140.
2. ASSEM, E.S.K. & SCHILD, H.O. (1969). Beta-adrenergic receptors concerned with the anaphylactic mechanism. Im. Archs Allergy Appl. Immunol., 45, 62-69.
3. AVNER, B.P. & JENNE, J.W. (1981). Desensitization of isolated human bronchial smooth muscle to β-receptor agonists. J. Allergy Clin. Immunol., 68, 51-57.
4. 2-adrenoceptor agonists in asthma. Trends Pharmacol. Sci., 13, 20-23.
5. BUTCHERS, P.R., SKIDMORE, I.F., VARDEY, C.J. & WHEELDON, A. (1980). Characterisation of the receptor mediating the anti-anaphylactic activities of β-adrenoceptor agonists in human lung tissue in vitro. Br. J. Pharmacol., 71, 663-667.
6. CHONG, L.K., MORICE, A.H., YEO, W.W., SCHLEIMER, R.P. & PEACHELL, P.T. (1995). Functional desensitization of β agonist responses in human lung mast cells. Am. J. Respir. Cell Mol. Biol., 13, 540-546.
7. CHURCH, M.K. & HIROI, J. (1987). Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Br. J. Pharmacol., 90, 421-429.
8. COCKCROFT, D.W., MCPARLAND, C.P., BRITTO, S.A., SWYSTUN, V.A. & RUTHERFORD, B.C. (1993). Regular inhaled salbutamol and airway responsiveness to allergen. Lancet, 342, 833-837.
9. CONOLLY, M.E. & GREENACRE, J.K. (1976). The lymphocyte adrenoceptor in normal subjects and patients with bronchial asthma. J. Clin. Invest., 58, 1307-1316.
10. DAVIS, C. & CONOLLY, M.E. (1980). Tachyphylaxis to beta adrenoreceptor agonists in human bronchial smooth muscle: studies in vitro. Br. J. Clin. Pharmacol., 10, 417-423.
11. DOSS, R.C., PERKINS, J.P. & HARDEN, T.K. (1981). Recovery of β adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis. J. Biol. Chem., 256, 12281-12286.
12. ENNIS, M. (1991). Current techniques of histamine determination. Automated fluorometric assays. Handbook Exp. Pharmacol., 97, 31-38.
13. GALANT, S.P., DURISETI, L., UNDERWOOD, S. & INSEL, P.A. (1980). Beta-adrenergic receptors of polymorphonuclear particulates in bronchial asthma. J. Clin. Invest., 65, 577-585.
14. GILBERT, H.S. & ORNSTEIN, L. (1975). Basophil counting with a new staining method using Alcian Blue. Blood, 46, 279-282.
15. GRAINGER, J., WOODMAN, K., PEARCE, N., CRANE, J., BURGESS, C., KEANE, A. & BEASLEY, R. (1991). Prescribed fenoterol and death from asthma in New Zealand, 1981-7; a further case-control study. Thorax, 46, 105-111.
16. 2 adrenergic receptor structure. Pulmon. Pharmacol., 8, 1-10.
17. HASEGAWA, M. & TOWNLEY, R.G. (1983). Differences between lung and spleen susceptibility of beta-adrenergic receptors to desensitization by terbulaline. J. Allergy Clin. Immunol., 71, 230-238.
18. HAUDSORFF, W.P., CARON, M.G. & LEFKOWITZ, R.J. (1990). Turning off the signal: desensitization of β-adrenergic receptor function. FASEB J., 4, 2881-2889.
19. HERTEL, C. & STAEHELIN, M. (1983). Reappearance of β adrenergic receptors after isoproterenol treatment in intact C6-cells. J. Cell Biol., 97, 1538-1543.
20. HOLGATE, S.T., BALDWIN, C.J. & TATTERSFIELD, A.E. (1977). β-adrenergic agonist resistance in normal human airways. Lancet, 2, 375-377.
21. HOLGATE, S.T. STUBBS, W.A., WOOD, P.J., MCCAUGHEY, E.S., ALBERTI, K.G.M.M. & TATTERSFIELD, A.E. (1980). Airway and metabolic resistance to intravenous salbutamol: A study in normal man. Clin. Sci., 59, 155-161.
22. HUI, K.K., CONOLLY, M.E. & TASHKIN, D.P. (1982). Reversal of human lymphocyte β-adrenoceptor desensitization by glucocorticoids. Clin. Pharmacol. Ther., 32, 566-571.
23. 2-adrenergic receptor transcription in human lung. Am. J. Physiol., 268, L41-L46.
24. 2-agonists in asthma. N. Engl. J. Med., 327, 1204-1208.
25. ORANGE, R.P., AUSTEN, W.G. & AUSTEN, K.F. (1971). Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. I. Modulation by agents influencing cellular levels of cyclic 3′5′-adenosine monophosphate. J. Exp. Med., 134, 136-148.
26. PEACHELL, P.T., MACGLASHAN, D.W., LICHTENSTEIN, L.M. & SCHLEIMER, R.P. (1988). Regulation of human basophil and lung mast cell function by cAMP. J. Immunol., 140, 571-579.
27. SCARPACE, P.J., BARESI, L.A., SANFORD, D.A. & ABRASS, I.B. (1985). Desensitization and resensitization of β adrenergic receptors in a smooth muscle cell line. Mol. Pharmacol., 28, 495-501.
28. SCHLEIMER, R.P. (1990). Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma. Am. Rev. Respir. Dis., 141, S59-S69.
29. SCHLEIMER, R.P., SCHULMAN, E.S., MACGLASHAN, D.W., PETERS, S.P., HAYES, E.C., ADAMS, G.K., LICHTENSTEIN, L.M. & ADKINSON, N.F. (1983). Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J. Clin. Invest., 71, 1830-1835.
30. SEARS, M.R., TAYLOR, D.R., PRINT, C.G., LAKE, D.C., LI, Q., FLANNERY, E.M., YATES, D.M., LUCAS, M.K. & HERBISON, G.P. (1990). Regular inhaled beta-agonist treatment in bronchial asthma. Lancet, 336, 1391-1396.
31. SIRAGANIAN, R.P. (1974). An automated continuous-flow system for the extraction and fluorometric analysis of histamine. Anal. Biochem., 57, 283-287.
32. SPITZER, W.O., SUISSA, S., ERNST, P., HORWITZ, R.I., HABBICK, B., COCKCROFT, D., BOIVIN, J-F., MCNUTT, M., BUIST, A.S. & REBUCK, A.S. (1992). The use of β-agonists and the risk of death and near death from asthma. N. Eng. J. Med., 326, 501-506.
33. STADEL, J.M., STRULOVICI, B., NAMBI, P., LAVIN, T.M., BRIGGS, M.M., CARON, M.G. & LEFKOWITZ, R.J. (1983). Desensitization of the β adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles. J. Biol. Chem., 258, 3032-3038.
34. SVEDMYR, N. (1990). Action of corticosteroids on beta-adrenergic receptors. Am. Rev. Respir. Dis., 141, S31-S38.
35. TATTERSFIELD, A.E. (1992). Bronchodilators: new developments. Br. Med. Bull., 48, 51-64.
36. UNDEM, B.J., PEACHELL, P.T. & LICHTENSTEIN, L.M. (1988). Isoproterenol-induced inhibition of IgE-mediated release of histamine and arachidonic acid metabolites from the human lung mast cell. J. Pharmacol. Exp. Ther., 247, 209-217.
37. VAN DER HEIJDEN, P.J.C.M., VAN AMSTERDAM, J.G.C. & ZAAGSMA, J. (1984). Desensitization of smooth muscle and mast cell β-adrenoceptors in the airways of the guinea pig. Eur. J. Resp. Dis., (supplement 135) 65, 128-134.