Cluster analysis and clinical asthma phenotypes

American Journal of Respiratory and Critical Care Medicine

Volumn 178, Issue 3, 2008, Pages 218-224

  Haldar, Pranab ^a   Pavord, Ian D ^a   Shaw, Dominic E ^a   Berry, Michael A ^a   Thomas, Michael ^b   Brightling, Christopher E ^a   Wardlaw, Andrew J ^a   Green, Ruth H ^a  

^a GLENFIELD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Corticosteroid response; Multivariate classification; Taxonomy

Indexed keywords

BECLOMETASONE; CORTICOSTEROID; LEPTIN;

ADULT; ARTICLE; ASTHMA; CLINICAL TRIAL; CLUSTER ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DISEASE CLASSIFICATION; DISEASE EXACERBATION; EOSINOPHIL; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHENOTYPE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SYMPTOM; TREATMENT RESPONSE;

ADRENAL CORTEX HORMONES; ADULT; AGED; ASTHMA; CLASSIFICATION; CLUSTER ANALYSIS; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PHENOTYPE; PROSPECTIVE STUDIES;

EID: 48249085691     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200711-1754OC     Document Type: Article

References (25)

1. Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006;368:780-793.
2. Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, Chu HW. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-1008.
3. Wardlaw AJ, Silverman M, Siva R, Pavord ID, Green R. Multidimensional phenotyping: towards a new taxonomy for airway disease. Clin Exp Allergy 2005;35:1254-1262.
4. Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet 2006;368:804-813.
5. Heaney LG, Robinson DS. Severe asthma treatment: need for characterising patients. Lancet 2005;365:974-976.
6. Everitt BS, Landau S, Leese M. Cluster analysis, 4th ed. London: Arnold; 2001.
7. Hartigan JA. Clustering. Annu Rev Biophys Bioeng 1973;2:81-101.
8. Sneath PH, Sokal RR. Numerical taxonomy. Nature 1962;193:855-860.
9. Everitt BS, Landau S. The use of multivariate statistical methods in psychiatry. Stat Methods Med Res 1998;7:253-277.
10. American Thoracic Society Refractory Asthma Workshop Committee. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations and unanswered questions. Am J Respir Crit Care Med 2000;162:2341-2351.
11. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002;360:1715-1721.
12. Haldar P, Berry MA, Wardlaw AJ, Pavord ID, Green RH. Refractory asthma phenotypes and the response to sputum eosinophil guided therapy. Thorax 2006;61:ii31.
13. Shaw DE, Berry MA, Thomas M, Green RH, Brightling CE, Wardlaw AJ, Pavord ID. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med 2007;176:231-237.
14. Ball GH, Hall DJ. A clustering technique for summarising multivariate data. Behav Sci 1967;12:153-155.
15. Rackemann FM. Studies in asthma: a clinical survey of 1074 patients with asthma followed for 2 years. J Lab Clin Med 1927;12:1185-1197.
16. Wenzel SE, Busse WW. Severe asthma: lessons from the Severe Asthma Research Program. J Allergy Clin Immunol 2007;119:14-21.
17. Smith JR, Mildenhall S, Noble M, Mugford M, Shepstone L, Harrison BD. Clinician-assessed poor compliance identifies adults with severe asthma who are at risk of adverse outcomes. J Asthma 2005;42: 437-445.
18. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999;353:2213-2214.
19. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006;27:495-503.
20. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax 2003;58:i1-i94.
21. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005;352:2163-2173.
22. Jatakanon A, Lim S, Barnes PJ. Changes in sputum eosinophils predict loss of asthma control. Am J Respir Crit Care Med 2000;161:64-72.
23. Fraley C, Raftery AE. How many clusters? Which clustering method? Answers via model-based cluster analysis. The Computer Journal 1998;41:578-588.
24. Vansteenkiste J, Rochette F, Demedts M. Diagnostic tests of hyperventilation syndrome. Eur Respir J 1991;4:393-399.
25. Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale: an updated literature review. J Psychosom Res 2002;52:69-77.