메뉴 건너뛰기




Volumn 57, Issue 1, 2008, Pages 1-10

The airway epithelium is central to the pathogenesis of asthma

Author keywords

Airway remodeling; Asthma; Disease susceptible genes; Epithelial mesenchymal trophic unit (EMTU); Thymic stromal lymphopoietin (TSLP)

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 11; INTERLEUKIN 13; NEUROTROPHIN; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 40949121542     PISSN: 13238930     EISSN: 14401592     Source Type: Journal    
DOI: 10.2332/allergolint.R-07-154     Document Type: Review
Times cited : (274)

References (91)
  • 2
    • 0033060552 scopus 로고    scopus 로고
    • How much asthma is really attributable to atopy?
    • Pearce N, Pekkanen J, Beasley R. 1999. How much asthma is really attributable to atopy? Thorax 2006;54:268-272.
    • (1999) Thorax , vol.2006 , Issue.54 , pp. 268-272
    • Pearce, N.1    Pekkanen, J.2    Beasley, R.3
  • 3
    • 33746571623 scopus 로고    scopus 로고
    • Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation
    • Hammad H, Lambrecht BN. Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation. J. Allergy Clin. Immunol. 2006;118:331-336.
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 331-336
    • Hammad, H.1    Lambrecht, B.N.2
  • 4
    • 0141816690 scopus 로고    scopus 로고
    • Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
    • Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T, Simmet T. Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 2003;102:2645-2652.
    • (2003) Blood , vol.102 , pp. 2645-2652
    • Colognato, R.1    Slupsky, J.R.2    Jendrach, M.3    Burysek, L.4    Syrovets, T.5    Simmet, T.6
  • 5
    • 34249337763 scopus 로고    scopus 로고
    • The epithelium takes centre stage in asthma and atopic dermatitis
    • Holgate ST. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol. 2007;28:248-251.
    • (2007) Trends Immunol , vol.28 , pp. 248-251
    • Holgate, S.T.1
  • 6
    • 33847134006 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    • Allakhverdi Z, Comeau MR, Jessup HK et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 2007;204:253-258.
    • (2007) J. Exp. Med , vol.204 , pp. 253-258
    • Allakhverdi, Z.1    Comeau, M.R.2    Jessup, H.K.3
  • 8
    • 33748092015 scopus 로고    scopus 로고
    • Rhinoviruses in the pathogenesis of asthma: The bronchial epithelium as a major disease target
    • Holgate ST. Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target. J. Allergy Clin. Immunol. 2006;118:587-590.
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 587-590
    • Holgate, S.T.1
  • 9
    • 34548713042 scopus 로고    scopus 로고
    • TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells
    • Kato A, Favoreto S Jr, Avila PC, Schleimer RP. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol. 2007;179:1080-1087.
    • (2007) J. Immunol , vol.179 , pp. 1080-1087
    • Kato, A.1    Favoreto Jr, S.2    Avila, P.C.3    Schleimer, R.P.4
  • 10
    • 33750592575 scopus 로고    scopus 로고
    • Epithelial damage and angiogenesis in the airways of children with asthma
    • Barbato A, Turato G, Baraldo S et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am. J. Respir. Crit. Care Med. 2006;174:975-981.
    • (2006) Am. J. Respir. Crit. Care Med , vol.174 , pp. 975-981
    • Barbato, A.1    Turato, G.2    Baraldo, S.3
  • 11
    • 18844401152 scopus 로고    scopus 로고
    • Epithelial stress and structural remodelling in childhood asthma
    • Fedorov LA, Wilson SJ, Davies DE, Holgate ST. Epithelial stress and structural remodelling in childhood asthma. Thorax 2005;60:389- 394.
    • (2005) Thorax , vol.60 , pp. 389-394
    • Fedorov, L.A.1    Wilson, S.J.2    Davies, D.E.3    Holgate, S.T.4
  • 12
    • 0033778159 scopus 로고    scopus 로고
    • Is allergic asthma associated with delayed fetal maturation or the persistence of conserved fetal genes?
    • Bousquet J, Yssel H, Vignola AM. Is allergic asthma associated with delayed fetal maturation or the persistence of conserved fetal genes? Allergy 2000;55:1194-1197.
    • (2000) Allergy , vol.55 , pp. 1194-1197
    • Bousquet, J.1    Yssel, H.2    Vignola, A.M.3
  • 13
    • 33847256332 scopus 로고    scopus 로고
    • Asthma/allergic airways disease: Does postnatal exposure to environmental toxicants promote airway pathobiology?
    • Plopper CG, Smiley-Jewell SM, Miller LA et al. Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology? Toxicol. Pathol. 2007;35:97-110.
    • (2007) Toxicol. Pathol , vol.35 , pp. 97-110
    • Plopper, C.G.1    Smiley-Jewell, S.M.2    Miller, L.A.3
  • 16
    • 0036039032 scopus 로고    scopus 로고
    • Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?
    • Knight D. Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal? Clin. Exp. Allergy 2002;32:1263-1265.
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 1263-1265
    • Knight, D.1
  • 18
    • 33749347611 scopus 로고    scopus 로고
    • Ultrastructural investigation of epithelial damage in asthmatic and non-asthmatic nasal polyps
    • Shahana S, Jaunmuktane Z, Asplund MS, Roomans GM. Ultrastructural investigation of epithelial damage in asthmatic and non-asthmatic nasal polyps. Respir. Med. 2006;100:2018-2028.
    • (2006) Respir. Med , vol.100 , pp. 2018-2028
    • Shahana, S.1    Jaunmuktane, Z.2    Asplund, M.S.3    Roomans, G.M.4
  • 19
    • 14544286365 scopus 로고    scopus 로고
    • Attachment of columnar airway epithelial cells in asthma
    • Shebani E, Shahana S, Janson C, Roomans GM. Attachment of columnar airway epithelial cells in asthma. Tissue Cell 2005;37:145-152.
    • (2005) Tissue Cell , vol.37 , pp. 145-152
    • Shebani, E.1    Shahana, S.2    Janson, C.3    Roomans, G.M.4
  • 20
    • 0031809633 scopus 로고    scopus 로고
    • Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids
    • Bertorelli G, Bocchino V, Zhuo X et al. Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids. Clin. Exp. Allergy 1998;8:551-560.
    • (1998) Clin. Exp. Allergy , vol.8 , pp. 551-560
    • Bertorelli, G.1    Bocchino, V.2    Zhuo, X.3
  • 21
    • 0035984581 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    • Bucchieri F, Puddicombe SM, Lordan JL et al. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. Am. J. Respir. Cell Mol. Biol. 2002;27:179-185.
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , pp. 179-185
    • Bucchieri, F.1    Puddicombe, S.M.2    Lordan, J.L.3
  • 22
    • 0035161960 scopus 로고    scopus 로고
    • Extracellular glutathione peroxidase induction in asthmatic lungs: Evidence for redox regulation of expression in human airway epithelial cells
    • Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J. 2001;15:70-78.
    • (2001) FASEB J , vol.15 , pp. 70-78
    • Comhair, S.A.1    Bhathena, P.R.2    Farver, C.3    Thunnissen, F.B.4    Erzurum, S.C.5
  • 23
    • 33750523252 scopus 로고    scopus 로고
    • Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma
    • Ercan H, Birben E, Dizdar EA et al. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. J. Allergy Clin. Immunol. 2006;118:1097-1104.
    • (2006) J. Allergy Clin. Immunol , vol.118 , pp. 1097-1104
    • Ercan, H.1    Birben, E.2    Dizdar, E.A.3
  • 24
    • 34248356290 scopus 로고    scopus 로고
    • Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics
    • Mak JC, Ho SP, Leung HC et al. Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics. Clin. Exp. Allergy 2007;37:1150-1157.
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 1150-1157
    • Mak, J.C.1    Ho, S.P.2    Leung, H.C.3
  • 25
    • 34447318645 scopus 로고    scopus 로고
    • Epithelial cell proliferation contributes to airway remodeling in severe asthma
    • Cohen L, Tarsi EX J, Ramkumar T et al. Epithelial cell proliferation contributes to airway remodeling in severe asthma. Am. J. Respir. Crit. Care Med. 2007;176:138-145.
    • (2007) Am. J. Respir. Crit. Care Med , vol.176 , pp. 138-145
    • Cohen, L.1    Tarsi, E.J.2    Ramkumar, T.3
  • 26
    • 0036727147 scopus 로고    scopus 로고
    • Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation
    • Truong-Tran AQ, Ruffin RE, Foster PS. Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2002;27:286-296.
    • (2002) Am. J. Respir. Cell Mol. Biol , vol.27 , pp. 286-296
    • Truong-Tran, A.Q.1    Ruffin, R.E.2    Foster, P.S.3
  • 27
    • 0036152688 scopus 로고    scopus 로고
    • Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    • Polosa R, Puddicombe SM, Krishna MT et al. Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. J. Allergy Clin. Immunol. 2002;109:75-81.
    • (2002) J. Allergy Clin. Immunol , vol.109 , pp. 75-81
    • Polosa, R.1    Puddicombe, S.M.2    Krishna, M.T.3
  • 28
    • 20444445863 scopus 로고    scopus 로고
    • Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium
    • Hamilton LM, Puddicombe SM, Dearman RJ et al. Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium. Eur. Respir. J. 2005;25:978-985.
    • (2005) Eur. Respir. J , vol.25 , pp. 978-985
    • Hamilton, L.M.1    Puddicombe, S.M.2    Dearman, R.J.3
  • 29
    • 0037329290 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma
    • Hamilton LM, Torres-Lozano C, Puddicombe SM et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin. Exp. Allergy 2003;33:233-240.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 233-240
    • Hamilton, L.M.1    Torres-Lozano, C.2    Puddicombe, S.M.3
  • 30
    • 33746829202 scopus 로고    scopus 로고
    • CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death
    • Merendino AM, Bucchieri F, Gagliardo R et al. CD40 ligation protects bronchial epithelium against oxidant-induced caspase-independent cell death. Am. J. Respir. Cell Mol. Biol. 2006;35:155-164.
    • (2006) Am. J. Respir. Cell Mol. Biol , vol.35 , pp. 155-164
    • Merendino, A.M.1    Bucchieri, F.2    Gagliardo, R.3
  • 31
    • 29144532165 scopus 로고    scopus 로고
    • Characterization of Toll-like receptors in primary lung epithelial cells: Strong impact of the TLR3 ligand poly (I: C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response
    • Ritter M, Mennerich D, Weith A, Seither P. Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly (I: C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. J. Inflamm. (Lond) 2005;2:16.
    • (2005) J. Inflamm. (Lond) , vol.2 , pp. 16
    • Ritter, M.1    Mennerich, D.2    Weith, A.3    Seither, P.4
  • 32
    • 0036039032 scopus 로고    scopus 로고
    • Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal?
    • Knight D. Increased permeability of asthmatic epithelial cells to pollutants. Does this mean that they are intrinsically abnormal? Clin. Exp. Allergy 2002;32:1263-1265.
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 1263-1265
    • Knight, D.1
  • 33
    • 0346888342 scopus 로고    scopus 로고
    • The airway epithelium: Structural and functional properties in health and disease
    • Knight DA, Holgate ST. The airway epithelium: structural and functional properties in health and disease. Respirology 2003;8:432-446.
    • (2003) Respirology , vol.8 , pp. 432-446
    • Knight, D.A.1    Holgate, S.T.2
  • 35
    • 0034112105 scopus 로고    scopus 로고
    • Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1
    • Wan H, Winton HL, Soeller C et al. Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1. Clin. Exp. Allergy 2000;30:685-698.
    • (2000) Clin. Exp. Allergy , vol.30 , pp. 685-698
    • Wan, H.1    Winton, H.L.2    Soeller, C.3
  • 36
    • 0037214465 scopus 로고    scopus 로고
    • Increased expression of p21 (waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium
    • Puddicombe SM, Torres-Lozano C, Richter A et al. Increased expression of p21 (waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium. Am. J. Respir. Cell Mol. Biol. 2003;28:61-68.
    • (2003) Am. J. Respir. Cell Mol. Biol , vol.28 , pp. 61-68
    • Puddicombe, S.M.1    Torres-Lozano, C.2    Richter, A.3
  • 37
    • 33845383064 scopus 로고    scopus 로고
    • Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells
    • Chu EK, Cheng J, Foley JS et al. Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2006;35:628-638.
    • (2006) Am. J. Respir. Cell Mol. Biol , vol.35 , pp. 628-638
    • Chu, E.K.1    Cheng, J.2    Foley, J.S.3
  • 38
  • 39
    • 33751082383 scopus 로고    scopus 로고
    • Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    • Kicic A, Sutanto EN, Stevens PT, Knight DA, Stick SM. Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am. J. Respir. Crit Care Med. 2006;174:1110-1118.
    • (2006) Am. J. Respir. Crit Care Med , vol.174 , pp. 1110-1118
    • Kicic, A.1    Sutanto, E.N.2    Stevens, P.T.3    Knight, D.A.4    Stick, S.M.5
  • 41
    • 0042381861 scopus 로고    scopus 로고
    • Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma
    • Karjalainen EM, Lindqvist A, Laitinen LA et al. Airway inflammation and basement membrane tenascin in newly diagnosed atopic and nonatopic asthma. Respir. Med. 2003;97:1045-1051.
    • (2003) Respir. Med , vol.97 , pp. 1045-1051
    • Karjalainen, E.M.1    Lindqvist, A.2    Laitinen, L.A.3
  • 42
    • 0037214337 scopus 로고    scopus 로고
    • Early thickening of the reticular basement membrane in children with difficult asthma
    • Payne DN, Rogers AV, Adelroth E et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am. J. Respir. Crit. Care Med. 2003;167:78-82.
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , pp. 78-82
    • Payne, D.N.1    Rogers, A.V.2    Adelroth, E.3
  • 43
    • 14644412828 scopus 로고    scopus 로고
    • Markers of eosinophilic inflammation and tissue remodelling in children before clinically diagnosed bronchial asthma
    • Pohunek P, Warner JO, Turzikova J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue remodelling in children before clinically diagnosed bronchial asthma. Pediatr. Allergy Immunol. 2005;16:43-51.
    • (2005) Pediatr. Allergy Immunol , vol.16 , pp. 43-51
    • Pohunek, P.1    Warner, J.O.2    Turzikova, J.3    Kudrmann, J.4    Roche, W.R.5
  • 44
    • 20144387227 scopus 로고    scopus 로고
    • Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
    • Saglani S, Malmstrom K, Pelkonen AS et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am. J. Respir. Crit. Care Med. 2005;171:722-727.
    • (2005) Am. J. Respir. Crit. Care Med , vol.171 , pp. 722-727
    • Saglani, S.1    Malmstrom, K.2    Pelkonen, A.S.3
  • 45
    • 11144258419 scopus 로고    scopus 로고
    • A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients
    • Ward C, De SA, Fisher AJ, Pritchard G, Forrest I, Corris P. A descriptive study of small airway reticular basement membrane thickening in clinically stable lung transplant recipients. J. Heart Lung Transplant 2005;24:533-537.
    • (2005) J. Heart Lung Transplant , vol.24 , pp. 533-537
    • Ward, C.1    De, S.A.2    Fisher, A.J.3    Pritchard, G.4    Forrest, I.5    Corris, P.6
  • 46
    • 25844479919 scopus 로고    scopus 로고
    • Early changes in basement membrane thickness in airway walls post-lung transplantation
    • Law L, Zheng L, Orsida B et al. Early changes in basement membrane thickness in airway walls post-lung transplantation. J. Heart Lung Transplant 2005;24:1571-1576.
    • (2005) J. Heart Lung Transplant , vol.24 , pp. 1571-1576
    • Law, L.1    Zheng, L.2    Orsida, B.3
  • 47
    • 33747811511 scopus 로고    scopus 로고
    • Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants
    • Saglani S, Molyneux C, Gong H et al. Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants. Eur. Respir. J. 2006;28:505-512.
    • (2006) Eur. Respir. J , vol.28 , pp. 505-512
    • Saglani, S.1    Molyneux, C.2    Gong, H.3
  • 48
    • 33751173229 scopus 로고    scopus 로고
    • Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling
    • Leung SY, Niimi A, Noble A et al. Effect of transforming growth factor-beta receptor I kinase inhibitor 2,4-disubstituted pteridine (SD-208) in chronic allergic airway inflammation and remodeling. J. Pharmacol. Exp. Ther. 2006;319:586-594.
    • (2006) J. Pharmacol. Exp. Ther , vol.319 , pp. 586-594
    • Leung, S.Y.1    Niimi, A.2    Noble, A.3
  • 50
    • 0032903716 scopus 로고    scopus 로고
    • Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: An in vitro co-culture model of airway remodeling in asthma
    • Zhang S, Smartt H, Holgate ST, Roche WR. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Lab. Invest. 1999;79:395-405.
    • (1999) Lab. Invest , vol.79 , pp. 395-405
    • Zhang, S.1    Smartt, H.2    Holgate, S.T.3    Roche, W.R.4
  • 51
    • 0041343256 scopus 로고    scopus 로고
    • Choe MM, Sporn PH, Swartz MA. An in vitro airway wall model of remodeling. Am. J. Physiol. Lung Cell Mol. Physiol 2003;285:L427- L433.
    • Choe MM, Sporn PH, Swartz MA. An in vitro airway wall model of remodeling. Am. J. Physiol. Lung Cell Mol. Physiol 2003;285:L427- L433.
  • 53
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am. J. Respir. Crit. Care Med. 2003;167:199-204.
    • (2003) Am. J. Respir. Crit. Care Med , vol.167 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 54
    • 0036884097 scopus 로고    scopus 로고
    • Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process
    • Liu LY, Sedgwick JB, Bates ME et al. Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process. J. Immunol. 2002;169:6459-6466.
    • (2002) J. Immunol , vol.169 , pp. 6459-6466
    • Liu, L.Y.1    Sedgwick, J.B.2    Bates, M.E.3
  • 55
    • 0031723068 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor is the main cytokine enhancing survival of eosinophils in asthmatic airways
    • Park CS, Choi YS, Ki SY et al. Granulocyte macrophage colony-stimulating factor is the main cytokine enhancing survival of eosinophils in asthmatic airways. Eur. Respir. J. 1998;12:872-878.
    • (1998) Eur. Respir. J , vol.12 , pp. 872-878
    • Park, C.S.1    Choi, Y.S.2    Ki, S.Y.3
  • 56
    • 6644229440 scopus 로고    scopus 로고
    • Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
    • Leckie MJ, ten Brinke A, Khan J et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2149-2153.
    • (2000) Lancet , vol.356 , pp. 2149-2153
    • Leckie, M.J.1    ten Brinke, A.2    Khan, J.3
  • 57
    • 5444268690 scopus 로고    scopus 로고
    • A role for eosinophils in airway remodelling in asthma
    • Kay AB, Phipps S, Robinson DS. A role for eosinophils in airway remodelling in asthma. Trends Immunol. 2004;25:477-482.
    • (2004) Trends Immunol , vol.25 , pp. 477-482
    • Kay, A.B.1    Phipps, S.2    Robinson, D.S.3
  • 58
    • 0037108493 scopus 로고    scopus 로고
    • The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin
    • Phipps S, Ying S, Wangoo A, Ong YE, Levi-Schaffer F, Kay AB. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J. Immunol. 2002;169:4604- 4612.
    • (2002) J. Immunol , vol.169 , pp. 4604-4612
    • Phipps, S.1    Ying, S.2    Wangoo, A.3    Ong, Y.E.4    Levi-Schaffer, F.5    Kay, A.B.6
  • 59
    • 34247637976 scopus 로고    scopus 로고
    • Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma
    • Kariyawasam HH, Aizen M, Barkans J, Robinson DS, Kay AB. Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma. Am. J. Respir. Crit. Care Med. 2007;175:896- 904.
    • (2007) Am. J. Respir. Crit. Care Med , vol.175 , pp. 896-904
    • Kariyawasam, H.H.1    Aizen, M.2    Barkans, J.3    Robinson, D.S.4    Kay, A.B.5
  • 61
    • 10444279215 scopus 로고    scopus 로고
    • High-resolution CT findings in patients with near-fatal asthma: Comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment
    • Lee YM, Park JS, Hwang JH et al. High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment. Chest 2004;126:1840-1848.
    • (2004) Chest , vol.126 , pp. 1840-1848
    • Lee, Y.M.1    Park, J.S.2    Hwang, J.H.3
  • 62
    • 10444273257 scopus 로고    scopus 로고
    • Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD
    • Vignola AM, Paganin F, Capieu L et al. Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD. Eur. Respir. J. 2004;24:910-917.
    • (2004) Eur. Respir. J , vol.24 , pp. 910-917
    • Vignola, A.M.1    Paganin, F.2    Capieu, L.3
  • 63
    • 24644511857 scopus 로고    scopus 로고
    • Differences in airway remodeling between subjects with severe and moderate asthma
    • Pepe C, Foley S, Shannon J et al. Differences in airway remodeling between subjects with severe and moderate asthma. J. Allergy Clin. Immunol. 2005;116:544-549.
    • (2005) J. Allergy Clin. Immunol , vol.116 , pp. 544-549
    • Pepe, C.1    Foley, S.2    Shannon, J.3
  • 64
    • 33846262518 scopus 로고    scopus 로고
    • Differences in proteoglycan deposition in the airways of moderate and severe asthmatics
    • Pini L, Hamid Q, Shannon J et al. Differences in proteoglycan deposition in the airways of moderate and severe asthmatics. Eur. Respir. J. 2007;29:71-77.
    • (2007) Eur. Respir. J , vol.29 , pp. 71-77
    • Pini, L.1    Hamid, Q.2    Shannon, J.3
  • 65
    • 0007917440 scopus 로고    scopus 로고
    • High-resolution computed tomography in patients with bronchial asthma: Correlation with clinical features, pulmonary functions and bronchial hyperresponsiveness
    • Park JW, Hong YK, Kim CW, Kim DK, Choe KO, Hong CS. High-resolution computed tomography in patients with bronchial asthma: correlation with clinical features, pulmonary functions and bronchial hyperresponsiveness. J. Investig. Allergol. Clin. Immunol. 1997;7:186-192.
    • (1997) J. Investig. Allergol. Clin. Immunol , vol.7 , pp. 186-192
    • Park, J.W.1    Hong, Y.K.2    Kim, C.W.3    Kim, D.K.4    Choe, K.O.5    Hong, C.S.6
  • 66
    • 30844442805 scopus 로고    scopus 로고
    • Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: Implication for bronchial responsiveness
    • Park SW, Park JS, Lee YM et al. Differences in radiological/HRCT findings in eosinophilic bronchitis and asthma: implication for bronchial responsiveness. Thorax 2006;61:41-47.
    • (2006) Thorax , vol.61 , pp. 41-47
    • Park, S.W.1    Park, J.S.2    Lee, Y.M.3
  • 67
    • 3042597938 scopus 로고    scopus 로고
    • Endobronchial ultrasound to assess airway wall thickening: Validation in vitro and in vivo
    • Shaw TJ, Wakely SL, Peebles CR et al. Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo. Eur. Respir. J. 2004;23:813-817.
    • (2004) Eur. Respir. J , vol.23 , pp. 813-817
    • Shaw, T.J.1    Wakely, S.L.2    Peebles, C.R.3
  • 69
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta 1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta 1: potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 2005;166:1321-1332.
    • (2005) Am. J. Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3
  • 71
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • Kim KK, Kugler MC, Wolters PJ et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl. Acad. Sci. U.S.A. 2006;103:13180-13185.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3
  • 72
    • 34347364932 scopus 로고    scopus 로고
    • Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
    • Wu Z, Yang L, Cai L et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir. Res. 2007;8:1.
    • (2007) Respir. Res , vol.8 , pp. 1
    • Wu, Z.1    Yang, L.2    Cai, L.3
  • 73
    • 26944463075 scopus 로고    scopus 로고
    • Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients
    • Ward C, Forrest IA, Murphy DM et al. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005;60:865- 871.
    • (2005) Thorax , vol.60 , pp. 865-871
    • Ward, C.1    Forrest, I.A.2    Murphy, D.M.3
  • 74
    • 0038544594 scopus 로고    scopus 로고
    • Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    • Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J. Immunol. 2003;171:380-389.
    • (2003) J. Immunol , vol.171 , pp. 380-389
    • Schmidt, M.1    Sun, G.2    Stacey, M.A.3    Mori, L.4    Mattoli, S.5
  • 75
    • 34547960749 scopus 로고    scopus 로고
    • The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
    • Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab. Invest. 2007;87:858-870.
    • (2007) Lab. Invest , vol.87 , pp. 858-870
    • Bellini, A.1    Mattoli, S.2
  • 76
    • 34447632197 scopus 로고    scopus 로고
    • Allelic Association and Recombination Hotspots in the Mucin Gene (MUC) Complex on Chromosome 11p15.5
    • Rousseau K, Byrne C, Griesinger G et al. Allelic Association and Recombination Hotspots in the Mucin Gene (MUC) Complex on Chromosome 11p15.5. Ann. Hum. Genet. 2007;71:561-569.
    • (2007) Ann. Hum. Genet , vol.71 , pp. 561-569
    • Rousseau, K.1    Byrne, C.2    Griesinger, G.3
  • 77
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordonez CL, Khashayar R, Wong HH et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. J. Respir. Crit. Care Med. 2001;163:517-523.
    • (2001) Am. J. Respir. Crit. Care Med , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3
  • 78
    • 0030058496 scopus 로고    scopus 로고
    • Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma
    • Shimura S, Andoh Y, Haraguchi M, Shirato K. Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. Eur. Respir. J. 1996;9:1395-1401.
    • (1996) Eur. Respir. J , vol.9 , pp. 1395-1401
    • Shimura, S.1    Andoh, Y.2    Haraguchi, M.3    Shirato, K.4
  • 79
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 2006;86:245-278.
    • (2006) Physiol. Rev , vol.86 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 80
    • 33847084360 scopus 로고    scopus 로고
    • A morphometric study of mucins and small airway plugging in cystic fibrosis
    • Burgel PR, Montani D, Danel C, Dusser DJ, Nadel JA. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax 2007;62:153-161.
    • (2007) Thorax , vol.62 , pp. 153-161
    • Burgel, P.R.1    Montani, D.2    Danel, C.3    Dusser, D.J.4    Nadel, J.A.5
  • 81
    • 13544262442 scopus 로고    scopus 로고
    • Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
    • Deshmukh HS, Case LM, Wesselkamper SC et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am. J. Respir. Crit. Care Med. 2005;171:305-314.
    • (2005) Am. J. Respir. Crit. Care Med , vol.171 , pp. 305-314
    • Deshmukh, H.S.1    Case, L.M.2    Wesselkamper, S.C.3
  • 82
    • 0036644701 scopus 로고    scopus 로고
    • Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    • Lordan JL, Bucchieri F, Richter A et al. Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J. Immunol. 2002;169:407-414.
    • (2002) J. Immunol , vol.169 , pp. 407-414
    • Lordan, J.L.1    Bucchieri, F.2    Richter, A.3
  • 83
    • 14144251241 scopus 로고    scopus 로고
    • Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells
    • Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 2005;102:767-772.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 767-772
    • Shao, M.X.1    Nadel, J.A.2
  • 84
    • 33747858399 scopus 로고    scopus 로고
    • State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: Insights from transgenic mice
    • Elias JA, Kang MJ, Crouthers K, Homer R, Lee CG. State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice. Proc. Am. Thorac. Soc. 2006;3:494-498.
    • (2006) Proc. Am. Thorac. Soc , vol.3 , pp. 494-498
    • Elias, J.A.1    Kang, M.J.2    Crouthers, K.3    Homer, R.4    Lee, C.G.5
  • 85
    • 33748449812 scopus 로고    scopus 로고
    • Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation
    • Long AJ, Sypek JP, Askew R et al. Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am. J. Respir. Cell Mol. Biol. 2006;35:357-365.
    • (2006) Am. J. Respir. Cell Mol. Biol , vol.35 , pp. 357-365
    • Long, A.J.1    Sypek, J.P.2    Askew, R.3
  • 86
    • 33646488054 scopus 로고    scopus 로고
    • Long-term inhaled corticosteroids in preschool children at high risk for asthma
    • Guilbert TW, Morgan WJ, Zeiger RS et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N. Engl. J. Med. 2006;354:1985-1997.
    • (2006) N. Engl. J. Med , vol.354 , pp. 1985-1997
    • Guilbert, T.W.1    Morgan, W.J.2    Zeiger, R.S.3
  • 87
    • 33747758047 scopus 로고    scopus 로고
    • Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): Double-blind, randomised, controlled study
    • Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet 2006;368:754-762.
    • (2006) Lancet , vol.368 , pp. 754-762
    • Murray, C.S.1    Woodcock, A.2    Langley, S.J.3    Morris, J.4    Custovic, A.5
  • 88
    • 0034642066 scopus 로고    scopus 로고
    • Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group
    • No Authors listed. Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N. Engl. J. Med. 2000;343:1054-1063.
    • (2000) N. Engl. J. Med , vol.343 , pp. 1054-1063
  • 89
    • 0037471787 scopus 로고    scopus 로고
    • Early intervention with budesonide in mild persistent asthma: A randomised, double-blind trial
    • Pauwels RA, Pedersen S, Busse WW et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet 2003;361:1071-1076.
    • (2003) Lancet , vol.361 , pp. 1071-1076
    • Pauwels, R.A.1    Pedersen, S.2    Busse, W.W.3
  • 90
    • 17044408806 scopus 로고    scopus 로고
    • Identification and function of a novel candidate gene for asthma
    • Holloway J, Holgate ST. Identification and function of a novel candidate gene for asthma. Allergol. Int. 2005;54:25-30.
    • (2005) Allergol. Int , vol.54 , pp. 25-30
    • Holloway, J.1    Holgate, S.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.