메뉴 건너뛰기




Volumn 202, Issue , 2004, Pages 175-190

Interleukin-13 in asthma pathogenesis

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5; INTERLEUKIN 9; STAT6 PROTEIN;

EID: 9644281044     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2004.00215.x     Document Type: Review
Times cited : (556)

References (107)
  • 1
    • 0032968706 scopus 로고    scopus 로고
    • Immunologic basis of antigen-induced airway hyperresponsiveness
    • Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu Rev Immunol 1999;17:255-281.
    • (1999) Annu Rev Immunol , vol.17 , pp. 255-281
    • Wills-Karp, M.1
  • 2
    • 0028176655 scopus 로고
    • Interleukin-13, an interleukin-4 like cytokine that acts on monocytes and B cells but not T-cells
    • Zurawski G, deVries J. Interleukin-13, an interleukin-4 like cytokine that acts on monocytes and B cells but not T-cells. Immunol Today 1994;15:19-26.
    • (1994) Immunol Today , vol.15 , pp. 19-26
    • Zurawski, G.1    DeVries, J.2
  • 3
    • 0027274890 scopus 로고
    • Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
    • Zurawski SM, Vega F, Juyghe B, Zurawski G. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J 1993;12:2663-2670.
    • (1993) EMBO J , vol.12 , pp. 2663-2670
    • Zurawski, S.M.1    Vega, F.2    Juyghe, B.3    Zurawski, G.4
  • 4
    • 0037911660 scopus 로고    scopus 로고
    • Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    • Akbari O, et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003;9:582-588.
    • (2003) Nat Med , vol.9 , pp. 582-588
    • Akbari, O.1
  • 5
    • 0037100414 scopus 로고    scopus 로고
    • Eosinophils express functional IL-13 in eosinophilic inflammatory diseases
    • Schmid-Grendelmeier P, et al. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J Immunol 2002;169:1021-1027.
    • (2002) J Immunol , vol.169 , pp. 1021-1027
    • Schmid-Grendelmeier, P.1
  • 6
    • 0037013925 scopus 로고    scopus 로고
    • Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    • Mattes J, et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 2002;195:1433-1444.
    • (2002) J Exp Med , vol.195 , pp. 1433-1444
    • Mattes, J.1
  • 7
    • 0036088040 scopus 로고    scopus 로고
    • IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle
    • Grunstein MM, et al. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2002;282:L520-L528.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Grunstein, M.M.1
  • 8
    • 0032487434 scopus 로고    scopus 로고
    • Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness
    • Temann UA, Geba GP, Rankin JA, Flavell RA. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J Exp Med 1998;188:1307-1320.
    • (1998) J Exp Med , vol.188 , pp. 1307-1320
    • Temann, U.A.1    Geba, G.P.2    Rankin, J.A.3    Flavell, R.A.4
  • 9
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • Fort MM, et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001;15:985-995.
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1
  • 10
    • 0036141448 scopus 로고    scopus 로고
    • Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
    • Temann UA, Ray P, Flavell RA. Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology. J Clin Invest 2002;109:29-39.
    • (2002) J Clin Invest , vol.109 , pp. 29-39
    • Temann, U.A.1    Ray, P.2    Flavell, R.A.3
  • 11
    • 0036644547 scopus 로고    scopus 로고
    • New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25
    • Hurst SD, et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J Immunol 2002;169:443-453.
    • (2002) J Immunol , vol.169 , pp. 443-453
    • Hurst, S.D.1
  • 12
    • 0034839238 scopus 로고    scopus 로고
    • Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells
    • Elliott KA, Osna NA, Scofield MA, Khan MM. Regulation of IL-13 production by histamine in cloned murine T helper type 2 cells. Int Immunopharmacol 2001;1: 1923-1937.
    • (2001) Int Immunopharmacol , vol.1 , pp. 1923-1937
    • Elliott, K.A.1    Osna, N.A.2    Scofield, M.A.3    Khan, M.M.4
  • 13
    • 0042388120 scopus 로고    scopus 로고
    • Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway
    • Blackburn MR, et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest 2003:112:332-344.
    • (2003) J Clin Invest , vol.112 , pp. 332-344
    • Blackburn, M.R.1
  • 14
    • 2942560494 scopus 로고    scopus 로고
    • Adenosine-activated mast cells induce IgE synthesis by B lymphocytes, an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
    • Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes, an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 2004;172:7726-7733.
    • (2004) J Immunol , vol.172 , pp. 7726-7733
    • Ryzhov, S.1    Goldstein, A.E.2    Matafonov, A.3    Zeng, D.4    Biaggioni, I.5    Feoktistov, I.6
  • 15
    • 1342324089 scopus 로고    scopus 로고
    • Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils
    • Cui P, et al. Endothelin-1 peptides and IL-5 synergistically increase the expression of IL-13 in eosinophils. Biochem Biophys Res Commun 2004:315:782-787.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 782-787
    • Cui, P.1
  • 16
    • 0030068217 scopus 로고    scopus 로고
    • Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of interleukin 4 receptor
    • Hilton DJ, Zhang J-G, Metcalf D, Alexander WS, Nicols NA, Wilson TA. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of interleukin 4 receptor. Proc Natl Acad Sci USA 1996;93:497-501.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 497-501
    • Hilton, D.J.1    Zhang, J.-G.2    Metcalf, D.3    Alexander, W.S.4    Nicols, N.A.5    Wilson, T.A.6
  • 17
    • 10544246077 scopus 로고    scopus 로고
    • cDNA cloning and characterization of the human interleukin-13 receptor alpha chain
    • Aman MJ, Tayebi N, Obii NI, Puri RK, Modi WS, Leonard WJ. cDNA cloning and characterization of the human interleukin-13 receptor alpha chain. J Biol Chem 1996:271:29265-29270.
    • (1996) J Biol Chem , vol.271 , pp. 29265-29270
    • Aman, M.J.1    Tayebi, N.2    Obii, N.I.3    Puri, R.K.4    Modi, W.S.5    Leonard, W.J.6
  • 18
    • 0029927153 scopus 로고    scopus 로고
    • Cloning and characterization of specific interleukin (IL)-13 binding protein and structurally related to the IL-5 receptor α chain
    • Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P. Cloning and characterization of specific interleukin (IL)-13 binding protein and structurally related to the IL-5 receptor α chain. J Biol Chem 1996:271:16921-16926.
    • (1996) J Biol Chem , vol.271 , pp. 16921-16926
    • Caput, D.1    Laurent, P.2    Kaghad, M.3    Lelias, J.M.4    Lefort, S.5    Vita, N.6    Ferrara, P.7
  • 19
    • 0029035685 scopus 로고
    • The primary binding subunit of the human interleukin-4-receptor is also a component of the interleukin-13 receptor
    • Zurawski S, et al. The primary binding subunit of the human interleukin-4-receptor is also a component of the interleukin-13 receptor. J Biol Chem 1995:270: 13869-13878.
    • (1995) J Biol Chem , vol.270 , pp. 13869-13878
    • Zurawski, S.1
  • 20
    • 15644383836 scopus 로고    scopus 로고
    • The distribution of IL-13 receptor alpha 1 expression on B cells, T cells, and monocytes and its regulation by IL-13 and IL-4
    • Graber P, Gretener D, Herren S, Aubry JP, Elson G, Poudrier J. The distribution of IL-13 receptor alpha 1 expression on B cells, T cells, and monocytes and its regulation by IL-13 and IL-4. Eur J Immunol 1998:28:4286-4298.
    • (1998) Eur J Immunol , vol.28 , pp. 4286-4298
    • Graber, P.1    Gretener, D.2    Herren, S.3    Aubry, J.P.4    Elson, G.5    Poudrier, J.6
  • 21
    • 0029876629 scopus 로고    scopus 로고
    • STAT6 is required for mediating responses to IL-4 and for the development of Th2 cells
    • Kaplan M, Schindler U, Smiley S, Grusby M. STAT6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-319.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.1    Schindler, U.2    Smiley, S.3    Grusby, M.4
  • 22
    • 0032536837 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
    • Kuperman D, Schofield B, Wills-Karp M, Grusby MJ. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 1998:187:939-948.
    • (1998) J Exp Med , vol.187 , pp. 939-948
    • Kuperman, D.1    Schofield, B.2    Wills-Karp, M.3    Grusby, M.J.4
  • 23
    • 0029266795 scopus 로고
    • Allergen-induced airway inflammation and bronchial responsiveness in wildtype and interleukin-4-deficient mice
    • Brusselle G, Kips J, Joos G, Bluethmann H, Pauwels R. Allergen-induced airway inflammation and bronchial responsiveness in wildtype and interleukin-4-deficient mice. Am J Respir Cell Mol Biol 1995;12:254-259.
    • (1995) Am J Respir Cell Mol Biol , vol.12 , pp. 254-259
    • Brusselle, G.1    Kips, J.2    Joos, G.3    Bluethmann, H.4    Pauwels, R.5
  • 24
    • 0029335074 scopus 로고
    • Interleukin-4 is required for the induction of lung Th2 mucosal immunity
    • Coyle AJ, et al. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol 1995;13:54-59.
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 54-59
    • Coyle, A.J.1
  • 25
    • 0032531571 scopus 로고    scopus 로고
    • IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
    • Cohn L, Tepper JS, Bottomly K. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol 1998:161:3813-3816.
    • (1998) J Immunol , vol.161 , pp. 3813-3816
    • Cohn, L.1    Tepper, J.S.2    Bottomly, K.3
  • 26
    • 0031004365 scopus 로고    scopus 로고
    • Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
    • Gavett SH, et al. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice. Am J Physiol 1997;272:L253-L261.
    • (1997) Am J Physiol , vol.272
    • Gavett, S.H.1
  • 27
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: Central mediator of allergic asthma
    • Wills-Karp M, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261.
    • (1998) Science , vol.282 , pp. 2258-2261
    • Wills-Karp, M.1
  • 28
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • Grunig G, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263.
    • (1998) Science , vol.282 , pp. 2261-2263
    • Grunig, G.1
  • 29
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999;103:779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1
  • 31
    • 0035888013 scopus 로고    scopus 로고
    • Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    • Walter DM, et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001;167: 4668-4675.
    • (2001) J Immunol , vol.167 , pp. 4668-4675
    • Walter, D.M.1
  • 32
    • 1642454710 scopus 로고    scopus 로고
    • Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice
    • Webb DC, Matthaei KI, Cai Y, McKenzie AN, Foster PS. Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice. J Immunol 2004:172:1092-1098.
    • (2004) J Immunol , vol.172 , pp. 1092-1098
    • Webb, D.C.1    Matthaei, K.I.2    Cai, Y.3    McKenzie, A.N.4    Foster, P.S.5
  • 33
    • 16044371529 scopus 로고    scopus 로고
    • Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
    • Rankin JA, et al. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc Natl Acad Sci USA 1996:93:7821-7825.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7821-7825
    • Rankin, J.A.1
  • 34
    • 0029982434 scopus 로고    scopus 로고
    • Endobronchial secretion of interleukin-13 following local allergen challenge in atopic asthma: Relationship to interleukin-4 and eosinophil counts
    • Kroegel C, Julius P, Matthys H, Virchow JC Jr, Luttmann W. Endobronchial secretion of interleukin-13 following local allergen challenge in atopic asthma: relationship to interleukin-4 and eosinophil counts. Eur Respir 1996;9:899-904.
    • (1996) Eur Respir , vol.9 , pp. 899-904
    • Kroegel, C.1    Julius, P.2    Matthys, H.3    Virchow Jr., J.C.4    Luttmann, W.5
  • 35
    • 0035424185 scopus 로고    scopus 로고
    • IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung
    • Mattes J, et al. IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J Immunol 2001;167:1683-1692.
    • (2001) J Immunol , vol.167 , pp. 1683-1692
    • Mattes, J.1
  • 36
    • 0032167603 scopus 로고    scopus 로고
    • The murine IL-13 receptor alpha 2: Molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1
    • Donaldson DD, et al. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol 1998;161:2317-2324.
    • (1998) J Immunol , vol.161 , pp. 2317-2324
    • Donaldson, D.D.1
  • 37
    • 0037155828 scopus 로고    scopus 로고
    • A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha-2 and their rapid mobilization by interferon-gamma
    • Daines MO, Hershey GK. A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha-2 and their rapid mobilization by interferon-gamma. J Biol Chem 2002;277:10387-10393.
    • (2002) J Biol Chem , vol.277 , pp. 10387-10393
    • Daines, M.O.1    Hershey, G.K.2
  • 38
    • 10744229896 scopus 로고    scopus 로고
    • The negative feedback regulation of the IL-13 signal by the IL-13 receptor α2 chain in bronchial epithelial cells
    • Yasunaga S, et al. The negative feedback regulation of the IL-13 signal by the IL-13 receptor α2 chain in bronchial epithelial cells. Cytokine 2003;24:293-303.
    • (2003) Cytokine , vol.24 , pp. 293-303
    • Yasunaga, S.1
  • 39
    • 0037451128 scopus 로고    scopus 로고
    • Regulation and function of the interleukin 13 receptor a 2 during a T helper cell type-2-dominant immune response
    • Chiaramonte MG, et al. Regulation and function of the interleukin 13 receptor a 2 during a T helper cell type-2-dominant immune response. J Exp Med 2003;197: 687-701.
    • (2003) J Exp Med , vol.197 , pp. 687-701
    • Chiaramonte, M.G.1
  • 40
    • 2342541843 scopus 로고    scopus 로고
    • Soluble interleukin-13RA2 decoy receptor inhibits Hodgkin's Lymphoma growth in vitro and in vivo
    • Trieu Y, et al. Soluble interleukin-13RA2 decoy receptor inhibits Hodgkin's Lymphoma growth in vitro and in vivo. Can Res 2004;64:3271-3275.
    • (2004) Can Res , vol.64 , pp. 3271-3275
    • Trieu, Y.1
  • 42
    • 0037393502 scopus 로고    scopus 로고
    • Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro
    • Zheng T, et al. Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. J Allergy Clin Immunol 2003:111:720-728.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 720-728
    • Zheng, T.1
  • 43
    • 0030975719 scopus 로고    scopus 로고
    • Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein: Evidence that it is distinct from the cloned IL-13 receptor and IL-4 receptor α-chains
    • Zhang JG, et al. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein: Evidence that it is distinct from the cloned IL-13 receptor and IL-4 receptor α-chains. J Biol Chem 1997;272:9474-9480.
    • (1997) J Biol Chem , vol.272 , pp. 9474-9480
    • Zhang, J.G.1
  • 44
    • 0033761127 scopus 로고    scopus 로고
    • Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema
    • Zheng T. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and cathepsin-dependent emphysema. J Clin Invest 2000;106:1081-1093.
    • (2000) J Clin Invest , vol.106 , pp. 1081-1093
    • Zheng, T.1
  • 46
    • 0028815074 scopus 로고
    • IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells
    • Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer RP. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J Immunol 1995;154:799-803.
    • (1995) J Immunol , vol.154 , pp. 799-803
    • Bochner, B.S.1    Klunk, D.A.2    Sterbinsky, S.A.3    Coffman, R.L.4    Schleimer, R.P.5
  • 47
    • 0035879289 scopus 로고    scopus 로고
    • Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms
    • Lukacs NW, et al. Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms. J Immunol 2001:167:1060-1065.
    • (2001) J Immunol , vol.167 , pp. 1060-1065
    • Lukacs, N.W.1
  • 48
    • 0037087365 scopus 로고    scopus 로고
    • IL-13-induced chemokine responses in the lung: Role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling
    • Zhu Z, et al. IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2002:168: 2953-2962.
    • (2002) J Immunol , vol.168 , pp. 2953-2962
    • Zhu, Z.1
  • 51
    • 0141791326 scopus 로고    scopus 로고
    • IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: Role of IL-4 receptor genotype
    • Faffe DS, et al. IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype. Am J Physiol Lung Cell Mol Physiol 2003;285:L907-L914.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285
    • Faffe, D.S.1
  • 52
    • 1642566536 scopus 로고    scopus 로고
    • The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling
    • Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2004;172:1872-1881.
    • (2004) J Immunol , vol.172 , pp. 1872-1881
    • Ma, B.1    Zhu, Z.2    Homer, R.J.3    Gerard, C.4    Strieter, R.5    Elias, J.A.6
  • 53
    • 3543136879 scopus 로고    scopus 로고
    • Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell regression through decreased CC chemokines
    • Corry DB, et al. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell regression through decreased CC chemokines. FASEB J 2004;18:995-997.
    • (2004) FASEB J , vol.18 , pp. 995-997
    • Corry, D.B.1
  • 54
    • 0036679426 scopus 로고    scopus 로고
    • Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling
    • Lanone S, et al. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest 2002;110:463-474.
    • (2002) J Clin Invest , vol.110 , pp. 463-474
    • Lanone, S.1
  • 55
    • 0032697042 scopus 로고    scopus 로고
    • An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    • Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest 1999;104:777-785.
    • (1999) J Clin Invest , vol.104 , pp. 777-785
    • Chiaramonte, M.G.1    Donaldson, D.D.2    Cheever, A.W.3    Wynn, T.A.4
  • 56
    • 0031056613 scopus 로고    scopus 로고
    • Elevated serum levels of IL-14 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis
    • Hasegawa M, Fujimoto K, Kikuchi K, Takehara K. Elevated serum levels of IL-14 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. J Rheumatol 1997:24:328-332.
    • (1997) J Rheumatol , vol.24 , pp. 328-332
    • Hasegawa, M.1    Fujimoto, K.2    Kikuchi, K.3    Takehara, K.4
  • 57
    • 0035576207 scopus 로고    scopus 로고
    • Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/ type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of 1-arginine metabolism
    • Hesse M, et al. Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/ type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of 1-arginine metabolism. J Immunol 2001:167:6533-6544.
    • (2001) J Immunol , vol.167 , pp. 6533-6544
    • Hesse, M.1
  • 58
    • 0042243556 scopus 로고    scopus 로고
    • Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    • Zimmermann N, et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003;111: 1863-1874.
    • (2003) J Clin Invest , vol.111 , pp. 1863-1874
    • Zimmermann, N.1
  • 59
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by simulating and activating transforming growth factor beta (1)
    • Lee CG, et al. Interleukin-13 induces tissue fibrosis by simulating and activating transforming growth factor beta (1). J Exp Med 2001;194:809-821.
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1
  • 60
    • 0036009463 scopus 로고    scopus 로고
    • Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma
    • Wen FQ, et al. Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am J Respir Cell Mol Biol 2002:26:484-490.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 484-490
    • Wen, F.Q.1
  • 61
    • 0033567017 scopus 로고    scopus 로고
    • Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models
    • Hogaboam CM, et al. Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models. J Immunol 1999;163:2193-2201.
    • (1999) J Immunol , vol.163 , pp. 2193-2201
    • Hogaboam, C.M.1
  • 62
    • 0037335938 scopus 로고    scopus 로고
    • Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: A possible mechanism for the development of airway fibrosis in asthma
    • Ingram JL, Rice A, Geisenhoffer K, Madtes DK, Bonner JC. Interleukin-13 stimulates the proliferation of lung myofibroblasts via a signal transducer and activator of transcription-6-dependent mechanism: a possible mechanism for the development of airway fibrosis in asthma. Chest 2003;123:422S-424S.
    • (2003) Chest , vol.123
    • Ingram, J.L.1    Rice, A.2    Geisenhoffer, K.3    Madtes, D.K.4    Bonner, J.C.5
  • 63
    • 0033562979 scopus 로고    scopus 로고
    • Th2-induced airway mucus production is dependent on IL-4 Ralpha, but not on eosinophils
    • Cohn L, Homer RJ, MacLeod H, Mohrs M, Brombacher F, Bottomly K. Th2-induced airway mucus production is dependent on IL-4 Ralpha, but not on eosinophils. J Immunol 1999;162:6178-6183.
    • (1999) J Immunol , vol.162 , pp. 6178-6183
    • Cohn, L.1    Homer, R.J.2    MacLeod, H.3    Mohrs, M.4    Brombacher, F.5    Bottomly, K.6
  • 64
    • 0012008421 scopus 로고    scopus 로고
    • Upregulation of mucin related genes is associated with susceptibility to allergen-induced hyperresponsiveness
    • Dudley KL, Chiaramonte M, Wills-Karp M. Upregulation of mucin related genes is associated with susceptibility to allergen-induced hyperresponsiveness. Am J Respir Crit Care Med 2002;163:A693.
    • (2002) Am J Respir Crit Care Med , vol.163
    • Dudley, K.L.1    Chiaramonte, M.2    Wills-Karp, M.3
  • 65
    • 0035202405 scopus 로고    scopus 로고
    • Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha
    • Booth BW, Adler KB, Bonner JC, Tournier F, Martin LD. Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha. Am J Respir Cell Mol Biol 2001;25:739-743.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 739-743
    • Booth, B.W.1    Adler, K.B.2    Bonner, J.C.3    Tournier, F.4    Martin, L.D.5
  • 66
    • 0035667908 scopus 로고    scopus 로고
    • IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells
    • Laoukili J, et al. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Invest 2001;108:1817-1824.
    • (2001) J Clin Invest , vol.108 , pp. 1817-1824
    • Laoukili, J.1
  • 68
    • 1342283994 scopus 로고    scopus 로고
    • Foxa2 regulates alveolarization and goblet cell hyperplasia
    • Wan H, et al. Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 2003;131:953-964.
    • (2003) Development , vol.131 , pp. 953-964
    • Wan, H.1
  • 69
    • 0035942265 scopus 로고    scopus 로고
    • Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma
    • Nakanishi A, et al. Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci USA 2001;98:5175-5180.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5175-5180
    • Nakanishi, A.1
  • 70
    • 0034755576 scopus 로고    scopus 로고
    • Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma
    • Zhou Y, et al. Characterization of a calcium-activated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001:25:486-491.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 486-491
    • Zhou, Y.1
  • 71
    • 0036295087 scopus 로고    scopus 로고
    • The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells
    • Leverkoehne I, Gruber AD. The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J Histochem Cytochem 2002:50:829-838.
    • (2002) J Histochem Cytochem , vol.50 , pp. 829-838
    • Leverkoehne, I.1    Gruber, A.D.2
  • 72
    • 0037311003 scopus 로고    scopus 로고
    • Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lung
    • Vargaftig BB, Singer M. Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lung. Am J Physiol Cell Mol Physiol 2003;284:L260-L269.
    • (2003) Am J Physiol Cell Mol Physiol , vol.284
    • Vargaftig, B.B.1    Singer, M.2
  • 73
    • 0037385864 scopus 로고    scopus 로고
    • Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13
    • Vargaftig BB, Singer M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am J Respir Cell Mol Biol 2003;28:410-419.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 410-419
    • Vargaftig, B.B.1    Singer, M.2
  • 74
    • 0036006804 scopus 로고    scopus 로고
    • Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen
    • Singer M, Lefort J, Vargaftig BB. Granulocyte depletion and dexamethasone differentially modulate airways hyperreactivity, inflammation, mucus accumulation, and secretion induced by rmIL-13 or antigen. Am J Respir Cell Mol Biol 2002;26:74-84.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 74-84
    • Singer, M.1    Lefort, J.2    Vargaftig, B.B.3
  • 75
    • 0036007308 scopus 로고    scopus 로고
    • The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells
    • Venkayya R, Lam M, Willkom M, Grunig G, Corry DB, Erie DJ. The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 2002:26:202-208.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 202-208
    • Venkayya, R.1    Lam, M.2    Willkom, M.3    Grunig, G.4    Corry, D.B.5    Erie, D.J.6
  • 76
    • 0037215576 scopus 로고    scopus 로고
    • Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness and goblet cell hyperplasia in mouse airways
    • Kibe A, et al. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness and goblet cell hyperplasia in mouse airways. Am J Respir Crit Care Med 2003;167:50-56.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 50-56
    • Kibe, A.1
  • 77
    • 0034755167 scopus 로고    scopus 로고
    • Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
    • Yang M, et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 2001;25:522-530.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 522-530
    • Yang, M.1
  • 78
    • 1642545168 scopus 로고    scopus 로고
    • IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    • Tliba O, et al. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol 2003:140:1159-1162.
    • (2003) Br J Pharmacol , vol.140 , pp. 1159-1162
    • Tliba, O.1
  • 81
    • 0038404961 scopus 로고    scopus 로고
    • CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4
    • Espinosa K, Bosse Y, Stankova J, Rola-Pleszczynski M. CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J Allergy Clin Immunol 2003:111:1032-1040.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1032-1040
    • Espinosa, K.1    Bosse, Y.2    Stankova, J.3    Rola-Pleszczynski, M.4
  • 82
    • 3042795833 scopus 로고    scopus 로고
    • Modulation of calcium signaling by IL-13 in human airway smooth muscle: Role of CD38/cyclic adenosine diphosphate ribose pathway
    • Deshpande DA, et al. Modulation of calcium signaling by IL-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol Biol 2004:31:36-42.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 36-42
    • Deshpande, D.A.1
  • 83
    • 0035402376 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    • Laporte JC, et al. Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 2001;164:141-148.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 141-148
    • Laporte, J.C.1
  • 84
    • 0038518094 scopus 로고    scopus 로고
    • Th2 cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids
    • Wen FQ, et al. Th2 cytokine-enhanced and TGF-β-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids. J Allergy Clin Immunol 2003:111:1307-1318.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1307-1318
    • Wen, F.Q.1
  • 85
    • 1242306794 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced secretion of fibronectin is ERK-dependent
    • Kazi AS, et al. Vascular endothelial growth factor-induced secretion of fibronectin is ERK-dependent. AM J Physiol Lung Cell Mol Physiol 2004;286:L539-L545.
    • (2004) AM J Physiol Lung Cell Mol Physiol , vol.286
    • Kazi, A.S.1
  • 86
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman DA, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002:8:885-889.
    • (2002) Nat Med , vol.8 , pp. 885-889
    • Kuperman, D.A.1
  • 87
    • 0036016110 scopus 로고    scopus 로고
    • Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness
    • Meurs H, et al. Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness. Br J Pharmacol 2002:136:391-398.
    • (2002) Br J Pharmacol , vol.136 , pp. 391-398
    • Meurs, H.1
  • 88
    • 0011930954 scopus 로고    scopus 로고
    • Interleukin-13 regulation of complement factor 3 production by human bronchial epithelial cells
    • Dienger KM, Wills-Karp M. Interleukin-13 regulation of complement factor 3 production by human bronchial epithelial cells. Am J Respir Crit Care Med 2002;165:A733.
    • (2002) Am J Respir Crit Care Med , vol.165
    • Dienger, K.M.1    Wills-Karp, M.2
  • 89
    • 0034669961 scopus 로고    scopus 로고
    • Cutting edge: Guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: Evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma
    • Bautsch W, et al. Cutting edge: guinea pigs with a natural C3a-receptor defect exhibit decreased bronchoconstriction in allergic airway disease: evidence for an involvement of the C3a anaphylatoxin in the pathogenesis of asthma. J Immunol 2000;165:5401-5405.
    • (2000) J Immunol , vol.165 , pp. 5401-5405
    • Bautsch, W.1
  • 90
    • 0034739041 scopus 로고    scopus 로고
    • A role for the C3a anaphylatoxin receptor in the effector phase of asthma
    • Humbles AA, et al. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 2000;406:998-1001.
    • (2000) Nature , vol.406 , pp. 998-1001
    • Humbles, A.A.1
  • 92
    • 2942668626 scopus 로고    scopus 로고
    • Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathways activation
    • Zhu A, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathways activation. Science 2004:304:1678-1682.
    • (2004) Science , vol.304 , pp. 1678-1682
    • Zhu, A.1
  • 93
    • 0038785779 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma
    • Vermaelen KY, et al. Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma. J Immunol 2003:171:1016-1022.
    • (2003) J Immunol , vol.171 , pp. 1016-1022
    • Vermaelen, K.Y.1
  • 94
    • 10744220160 scopus 로고    scopus 로고
    • The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen. Der p 1
    • Sakata Y, et al. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen. Der p 1. J Biol Chem 2004:279:5081-5087.
    • (2004) J Biol Chem , vol.279 , pp. 5081-5087
    • Sakata, Y.1
  • 95
    • 0037111369 scopus 로고    scopus 로고
    • A protease activated pathway underlying Th cell type 2 activation and allergic lung disease
    • Kheradmand F, Kiss A, Xu J, Lee S-H, Kolattukudy PE, Corry DB. A protease activated pathway underlying Th cell type 2 activation and allergic lung disease. J Immunol 2002;169:5904-5911.
    • (2002) J Immunol , vol.169 , pp. 5904-5911
    • Kheradmand, F.1    Kiss, A.2    Xu, J.3    Lee, S.-H.4    Kolattukudy, P.E.5    Corry, D.B.6
  • 96
    • 0029038120 scopus 로고
    • IL-13 expression at the sites of allergen challenge in patients with asthma
    • Huang SK, et al. IL-13 expression at the sites of allergen challenge in patients with asthma. J Immunol 1995;155:2688-2694.
    • (1995) J Immunol , vol.155 , pp. 2688-2694
    • Huang, S.K.1
  • 97
    • 0030922389 scopus 로고    scopus 로고
    • Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
    • Humbert M, et al. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J Allergy Clin Immunol 1997;99:657-665.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 657-665
    • Humbert, M.1
  • 98
    • 0031569973 scopus 로고    scopus 로고
    • Association between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects
    • Ying S, et al. Association between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Immunol 1997;158:5050-5057.
    • (1997) J Immunol , vol.158 , pp. 5050-5057
    • Ying, S.1
  • 99
    • 0030934422 scopus 로고    scopus 로고
    • Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy
    • Naseer T, et al. Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy. Am J Respir Crit Care Med 1997;155:845-851.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 845-851
    • Naseer, T.1
  • 100
    • 0036154870 scopus 로고    scopus 로고
    • Dysregulation of IL-13 production by cord blood CD4+ T cells is associated with the subsequent development of atopic disease in infants
    • Ohshima Y, et al. Dysregulation of IL-13 production by cord blood CD4+ T cells is associated with the subsequent development of atopic disease in infants. Pediatr Res 2002;51:195-200.
    • (2002) Pediatr Res , vol.51 , pp. 195-200
    • Ohshima, Y.1
  • 101
    • 0033188305 scopus 로고    scopus 로고
    • An IL-13 promoter polymorphism associated with increased risk of allergic asthma
    • van der Pouw Kraan TC, et al. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1999;1:61-65.
    • (1999) Genes Immun , vol.1 , pp. 61-65
    • Van Der Pouw Kraan, T.C.1
  • 102
    • 0034102759 scopus 로고    scopus 로고
    • A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children
    • Graves PE, et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 2000;105:506-513.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 506-513
    • Graves, P.E.1
  • 103
    • 0034162827 scopus 로고    scopus 로고
    • Genetic variants of IL-13 signaling and human asthma and atopy
    • Heinzmann A, et al. Genetic variants of IL-13 signaling and human asthma and atopy. Hum Mol Genet 2000:9:549-559.
    • (2000) Hum Mol Genet , vol.9 , pp. 549-559
    • Heinzmann, A.1
  • 104
    • 0036230109 scopus 로고    scopus 로고
    • Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica
    • Celedon JC, et al. Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy 2002:32:387-390.
    • (2002) Clin Exp Allergy , vol.32 , pp. 387-390
    • Celedon, J.C.1
  • 105
    • 0036279758 scopus 로고    scopus 로고
    • Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
    • Arima K, et al. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol 2002:109:980-987.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 980-987
    • Arima, K.1
  • 106
    • 0036888556 scopus 로고    scopus 로고
    • Present status of the genetic studies of asthma
    • Hoffjan S, Ober C. Present status of the genetic studies of asthma. Curr Opin Immunol 2002:14:709-717.
    • (2002) Curr Opin Immunol , vol.14 , pp. 709-717
    • Hoffjan, S.1    Ober, C.2
  • 107
    • 0036138963 scopus 로고    scopus 로고
    • Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    • Howard TD, et al. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 2002:70:230-236.
    • (2002) Am J Hum Genet , vol.70 , pp. 230-236
    • Howard, T.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.