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Volumn 188, Issue 7, 1998, Pages 1307-1320

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

Author keywords

Asthma; Eosinophilia; Interleukin 9; Mast cells; Transgenic mice

Indexed keywords

INTERLEUKIN 9;

EID: 0032487434     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.7.1307     Document Type: Article
Times cited : (417)

References (67)
  • 1
    • 0025900437 scopus 로고
    • Asthma and inflammation
    • Kay, A.B. 1991. Asthma and inflammation. J. Allergy Clin. Immunol. 87:893-910.
    • (1991) J. Allergy Clin. Immunol. , vol.87 , pp. 893-910
    • Kay, A.B.1
  • 4
    • 0028143099 scopus 로고
    • Cytokines as mediators of chronic asthma
    • Barnes, P.J. 1994. Cytokines as mediators of chronic asthma. Am. J. Respir. Crit. Care Med. 150:542-549.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150 , pp. 542-549
    • Barnes, P.J.1
  • 5
    • 0030024839 scopus 로고    scopus 로고
    • Activation and regulation of chemokines in allergic airway inflammation
    • Lukacs, N.W., R.M. Stricter, S.W. Chensue, and S.L. Kunkel. 1996. Activation and regulation of chemokines in allergic airway inflammation. J. Leukocyte Biol. 59:13-17.
    • (1996) J. Leukocyte Biol. , vol.59 , pp. 13-17
    • Lukacs, N.W.1    Stricter, R.M.2    Chensue, S.W.3    Kunkel, S.L.4
  • 6
    • 0027086958 scopus 로고
    • Major loci for atopy?
    • Morton, N.E. 1992. Major loci for atopy? Clin. Exp. Allergy. 22:1041-1043.
    • (1992) Clin. Exp. Allergy. , vol.22 , pp. 1041-1043
    • Morton, N.E.1
  • 7
    • 0030903861 scopus 로고    scopus 로고
    • A genome-wide search for asthma susceptibility loci in ethnically diverse populations
    • The Collaborative Study on the Genetics of Asthma (CSGA). 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat. Genet. 15:389-392.
    • (1997) Nat. Genet. , vol.15 , pp. 389-392
  • 11
    • 0024582587 scopus 로고
    • Molecular organization of the cytokine gene cluster, involving human IL-3, IL-4, IL-5, and GM-CSF genes, on chromosome 5
    • Van Leeuwen, B.H., M.E. Martinson, G.C. Webb, and I.G. Young. 1989. Molecular organization of the cytokine gene cluster, involving human IL-3, IL-4, IL-5, and GM-CSF genes, on chromosome 5. Blood. 73:1142-1148.
    • (1989) Blood , vol.73 , pp. 1142-1148
    • Van Leeuwen, B.H.1    Martinson, M.E.2    Webb, G.C.3    Young, I.G.4
  • 12
    • 0025829189 scopus 로고
    • Human interleukin-9: Genomic sequence, chromosomal location, and sequences essential for its expression in human T cell leukemia virus (HTLV)-I-transformed human T cells
    • Kelleher, K., K. Bean, S.C. Clark, W.-Y. Leung, T.L. Yang. 1991. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T cell leukemia virus (HTLV)-I-transformed human T cells. Blood. 77:1436-1441.
    • (1991) Blood. , vol.77 , pp. 1436-1441
    • Kelleher, K.1    Bean, K.2    Clark, S.C.3    Leung, W.-Y.4    Yang, T.L.5
  • 15
    • 0028967123 scopus 로고
    • Interleukin-9 and its receptor: Involvement in mast cell differentiation and T cell oncogenesis
    • Renauld, J.-C., A. Kermouni, A. Vink, J. Louahed, and J. van Snick. 1995. Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis. J. Leukocyte Biol. 57:353-360.
    • (1995) J. Leukocyte Biol. , vol.57 , pp. 353-360
    • Renauld, J.-C.1    Kermouni, A.2    Vink, A.3    Louahed, J.4    Van Snick, J.5
  • 17
    • 0026044456 scopus 로고
    • Host protective immunity to Trichinells spiralis in mice: Activation of TH2 cell subsets and lymphokine secretion in mice expressing different response phenotypes
    • Grencis, R.K., L. Hültner, and K.J. Else. 1991. Host protective immunity to Trichinells spiralis in mice: activation of TH2 cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology. 74:329-332.
    • (1991) Immunology. , vol.74 , pp. 329-332
    • Grencis, R.K.1    Hültner, L.2    Else, K.J.3
  • 18
    • 0026556392 scopus 로고
    • Cellular immune response to the murine nematode parasite Trichuris muris. II. Differential induction of TH-subsets in resistant versus susceptible mice
    • Else, K.J., L. Hültner, and R.K. Grencis. 1992. Cellular immune response to the murine nematode parasite Trichuris muris. II. Differential induction of TH-subsets in resistant versus susceptible mice. Immunology. 75:232-237.
    • (1992) Immunology. , vol.75 , pp. 232-237
    • Else, K.J.1    Hültner, L.2    Grencis, R.K.3
  • 19
    • 0027717408 scopus 로고
    • Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice
    • Gessner, A., H. Blum, and M. Röllinghoff. 1993. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology. 189: 419-435.
    • (1993) Immunobiology. , vol.189 , pp. 419-435
    • Gessner, A.1    Blum, H.2    Röllinghoff, M.3
  • 20
    • 0027245996 scopus 로고
    • A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3
    • Svetic, A., K.B. Madden, X.D. Zhou, P. Lu, I.M. Katona, F.D. Finkelman, J.F. Urban, Jr., and W.C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150:3434-3441.
    • (1993) J. Immunol. , vol.150 , pp. 3434-3441
    • Svetic, A.1    Madden, K.B.2    Zhou, X.D.3    Lu, P.4    Katona, I.M.5    Finkelman, F.D.6    Urban Jr., J.F.7    Gause, W.C.8
  • 23
    • 0023739985 scopus 로고
    • Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity
    • Uyttenhove, C., R.J. Simpson, and J. van Snick. 1988. Functional and structural characterization of P40, a mouse glycoprotein with T cell growth factor activity. Proc. Natl. Acad. Sci. USA. 85:6934-6938.
    • (1988) Proc. Natl. Acad. Sci. USA. , vol.85 , pp. 6934-6938
    • Uyttenhove, C.1    Simpson, R.J.2    Van Snick, J.3
  • 27
    • 0027180597 scopus 로고
    • Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes
    • Petit-Frère, C., B. Dugas, P. Braquet, and M. Mencia-Huerta. 1993. Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. Immunology. 79:146-151.
    • (1993) Immunology. , vol.79 , pp. 146-151
    • Petit-Frère, C.1    Dugas, B.2    Braquet, P.3    Mencia-Huerta, M.4
  • 28
    • 0025306952 scopus 로고
    • Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGF III (interleukin-9)
    • Hültner, L., C. Druez, J. Moeller, C. Uyttenhove, E. Schmitt, E. Rüde, P. Dörmer, and J. van Snick. 1990. Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGF III (interleukin-9). Eur. J. Immunol. 20: 1413-1416.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1413-1416
    • Hültner, L.1    Druez, C.2    Moeller, J.3    Uyttenhove, C.4    Schmitt, E.5    Rüde, E.6    Dörmer, P.7    Van Snick, J.8
  • 29
    • 0027376039 scopus 로고
    • Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases
    • Eklund, K.K., N. Ghildyal, K.F. Austen, and R.L. Stevens. 1993. Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J. Immunol. 151: 4266-4273.
    • (1993) J. Immunol. , vol.151 , pp. 4266-4273
    • Eklund, K.K.1    Ghildyal, N.2    Austen, K.F.3    Stevens, R.L.4
  • 30
    • 0025336180 scopus 로고
    • Human P40 T cell growth factor (interleukin-9) supports erythroid colony formation
    • Donahue, R.E., Y.-C. Yang, and S.C. Clark. 1990. Human P40 T cell growth factor (interleukin-9) supports erythroid colony formation. Blood. 75:2271-2275.
    • (1990) Blood. , vol.75 , pp. 2271-2275
    • Donahue, R.E.1    Yang, Y.-C.2    Clark, S.C.3
  • 33
    • 16044371529 scopus 로고    scopus 로고
    • Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity
    • Rankin, J.A., D.E. Picarella, G.P. Geba, U.-A. Temann, B. Prasad, B. DiCosmo, A. Tarallo, B. Stripp, J.A. Whitsett, and R.A. Flavell. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA. 93:7821-7825.
    • (1996) Proc. Natl. Acad. Sci. USA. , vol.93 , pp. 7821-7825
    • Rankin, J.A.1    Picarella, D.E.2    Geba, G.P.3    Temann, U.-A.4    Prasad, B.5    Dicosmo, B.6    Tarallo, A.7    Stripp, B.8    Whitsett, J.A.9    Flavell, R.A.10
  • 34
    • 0028173026 scopus 로고
    • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity
    • DiCosmo, B., G.P. Geba, D. Picarella, J.A. Elias, J.A. Rankin, B.R. Stripp, J.A. Whitsett, and R.A. Flavell. 1994. Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2035.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2028-2035
    • DiCosmo, B.1    Geba, G.P.2    Picarella, D.3    Elias, J.A.4    Rankin, J.A.5    Stripp, B.R.6    Whitsett, J.A.7    Flavell, R.A.8
  • 36
    • 0031137616 scopus 로고    scopus 로고
    • Induction of IL-4 producing CD4+ T cells by antigenic peptides altered for TCR binding
    • Tao, X., C. Grant, S. Constant, and K. Bottomly. 1997. Induction of IL-4 producing CD4+ T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4237-4244.
    • (1997) J. Immunol. , vol.158 , pp. 4237-4244
    • Tao, X.1    Grant, C.2    Constant, S.3    Bottomly, K.4
  • 37
    • 0031135533 scopus 로고    scopus 로고
    • Peptide antagonists inhibit proliferation and the production of IL-4 and/or INF-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR
    • Dittel, B.N., D.B. Sant'Angelo, and C.A. Janeway. 1997. Peptide antagonists inhibit proliferation and the production of IL-4 and/or INF-gamma in T helper 1, T helper 2, and T helper 0 clones bearing the same TCR. J. Immunol. 158: 4065-4073.
    • (1997) J. Immunol. , vol.158 , pp. 4065-4073
    • Dittel, B.N.1    SanT'Angelo, D.B.2    Janeway, C.A.3
  • 38
    • 0023896897 scopus 로고
    • Pulmonary responses to bronchoconstrictor agonists in the mouse
    • Martin, T., N. Gerard, S. Galli, and J. Drazen. 1988. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64:2318-2323.
    • (1988) J. Appl. Physiol. , vol.64 , pp. 2318-2323
    • Martin, T.1    Gerard, N.2    Galli, S.3    Drazen, J.4
  • 39
    • 84960644136 scopus 로고
    • Mechanics of respiration in unanesthetized guinea pigs
    • Amdur, M.O., and J. Mead. 1958. Mechanics of respiration in unanesthetized guinea pigs. Am. J. Physiol. 192:364-368.
    • (1958) Am. J. Physiol. , vol.192 , pp. 364-368
    • Amdur, M.O.1    Mead, J.2
  • 41
    • 0030476382 scopus 로고    scopus 로고
    • Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction
    • Tang, W., G.P. Geba, T. Zheng, P. Ray, R.J. Homer, C. Kuhn III, R.A. Flavell, and J.A. Elias. 1996. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. J. Clin. Invest. 98:2845-2853.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2845-2853
    • Tang, W.1    Geba, G.P.2    Zheng, T.3    Ray, P.4    Homer, R.J.5    Kuhn III, C.6    Flavell, R.A.7    Elias, J.A.8
  • 42
  • 44
    • 0026625347 scopus 로고
    • Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness
    • Bentley, A.M., G. Menz, C. Storz, D.S. Robinson, B. Bradley, P.K. Jeffrey, S.R. Durham, and A.B. Kay. 1992. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am. Rev. Respir. Dis. 146:500-506.
    • (1992) Am. Rev. Respir. Dis. , vol.146 , pp. 500-506
    • Bentley, A.M.1    Menz, G.2    Storz, C.3    Robinson, D.S.4    Bradley, B.5    Jeffrey, P.K.6    Durham, S.R.7    Kay, A.B.8
  • 45
    • 0023212275 scopus 로고
    • Peripheral blood eosinophil counts and bronchial responsiveness
    • Taylor, K.J., A.R. Luksza. 1987. Peripheral blood eosinophil counts and bronchial responsiveness. Thorax. 42:452-456.
    • (1987) Thorax. , vol.42 , pp. 452-456
    • Taylor, K.J.1    Luksza, A.R.2
  • 46
    • 0025721109 scopus 로고
    • Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness
    • Bradley, B.L., M. Azzawi, M. Jacobson, B. Assoufi, J.V. Collins, A.-M.A. Irani, L.B. Schwartz, S.R. Durham, P.K. Jeffery, and A.B. Kay. 1991. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 88:661-674.
    • (1991) J. Allergy Clin. Immunol. , vol.88 , pp. 661-674
    • Bradley, B.L.1    Azzawi, M.2    Jacobson, M.3    Assoufi, B.4    Collins, J.V.5    Irani, A.-M.A.6    Schwartz, L.B.7    Durham, S.R.8    Jeffery, P.K.9    Kay, A.B.10
  • 47
    • 0030953977 scopus 로고    scopus 로고
    • Aeroallergen-induced eosinophilic inflammation, lung damage, and airway hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins
    • Hogan, S.P., A. Mould, H. Kikutani, A.J. Ramsay, and P.S. Foster. 1997. Aeroallergen-induced eosinophilic inflammation, lung damage, and airway hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins J. Clin. Invest. 99:1329-1339.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1329-1339
    • Hogan, S.P.1    Mould, A.2    Kikutani, H.3    Ramsay, A.J.4    Foster, P.S.5
  • 54
    • 0026666718 scopus 로고
    • Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
    • Walker, C., E. Bode, L. Boer, T.T. Hansel, K. Blaser, and J.-C. Virchow, Jr. 1992. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am. Rev. Respir. Dis. 146:109-115.
    • (1992) Am. Rev. Respir. Dis. , vol.146 , pp. 109-115
    • Walker, C.1    Bode, E.2    Boer, L.3    Hansel, T.T.4    Blaser, K.5    Virchow Jr., J.-C.6
  • 55
  • 56
    • 0025186709 scopus 로고
    • Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells
    • Favre, C., S. Saeland, C. Caux, V. Duvert, and J.E. De Vries. 1990. Interleukin-4 has basophilic and eosinophilic cell growth-promoting activity on cord blood cells. Blood. 75: 67-73.
    • (1990) Blood. , vol.75 , pp. 67-73
    • Favre, C.1    Saeland, S.2    Caux, C.3    Duvert, V.4    De Vries, J.E.5
  • 58
    • 0023875104 scopus 로고
    • Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors
    • Yamaguchi, Y., T. Suda, J. Suda, M. Eguchi, Y. Miura, N. Harada, A. Tominaga, and K. Takatsu. 1988. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167:43-56.
    • (1988) J. Exp. Med. , vol.167 , pp. 43-56
    • Yamaguchi, Y.1    Suda, T.2    Suda, J.3    Eguchi, M.4    Miura, Y.5    Harada, N.6    Tominaga, A.7    Takatsu, K.8
  • 62
    • 0026129169 scopus 로고
    • The pathology of primary pulmonary hypertension
    • Burke, A.P., A. Farb, R. Virmani. 1991. The pathology of primary pulmonary hypertension. Mod. Pathol. 4:269-282.
    • (1991) Mod. Pathol. , vol.4 , pp. 269-282
    • Burke, A.P.1    Farb, A.2    Virmani, R.3
  • 66
    • 0027457861 scopus 로고
    • Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatics and normal subjects
    • Pesci, A., A. Foresi, G. Bertorelli, A. Chetta, and D. Oliveri. 1993. Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatics and normal subjects. Am. Rev. Respir. Dis. 147:684-689.
    • (1993) Am. Rev. Respir. Dis. , vol.147 , pp. 684-689
    • Pesci, A.1    Foresi, A.2    Bertorelli, G.3    Chetta, A.4    Oliveri, D.5
  • 67
    • 0030667854 scopus 로고    scopus 로고
    • Interleukin-9 is involved in host protective immunity to intestinal nematode infection
    • Faulkner, H., N. Humphreys, J.C. Renauld, J. van Snick, and R. Grencis. 1997. Interleukin-9 is involved in host protective immunity to intestinal nematode infection. Eur. J. Immunol. 27:2536-2540.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2536-2540
    • Faulkner, H.1    Humphreys, N.2    Renauld, J.C.3    Van Snick, J.4    Grencis, R.5


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