Epithelial cells and airway diseases

Immunological Reviews

Volumn 242, Issue 1, 2011, Pages 186-204

  Proud, David ^a   Leigh, Richard ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Airway remodeling; Epithelial cell; Host defense; Inflammation; Innate immunity

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; CYTOKINE; FLUTICASONE; GROWTH FACTOR; MUCIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SALMETEROL;

AIRWAY REMODELING; ANTIMICROBIAL ACTIVITY; ARTICLE; ASTHMA; ENVIRONMENTAL FACTOR; EPITHELIUM CELL; HOST RESISTANCE; HUMAN; IMMUNOREGULATION; INNATE IMMUNITY; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT MUCOSA; RHINOVIRUS; STIMULUS RESPONSE;

AIRWAY REMODELING; ALLERGENS; ANIMALS; ASTHMA; BRONCHODILATOR AGENTS; CELL ADHESION MOLECULES; CHILD; CYTOKINES; EPITHELIAL CELLS; EPITHELIUM; HUMANS; HYPERSENSITIVITY; IMMUNITY, INNATE; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; PICORNAVIRIDAE INFECTIONS; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS; RHINOVIRUS; SIGNAL TRANSDUCTION;

EID: 79959345632     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01033.x     Document Type: Article

References (180)

1. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992;258:593-597.
2. + T cells. J Exp Med 1997;185:461-469.
3. Cromwell O, et al. Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1ß and tumour necrosis factor-α. Immunology 1992;77:330-337.
4. Tomee JF, Wierenga ATJ, Hiemstra PS, Kaufman HK. Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J Infect Dis 1997;176:300-303.
5. King C, Brennan S, Thompson PJ, Stewart GA. Dust mite proteolytic allergens induce cytokine release from cultured airway epithelium. J Immunol 1998;161:3645-3651.
6. Subauste MC, Jacoby DB, Richards SM, Proud D. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 1995;96:549-557.
7. DiCosmo BF, et al. Airway epithelial cell expression of interleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest 1994;94:2028-2035.
8. Einarsson O, Geba GP, Zhu Z, Landry M, Elias JA. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J Clin Invest 1996;97:915-924.
9. Minshall E, et al. IL-11 expression is increased in severe asthma: association with epithelial cells and eosinophils. J Allergy Clin Immunol 2000;105:232-238.
10. Ying S, et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005;174:8183-8190.
11. Huston DP, Liu YJ. Thymic stromal lymphopoietin: a potential therapeutic target for allergy and asthma. Curr Allergy Asthma Rep 2006;6:372-376.
12. Regamey N, et al. Airway epithelial IL-15 transforms monocytes into dendritic cells. Am J Respir Cell Mol Biol 2007;37:75-84.
13. Laberge S, et al. Increased expression of interleukin-16 in bronchial mucosa of subjects with atopic asthma. Am J Respir Cell Mol Biol 1997;17:193-202.
14. Osterlund C, Grönlund H, Gafvelin G, Bucht A. Non-proteolytic aeroallegens from mites, cat and dog exert adjuvant-like activation of bronchial epithelial cells. Int Arch Allergy Immunol 2010;155:111-118.
15. Churchill L, Friedman B, Schleimer RP, Proud D. Production of granulocyte-macrophage colony-stimulating factor by cultured human tracheal epithelial cells. Immunology 1992;75:189-195.
16. Nonaka M, Nonake R, Jordana M, Dolovich J. GM-CSF, IL-8, IL-1R, TNF-αR, and HLA-DR in nasal epithelial cells in allergic rhinitis. Am J Respir Crit Care Med 1996;153:1675-1681.
17. Shibata Y, Nakamura H, Kato S, Tomoike H. Cellular detachment and deformation induce IL-8 gene expression in human bronchial epithelial cells. J Immunol 1996;156:772-777.
18. 2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells. J Biol Chem 2001;276:19267-19275.
19. Tuthope SJ, et al. The role of IκB kinase 2, but not activation of NF-κB, in the release of CXCR3 ligands from IFN-γ-stimulated human bronchial epithelial cells. J Immunol 2007;179:6237-6245.
20. Spurrell JCL, Wiehler S, Zaheer RS, Sanders SP, Proud D. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 2005;289:L85-L95.
21. van Wetering S, Zuyderduyn S, Ninaber DK, van Sterkenburg MAJA, Rabe KF, Hiemstra PS. Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13. Mol Immunol 2007;44:803-811.
22. Venge J, Lampinen M, Hakansson L, Rak S, Venge P. Identification of IL-5 and RANTES as the major eosinophilic chemoattractants in the human lung. J Allergy Clin Immunol 1996;97:1110-1115.
23. Sim TC, Reece LM, Hilsmeier KA, Grant JA, Alam R. Secretion of chemokines and other cytokines in allergen-induced nasal responses: inhibition by topical steroid treatment. Am J Respir Crit Care Med 1995;152:927-933.
24. Beck LA, et al. Detection of the chemokine RANTES and endothelial cell adhesion molecules in nasal polyps. J Allergy Clin Immunol 1996;98:766-780.
25. Heijink IH, Kies M, van Oosterhout AJM, Postma DS, Kauffman HF, Vellebga E. Der p, IL-4, and TGF-β cooperatively induce EGFR-dependent TARC expression in airway epithelium. Am J Respir Cell Mol Biol 2007;36:351-359.
26. Panina-Bordignon P, et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen challenged atopic asthmatics. J Clin Invest 2001;107:1357-1364.
27. Bochner BS, Hudson SA, Xiao HQ, Liu MC. Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 2003;112:930-934.
28. Reibman J, Hsu Y, Chen LC, Bleck B, Gordon T. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol 2003;28:648-654.
29. Olszewska-Pazdrak B, et al. Cell-specific expression of RANTES, MCP-1, and MIP-1α by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J Virol 1998;72:4756-4764.
30. Sousa AR, Lane SJ, Nakhosteen JA, Yoshimura T, Lee TH, Poston RN. Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol 1994;10:142-147.
31. Lamkhioued B, et al. Monocyte chemoattractant protein (MCP)-4 expression in the airway of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory peptides. Am J Respir Crit Care Med 2000;162:723-732.
32. O'Gorman MT, Jatoi NA, Lane SJ, Mahon BP. IL-1β and TNF-α induce increased expression of CCL28 by airway epithelial cells via an NFκB-dependent pathway. Cell Immunol 2005;238:87-96.
33. Fujimoto K, Imaizumi T, Yoshida H, Takanashi S, Okumura K, Satoh K. Interferon-γ stimulates fractalkine expression in human bronchial epithelial cells and regulates mononuclear cell adherence. Am J Respir Cell Mol Biol 2001;25:233-238.
34. Rimaniol AC, et al. The CX3C chemokine fractalkine in allergic asthma and rhinitis. J Allergy Clin Immunol 2003;112:1139-1146.
35. Eddleston J, Christiansen SC, Zuraw BL. Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators. J Immunol 2002;169:6445-6451.
36. Kelsen SG, et al. The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004;287:L584-L591.
37. Beck LA, et al. Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. J Immunol 2006;177:3344-3354.
38. Zhao Y, et al. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. Am J Respir Cell Mol Biol 2009;40:19-30.
39. Redington AE, et al. Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax 2001;56:351-357.
40. Churchill L, Chilton FH, Resau JH, Bascom R, Hubbard WC, Proud D. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am Rev Respir Dis 1989;140:449-459.
41. Liu MC, et al. Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics: Cellular, mediator, and permeability changes. Am Rev Respir Dis 1991;144:51-58.
42. Pavord ID, Wong CS, Williams J, Tattersfield AE. Effect of inhaled prostaglandin E2 on allergen-induced asthma. Am Rev Respir Dis 1993;148:87-90.
43. Chung KF. Evaluation of selective prostaglandin E2 (PGE2) receptor agonists as therapeutic agents for the treatment of asthma. Sci STKE 2005;303:pe47.
44. Chu HW, et al. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen depostion. Clin Exp Allergy 2002;32:1558-1565.
45. Liu C, et al. 15-lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells. Am J Physiol Lung Cell Mol Biol 2009;297:L196-L203.
46. Sachs-Olsen C, et al. Eoxins: A new inflammatory pathway in childhood asthma. J Allergy Clin Immunol 2010;126:859-867.
47. Claesson H-E. On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins Other Lipid Mediat 2009;89:120-125.
48. Ryan A, Godson C. Lipoxins: regulators of resolution. Curr Opin Pharmacol 2010;10:166-172.
49. Jacobs ER, Zeldin DC. The lung HETEs (and EETs) up. Am J Physiol Heart Circ Physiol 2001;280:H1-H10.
50. Ackerman V, Carpi S, Bellini A, Vassalli G, Marini M, Mattoli S. Constitutive expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by histamine and interleukin-1. J Allergy Clin Immunol 1995;91:618-627.
51. Nomura A, Uchida Y, Kameyama M, Saotome M, Oki K, Hasegawa S. Endothelin and bronchial asthma. Lancet 1989;1:747-748.
52. Goldie RG, Henry PJ. Endothelins and asthma. Life Sci 1999;65:1-15.
53. Riccio MM, Reynolds CJ, Hay DW, Proud D. Effects of intranasal administration of endothelin-1 to allergic and nonallergic individuals. Am J Respir Crit Care Med 1995;152:1757-1764.
54. Moskwa P, et al. A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med 2007;175:174-183.
55. Rochelle LG, Fischer BM, Adler KB. Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. Free Radic Biol Med 1998;24:863-868.
56. Chapman KE, Sinclair SE, Zhuang D, Hassid A, Desai LP, Waters CM. Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 2005;289:L834-L841.
57. Proud D. Nitric oxide and the common cold. Curr Opin Allergy Clin Immunol 2005;5:37-42.
58. Lane C, et al. Epithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breath. Thorax 2004;59:757-760.
59. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne E, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-135.
60. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J 1995;8:295-297.
61. Bove PF, van der Vliet A. Nitric oxide and reactive nitrogen species in airway epithelial cell signaling and inflammation. Free Radic Biol Med 2006;41:515-527.
62. Granger DN, Kubes P. Nitric oxide as an antiinflammatory agent. Methods Enzymol 1996;269:434-442.
63. Subauste MC, Choi D-C, Proud D. Transient exposure of human bronchial epithelial cells to cytokines leads to persistent increased expression of ICAM-1. Inflammation 2001;25:373-380.
64. Kidney JC, Proud D. Neutrophil transmigration across human airway epithelial monolayers; mechanisms and dependence on electrical resistance. Am J Respir Cell Mol Biol 2000;23:389-395.
65. Zen K, Parkos CA. Leukocyte-epithelial interactions. Curr Opin Cell Biol 2003;15:557-564.
66. Zen K, Babbin BA, Liu Y, Whelan JB, Nusrat A, Parkos CA. JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. Mol Biol Cell 2004;15:3926-3937.
67. Imhof BA, et al. Pulmonary dysfunction and impaired granulocyte homeostasis result in poor survival of Jam-C-deficient mice. J Pathol 2007;212:198-202.
68. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 2006;86:2006.
69. Plotkowski MC, Bajolet-Laudinet O, Puchelle E. Cellular and molecular mechanisms of bacterial adhesion to respiratory mucosa. Eur Respir J 1993;6:903-916.
70. Proud D, Subauste MC, Ward PE. Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line. Am J Respir Cell Mol Biol 1994;11:57-65.
71. McElvaney NG, et al. Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest 1992;90:1296-1301.
72. Wan H, et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest 1999;104:123-133.
73. Wan H, et al. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine proteins from faecal pellets of Dermatophagoides pteronyssinus. Clin Exp Allergy 2001;31:279-294.
74. Tai HY, et al. Pen ch 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells. Allergy 2006;61:382-388.
75. Asokananthan N, et al. House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immunol 2002;169:4572-4578.
76. Palmenberg AC, et al. Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution. Science 2009;324:55-59.
77. Sanders SP, Siekierski ES, Porter JD, Richards SM, Proud D. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line. J Virol 1998;72:934-942.
78. Sanders SP, Kim J, Connolly KR, Porter JD, Siekierski ES, Proud D. Nitric oxide inhibits rhinovirus-induced GM-CSF production in bronchial epithelial cells. Am J Respir Cell Mol Biol 2001;24:317-325.
79. Newcomb DC, et al. Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression. J Biol Chem 2005;280:36952-36961.
80. Lau C, et al. Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization. J Immunol 2008;180:870-880.
81. Wang X, et al. Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells. J Immunol 2006;177:6859-6870.
82. Bentley JK, Newcomb DC, Goldsmith AM, Jia Y, Sajjan US, Hershenson MB. Rhinovirus activates interleukin-8 expression via a Src/p110β phosphatylinositol 3-kinase pathway in human airway epithelial cells. J Virol 2007;81:1186-1194.
83. Allen IC, et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza virus through recognition of viral RNA. Immunity 2009;30:556-565.
84. Muruve DA, et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008;452:103-107.
85. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MBA. Does Toll-like receptor 3 play a biological role in virus infections? Virology 2004;322:231-238.
86. Kato H, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;414:101-105.
87. Kato H, et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005;23:19-28.
88. Wang Q, et al. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol 2009;183:6989-6997.
89. Slater L, et al. Co-ordinated role of TLR-3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog 2010;6:e1001178.
90. Triantafilou K, Vakakis E, Richer EAJ, Evans GL, Villiers JP, Triantafilou M. Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors amd MDA-5, which trigger a synergetic pro-inflammatory immune response. Virulence 2011;2:22-29.
91. Hament JM, et al. Enhanced adherence of Streptococcus pneumoniae to human epithelial cells infected with respiratory syncytial virus. Pediatr Res 2004;55:972-978.
92. Sajjan US, et al. H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression. FASEB J 2006;20:2121-2123.
93. Lachowicz-Scroggins ME, Boushey HA, Finkbeiner WE, Widdicombe JH. Interleukin-13 induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection. Am J Respir Cell Mol Biol 2010;43:652-661.
94. Wiehler S, Proud D. Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection. Am J Physiol Cell Mol Physiol 2007;293:L505-L515.
95. Wark PAB, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2002;19:68-75.
96. Hudy MH, Traves SL, Wiehler S, Proud D. Cigarette smoke modulates rhinovirus-induced airway epithelial chemokine production. Eur Respir J 2010;35:1256-1263.
97. Cohen S, Tyrrell DA, Russell MA, Jarvis MJ, Smith AP. Smoking, alcohol consumption, and susceptibility to the common cold. Am J Public Health 1993;83:1277-1283.
98. McLeish AC, Zvolensky MJ. Asthma and cigarette smoking: a review of the empirical literature. J Asthma 2010;47:345-361.
99. Kao C-Y, et al. IL-17 markedly up-regulates β-Defensin-2 expression in human airway epithelium via JAK and NF-κB signaling pathways. J Immunol 2004;173:3482-3491.
100. Proud D, Sanders SP, Wiehler S. Human rhinovirus infection induces airway epithelial cell production of human β-defensin-2 both in vitro and in vivo. J Immunol 2004;172:4637-4645.
101. Sahl H-G, Pag U, Bonness S, Wagner S, Antcheva N, Tossi A. Mammalian defensins: structures and mechanism of antibiotic activity. J Leukoc Biol 2005;77:466-475.
102. Proud D. The role of defensins in virus-induced asthma. Curr Allergy Asthma Rep 2006;6:81-85.
103. Bals R, Hiemstra PS. Innate immunity in the lung; how epithelial cells fight against respiratory pathogens. Eur Respir J 2004;23:327-333.
104. Kishore U, et al. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol 2006;43:1293-1315.
105. Bochkov YA, Hanson KM, Keles S, Brockman-Schneider RA, Jarjour NN, Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol 2010;3:69-80.
106. Proud D, et al. Gene expression profiles during in vivo human rhinovirus infection: insights into the host response. Am J Respir Crit Care Med 2008;178:962-968.
107. Wark PAB, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005;201:937-947.
108. Contoli M, et al. Role of deficient type-III interferon-l production in asthma exacerbations. Nat Med 2006;12:1023-1026.
109. Lopez-Souza N, et al. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol 2009;123:1384-1390.
110. Schneider D, et al. Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:332-340.
111. Schmid S, Mordstein M, Kochs G, García-Sastre A, tenOever BR. Transcription factor redundancy ensures induction of the antiviral state. J Biol Chem 2010;285:42013-42022.
112. Stirnweiss A, et al. IFN regulatory factor-1 bypassess IFN-mediated antiviral effects through viperin gene induction. J Immunol 2010;184:5179-5185.
113. Zaheer RS, Proud D. Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN regulatory factor-1. Am J Respir Cell Mol Biol 2010;43:413-421.
114. Zaheer RS, Koetzler R, Holden NS, Wiehler S, Proud D. Selective transcriptional downregulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway. J Immunol 2009;182:4854-4864.
115. Wang X, Hinson ER, Cresswell P. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe 2007;2:96-105.
116. Shaveta G, Shi J, Chow VTK, Song J. Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme. Biochem Biophys Res Commun 2010;391:1390-1395.
117. Sanders SP, Siekierski ES, Richards SM, Porter JD, Imani F, Proud D. Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo. J Allergy Clin Immunol 2001;107:235-243.
118. Sanders SP, Proud D, Siekierski ES, Yachechko R, Liu MC. Role of nasal nitric oxide in the resolution of experimental rhinovirus infection. J Allergy Clin Immunol 2004;113:697-702.
119. Koetzler R, Zaheer RS, Wiehler S, Holden NS, Giembycz MA, Proud D. Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells. J Allergy Clin Immunol 2009;123:201-208.
120. Koetzler R, Zaheer RS, Newton R, Proud D. Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-κB pathways in rhinovirus-infected epithelial cells. J Allergy Clin Immunol 2009;124:551-557.
121. Upham JW, Stick SM. Interactions between airway epithelial cells and dendritic cells: implications for the regulation of airway inflammation. Curr Drug Targets 2006;7:541-545.
122. Papi A, Stanciu LA, Papadopoulos NG, Teran LM, Holgate ST, Johnston SL. Rhinovirus infection induces major histocompatability complex class I and costimulatory molecule upregulation on respiratory epithelial cells. J Infect Dis 2000;181:1780-1784.
123. Vignola AM, et al. HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis. Am Rev Respir Dis 1993;148:689-694.
124. Kim J, et al. Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells. Am J Respir Cell Mol Biol 2005;33:280-289.
125. Heinecke L, Proud D, Sanders S, Schleimer RP, Kim J. Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies. J Allergy Clin Immunol 2008;121:1155-1160.
126. Salomon B, Bluestone JA. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 1998;161:5138-5142.
127. Salik E, et al. Antigen trafficking and accessory cell function in respiratory epithelial cells. Am J Respir Cell Mol Biol 1999;21:365-379.
128. + cytotoxic T lymphocytes. J Virol 1998;72:4534-4536.
129. Holgate ST. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007;120:1233-1244.
130. Saetta M, Di Stefano A, Rosina C, Thiene G, Fabbri LM. Qantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991;143:138-143.
131. Siddiqui S, et al. Vascular remodeling is a feature of asthma and nonasthmatic eosinophil bronchitis. J Allergy Clin Immunol 2007;120:813-819.
132. O'Byrne PM, Gauvreau GM, Brannan JD. Provoked models of asthma: what have we learnt? Clin Exp Allergy 2009;39:181-192.
133. Pohunek P, Warner JO, Turzíková J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol 2005;16:43-51.
134. Saglani S, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722-727.
135. Busse WW. The relationship between airway hyperresponsiveness and airway inflammation: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest 2010;138:4S-10S.
136. Gern JE. Viral respiratory infection and the link to asthma. Pediatr Infect Dis J 2008;27:S97-S103.
137. Martinez FD, et al. Asthma and wheezing in the first six years of life. N Engl J Med 1995;332:133-138.
138. Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 2000;161:1501-1507.
139. Kotaniemi-Syrjänen A, Vainionpää R, Reijonen TM, Waris M, Korhonen K, Korppi M. Rhinovirus-induced wheezing in infancy-the first sign of childhood asthma? J Allergy Clin Immunol 2003;111:66-71.
140. Thomsen SF, et al. Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am J Respir Crit Care Med 2009;179:1091-1097.
141. Jackson DJ, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008;178:667-672.
142. Kusel MM, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007;119:1105-1110.
143. Jartti T, Lee W-M, Pappas T, Evans M, Lemanske RFJ, Gern JE. Serial viral infections in infants with recurrent respiratory illnesses. Eur Respir J 2008;32:314-320.
144. Volonaki E, Psarras S, Xepapadaki P, Psomali D, Gourgiotis D, Papadopoulos NG. Synergistic effects of fluticasone propionate and salmeterol on inhibiting rhinovirus-induced epithelial production of remodelling-associated growth factors. Clin Exp Allergy 2006;36:1268-1273.
145. Leigh R, et al. Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling. J Allergy Clin Immunol 2008;121:1238-1245.
146. Jackson DJ, Johnston SL. The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol 2010;125:1178-1187.
147. Enomoto Y, et al. Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack. J Allergy Clin Immunol 2009;124:913-920.
148. Tacon CE, Wiehler S, Holden NS, Newton R, Proud D, Leigh R. Human rhinovirus infection of airway epithelial cells upregulates MMP-9 production via NF-κB. Am J Respir Cell Mol Biol 2010;43:201-209.
149. Manicone AM, McGuire JK. Matrix metalloproteinases as modulators of inflammation. Semin Cell Dev Biol 2008;19:34-41.
150. Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation and wound repair. J Allergy Clin Immunol 2003;111:1345-1352.
151. Erlwyn-Lajeunesse MD, et al. Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persitent wheeze. Pediatr Res 2008;64:194-199.
152. Dolhnikoff M, et al. The outer wall of small airways is a major site of remodeling in fatal asthma. J Allergy Clin Immunol 2009;123:1090-1097.
153. Simcock DE, Kanabar V, Clarke GW, O'Connor BJ, Lee TH, Hirst SJ. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am J Respir Crit Care Med 2007;176:146-153.
154. Psarras S, et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinovirus. J Allergy Clin Immunol 2006;117:291-297.
155. Inoue D, et al. Mechanisms of mucin production by rhinovirus infection in cultured human airway epithelial cells. Respir Physiol Neurobiol 2006;154:484-499.
156. Zhu L, Lee P, Lee W-M, Zhao Y, Yu D, Chen Y. Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway. Am J Respir Cell Mol Biol 2009;40:610-619.
157. Hewson CA, et al. Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways. Eur Respir J 2010;36:1425-1435.
158. Adams NP, Bestall JC, Malouf R, Lasserson TJ, Jones P. Beclomethasone versus placebo for chronic asthma. Cochrane Database Syst Rev 2005; Issue 1. Art. No.: CD002738.
159. Kelly MM, Leigh R, L J, Goldsmith CH, Parameswaran K, Hargreave FE. Eosinophilic bronchitis in asthma: a model for establishing dose-response and relative potency of inhaled corticosteroids. J Allergy Clin Immunol 2006;117:989-994.
160. Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 2000;343:332-336.
161. Chivers JE, et al. Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release. Eur J Biochem 2004;271:4042-4052.
162. Newton R, Holden NS. Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor. Mol Pharmacol 2007;72:799-809.
163. De Bosscher K, Vanden Berghe W, Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 2003;24:488-522.
164. Newton R. Molecular mechanisms of glucocorticoid action: what is important? Thorax 2000;55:603-613.
165. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N Engl J Med 2005;353:1711-1723.
166. Mittelstadt PR, Ashwell JD. Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J Biol Chem 2001;276:29603-29610.
167. Eddleston J, Herschbach J, Wagelie-Steffen AL, Christiansen SC, Zuraw BL. The anti-inflammatory effects of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells. J Allergy Clin Immunol 2007;119:115-122.
168. 2-adrenoreceptor signalling in the airways. Eur Respir J 2006;27:1286-1306.
169. Nelson HS, Weiss ST, Bleecker ER, Yancey SW, Dorinsky PM. The Salmeterol Multicenter Asthma Reseach Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006;129:15-26.
170. Greening AP, Ind PW, Northfield M, Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994;344:219-224.
171. Rabe KF, Atienza T, Magyar P, Larsson P, Jorup C, Lalloo UG. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomized controlled, double-blind study. Lancet 2006;368:744-753.
172. Bateman ED, et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control study. Am J Respir Crit Care Med 2004;170:836-844.
173. 2-adrenergic receptor transcription in human lung. Am J Physiol Lung Cell Mol Physiol 1995;268:L41-L46.
174. 2-adrenoreceptor-mediated responses in human lung mast cells. Br J Pharmacol 1997;121:717-722.
175. sα protein expression in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2000;278:L1101-L1106.
176. 2-adrenoreceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol 2008;153:1090-1104.
177. 2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur Respir J 1999;14:275-282.
178. 2-adrenoreceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells. Mol Pharmacol 2008;73:203-214.
179. Edwards MR, Johnson MW, Johnston SL. Combination therapy. Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 2006;34:616-624.
180. Skevaki CL, et al. Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus. Clin Exp Allergy 2009;39:1700-1710.