IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells

International Immunology

Volumn 19, Issue 1, 2007, Pages 1-10

  Temann, Ulla Angela ^a   Laouar, Yasmina ^a   Eynon, Elizabeth E ^a   Homer, Robert ^a,b   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVATOR; INTERLEUKIN 13; INTERLEUKIN 9; MESSENGER RNA; RECOMBINASE ACTIVATING PROTEIN 1; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EPITHELIUM CELL; HYPERPLASIA; IMMUNOPATHOGENESIS; IN SITU HYBRIDIZATION; LOEFFLER PNEUMONIA; LUNG PARENCHYMA; MAST CELL; MOUSE; MUCUS SECRETION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; EPITHELIAL CELLS; GENES, RAG-1; INTERLEUKIN-13; INTERLEUKIN-5; INTERLEUKIN-9; LUNG; LYMPHOCYTES; MAST CELLS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PNEUMONIA; STAT6 TRANSCRIPTION FACTOR;

EID: 33845905754     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl117     Document Type: Article

References (35)

1. Lukacs, N. W., Strieter, R. M. and Kunkel, S. L. 1995. Leukocyte infiltration in allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 13:1.
2. Robinson, D. S., Hamid, Q., Ying, S. et al. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
3. Nicolaides, N. C., Holroyd, K. J., Ewart, S. L. et al. 1997. Interleukin 9: A candidate gene for asthma. Proc. Natl Acad. Sci. USA 94:13175.
4. Uyttenhove, C., Simpson, R. J. and Van Snick, J. 1988. Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc. Natl Acad. Sci. USA 85:6934.
5. Hultner, L. and Moeller, J. 1990. Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline. Exp. Hematol. 18:873.
6. Williams, D. E., Morrissey, P. J., Mochizuki, D. Y. et al. 1990. T-cell growth factor P40 promotes the proliferation of myeloid cell lines and enhances erythroid burst formation by normal murine bone marrow cells in vitro. Blood 76:906.
7. Dugas, B., Renauld, J. C., Pene, J. et al. 1993. Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur. J. Immunol. 23:1687.
8. Donahue, R. E., Yang, Y. C. and Clark, S. C. 1990. Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation. Blood 75:2271.
9. Abdelilah, S., Latifa, K., Esra, N. et al. 2001. Functional expression of IL9 receptor by human neutrophils from asthmatic donors: Role in IL8 release. J. Immunol. 166:2768.
10. Longphre, M., Li, D., Gallup, M. et al. 1999. Allergen-induced IL9 directly stimulates mucin transcription in respiratory epithelial cells. J. Clin. Invest. 104:1375.
11. Gounni, A. S., Gregory, B., Nutku, E. et al. 2000. Interleukin-9 enhances interleukin-5 receptor expression, differentiation, and survival of human eosinophils. Blood 96:2163.
12. Louahed, J., Zhou, Y., Maloy, W. L. et al. 2001. Interleukin 9 promotes influx and local maturation of eosinophils. Blood 97:1035.
13. Little, F. F., Cruilkshank, W. W. and Center, D. M. 2001. IL9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 25:347.
14. Townsend, J. M., Fallon, G. P., Matthews, J. D., Smith, P., Jolin, E. H. and McKenzie, N. A. 2000. IL9-deficient mice establish fundamental roles for IL9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity 13:573.
15. Temann, U. A., Geba, G. P., Rankin, J. A. and Flavell, R. A. 1998. Expression of interleukin 9 in the lungs of Tg mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness. J. Exp. Med. 188:1307.
16. Temann, U. A., Ray, P. and Flavell, R. A. 2002. Pulmonary overexpression of IL9 induces Th2 cytolkine expression, leading to immune pathology. J. Clin. Invest. 109:29.
17. Kaplan, M. H., Schindler, U., Smiley, S. T. and Grusby, M. J. 1996. Stat6 is required for mediating responses to IL4 and for development of Th2 cells. Immunity 4:313.
18. Kopf, M., Brombacher, F., Hodgkin, P. D. et al. 1996. IL5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4:15.
19. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E. 1992. RAG-1-cleficient mice have no mature B and T lymphocytes. Cell 68:869.
20. McKenzie, G. J., Emson, C. L., Bell, S. E. et al. 1998. Impaired development of Th2 cells in IL13-deficient mice. Immunity 9:423.
21. Kitamura, Y., Go, S. and Hatanaka, K. 1978. Decrease of mast cells in W/ Wv mice and their increase by bone marrow transplantation. Blood 52:447.
22. Kuperman, D., Schofield, B., Wills-Karp, M. and Grusby M. J. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J. Exp. Med. 187:939.
23. Akimoto, T., Numata, F., Tamura, M. et al. 1998. Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J. Exp. Med. 187:1537.
24. de Vries, J. E. 1998. The role of IL13 and its receptor in allergy and inflammatory responses. J. Allergy Clin. Immunol. 102:165.
25. Gavett, S. H., Chen, X., Finkelman, F. and Wills-Karp, M. 1994. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am. J. Respir. Cell Mol. Biol. 10:587.
26. Corry, D. B., Grunig, G., Hadeiba, H. et al. 1998. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol. Med. 4:344.
27. Grunig, G., Warnock, M., Wakil, A. E. et al. 1998. Requirement for IL13 independently of IL4 in experimental asthma. Science 282:2261.
28. Krzesicki, R. F., Winterrowd, G. E., Brashler, J. R. et al. 1997. Identification of cytokine and adhesion molecule mRNA in murine lung tissue and isolated T cells and eosinophils by semi-quantitative reverse transcriptase-polymerase chain reaction. Am. J. Respir. Cell Mol. Biol. 16:693.
29. Burd, P. R., Thompson, W. C., Max, E. E. and Mills, F. C. 1995. Activated mast cells produce interleukin 13. J. Exp. Med. 181:1373.
30. Schmid-Grendelmeier, P., Altznauer, F., Fischer, B. et al. 2002. Eosinophils express functional IL13 in eosinophilic inflammatory diseases. J. Immunol. 169:1021.
31. Louahed, J., Toda, M., Jen, J. et al. 2000. Interleukin-9 upregulates mucus expression in the airways. Am. J. Respir. Cell Mol. Biol. 22:649.
32. Dong, Q., Louahed, J., Vink, A. et al. 1999. IL9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in Tg mice. Eur. J. Immunol. 29:2130.
33. Ando, M., Miyazaki, E., Fukami, T., Kumamoto, T. and Tsuda, T. 1999. Interieukin-4-producing cells in idiopathic pulmonary fibrosis: An immunohistochemical study. Respirology 4:383.
34. Pathmanathan, S., Krishna, M. T., Blomberg, A. et al. 2003. Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL5, IL10, IL13, and ICAM-1 in the bronchial epithelium of healthy human airways. Occup. Environ. Med. 60:892.
35. Hancock, A., Armstrong, L., Gama, R. and Millar, A. 1998. Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am. J. Respir. Cell Mol. Biol. 18:60.