Requirement for IL-13 independently of IL-4 in experimental asthma

Science

Volumn 282, Issue 5397, 1998, Pages 2261-2263

  Grünig, Gabriele ^a   Warnock, Martha ^b   Wakil, Adil E ^c   Venkayya, Rajeev ^a   Brombacher, Frank ^d   Rennick, Donna M ^e   Sheppard, Dean ^a   Mohrs, Markus ^b   Donaldson, Debra D ^f   Locksley, Richard M ^a   Corry, David B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e MERCK RESEARCH LABORATORIES   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 5Q; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC ASSOCIATION; HISTOPATHOLOGY; HUMAN TISSUE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; CHROMOSOMES, HUMAN, PAIR 5; GOBLET CELLS; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; OVALBUMIN; PHENOTYPE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-13; RECEPTORS, INTERLEUKIN-4; RECOMBINANT FUSION PROTEINS; TH2 CELLS;

ANIMALIA; MURINAE;

EID: 0032545433     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.282.5397.2261     Document Type: Article

References (39)

1. N. A. Molfino, L. J. Nannini, A. N. Martelli, A. S. Slutsky, N. Engl. J. Med. 324, 285 (1991).
2. R. A. Goldstein, W. E. Paul, D. D. Metcalfe, W. W. Busse, E. R. Reece, Ann. Intern. Med. 121, 698 (1994).
3. S. H. Gavett, X. Chen, F. Finkelman, M. Wills-Karp, Am. J. Respir. Cell Mol. Biol. 10, 587 (1994).
4. A. Watanabe et al., ibid. 16, 69 (1997); J. Garssen, F. P. Nijkamp, H. Van Der Vliet, H. Van Loveren, Am. Rev. Respir. Dis. 144, 931 (1991); J. A. Rankin et al., Proc. Natl. Acad. Sci. U.S.A. 93, 7821 (1996); P. S. Foster, S. P. Hogan, A. J. Ramsay, K. I. Matthaei, I. G. Young, J. Exp. Med. 183, 195 (1996); P. J. Mauser et al., Am. Rev. Respir. Dis. 148, 1623 (1993).
5. A. Watanabe et al., ibid. 16, 69 (1997); J. Garssen, F. P. Nijkamp, H. Van Der Vliet, H. Van Loveren, Am. Rev. Respir. Dis. 144, 931 (1991); J. A. Rankin et al., Proc. Natl. Acad. Sci. U.S.A. 93, 7821 (1996); P. S. Foster, S. P. Hogan, A. J. Ramsay, K. I. Matthaei, I. G. Young, J. Exp. Med. 183, 195 (1996); P. J. Mauser et al., Am. Rev. Respir. Dis. 148, 1623 (1993).
6. A. Watanabe et al., ibid. 16, 69 (1997); J. Garssen, F. P. Nijkamp, H. Van Der Vliet, H. Van Loveren, Am. Rev. Respir. Dis. 144, 931 (1991); J. A. Rankin et al., Proc. Natl. Acad. Sci. U.S.A. 93, 7821 (1996); P. S. Foster, S. P. Hogan, A. J. Ramsay, K. I. Matthaei, I. G. Young, J. Exp. Med. 183, 195 (1996); P. J. Mauser et al., Am. Rev. Respir. Dis. 148, 1623 (1993).
7. A. Watanabe et al., ibid. 16, 69 (1997); J. Garssen, F. P. Nijkamp, H. Van Der Vliet, H. Van Loveren, Am. Rev. Respir. Dis. 144, 931 (1991); J. A. Rankin et al., Proc. Natl. Acad. Sci. U.S.A. 93, 7821 (1996); P. S. Foster, S. P. Hogan, A. J. Ramsay, K. I. Matthaei, I. G. Young, J. Exp. Med. 183, 195 (1996); P. J. Mauser et al., Am. Rev. Respir. Dis. 148, 1623 (1993).
8. A. Watanabe et al., ibid. 16, 69 (1997); J. Garssen, F. P. Nijkamp, H. Van Der Vliet, H. Van Loveren, Am. Rev. Respir. Dis. 144, 931 (1991); J. A. Rankin et al., Proc. Natl. Acad. Sci. U.S.A. 93, 7821 (1996); P. S. Foster, S. P. Hogan, A. J. Ramsay, K. I. Matthaei, I. G. Young, J. Exp. Med. 183, 195 (1996); P. J. Mauser et al., Am. Rev. Respir. Dis. 148, 1623 (1993).
9. G. Brusselle, J. Kips, G. Joos, H. Bluethmann, R. Pauwels, Am. J. Respir. Cell Mol. Biol. 12, 254 (1995).
10. D. B. Corry et al., J. Exp. Med. 183, 109 (1996).
11. D. B. Corry et al., Mol. Med. 4, 344 (1998).
12. A. K. Abbas, K. M. Murphy. A. Sher, Nature 383, 787 (1996).
13. 200) or Wilcoxon test (goblet cell score, BAL cytology).
14. 200 of OVA-challenged wild-type, IL-4-deficient, and IL-4Rα-deficient mice were 0.24 ± 0.025, 0.36 ± 0.026, and 0.45 ± 0.058 mg/kg, respectively.
15. A. Minty et al., Nature 362, 248 (1993); J. Punnonen et al. Proc. Natl. Acad. Sci. U.S.A. 90, 3730 (1993); T. Naseer et al., Am. J. Respir. Crit. Care Med. 155, 845 (1997); S. Till et al., Immunology 91, 53 (1997).
16. A. Minty et al., Nature 362, 248 (1993); J. Punnonen et al. Proc. Natl. Acad. Sci. U.S.A. 90, 3730 (1993); T. Naseer et al., Am. J. Respir. Crit. Care Med. 155, 845 (1997); S. Till et al., Immunology 91, 53 (1997).
17. A. Minty et al., Nature 362, 248 (1993); J. Punnonen et al. Proc. Natl. Acad. Sci. U.S.A. 90, 3730 (1993); T. Naseer et al., Am. J. Respir. Crit. Care Med. 155, 845 (1997); S. Till et al., Immunology 91, 53 (1997).
18. A. Minty et al., Nature 362, 248 (1993); J. Punnonen et al. Proc. Natl. Acad. Sci. U.S.A. 90, 3730 (1993); T. Naseer et al., Am. J. Respir. Crit. Care Med. 155, 845 (1997); S. Till et al., Immunology 91, 53 (1997).
19. After subcutaneous priming with OVA on days -14 and -7, BALB/c wild-type mice were administered intranasally 55 μl of IL-13R-FC (13) or immunoglobulin control protein (Ig control) in phosphate-buffered saline (PBS). We administered 110 μg of IL-13R-Fc on days 0, 1, 2, 3, 3.5, 4, and 4.5, and 110 μg of Ig control was given on days 0.1,2, and 4. Both proteins were administered with 750 μg of OVA on days 1,2, and 4. Data were collected on day 5 (9).
20. D. D. Donaldson et al., J. Immunol. 161, 2317 (1998).
21. -/- mice were administered 3 to 5 μg of recombinant IL-4 or IL-13, or control protein (bovine serum albumin or irrelevant rat antibody) intranasally on days 1, 3, and 5, and data were collected 12 to 15 hours later (9). For clarity, only data from BALB/c wild-type mice are shown.
22. 7 washed cells intravenously. The mice were challenged intranasally with OVA for 6 consecutive days. Data were collected on day 7 (9).
23. G. Grünig and D. B. Corry, unpublished data.
24. S. P. Hogan et al., J. Immunol. 161, 1501 (1998); L. Cohn, R. J. Homer, A. Marinov, J. Rankin, K. Bottomly, J. Exp. Med. 186, 1727 (1997).
25. S. P. Hogan et al., J. Immunol. 161, 1501 (1998); L. Cohn, R. J. Homer, A. Marinov, J. Rankin, K. Bottomly, J. Exp. Med. 186, 1727 (1997).
26. A. J. Bancroft, A. N. McKenzie. R. K. Grencis, J. Immunol. 160, 3453 (1998); J. F. Urban Jr. et al., Immunity 8, 255 (1998); J. F. Urban Jr., I. M. Katona, W. E. Paul, F. D. Finkelman, Proc. Natl. Acad. Sci. U.S.A. 88, 5513 (1991); M. Barner, M. Mohrs, F. Brombacher, M. Kopf, Curr. Biol. 8, 669 (1998).
27. A. J. Bancroft, A. N. McKenzie. R. K. Grencis, J. Immunol. 160, 3453 (1998); J. F. Urban Jr. et al., Immunity 8, 255 (1998); J. F. Urban Jr., I. M. Katona, W. E. Paul, F. D. Finkelman, Proc. Natl. Acad. Sci. U.S.A. 88, 5513 (1991); M. Barner, M. Mohrs, F. Brombacher, M. Kopf, Curr. Biol. 8, 669 (1998).
28. A. J. Bancroft, A. N. McKenzie. R. K. Grencis, J. Immunol. 160, 3453 (1998); J. F. Urban Jr. et al., Immunity 8, 255 (1998); J. F. Urban Jr., I. M. Katona, W. E. Paul, F. D. Finkelman, Proc. Natl. Acad. Sci. U.S.A. 88, 5513 (1991); M. Barner, M. Mohrs, F. Brombacher, M. Kopf, Curr. Biol. 8, 669 (1998).
29. A. J. Bancroft, A. N. McKenzie. R. K. Grencis, J. Immunol. 160, 3453 (1998); J. F. Urban Jr. et al., Immunity 8, 255 (1998); J. F. Urban Jr., I. M. Katona, W. E. Paul, F. D. Finkelman, Proc. Natl. Acad. Sci. U.S.A. 88, 5513 (1991); M. Barner, M. Mohrs, F. Brombacher, M. Kopf, Curr. Biol. 8, 669 (1998).
30. A. A. Ten Have-Opbroek, Exp. Lung Res. 17, 111 (1991).
31. D. S. Postma et al., N. Engl. J. Med. 333, 894 (1995).
32. H. Mitsuyasu et al., Nature Genet. 19, 119 (1998); G. K. Hershey, M. F. Friedrich, L. A. Esswein, M. L. Thomas, T. A. Chatila, N. Engl. J. Med. 337, 1720 (1997).
33. H. Mitsuyasu et al., Nature Genet. 19, 119 (1998); G. K. Hershey, M. F. Friedrich, L. A. Esswein, M. L. Thomas, T. A. Chatila, N. Engl. J. Med. 337, 1720 (1997).
34. S. E. Daniels et al., Nature 383, 247 (1996); A. Sandford, T. Weir, P. Pare, Am. J. Respir. Crit. Care Med. 153, 1749 (1996).
35. S. E. Daniels et al., Nature 383, 247 (1996); A. Sandford, T. Weir, P. Pare, Am. J. Respir. Crit. Care Med. 153, 1749 (1996).
36. N. Noben-Trauth, G. Kohler, K. Burki, B. Ledermann, Transgenic Res. 5, 487 (1996).
37. P. Mombaerts et al., Cell 68, 869 (1992).
38. K. M. Murphy, A. B. Heimberger, D. Y. Loh, Science 250, 1720 (1990).
39. We thank D. Erle, M. Wills-Karp, R. Coffman, and F. Finkelman for helpful discussions, the Research Support Team of Genetics Institute for IL-13Rα2-Fc protein, and R. Coffman for IL-4. Supported by NIH grants T32 HL07185 (G.G.), 03344 (D.B.C), 47412, 53949, 33259 (D.S.), 09883 (R.V.), and P01-HL56385; the Crohn's and Colitis foundation and the Hefni Scholars Fund (A.E.W.); Howard Hughes Medical Institute (M.M. and R.M.L); and Schering-Plough Corporation (D.M.R.).