Involvement of the epidermal growth factor receptor in epithelial repair in asthma

FASEB Journal

Volumn 14, Issue 10, 2000, Pages 1362-1374

  Puddicombe, S M ^a   Polosa, R ^a   Richter, A ^a   Krishna, M T ^a   Howarth, P H ^a   Holgate, S T ^a   Davies, D E ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

c erbB1; Phosphorylation; Remodeling; TGF ; Tyrphostin

Indexed keywords

CORTICOSTEROID; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; TYRPHOSTIN;

ADULT; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WOUND HEALING;

BRONCHUS;

EID: 0033923224     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.10.1362     Document Type: Article

References (13)

1. Laitinen, L. A., Heino, M., Laitinen, A., Kava, T., and Haahtela, T. (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am. Rev. Resp. Dis. 131, 599-606
2. Beasley, R., Roche, W. R., Roberts, J. A., and Holgate, S. T. (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Resp. Dis. 139, 806-817
3. Jeffery, P. K., Wardlaw, A. J., Nelson, F. C., Collins, J. V., and Kay, A. B. (1989) Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am. Rev. Resp. Dis. 140, 1745-1753
4. Montefort, S., Roberts, J. A., Beasley, R., Holgate, S. T., and Roche, W. R. (1992) The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax 47, 499-503
5. Campbell, A. M. (1997) Bronchial epithelial cells in asthma. Allergy 52, 483-489
6. Holgate, S. T. (1996) Asthma: a dynamic disease of inflammation and repair. In The Rising Trends of Asthma (Ciba Foundation Symposium) Vol. 206, pp. 5-34, Wiley, Chichester
7. Roche, W. H., Beasley, R., Williams, J., and Holgate, S. T. (1989) Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1, 520-524
8. Pohunek, P., Roche, W. R., Tarzikova, J., Kurdmann, J., and Warner, J. O. (1997) Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma. Eur. Resp. J. 10 (Suppl. 25), 160s (abstr.)
9. Boulet, L. P., Laviolette, M., Turiotte, H., Cartier, A., Dugas, M., Malo, J. L., and Boutet, M. (1997) Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest 112, 45-52
10. Minshall, E. M., Leung, D. Y. M., Martin, R. J., Song, Y. L., Cameron, L., Ernst, P., and Hamid, Q. (1997) Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma. Am. J. Resp. Cell Mol. Biol. 17, 326-333
11. Hoshino, M., Nakamura, Y., and Sim, J. J. (1998) Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 53, 21-27
12. Altraja, A., Laitinen, A., Virtanen, I., Kampe, M., Simonsson, B. G., Karlsson, S. E., and Hakansson, L., Venge, P., Sillastu, H., and Laitinen, L. A. (1996) Expression of laminins in the airways in various types of asthmatic patients: A morphometric study. Am. J. Resp. Cell Mol. Biol. 15, 482-488
13. Laitinen, A., Altraja, A., Kampe, M., Linden, M., Virtanen, I., and Laitinen, L. A. (1997) Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am. J. Resp. Crit. Care Med. 156, 951-958