The interleukin-13 receptor α2 chain: An essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway

Blood

Volumn 97, Issue 9, 2001, Pages 2673-2679

  Kawakami, Koji ^a   Taguchi, Jun ^a   Murata, Takashi ^a   Puri, Raj K ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 BINDING PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER THERAPY; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; GLIOBLASTOMA; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 0035353154     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.9.2673     Document Type: Article

References (40)

1. Minty A, Chalon P, Dorocq J-M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature. 1993;362:248-250.
2. Zurawski G, de Vries JE. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells but not on T cells. Immunol Today. 1994;15:19-26.
3. de Waal Malefyt R, Figdor CG, Huijbens R, et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-γ or IL-10. J Immunol. 1993;151:6370-6381.
4. de Waal Malefyt R, Figdor CG, de Vries JE. Effects of interleukin 4 on monocyte functions: comparison to interleukin 13. Res Immunol. 1993;144:629-633.
5. McKenzie ANJ, Culpepper, JA, de Waal Matelyt R, et al. Interleukin 13, a novel T cell-derived cytokine that regulates human monocytes and B cell function. Proc Natl Acad Sci U S A. 1993;90:3735-3739.
6. Defrance T, Carayon P, Billian G, et al. Interleukin 13 is a B cell stimulating factor. J Exp Med. 1994;179:1325-1333.
7. Cooks BG, de Waal Malefyt R, Galizzi J-P, de Vries JE. IL-13 induces proliferation and differentiation of human B-cells activated by the CD40 ligand. Int Immunol. 1993;5:657-663.
8. Obiri NI, Debinski W, Leonard WJ, Puri RK. Receptor for interleukin 13: interaction with interleukin 4 by a mechanism that does not involve the common γ chain shared by receptors for interleukins 2, 4, 7, 9, and 15. J Biol Chem. 1995;270:8797-8804.
9. Murata T, Obiri NI, Debinski W, Puri RK. Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells. Biochem Biophys Res Commun. 1997;238:90-94.
10. Murata T, Obiri NI, Puri RK. Human ovarian carcinoma cell lines express IL-4 and IL-13 receptors: comparison between IL-4- and IL-13-induced signal transduction. Int J Cancer. 1997;70:230-240.
11. Murata T, Obiri NI, Puri RK. Structure of and signal transduction through interleukin-4 and interleukin-13 receptors. Int J Mol Med. 1998;1:551-557.
12. Obiri NI, Leland P, Murata T, Debinski W, Puri RK. The IL-13 receptor structure differs on various cell types and may share more than one component with IL-4 receptor. J Immunol. 1997;158:756-764.
13. Idzerda RL, March CJ, Mosley B, et al. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med. 1990;171:861-873.
14. Aman MJ, Tayebi N, Obiri NI, Puri RK, Modi WS, Leonard WJ. cDNA cloning and characterization of the human interleukin 13 receptor α chain. J Biol Chem. 1996;271:29265-29270.
15. Murata T, Taguchi J, Puri RK. Interleukin-13 receptor α′ but not a chain: α functional component of interieukin-4 receptors. Blood. 1998;91:3884-3891.
16. Russell SM, Keegan AD, Harada N, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 1993;262:1880-1883.
17. c chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. J Biol Chem. 1995;270:30829-30836.
18. Hilton DJ, Zhang J-G, Metcalf D, Alexander WS, Nicola NA, Willson TA. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci U S A. 1996;93:497-501.
19. Caput D, Laurent P, Kaghad M, et al. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain. J Biol Chem. 1996;271:16921-16926.
20. c chain of the IL-2 receptor. J Biol Chem. 1997;272:20251-20258.
21. Kuznetsov VA, Puri RK. Kinetic analysis of high affinity forms of interleukin (IL)-13 receptors: suppression of IL-13 binding by IL-2 receptor γ chain. Biophys J. 1999;77:154-172.
22. Murata T, Noguchi PD, Puri RK. IL-13 induces phosphorylation and activation of JAK2 janus kinase in human colon carcinoma cell lines. J Immunol. 1996;156:2972-2978.
23. Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem. 1995;64:621-651.
24. Zhang J-G, Hilton DJ, Willson TA, et al. Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. J Biol Chem. 1997;272:9474-9480.
25. Gauchat J-F, Schlagenhauf E, Feng N-P, et al. A novel 4-kb interieukin-13 receptor α mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Eur J Immunol. 1997;27:971-978.
26. Debinski W, Obiri NI, Pastan I, Puri RK. A novel chimeric protein composed of interleukin 13 and Pseudomonas extoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4. J Biol Chem. 1995;270:16775-16780.
27. Puri RK, Leland P, Obiri NI, et al. Targeting of interleukin-13 receptor on human renal carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR). Blood. 1996;87:4333-4339.
28. Oshima Y, Joshi BH, Puri RK. Conversion of interleukin-13 into a high affinity agonist by a single amino acid substitution. J Biol Chem. 2000;275:14375-14380.
29. Kreitman RJ, Puri RK, Pastan I. A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc Natl Acad Sci U S A. 1994;91:6889-6893.
30. Kreitman RJ, Puri RK, Pastan I. Increased antitumor activity of circularly permuted interleukin 4-toxin in mice with interleukin 4 receptor-bearing human carcinoma. Cancer Res. 1995;55:3357-3363.
31. Ohmori Y, Smith MF Jr, Hamilton TA. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by Stat6. J Immunol. 1996;157:2058-2065.
32. Kawakami K, Leland P, Puri RK. Structure, function, and targeting of interleukin 4 receptors on human head and neck cancer cells. Cancer Res. 2000;60:2981-2987.
33. Keppler-Hafkemeyer A, Kreitman RJ, Pastan I. Apoptosis induced by immunotoxins used in the treatment of haematologic malignancies. Int J Cancer. 2000;87:86-94.
34. Murakami M, Hibi M, Nakagawa N, et al. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993;260:1808-1810.
35. Thiel S, Behrmann I, Dittrich E, et al. Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. Biochem J. 1998;330:47-54.
36. Dittrich E, Haft CR, Muys L, Heinrich PC, Graeve L. A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor. J Biol Chem. 1996;271:5487-5494.
37. Hunter MG, Avalos BR. Deletion of a critical internalization domain in the G-CSFR in acute myelogenous leukemia preceded by severe congenital neutropenia. Blood. 1999;93:440-446.
38. Kil SJ, Hobert M, Carlin C. A leucine-based determinant in the epidermal growth factor receptor juxtamembrane domain is required for the efficient transport of ligand-receptor complexes to lysosomes. J Biol Chem. 1999;274:3141-3450.
39. Govers R, Kerkhof PV, Schwartz AL, Strous GJ. Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system. J Biol Chem. 1998;273:16426-16433.
40. Hamer I, Haft CR, Paccaud J-P, Maeder C, Taylor S, Carpentier J-L. Dual role of a dileucine motif in insulin receptor endocytosis. J Biol Chem. 1997;272:21685-21691.