TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways

Pulmonary Pharmacology and Therapeutics

Volumn 24, Issue 2, 2011, Pages 203-214

  Duechs, Matthias J ^a   Hahn, Christian ^a   Benediktus, Ewald ^a   Werner Klein, Melanie ^a   Braun, Armin ^b   Hoymann, Heinz Gerd ^b   Gantner, Florian ^a   Erb, Klaus J ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Allergy; Asthma; Eosinophils; Innate inflammation; Mouse; Neutrophils; TLR agonists

Indexed keywords

ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 3 AGONIST; TOLL LIKE RECEPTOR 4 AGONIST; TOLL LIKE RECEPTOR 7 AGONIST; TOLL LIKE RECEPTOR 9 AGONIST; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIRWAY; AIRWAY RESISTANCE; ALLERGIC ASTHMA; ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; INFLAMMATION; INNATE IMMUNITY; LUNG LAVAGE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH2 CELL;

AIRWAY RESISTANCE; ANIMALS; ASTHMA; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; FEMALE; INFLAMMATION; INTERLEUKIN-10; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; OVALBUMIN; TIME FACTORS; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTORS;

EID: 79951956167     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2010.12.009     Document Type: Article

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