Bronchial matrix and inflammation respond to inhaled steroids despite ongoing allergen exposure in asthma

Clinical and Experimental Allergy

Volumn 35, Issue 10, 2005, Pages 1361-1369

  De Kluijver, J ^a   Schrumpf, J A ^a   Evertse, C E ^a   Sont, J K ^a   Roughley, P J ^b   Rabe, K F ^a   Hiemstra, P S ^a   Mauad, T ^a,c   Sterk, P J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Allergens; Asthma; Bronchial biopsy; Decorin; Extracellular matrix; Inflammation; Proteoglycans; Remodelling steroids; Versican

Indexed keywords

ALLERGEN; BIGLYCAN; BUDESONIDE; DECORIN; PLACEBO; PROTEOGLYCAN; SCLEROPROTEIN; STEROID; VERSICAN; ANTIINFLAMMATORY AGENT; FIBRONECTIN; GLUCOCORTICOID;

ARTICLE; ASTHMA; BRONCHUS; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; EOSINOPHIL; EXTRACELLULAR MATRIX; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; MACROPHAGE; MUCOSA INFLAMMATION; NEUTROPHIL; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFLAMMATION; RESPIRATORY TRACT MUCOSA; STEROID THERAPY; T LYMPHOCYTE; BIOPSY; BRONCHOSCOPY; EXPOSURE; GOBLET CELL; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; MUCOSA; PATHOLOGY;

ADMINISTRATION, INHALATION; ALLERGENS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BIOPSY; BRONCHI; BRONCHOSCOPY; BUDESONIDE; DOUBLE-BLIND METHOD; EXTRACELLULAR MATRIX; FIBRONECTINS; GLUCOCORTICOIDS; GOBLET CELLS; HUMANS; INHALATION EXPOSURE; MUCOUS MEMBRANE; PROTEOGLYCANS; RESPIRATORY MUCOSA;

EID: 33644845766     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02334.x     Document Type: Article

References (50)

1. National Institutes of Health, National Heart Lung and Blood Institute, Global strategy for asthma management and prevention. 1-176. 2002..
2. Lange P Parner J Vestbo J Schnohr P Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998 339: 1194 200.
3. Ulrik CS. Outcome of asthma: longitudinal changes in lung function. Eur Respir J 1999 13: 904 18.
4. Platts-Mills TA Carter MC. Asthma and indoor exposure to allergens. N Engl J Med 1997 336: 1382 4.
5. Ihre E Zetterström O. Increase in non-specific bronchial responsiveness after repeated inhalation of low doses of allergen. Clin Exp Allergy 1993 23: 298 305.
6. Sulakvelidze I Inman MD Rerecich T O'Byrne PM. Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics. Eur Respir J 1998 11: 821 7.
7. Lensmar C Prieto J Dahlen B Eklund A Grunewald J Roquet A. Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin Exp Allergy 1999 29: 1632 40.
8. Gauvreau GM Sulakvelidze I Watson RM Inman MD Rerecich TJ O'Byrne PM. Effects of once daily dosing with inhaled budesonide on airway hyperresponsiveness and airway inflammation following repeated low-dose allergen challenge in atopic asthmatics. Clin Exp Allergy 2000 30: 1235 43.
9. de Kluijver J Evertse CE Schrumpf JA et al. Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma. Protection by inhaled steroids. Am J Respir Crit Care Med 2002 166: 294 300.
10. Palmans E Kips JC Pauwels RA. Prolonged allergen exposure induces structural airway changes in sensitized rats. Am J Respir Crit Care Med 2000 161: 627 35.
11. Vanacker NJ Palmans E Kips JC Pauwels RA. Fluticasone inhibits but does not reverse allergen-induced structural airway changes. Am J Respir Crit Care Med 2001 163: 674 9.
12. Leigh R Ellis R Wattie J Southam DS De Hoogh M Gauldie J et al. Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation. Am J Respir Cell Mol Biol 2002 27: 526 35.
13. Bousquet J Jeffery PK Busse WW Johnson M Vignola AM. Asthma from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000 161: 1720 45.
14. Laitinen LA Laitinen A. Inhaled corticosteroid treatment and extracellular matrix in the airways in asthma. Int Arch Allergy Immunol 1995 107: 215 6.
15. Roberts CR Wight TN Hascall VC. Proteoglycans. In: Crystal RG West JB Weibel ER Barnes PJ, eds. The lung: scientific foundations. Philadelphia: Lippincott-Raven Publishers, 1997 757 67.
16. Venkatesan N Ebihara T Roughley PJ Ludwig MS. Alterations in large and small proteoglycans in bleomycin-induced pulmonary fibrosis in rats. Am J Respir Crit Care Med 2000 161: 2066 73.
17. Iozzo RV. Matrix proteoglycans: from molecular design to cellular function. Annu Rev Biochem 1998 67: 609 52.
18. Laitinen A Altraja A Kampe M Linden M Virtanen I Laitinen LA. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Am J Respir Crit Care Med 1997 156: 951 8.
19. Redington AE Roche WR Holgate ST Howarth PH. Co-localization of immunoreactive transforming growth factor-beta 1 and decorin in bronchial biopsies from asthmatic and normal subjects. J Pathol 1998 186: 410 5.
20. Huang J Olivenstein R Taha R Hamid Q Ludwig M. Enhanced proteoglycan deposition in the airway wall of atopic asthmatics. Am J Respir Crit Care Med 1999 160: 725 9.
21. Johnson PR Black JL Carlin S Ge Q Underwood PA. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am J Respir Crit Care Med 2000 162: 2145 51.
22. Westergren-Thorsson G Chakir J Lafreniere-Allard MJ Boulet LP Tremblay GM. Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. Int J Biochem Cell Biol 2002 34: 1256 67.
23. Hildebrand A Romaris M Rasmussen LM et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J 1994 302: 527 34.
24. Giri SN Hyde DM Braun RK Gaarde W Harper JR Pierschbacher MD. Antifibrotic effect of decorin in a bleomycin hamster model of lung fibrosis. Biochem Pharmacol 1997 54: 1205 16.
25. Sont JK Van Krieken JHJM Evertse CE Hooijer R Willems LN Sterk PJ. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. Thorax 1996 51: 496 502.
26. Louis R Lau LC Bron AO Roldaan AC Radermecker M Djukanovic R. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med 2000 161: 9 16.
27. Milanese M Crimi E Scordamaglia A et al. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol 2001 91: 1035 40.
28. de Kluijver J Grünberg K Sont JK et al. Rhinovirus infection in non-asthmatic subjects: effects on intrapulmonary airways. Eur Respir J 2002 20: 274 9.
29. Sont JK Willems LNA Evertse CE et al. Repeatability of measures of inflammatory cell number in bronchial biopsies in atopic asthma. Eur Respir J 1997 10: 2602 8.
30. Sont JK Willems LNA Bel EH Van Krieken JHJM Vandenbroucke JP Sterk PJ. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. Am J Respir Crit Care Med 1999 159: 1043 51.
31. Sont JK de Boer WI van Schadewijk WA et al. Fully automated assessment of inflammatory cell counts and cytokine expression in bronchial tissue. Am J Respir Crit Care Med 2003 167: 1496 503.
32. Kelly EA Busse WW Jarjour NN. Inhaled budesonide decreases airway inflammatory response to allergen. Am J Respir Crit Care Med 2000 162: 883 90.
33. Guerne PA Desgeorges A Jaspar JM et al. Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone. Matrix Biol 1999 18: 253 60.
34. Erjefält JS Persson CG. New aspects of degranulation and fates of airway mucosal eosinophils. Am J Respir Crit Care Med 2000 161: 2074 85.
35. Holgate ST Bodey KS Janezic A Frew AJ Kaplan AP Teran LM. Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997 156: 1377 83.
36. Senior RM Connolly NL Cury JD Welgus HG Campbell EJ. Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity. Am Rev Respir Dis 1989 139: 1251 6.
37. Vignola AM Chanez P Chiappara G et al. Release of transforming growth factor-beta (TGF-beta) and fibronectin by alveolar macrophages in airway diseases. Clin Exp Immunol 1996 106: 114 9.
38. Ludwig MS Ftouhi-Paquin N Huang W Page N Chakir J Hamid Q. Mechanical strain enhances proteoglycan message in fibroblasts from asthmatic subjects. Clin Exp Allergy 2004 34: 926 30.
39. Westergren-Thorsson G Särnstrand B Fransson LA Malmström A. TGF-beta enhances the production of hyaluronan in human lung fibroblasts but not in skin fibroblasts. Exp Cell Res 1990 186: 192 5.
40. Westergren-Thorsson G Hernnas J Särnstrand B Oldberg A Heinegard D Malmström A. Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats. J Clin Invest 1993 92: 632 7.
41. Kolb M Margetts PJ Sime PJ Gauldie J. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol 2001 280: L1327 34.
42. Särnstrand B Sime PJ Gauldie J Malmström A Westergren-Thorsson G. Infection with recombinant human adenovirus constructs expressing the cDNA biglycan results in increased synthesis of connective tissue components in vitro and in vivo. Am J Respir Crit Care Med 1998 157: A245.
43. Särnstrand B Brattsand R Malmström A. Effect of glucocorticoids on glycosaminoglycan metabolism in cultured human skin fibroblasts. J Invest Dermatol 1982 79: 412 7.
44. Kofoed JA Fernandez Lemos SM Barbato O. Changes in mandible and femur proteoglycans. Physico-chemical properties after hydrocortisone treatment. Acta Odontol Latinoam 1990 5: 49 53.
45. Macklem PT. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 1996 153: 83 9.
46. Seow CY Wang L Pare PD. Airway narrowing and internal structural constraints. J Appl Physiol 2000 88: 527 33.
47. Chakir J Shannon J Molet S et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 2003 111: 1293 8.
48. Flood-Page P Menzies-Gow A Phipps S et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest 2003 112: 1029 36.
49. Payne DN Rogers AV Adelroth E et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003 167: 78 82.
50. Grover J Chen XN Korenberg JR, Roughley PJ. The human lumican gene. Organization, Chromosomal location, and expression in articular cartilage. J Biol Chem 1995 270: 21942 9.