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Volumn 103, Issue 6, 1999, Pages 779-788

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

Author keywords

[No Author keywords available]

Indexed keywords

EOTAXIN; INTERLEUKIN 13; MESSENGER RNA;

EID: 0033560126     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5909     Document Type: Article
Times cited : (1523)

References (71)
  • 1
    • 0029859871 scopus 로고    scopus 로고
    • Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
    • Lucey, D.R., Clerici, M., and Shearer, G.M. 1996. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases [review]. Clin. Microbiol. Rev. 9:532-562.
    • (1996) Clin. Microbiol. Rev. , vol.9 , pp. 532-562
    • Lucey, D.R.1    Clerici, M.2    Shearer, G.M.3
  • 2
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • Abbas, A.K., Murphy, K.M., and Sher, A. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 3
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell sub-sets: Th1, Th2 and more
    • Mosmann, T.R., and Sad, S. 1996. The expanding universe of T-cell sub-sets: Th1, Th2 and more. Immunol. Today. 17:138-146.
    • (1996) Immunol. Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 4
    • 15844421725 scopus 로고    scopus 로고
    • Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis
    • Moller, D.R., et al. 1996. Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis. J. Immunol. 156:4952-4960.
    • (1996) J. Immunol. , vol.156 , pp. 4952-4960
    • Moller, D.R.1
  • 5
    • 0032554784 scopus 로고    scopus 로고
    • Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
    • Barner, M., Mohrs, M., Brombacher, F., and Kopf, M. 1998. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr. Biol. 8:669-672.
    • (1998) Curr. Biol. , vol.8 , pp. 669-672
    • Barner, M.1    Mohrs, M.2    Brombacher, F.3    Kopf, M.4
  • 6
    • 0032032243 scopus 로고    scopus 로고
    • IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6)
    • Huffnagle, G.B., Boyd, M.B., Street, N.E., and Lipscomb, M.F. 1998. IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary Cryptococcus neoformans infection in genetically susceptible mice (C57BL/6). J. Immunol. 160:2393-2400.
    • (1998) J. Immunol. , vol.160 , pp. 2393-2400
    • Huffnagle, G.B.1    Boyd, M.B.2    Street, N.E.3    Lipscomb, M.F.4
  • 7
    • 0032510452 scopus 로고    scopus 로고
    • A distinct role for interleukin-13 in Th2-cell- Mediated immune responses
    • McKenzie, G.J., Bancroft, A., Grencis, R.K., and McKenzie, A.N. 1998. A distinct role for interleukin-13 in Th2-cell- mediated immune responses. Curr. Biol. 8:339-342.
    • (1998) Curr. Biol. , vol.8 , pp. 339-342
    • McKenzie, G.J.1    Bancroft, A.2    Grencis, R.K.3    McKenzie, A.N.4
  • 8
    • 0026610142 scopus 로고
    • Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma
    • Robinson, D.S., et al. 1992. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 298-304
    • Robinson, D.S.1
  • 9
    • 13344277358 scopus 로고    scopus 로고
    • IL-5-deficient mice have a developmental defect in CD5 B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses
    • Kopf, M., et al. 1996. IL-5-deficient mice have a developmental defect in CD5 B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 4:15-24.
    • (1996) Immunity , vol.4 , pp. 15-24
    • Kopf, M.1
  • 10
    • 0030028768 scopus 로고    scopus 로고
    • Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    • Foster, P.S., Hogan, S.P., Ramsay, A.J., Matthaei, K.I., and Young, I.G. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195-201.
    • (1996) J. Exp. Med. , vol.183 , pp. 195-201
    • Foster, P.S.1    Hogan, S.P.2    Ramsay, A.J.3    Matthaei, K.I.4    Young, I.G.5
  • 11
    • 0026683014 scopus 로고
    • CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea
    • Nakajima, H., et al. 1992. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis. 146:374-377.
    • (1992) Am. Rev. Respir. Dis. , vol.146 , pp. 374-377
    • Nakajima, H.1
  • 12
    • 0030907876 scopus 로고    scopus 로고
    • Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice
    • Mould, A.W., Matthaei, K.I., Young, I.G., and Foster, P.S. 1997. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J. Clin. Invest. 99:1064-1071.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1064-1071
    • Mould, A.W.1    Matthaei, K.I.2    Young, I.G.3    Foster, P.S.4
  • 13
    • 0023893708 scopus 로고
    • Highly purified murine interleukin-5 (IL-5) stimulates eosinophil function and prolongs in vitro survival
    • Yamaguchi, Y., et al. 1988. Highly purified murine interleukin-5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. J. Exp. Med. 167:1737-1742.
    • (1988) J. Exp. Med. , vol.167 , pp. 1737-1742
    • Yamaguchi, Y.1
  • 14
    • 0030068235 scopus 로고    scopus 로고
    • Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
    • Corry, D.B., et al. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
    • (1996) J. Exp. Med. , vol.183 , pp. 109-117
    • Corry, D.B.1
  • 15
    • 0023879839 scopus 로고
    • Recombinant human interleukin 5 is a selective activator of human eosinophil function
    • Lopez, A.F., et al. 1988. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219-224.
    • (1988) J. Exp. Med. , vol.167 , pp. 219-224
    • Lopez, A.F.1
  • 16
    • 0024591512 scopus 로고
    • Human interleukin 5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: Comparisons and interactions with IL-1, IL-3, IL-6 and GM-CSF
    • Clutterbuck, E.J., Hirst, E.M., and Sanderson, C.J. 1989. Human interleukin 5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparisons and interactions with IL-1, IL-3, IL-6 and GM-CSF. Blood. 73:1504-1512.
    • (1989) Blood , vol.73 , pp. 1504-1512
    • Clutterbuck, E.J.1    Hirst, E.M.2    Sanderson, C.J.3
  • 17
    • 0030689729 scopus 로고    scopus 로고
    • Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
    • Cohn, L., Homer, R.J., Marinov, A., Rankin, J., and Bottomly, K. 1997. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186:1737-1747.
    • (1997) J. Exp. Med. , vol.186 , pp. 1737-1747
    • Cohn, L.1    Homer, R.J.2    Marinov, A.3    Rankin, J.4    Bottomly, K.5
  • 18
    • 0032531571 scopus 로고    scopus 로고
    • IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells
    • Cohn, L., Tepper, J.S., and Bottomly, K. 1998. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J. Immunol. 161:3813-3816.
    • (1998) J. Immunol. , vol.161 , pp. 3813-3816
    • Cohn, L.1    Tepper, J.S.2    Bottomly, K.3
  • 19
    • 0032145438 scopus 로고    scopus 로고
    • A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
    • Hogan, S. P., et al. 1998. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 161:1501-1509.
    • (1998) J. Immunol. , vol.161 , pp. 1501-1509
    • Hogan, S.P.1
  • 20
    • 0026567221 scopus 로고
    • New insights into airway inflammation by endobronchial biopsy
    • Holgate, S.T., Wilson, J.R., and Howarth, P.H. 1992. New insights into airway inflammation by endobronchial biopsy. Am. Rev. Respir. Dis. 145:2s-6s.
    • (1992) Am. Rev. Respir. Dis. , vol.145
    • Holgate, S.T.1    Wilson, J.R.2    Howarth, P.H.3
  • 21
    • 0031472174 scopus 로고    scopus 로고
    • Airway goblet cell mucin: Its structure and regulation of secretion
    • Kim, K.C., et al. 1997. Airway goblet cell mucin: its structure and regulation of secretion. Eur. Respir. J. 10:2644-2649.
    • (1997) Eur. Respir. J. , vol.10 , pp. 2644-2649
    • Kim, K.C.1
  • 22
    • 0002771007 scopus 로고    scopus 로고
    • Airway wall remodelling in the pathogenesis of asthma: Cytokine expression in the airways
    • A.G. Stewart, editor. CRC Press. Boca Raton, FL
    • Bradding, P., Redington, A.E., and Holgate, S.T. 1997. Airway wall remodelling in the pathogenesis of asthma: cytokine expression in the airways. In Airway wall remodelling in asthma. A.G. Stewart, editor. CRC Press. Boca Raton, FL. 29-63.
    • (1997) Airway Wall Remodelling in Asthma , pp. 29-63
    • Bradding, P.1    Redington, A.E.2    Holgate, S.T.3
  • 23
    • 0024505353 scopus 로고
    • Subepithelial fibrosis in the bronchi of asthmatics
    • Roche, W.R., Williams, J.H., Beasley, R., and Holgate, S.T. 1989. Subepithelial fibrosis in the bronchi of asthmatics. Lancet. 1:520-524.
    • (1989) Lancet , vol.1 , pp. 520-524
    • Roche, W.R.1    Williams, J.H.2    Beasley, R.3    Holgate, S.T.4
  • 24
    • 0027233367 scopus 로고
    • Recent advances in pulmonary medicine
    • Weinberger, S. 1993. Recent advances in pulmonary medicine. N. Engl. J. Med. 328:1389-1397.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1389-1397
    • Weinberger, S.1
  • 25
    • 0027420025 scopus 로고
    • Bronchial hyperresponsiveness in patients recovering from acute severe asthma
    • Whyte, M.K.B., Choudry, N.B., and Ind, P.W. 1993. Bronchial hyperresponsiveness in patients recovering from acute severe asthma. Respir. Med. 87:29-35.
    • (1993) Respir. Med. , vol.87 , pp. 29-35
    • Whyte, M.K.B.1    Choudry, N.B.2    Ind, P.W.3
  • 26
    • 0026639759 scopus 로고
    • Inflammation of airway reactivity in asthma
    • Pueringer, R.J., and Hunninghake, G.W. 1992. Inflammation of airway reactivity in asthma. Am. J. Med. 92:32-38.
    • (1992) Am. J. Med. , vol.92 , pp. 32-38
    • Pueringer, R.J.1    Hunninghake, G.W.2
  • 27
    • 0027320031 scopus 로고
    • Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma
    • Robinson, D., et al. 1993. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J. Allergy Clin. Immunol. 92:313-324.
    • (1993) J. Allergy Clin. Immunol. , vol.92 , pp. 313-324
    • Robinson, D.1
  • 28
    • 0031722518 scopus 로고    scopus 로고
    • The role of IL-13 and its receptor in allergy and inflammatory responses
    • de Vries, J.E. 1998. The role of IL-13 and its receptor in allergy and inflammatory responses. J. Allergy Clin. Immunol. 102:165-169.
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 165-169
    • De Vries, J.E.1
  • 29
    • 0031411646 scopus 로고    scopus 로고
    • The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes
    • Minty, A., et al. 1997. The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes. Eur. Cytokine Netw. 8:203-213.
    • (1997) Eur. Cytokine Netw. , vol.8 , pp. 203-213
    • Minty, A.1
  • 30
    • 0031852973 scopus 로고    scopus 로고
    • Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
    • Emson, C.L., Bell, S.L., Jones, A., Wisden, W., and McKenzie, A.N.J. 1998. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J. Exp. Med. 188:399-404.
    • (1998) J. Exp. Med. , vol.188 , pp. 399-404
    • Emson, C.L.1    Bell, S.L.2    Jones, A.3    Wisden, W.4    McKenzie, A.N.J.5
  • 31
    • 0028176655 scopus 로고
    • Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski, G., and de Vries, J.E. 1994. Interleukin-13, an interleukin-4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today. 15:19-26.
    • (1994) Immunol. Today , vol.15 , pp. 19-26
    • Zurawski, G.1    De Vries, J.E.2
  • 32
    • 0028815074 scopus 로고
    • IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells
    • Bochner, B.S., Klunk, D.A., Sterbinsky, S.A., Coffman, R.L., and Schleimer, R.P. 1995. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J. Immunol. 154:799-803.
    • (1995) J. Immunol. , vol.154 , pp. 799-803
    • Bochner, B.S.1    Klunk, D.A.2    Sterbinsky, S.A.3    Coffman, R.L.4    Schleimer, R.P.5
  • 33
    • 0032009864 scopus 로고    scopus 로고
    • Structure of and signal transduction through interleukin-4 and interleukin-13 receptors
    • Murata, T., Obiri, N.I., and Puri, R.K. 1998. Structure of and signal transduction through interleukin-4 and interleukin-13 receptors [review]. Int. J. Mol. Med. 1:551-557.
    • (1998) Int. J. Mol. Med. , vol.1 , pp. 551-557
    • Murata, T.1    Obiri, N.I.2    Puri, R.K.3
  • 34
    • 0029839059 scopus 로고    scopus 로고
    • Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level
    • Sornasse, T., Larenas, P.V., Davis, K.A., de Vries, J.E., and Yssel, H. 1996. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J. Exp. Med. 184:473-483.
    • (1996) J. Exp. Med. , vol.184 , pp. 473-483
    • Sornasse, T.1    Larenas, P.V.2    Davis, K.A.3    De Vries, J.E.4    Yssel, H.5
  • 35
    • 0032133454 scopus 로고    scopus 로고
    • Comparison of the regulation by Th2-type cytokines of the atachidonic-acid metabolic pathway in human alveolar macrophages and monocytes
    • Endo, T., Ogushi, F., Kawano, T., and Sone, S. 1998. Comparison of the regulation by Th2-type cytokines of the atachidonic-acid metabolic pathway in human alveolar macrophages and monocytes. Am. J. Respir. Cell Mol. Biol 19:300-307.
    • (1998) Am. J. Respir. Cell Mol. Biol , vol.19 , pp. 300-307
    • Endo, T.1    Ogushi, F.2    Kawano, T.3    Sone, S.4
  • 36
    • 0031831628 scopus 로고    scopus 로고
    • Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: A comparative study with IL-4
    • Yu, C.R., Kirken, R.A., Malabarba, M.G., Young, H.A., and Ortaldo, J.R. 1998. Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4. J. Immunol. 161:218-227.
    • (1998) J. Immunol. , vol.161 , pp. 218-227
    • Yu, C.R.1    Kirken, R.A.2    Malabarba, M.G.3    Young, H.A.4    Ortaldo, J.R.5
  • 37
    • 0029922844 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin 13 differentially regulate epithelial chloride secretion
    • Zund, G., Madera, J.L., Dzus, A.L., Awtrey, C.S., and Colgan, S.P. 1996. Interleukin-4 and interleukin 13 differentially regulate epithelial chloride secretion. J. Biol. Chem. 271:7460-7464.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7460-7464
    • Zund, G.1    Madera, J.L.2    Dzus, A.L.3    Awtrey, C.S.4    Colgan, S.P.5
  • 38
    • 0030923641 scopus 로고    scopus 로고
    • Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis
    • Horie, S., et al. 1997. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern. Med. 36:179-185.
    • (1997) Intern. Med. , vol.36 , pp. 179-185
    • Horie, S.1
  • 39
    • 0030001762 scopus 로고    scopus 로고
    • Interleukin-13 is produced by activated CD45RA+ and CD45R0+ T cells: Modulation by interleukin-4 and interleukin-12
    • Jung, T., Wijdenes, J., Neumann, C., de Vries, J.E., and Yssel, H. 1996. Interleukin-13 is produced by activated CD45RA+ and CD45R0+ T cells: modulation by interleukin-4 and interleukin-12. Eur. J. Immunol. 26:571-577.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 571-577
    • Jung, T.1    Wijdenes, J.2    Neumann, C.3    De Vries, J.E.4    Yssel, H.5
  • 40
    • 0032006762 scopus 로고    scopus 로고
    • Differential regulation of interleukin 4 and interleukin 13 production by interferon alpha
    • Kaser, A., Molnar, C., and Tilg, H. 1998. Differential regulation of interleukin 4 and interleukin 13 production by interferon alpha. Cytokine. 10:75-81.
    • (1998) Cytokine , vol.10 , pp. 75-81
    • Kaser, A.1    Molnar, C.2    Tilg, H.3
  • 41
    • 0030922389 scopus 로고    scopus 로고
    • Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma
    • Humbert, M., et al. 1997. Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma. J. Allergy Clin. Immunol. 99:657-665.
    • (1997) J. Allergy Clin. Immunol. , vol.99 , pp. 657-665
    • Humbert, M.1
  • 42
    • 0030228818 scopus 로고    scopus 로고
    • Interleukin-13 and interleukin-4 are coexpressed in atopic asthma
    • Kotsimbos, T.C., Ernst, P., and Hamid, Q.A. 1996. Interleukin-13 and interleukin-4 are coexpressed in atopic asthma. Proc. Assoc. Am. Physicians. 108:368-373.
    • (1996) Proc. Assoc. Am. Physicians , vol.108 , pp. 368-373
    • Kotsimbos, T.C.1    Ernst, P.2    Hamid, Q.A.3
  • 43
    • 0029038120 scopus 로고
    • IL-13 expression at the sites of allergen challenge in patients with asthma
    • Huang, S.K., et al. 1995. IL-13 expression at the sites of allergen challenge in patients with asthma. J. Immunol. 155:2688-2694.
    • (1995) J. Immunol. , vol.155 , pp. 2688-2694
    • Huang, S.K.1
  • 44
    • 0031278414 scopus 로고    scopus 로고
    • Skinhoming, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-memory T cells
    • Akdis, M., Akdis, C.A., Weigl, L., Disch, R., and Blaser, K. 1997. Skinhoming, CLA+ memory T cells are activated in atopic dermatitis and regulate IgE by an IL-13-dominated cytokine pattern: IgG4 counter-regulation by CLA-memory T cells. J. Immunol. 159:4611-4619.
    • (1997) J. Immunol. , vol.159 , pp. 4611-4619
    • Akdis, M.1    Akdis, C.A.2    Weigl, L.3    Disch, R.4    Blaser, K.5
  • 45
    • 0030906932 scopus 로고    scopus 로고
    • Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD)
    • Katagiri, K., Itami, S., Hatano, Y., and Takayasu, S. 1997. Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD). Clin. Exp. Immunol. 108:289-294.
    • (1997) Clin. Exp. Immunol. , vol.108 , pp. 289-294
    • Katagiri, K.1    Itami, S.2    Hatano, Y.3    Takayasu, S.4
  • 46
    • 0028863602 scopus 로고
    • Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis
    • Pawankar, R.U., et al. 1995. Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am. J. Respir. Crit. Care Med. 152:2059-2067.
    • (1995) Am. J. Respir. Crit. Care Med. , vol.152 , pp. 2059-2067
    • Pawankar, R.U.1
  • 47
    • 0030267985 scopus 로고    scopus 로고
    • Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha
    • Hamilos, D.L., et al. 1996. Eosinophil infiltration in nonallergic chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha. Am. J. Respir. Cell Mol. Biol. 15:433-450.
    • (1996) Am. J. Respir. Cell Mol. Biol. , vol.15 , pp. 433-450
    • Hamilos, D.L.1
  • 48
    • 0031252325 scopus 로고    scopus 로고
    • Myobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: Analysis of local and regional cytokineandchemokine networks
    • Chensue, S.W., Warmington, K., Ruth, J.H., Lukacs, N., and Kunkel, S.L. 1997. Myobacterial and schistosomal antigen-elicited granuloma formation in IFN-gamma and IL-4 knockout mice: analysis of local and regional cytokineandchemokine networks. J. Immunol. 159:3565-3573.
    • (1997) J. Immunol. , vol.159 , pp. 3565-3573
    • Chensue, S.W.1    Warmington, K.2    Ruth, J.H.3    Lukacs, N.4    Kunkel, S.L.5
  • 49
    • 0030764961 scopus 로고    scopus 로고
    • Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene
    • Zhang, D.H., Cohn, L., Ray, P., Bottomly, K., and Ray, A. 1997. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J. Biol. Chem. 272:21597-21603.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21597-21603
    • Zhang, D.H.1    Cohn, L.2    Ray, P.3    Bottomly, K.4    Ray, A.5
  • 50
    • 0030476382 scopus 로고    scopus 로고
    • Targeted expression of IL-11 in the murine airway causes airways obstruction, bronchial remodeling and lymphocytic inflammation
    • Tang, W., et al. 1996. Targeted expression of IL-11 in the murine airway causes airways obstruction, bronchial remodeling and lymphocytic inflammation. J Clin. Invest. 98:2845-2853.
    • (1996) J Clin. Invest. , vol.98 , pp. 2845-2853
    • Tang, W.1
  • 51
    • 0019364354 scopus 로고
    • The cells of the tracheobronchial epithelium of the mouse: A quantitative light and electron microscope study
    • Pack, R.J., Al-Ugaily, L.H., and Morris, G. 1981. The cells of the tracheobronchial epithelium of the mouse: a quantitative light and electron microscope study. J. Anat. 132:71-84.
    • (1981) J. Anat. , vol.132 , pp. 71-84
    • Pack, R.J.1    Al-Ugaily, L.H.2    Morris, G.3
  • 52
    • 0030781142 scopus 로고    scopus 로고
    • Regulated overexpression of interleukin-11 in the lung: Use to dissociate development-dependent and -independent phenotypes
    • Ray, P., et al. 1997. Regulated overexpression of interleukin-11 in the lung: use to dissociate development-dependent and -independent phenotypes. J. Clin. Invest. 100:2501-2511.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2501-2511
    • Ray, P.1
  • 53
    • 0026753657 scopus 로고
    • Cis-acting elements that confer lung epithelial cell expression of the CC10 gene
    • Stripp, B.R., et al. 1992. Cis-acting elements that confer lung epithelial cell expression of the CC10 gene. J. Biol. Chem. 267:14703-14712.
    • (1992) J. Biol. Chem. , vol.267 , pp. 14703-14712
    • Stripp, B.R.1
  • 55
    • 0027998627 scopus 로고
    • Epithelial interleukin-11: Regulation by cytokines, respiratory syncytial virus and retinoic acid
    • Elias, J.A., et al. 1994. Epithelial interleukin-11: regulation by cytokines, respiratory syncytial virus and retinoic acid. J. Biol. Chem. 169:22261-22268.
    • (1994) J. Biol. Chem. , vol.169 , pp. 22261-22268
    • Elias, J.A.1
  • 56
    • 0030800586 scopus 로고    scopus 로고
    • Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
    • Hamelmann, E., et al. 1997. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care. Med. 156:766-775.
    • (1997) Am. J. Respir. Crit. Care. Med. , vol.156 , pp. 766-775
    • Hamelmann, E.1
  • 57
    • 0032521274 scopus 로고    scopus 로고
    • Cutting edge: Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
    • Kline, J.N., et al. 1998. Cutting edge: modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160:2555-2559.
    • (1998) J. Immunol. , vol.160 , pp. 2555-2559
    • Kline, J.N.1
  • 58
    • 0028173026 scopus 로고
    • Airway targeted incerleukin-6 in transgenic mice: Uncoupling of airway inflammation and bronchial hyperreactivity
    • DiCosmo, B.F., et al. 1994. Airway targeted incerleukin-6 in transgenic mice: uncoupling of airway inflammation and bronchial hyperreactivity. J. Clin. Invest. 94:2028-2035.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2028-2035
    • DiCosmo, B.F.1
  • 59
    • 0031110215 scopus 로고    scopus 로고
    • A novel role for murine IL-4 in vivo: Induction of MU5AC gene expression and mucin hypersecrerion
    • Temann, U.A., et al. 1997. A novel role for murine IL-4 in vivo: induction of MU5AC gene expression and mucin hypersecrerion. Am. J. Respir. Cell Mol. Biol. 16:471-478.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.16 , pp. 471-478
    • Temann, U.A.1
  • 60
    • 0344582171 scopus 로고    scopus 로고
    • Pulmonary cytopathology
    • A.P. Fishman et al., editors. McGraw-Hill, New York, NY
    • Gupta, P.K. 1998. Pulmonary cytopathology. In Fishman's pulmonary diseases and disorders. 3rd ed. A.P. Fishman et al., editors. McGraw-Hill, New York, NY. 487-504.
    • (1998) Fishman's Pulmonary Diseases and Disorders. 3rd Ed. , pp. 487-504
    • Gupta, P.K.1
  • 61
    • 0028874351 scopus 로고
    • The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-α-transgenic model
    • Hosken, N.A., Shibuya, K., Heath, A.W., Murphy, K.M., and O'Garra, A. 1995. The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-α-transgenic model. J. Exp. Med. 182:1579-1584.
    • (1995) J. Exp. Med. , vol.182 , pp. 1579-1584
    • Hosken, N.A.1    Shibuya, K.2    Heath, A.W.3    Murphy, K.M.4    O'Garra, A.5
  • 62
    • 0030892136 scopus 로고    scopus 로고
    • Selective expression of an interleukin-12 receptor component by human T helper 1 cells
    • Rogge, L., et al. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825-831.
    • (1997) J. Exp. Med. , vol.185 , pp. 825-831
    • Rogge, L.1
  • 63
    • 16044371529 scopus 로고    scopus 로고
    • Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreacrivity
    • Rankin, J.A., et al. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreacrivity. Proc. Natl. Acad. Sci. USA. 93:7821-7825.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7821-7825
    • Rankin, J.A.1
  • 64
    • 0031110968 scopus 로고    scopus 로고
    • Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression
    • DeFife, K.M. 1997. Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. J. Immunol. 158:3385-3390.
    • (1997) J. Immunol. , vol.158 , pp. 3385-3390
    • DeFife, K.M.1
  • 65
    • 0031606459 scopus 로고    scopus 로고
    • Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung
    • Hancock, A., Armstrong, L., Gama, R., and Millar, A. 1998. Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am. J. Respir. Cell. Mol. Biol. 18:60-65.
    • (1998) Am. J. Respir. Cell. Mol. Biol. , vol.18 , pp. 60-65
    • Hancock, A.1    Armstrong, L.2    Gama, R.3    Millar, A.4
  • 66
    • 0031280279 scopus 로고    scopus 로고
    • Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung
    • Jain-Vora, S., Wert, S.E., Temann, U.-A., Rankin, J.A., and Whitsett, J.A. 1997. Interleukin-4 alters epithelial cell differentiation and surfactant homeostasis in the postnatal mouse lung. Am. J. Respir. Cell Mol. Biol. 17:541-551.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.17 , pp. 541-551
    • Jain-Vora, S.1    Wert, S.E.2    Temann, U.-A.3    Rankin, J.A.4    Whitsett, J.A.5
  • 67
    • 0031056613 scopus 로고    scopus 로고
    • Elevated serum levels of interleukin 4 (IL-4) IL-10, and IL-13 in patients with systemic sclerosis
    • Hasegawa, M., Fujimoto, M., Kikuchi, K., and Takehara, K. 1997. Elevated serum levels of interleukin 4 (IL-4) IL-10, and IL-13 in patients with systemic sclerosis. J. Rheumatol. 24:328-332.
    • (1997) J. Rheumatol. , vol.24 , pp. 328-332
    • Hasegawa, M.1    Fujimoto, M.2    Kikuchi, K.3    Takehara, K.4
  • 68
    • 0032490569 scopus 로고    scopus 로고
    • The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsivness
    • Gonzalo, J.-A., et al. 1998. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsivness. J. Exp. Med. 188:157-167.
    • (1998) J. Exp. Med. , vol.188 , pp. 157-167
    • Gonzalo, J.-A.1
  • 69
    • 0028140133 scopus 로고
    • Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation
    • Jose, P.J., et al. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation. J. Exp. Med. 179:881-887.
    • (1994) J. Exp. Med. , vol.179 , pp. 881-887
    • Jose, P.J.1
  • 70
    • 0032568519 scopus 로고    scopus 로고
    • Eotaxin is required for the baseline level of tissue eosinophils
    • Matthews, A.N., et al. 1998. Eotaxin is required for the baseline level of tissue eosinophils. Proc. Natl. Acad. Sci. USA. 95:6273-6278.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6273-6278
    • Matthews, A.N.1
  • 71
    • 0029836124 scopus 로고    scopus 로고
    • Eotaxin triggers eosinophil selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin-5 in mice
    • Rothenberg, M.E., et al. 1996. Eotaxin triggers eosinophil selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin-5 in mice. Mol. Med. 2:334-348.
    • (1996) Mol. Med. , vol.2 , pp. 334-348
    • Rothenberg, M.E.1


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