Hypothalamic neuropeptides and feeding regulation

Appetite and Body Weight

Volumn , Issue , 2007, Pages 67-98

  Beck, Bernard ^a  

^a NONE

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EID: 84880581236     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012370633-1/50004-9     Document Type: Chapter

References (399)

1. Abbott C.R., Kennedy A.R., Wren A.M., Rossi M., Murphy K.G., Seal L.J., Todd J.F., Ghatei M.A., Small C.J., Bloom S.R. Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone. Endocrinology 2003, 144:3943-3949.
2. Abbott C.R., Small C.J., Kennedy A.R., Neary N.M., Sajedi A., Ghatei M.A., Bloom S.R. Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BHE0246 attenuates the effect of end ogenous and exogenous peptide YY(3-36) on food intake. Brain Res. 2005, 1043:139-144.
3. Acuna-Goycolea C., van den Pol A. Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: Implications for viscera-mediated arousal. J. Neurosci. 2004, 24:8141-8152.
4. Akabayashi A., Zaia C.T.B.V., Silva I., Chae H.J., Leibowitz S.F. Neuropeptide-Y in the arcuate nucleus is modulated by alterations in glucose utilization. Brain Res. 1993, 621:343-348.
5. Akabayashi A., Levin N., Paez X., Alexander I.T., Leibowitz S.F. Hypothalamic neuropeptide Y and its gene expression: relation to light/dark cycle and circulating corticosterone. Mol. Cell. Neurosci. 1994, 5:210-218.
6. Al Barazanji K.A., Wilson S., Baker J., Jessop D.S., Harbuz M.S. Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats. J. Neuroendocrinol. 2001, 13:421-424.
7. Allen J.M., Hughes J., Bloom S.R. Presence, distribution, and pharmacological effects of neuropeptide Y in mammalian gastrointestinal tract. Dig. Dis. Sci. 1987, 32:506-512.
8. Ammar A.A., Sederholm F., Saito T.R., Scheurink A.J.W., Johnson A.E., Sodersten P. NPY-leptin: opposing effects on appetitive and consummatory ingestive behavior and sexual behavior. Am J. Physiol. 2000, 278:R1627-R1633.
9. Ammoun S., Holmqvist T., Shariatmadari R., Oonk H.B., Detheux M., Parmentier M., Akerman K.E.O., Kukkonen J.P. Distinct recognition of OX1 and OX2 receptors by orexin peptides. J. Pharmacol. Exp. Ther. 2003, 305:507-514.
10. An S.Z., Cutler G., Zhao J.J., Huang S.G., Tian H., Li W.B., Liang L.M., Rich M., Bakleh A., Du J., Chen J.L., Dai K. Identification and characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:7576-7581.
11. Archer Z.A., Rayner D.V., Mercer J.G. Hypothalamic gene expression is altered in underweight but obese juvenile male Sprague-Dawley rats fed a high-energy diet. J. Nutr. 2004, 134:1369-1374.
12. Argiles J.M. The obese Zucker rat: a choice for fat metabolism. Prog. Lipid Res. 1989, 28:53-66.
13. Asensio C., Muzzin P., Rohner-Jeanrenaud F. Role of glucocorticoids in the physiopathology of excessive fat deposition and insulin resistance. Int. J. Obes. 2004, 28:S45-S52.
14. Bachner D., Kreienkamp H.J., Weise C., Buck F., Richter D. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Lett. 1999, 457:522-524.
15. Backberg M., Hervieu G., Wilson S., Meister B. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur. J. Neurosci. 2002, 15:315-328.
16. Bai F.L., Yamano M., Shiotani Y., Emson P.C., Smith A.D., Powell J.F., Toyama M. An arcuato-paraventricular and-dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res. 1985, 331:172-175.
17. Balasubramaniam A. Neuropeptide Y family of hormones: Receptor subtypes and antagonists. Peptides 1997, 18:445-457.
18. Balasubramaniam A., Sheriff S., Johnson M.E., Prabhakaran M., Huang Y., Fischer J.E., Chance W.T. [d-TRP(32)]Neuropeptide-Y-a competitive antagonist of NPY in rat hypothalamus. J. Med. Chem. 1994, 37:811-815.
19. Baldo B.A., Daniel R.A., Berridge C.W., Kelley A.E. Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation and stress. J. Comp. Neurol. 2003, 464:220-237.
20. Baran K., Preston E., Wilks D., Cooney G.J., Kraegen E.W., Sainsbury A. Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways. Diabetes 2002, 51:152-158.
21. Baskin D.G., Lattemann D.F., Seeley R.J., Woods S.C., Porte D., Schwartz M.W. Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res. 1999, 848:114-123.
22. Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W.K., Wang Y.P., Banks A.S., Lavery H.J., Haq A.K., Maratos-Flier E., Neel B.G., Schwartz M.W., Myers M.G. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
23. Bayer L., Poncet F., Fellmann D., Griffond B. Melanin-concentrating hormone expression in slice cultures of rat hypothalamus is not affected by 2-deoxyglucose. Neurosci Lett. 1999, 267:70-80.
24. Bayer L., Colard C., Nguyen N.U., Risold P.Y., Fellmann D., Griffond B. Alteration of the expression of the hypocretin (Orexin) gene by 2-deoxyglucose in the rat lateral hypothalamic area. Neuroreport 2000, 11:531-533.
25. Bayer L., Mairet-Coello G., Risold P.Y., Griffond B. Orexin/hypocretin neurons: chemical phenotype and possible interactions with melanin-concentrating hormone neurons. Regul. Pept. 2002, 104:33-39.
26. Bchini Hooft van Huijsduijnen O., Rohner-Jeanrenaud F., Jeanrenaud B. Hypothalamic neuropeptide-Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats-potential regulation thereof by corticotropin-releasing factor. J. Neuroendocrinol. 1993, 5:381-386.
27. Beck B. KO's and organisation of peptidergic feeding behavior mechanisms. Neurosci. Biobehov. Rev. 2001, 25:143-158.
28. Beck B. The arcuate nucleus: its special place in the central networks that regulate feeding behavior. Nutrient and Cell Signalling 2005, 665-699. Marcel Dekker, New York. J. Zempleni, K. Dakshinamurti (Eds.).
29. Beck B., Richy S. Hypothalamic hypocretin/orexin and neuropeptide Y: Divergent interaction with energy depletion and leptin. Biochem. Biophys. Res. Commun 1999, 258:119-122.
30. Beck B., Stricker-Krongrad A., Nicolas J.P., Burlet C. Chronic and continuous ICV infusion of neuropeptide Y disrupts the nyctohemeral feeding patterns in rats. Ann. N.Y. Acad. Sci. 1990, 611:491-494.
31. Beck B., Burlet A., Nicolas J.P., Burlet C. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats. J. Nutr. 1990, 120:806-811.
32. Beck B., Burlet A., Nicolas J.P., Burlet C. Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: implications in feeding and sexual behaviors. Physiol. Behav. 1990, 47:449-453.
33. Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Influence of diet composition on food intake and hypothalamic neuropeptide Y (NPY) in the rat. Neuropeptides 1990, 17:197-203.
34. Beck B., Jhanwar-Uniyal M., Burlet A., Chapleur-Chateau M., Leibowitz S.F., Burlet C. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 1990, 528:245-249.
35. Beck B., Stricker-Krongrad A., Nicolas J.P., Burlet C. Chronic and continuous intracerebroventicular infusion of neuropeptide Y in Long-Evans rats mimics the feeding behavior of obese Zucker rats. Int. J. Obes. 1992, 16:295-302.
36. Beck B., Stricker-Krongrad A., Burlet A., Nicolas J.P., Burlet C. Specific hypothalamic neuropeptide-Y variation with diet parameters in rats with food choice. Neuroreport 1992, 3:571-574.
37. Beck B., Burlet A., Bazin R., Nicolas J.P., Burlet C. Elevated neuropeptide-Y in the arcuate nucleus of young obese Zucker rats may contribute to the development of their overeating. J. Nutr. 1993, 123:1168-1172.
38. Beck B., Stricker-Krongrad A., Burlet A., Max J.P., Musse N., Nicolas J.P., Burlet C. Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evansrats. Brain Res. Bull. 1994, 34:85-91.
39. Beck B., Stricker-Krongrad A., Musse N., Nicolas J.P., Burlet C. Putative neuropeptide Y antagonist failed to decrease overeating in obese Zucker rats. Neurosci. Lett. 1994, 181:126-128.
40. Beck B., Richy S., Dimitrov T., Stricker-Krongrad A. Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats. Biochem. Biophys. Res. Commun. 2001, 286:518-523.
41. Beck B., Fernette B., Stricker-Krongrad A., Burlet A., Cumin F., Burlet C. Plasma leptin and hypothalamic neuropeptide Y and galanin levels in Long-Evans rats with marked dietary preferences. Nutr. Neurosci. 2001, 4:39-50.
42. Beck B., Fernette B., Stricker-Krongrad A. Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats. Biochem. Biophys. Res. Commun. 2005, 332:859-865.
43. Bednarek M.A., Hreniuk D.L., Tan C., Palyha O.C., MacNeil D.J., Van der Ploeg L.H.Y., Howard A.D., Feighner S.D. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor I. Biochemistry 2002, 41:6383-6390.
44. Benoit S.C., Clegg D.J., Woods S.C., Seeley R.J. The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides. Peptides 2005, 26:751-757.
45. Berelowitz M., Bruno J.F., White J.D. Regulation of hypothalamic neuropeptide expression by peripheral metabolism. Trends Endocrinol. Metab. 1992, 3:127-133.
46. Bergen H.T., Mizuno T., Taylor J., Mobbs C.V. Resistance to diet-induced obesity is associated with increased proopiomelanocortin mRNA and decreased neuropeptide Y mRNA in the hypothalamus. Brain Res. 1999, 851:198-203.
47. Bertile F., Oudart H., Criscuolo F., LeMaho Y., Raclot T. Hypothalamic gene expression in long-term fasted rats: relationship with body fat. Biochem. Biophys. Res. Commun. 2003, 303:1106-1113.
48. Bi S., Robinson B.M., Moran T.H. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am. J. Physiol. 2003, 285:R1030-R1036.
49. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.L., Vale W., Sawchenko P.E. The melanin concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 1992, 319:218-245.
50. Bjursell M., Egecioglu E., Gerdin A.K., Svensson L., Oscarsson J., Morgan D., Snaith M., Tornell J., Bohlooly Y.M. Importance of melaninconcentrating hormone receptor for the acute effects of ghrelin. Biochem. Biophys. Res. Commun. 2005, 326:759-765.
51. Blomqvist A.G., Herzog H. Y-receptor subtypes-How many more?. Trends Neurosci. 1997, 20:294-298.
52. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., Deleon J., Lagu B., Heurich R., Lichtblau H., Shaposhnik Z., Daniewska I., Blackburn T.P., Branchek T.A., Gerald C., Vaysse P.J., Forray C. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 2002, 8:825-830.
53. Bouret S.G., Draper S.J., Simerly R.B. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J. Neurosci. 2004, 24:2797-2805.
54. Brady L.S., Smith M.A., Gold P.W., Herkenham M. Altered expression of hypothalamic neuropeptide messenger RNAs in food-restricted and food-deprived rats. Neuroendocrinology 1990, 52:441-447.
55. Bray G.A. The Zucker-fatty rat: a review. Fed. Proc. 1977, 36:146-153.
56. Brischoux F., Fellmann D., Risold P.Y. Ontogenetic development of the diencephalic MCH neurons: a hypothalamic "MCH area" hypothesis. Eur. J. Neurosci. 2001, 13:1733-1744.
57. Broberger C. Hypothalamic cocaine-and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res. 1999, 848:101-113.
58. Broberger C., Delecea L., Sutcliffe J.G., Hokfelt T. Hypocretin/orexin-and melanin-concentrating hormone-expressing cells form distinct, populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol. 1998, 402:460-474.
59. Browning A. Recent developments in the discovery of melanin-concentrating hormone antagonists: novel antiobesity agents. Exp. Opin. Ther. Pat. 2004, 14:313-325.
60. Bullen J.W., Ziotopoulou M., Ungsunan L., Misra J., Alevizos I., Kokkotou E., Maratos-Flier E., Stephanopoulos G., Mantzoros C.S. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am. J. Physiol. 2004, 287:E662-E670.
61. Burdakov D., Liss B., Ashcroft F.M. Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J. Neurosci. 2003, 23:4951-4957.
62. Burdakov D., Gerasimenko O., Verkhratsky A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J. Neurosci. 2005, 25:2429-2433.
63. Burdyga G., Lal S., Spiller D., Jiang W., Thompson D., Attwodd S., Saeed S., Grundy D., Varro A., Dimaline R., Dockray G.J. Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 2003, 124:129-139.
64. Cabrele C., Langer M., Bader R., Wieland H.A., Doods H.N., Zerbe O., BeckSickinger A.G. The first selective agonist for the neuropeptide Y Y5 receptor increases food intake in rats. J. Biol. Chem. 2000, 275:36043-36048.
65. Cai X.J., Lister C.A., Buckingham R.E., Pickavance L., Wilding J., Arch J.R.S., Wilson S., Williams G. Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and Zucker diabetic fatty rats and effects of rosiglitazone. Mol. Brain Res. 2000, 77:131-137.
66. Cai X.J., Evans M.L., Lister C.A., Leslie R.A., Arch J.R.S., Wilson S., Williams G. Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels-Responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 2001, 50:105-112.
67. Caillol M., Aioun J., Baly C., Persuy M.A., Salesse R. Localization of orexins and their receptors in the rat olfactory system: possible modulation of olfactory perception by a neuropeptide synthetized centrally or locally. Brain Res. 2003, 960:48-61.
68. Calza L., Giardino L., Battistini N., Zanni M., Galetti S., Protopapa F., Velardo A. Increase of neuropeptide Y-like immunoreactivity in the paraventricular nucleus of fasting rats. Neurosci. Lett. 1989, 104:99-104.
69. Campfield L.A., Smith F.J. Transient declines in blood glucose signal meal initiation. Int. J. Obes. 1990, 14:15-33.
70. Ceccatelli S., Cintra A., Hokfelt T., Fuxe K., Wikstrom A., Gustafsson J. Coexistence of glucocorticoid receptor-like immunoreactivity with neuropeptides in the hypothalamic paraventricular nucleus. Exp. Brain Res. 1989, 78:33-42.
71. Chaffer C.L., Morris M.J. The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPYY1-receptor in the rat. Endocrinology 2002, 143:191-197.
72. Challis B.G., Pinnock S.B., Coll A.P., Carter R.N., Dickson S.L., O'Rahilly S. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem. Biophys. Res. Commun. 2003, 311:915-919.
73. Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., Park J., Ellis C., Ganguly S., Konchar S., Cluderay J., Leslie R., Wilson S., Sarau H.M. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 1999, 400:261-265.
74. Chang G.Q., Karatayev O., Davydova Z., Wortley K., Leibowitz S.F. Glucose injection reduces neuropeptide Y and agouti-related protein expression in the arcuate nucleus: A possible physiological role in eating behavior. Mol. Brain Res. 2005, 135:69-80.
75. Chen Y.Y., Hu C.Z., Hsu C.K., Zhang Q., Bi C., Asnicar M., Hsiung H.M., Fox N., Slieker L.J., Yang D.D., Heiman M.L., Shi Y.G. Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology 2002, 143:2469-2477.
76. Chou T.C., Lee C.E., Lu J., Elmquist J.K., Hara J., Willie J.T., Beuckmann C.T., Chemelli R.M., Sakurai T., Yanagisawa M., Saper C.B., Scammell T.E. Orexin (Hypocretin) neurons contain dynorphin. J. Neurosci. 2001, 21:U19-U24.
77. Chou T.C., Rotman S.R., Saper C.B. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neurosci. Lett. 2004, 370:123-126.
78. Chronwall B.M. Anatomy and physiology of the neuroendocrine arcuate nucleus. Peptides 1985, 6(suppl. 2):1-11.
79. Chronwall B.M., Di Maggio D.A., Massari V.J., Pickel V.M., Ruggiero D..A, O'Donohue T.L. The anatomy of neuropeptide Y-containing neurons in rat brain. Neuroscience 1985, 15:1159-1181.
80. Chua S.C., Leibel R.L., Hirsch J. Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Mol. Brain Res. 1991, 9:95-101.
81. Chua S.C., Brown A.W., Kim J.H., Hennessey K.L., Leibel R.L., Hirsch J. Food deprivation and hypothalamic neuropeptide gene expression-effects of strain background and the diabetes mutation. Mol. Brain Res. 1991, 11:291-299.
82. Chua S.C., Chung W.K., Wupeng X.S., Zhang Y.Y., Liu S.M., Tartaglia L., Leibel R.L. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996, 271:994-996.
83. Chua S.C., White D.W., Wupeng X.S., Liu S.M., Okada N., Kershaw E.E., Chung W.K., Powerkehoe L., Chua M., Tartaglia L.A., Leibel R.L. Phenotype of fatty due to Gln269Pro mutation in the leptin neceptor (lepr). Diabetes 1996, 45:1141-1143.
84. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 1984, 115:427-429.
85. Clegg D.J., Air E.L., Woods S.C., Seeley R.J. Eating elicited by orexin-A, but not melatin-concentrating hormone, is opioid mediated. Endocrinology 2002, 143:2995-3000.
86. Clegg D.J., Air E.L., Benoit S.C., Sakai R.S., Seeley R.J., Woods S.C. Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake. Am. J. Physiol. 2003, 284:R494-R499.
87. Cluderay J.E., Harrison D.C., Hervieu G.J. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul. Pept. 2002, 104:131-144.
88. Collin M., Backberg M., Onnestam K., Meister B. 5-HTIA receptor immunoreactivity in hypothalamic neurons involved in body weight control. Neuroreport 2002, 13:945-951.
89. Cone R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 2005, 8:571-578.
90. Corp E.S., Melville L.D., Greenberg D., Gibbs J., Smith G.P. Effect of 4th ventricular neuropeptide-Y and peptide-YY on ingestive and other behaviors. Am. J. Physiol. 1990, 259:R317-R323.
91. Cota D., Marsicano G., Tschop M., Grubler Y., Flachskamm C., Schubert M., Auer D., Yassouridis A., ThoneReineke C., Ortmann S., Tomassoni F., Cervino C., Nisoli E., Linthorst A.C.E., Pasquali R., Lutz B., Stalla G.K., Pagotto U. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J. Clin. Invest. 2003, 112:423-431.
92. Crawley J.N. The role of galanin in feeding behavior. Neuropeptides 1999, 33:369-375.
93. Currie P.J., Coscina D.V. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides 1995, 16:599-604.
94. Cvetkovic V., Poncet F., Fellmann D., Griffond B., Risold P.Y. Diencephalic neurons producing melanin-concentrating hormone are influenced by local and multiple extra-hypothalamic tachykininergic projections through the neurokinin 3 receptor. Neuroscience 2003, 119:1113-1145.
95. Cvetkovic V., Brischoux F., Griffond B., Bernard G., Jacquemard C., Fellmann D., Risold P.Y. Evidence of melanin-concentrating hormone-containing neurons supplying both cortical and neuroendocrine projections. Neuroscience 2003, 116:31-35.
96. Cvetkovic V., Brischoux F., Jacquemard C., Fellmann D., Griffond B., Risold P.Y. Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon. J. Neurochem. 2004, 91:911-919.
97. Daniels A.J., Grizzle M.K., Wiard R.P., Matthews J.E., Heyer D. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul. Pept. 2002, 106:47-54.
98. Date Y., Ueta Y., Yamashita H., Yamaguchi H., matsukura S., Kangawa K., Sakurai T., Yanagisawa M., Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:748-753.
99. Davies L., Marks J.L. Role of hypothalamic neuropeptide Y gene expression in body weight regulation. Am. J. Physiol. 1994, 266:R1687-R1691.
100. Day D.E., Keen-Rhinehart E., Bartness T.J. Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters. Am. J. Physiol. 2005, 289:R29-R36.
101. deLecea L., Kilduff T.S., Peyron C., Gao X., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L., Gautvik V.T., Bartlett F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:322-327.
102. Della Zuana O., Presse F., Ortola C., Duhault J., Nahon J.L., Levens N. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Int. J. Obes. 2002, 26:1289-1295.
103. Della Zuana O., Revereault L., Beck-Sickinger A., Monge A., Caignard D.H., Fauchere J.L., Henlin J.M., Audinot V., Boutin J.A., Chamorro S., Feletou M., Levens N. A potent and selective NPYY5 antagonist reduces food intake but not through blockade of the NPYY5 receptor. Int. J. Obes. 2004, 28:628-639.
104. Dhillon H., Ge Y.L., Minter R.M., Prima V., Moldawer L.L., Muzyczka N., Zolutukhin S., Kalra P.S., Kalra S.P. Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice- Relationship with body weight change. Regul. Pept. 2000, 92:97-105.
105. DiMarzo V., Matias I. Endocannabinoid control of food intake and energy balance. Nat. Neurosci. 2005, 8:585-589.
106. Drazen D.L., Coolen L.M., Strader A.D., Wortman M.D., Woods S.C., Seeley R.J. Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A. Endocrinology 2004, 145:3404-3412.
107. Drazen D.L., Wortman M.D., Seeley R.J., Woods S.C. Neuropeptide Y prepares rats for scheduled feeding. Am. J. Physiol. 2005, 288:R1606-R1611.
108. Dryden S., Pickavance L., Frankish H.M., Williams G. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 1995, 690:185-188.
109. Dube M.G., Xu B., Crowley W.R., Kalra P.S., Kalra S.P. Evidence that neuropeptide Y is a physiological signal for normal food intake. Brain Res. 1994, 646:341-344.
110. Dube M.G., Horvath T.L., Kalra P.S., Kalra S.P. Evidence of NPYY5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides 2000, 21:1557-1560.
111. Duhault J., Boulanger M., Chamorro S., Boutin J.A., Zuana O., Douillet E., Fauchere J.L., Feletou M., Germain M., Husson B., Vega A.M., Renard P., Tisserand E. Food intake regulation in rodents: Y-5 or Y1 NPY receptors or both?. Can. J. Physiol. Pharmacol. 2000, 78:173-185.
112. Duncan E.A., Proulx K., Woods S.C. Central administration of melanin-concentrating hormone increases alcohol and sucrose/quinine intake in rats. Alcohol. Clin. Exp. Res. 2005, 29:958-964.
113. Edwards C.M.B., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 1999, 160:R7-R12.
114. Elias C.F., Saper C.B., Maratos-Flier E., Tritos N.A., Lee C., Kelly J., Tatro J.B., Hoffman G.E., Ollmann M.M., Barsh G.S., Sakurai T., Yanagisawa M., Elmquist J.K. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 1998, 402:442-459.
115. Elliott J.C., Harrold J.A., Brodin P., Enquist K., Backman A., Bystrom M., Lindgren K., King P., Williams G. Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats. Mol. Brain Res. 2004, 128:150-159.
116. Everitt B.J., Hökfelt T., Terenius L., Tatemoto K., Mutt V., Goldstein M. Differential coexistence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience 1984, 11:443-462.
117. Erickson J.C., Hollopeter G., Palmiter R.D. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996, 274:1704-1707.
118. Flood J.F., Morley J.E. Increased food intake by neuropeptide Y is due to an increased motivation to eat. Peptides 1991, 12:1329-1332.
119. Frankish H.M., Dryden S., Hopkins D., Wang Q., Williams G. Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism. Peptides 1995, 16:757-771.
120. Fu L.Y., Acuna-Goycolea C., van den Pol A.N. Neuropeptide Y inhibits, hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J. Neurosci. 2004, 24:8741-8751.
121. Funahashi H., Hori T., Shimoda Y., Mizushima H., Ryushi T., Katoh S., Shioda S. Morphological evidence for neural interactions between leptin and orexin in the hypothalamus. Regul. Pept. 2000, 92:31-35.
122. Funahashi H., Yamada S., Kageyama H., Takenoya F., Guan J.L., Shioda S. Co-existence of leptin- and orexin-receptors in feeding-regulating neurons in the hypothalamic arcuate nucleus-a triple labeling study. Peptides 2003, 24:687-694.
123. Furudono Y., Ando C., Kobashi M., Yamamoto C., Yamamoto T. The role of orexigenic neuropeptides in the ingestion of sweet-tasting substances in rats. Chem. Senses 2005, 30(Suppl. 1):i186-i187.
124. Gamber K.M., MacArthur H., Westfall T.C. Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. Neuropharmacology 2005, 49:646-652.
125. Gao J., Ghibaudi L., van Heek M., Hwa J.J. Characterization of diet-induced obese rats that develop persistent obesity after 6 months of high-fat followed by 1 month of low-fat diet. Brain Res. 2002, 936:87-90.
126. Gardiner J.V., Kong W.M., Ward H., Murphy K.G., Dhillo W.S., Bloom S.R. AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem. Biophys. Res. Commun. 2005, 327:1088-1093.
127. Georgescu D., Sears R.M., Hommel J.D., Barrot M., Balanos C.A., Marsh D.J., Bednarek M.A., Bibb I.A., Maratos-Flier E., Nestler E.J., DiLeone R.J. The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J. Neurosci. 2005, 25:2933-2940.
128. Giraudo S.Q., Kim E.M., Grace M.K., Billington C.J., Levine A.S. Effect of peripheral 2-DG on opioid and neuropeptide Y gene expression. Brain Res 1998, 792:136-140.
129. Glass M.J., Cleary J.P., Billington C.J., Levine A.S. Role of carbohydrate type on diet selection in neuropeptide Y-stimulated rats. Am. J. Physiol. 1997, 42:R2040-R2045.
130. Godbole V., York D.a., Bloxham D.P. Developmental changes in the fatty (fa/fa) rat: evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinemia. Diabetologia 1978, 15:41-44.
131. Gomori A., Ishihara A., Ito M., Mashiko S., Matsushita H., Yumoto M., Ito M., Tanaka T., Tokita S., Moriya M., Iwaasa H., Kanatani A. Chronic intracerebroventricular infusion of MCH causes obesity in mice. Am. J. Physiol. 2003, 284:E583-E588.
132. Griffond B., Baker B.I. Cell and molecular cell biology of melanin-concentrating hormone. International Review of Cytology: A Survey of Cell Biology 2002, Vol. 213:233-277. Academic Press. K.W. Jeon (Ed.).
133. Griffond B., Risold P.Y., Jacquemard C., Colard C., Fellmann D. Insulin-induced hypoglycemia increases preprohypocretin (Orexin) mRNA in the rat lateral hypothalamic area. Neurosci. Lett. 1999, 262:77-80.
134. Grillon S., Herve C., Griffond B., Fellmann D. Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat lateral hypothalamus after goldthioglucose injection. Neuropeptides 1997, 31:131-136.
135. Guan J.L., Saotome T., Wang Q.P., Funahashi H., Hori T., Tanaka S., Shioda S. Orexiner gic innervation of POMC-containing neurons in the rat arcuate nucleus. Neuroreport 2001, 12:547-551.
136. Guan J.L., Suzuki R., Funahashi H., Wang Q.P., Kageyama H., Uehara K., Yamada S., Tsurugano S., Shioda S. Ultrastructural localization of orexin-1 receptor, in pre- and post-synaptic neurons in the rat arcuate nucleus. Neurosci. Lett. 2002, 329:209-212.
137. Guan J.L., Uehara K., Lu S., Wang Q.P., Funahashi H., Sakurai T., Yanagizawa M., Shioda S. Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus: a novel circuit implicated in feeding regulation. Int. J. Obes. 2002, 26:1523-1532.
138. Hahn T.M., Breininger J.F., Baskin D.G., Schwartz M.W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1998, 1:271-272.
139. Hakansson M.L., deLecea L., Sutcliffe J.G., Yanagisawa M., Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J. Neuroendocrinol. 1999, 11:653-663.
140. Hanada R., Nakazato M., Matsukura S., Murakami N., Yoshimatsu H., Sakata T. Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem. Biophys. Res. Commun. 2000, 268:88-91.
141. Hansen M.J., Jovanovska V., Morris M.J. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J. Neurochem. 2004, 88:909-916.
142. Hara J., Beuckmann C.T., Nambu T., Willie J.T., Chemelli R.M., Sinton C.M., Sugiyama F., Yagami K., Goto K., Yanagisawa M., Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001, 30:345-354.
143. Hawes B.E., Kil E., Green B., ONeill K., Fried S., Graziano M.P. The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signaling pathways. Endocrinology 2000, 141:4524-4532.
144. Haynes A.C., Arch J.R.S., Wilson S., McClue S., Buckingham R.E. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?. Regul. Pept. 1998, 75-76:355-361.
145. Haynes A.C., Jackson B., Chapman H., Tadayyon M., Johns A., Porter R.A., Arch J.R.S. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul. Pept. 2000, 96:45-51.
146. Haynes A.C., Chapman H., Taylor C., Moore G.B.T., Cawthorne M.A., Tadayyon M., Clapham J.C., Arch J.R.S. Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regul. Pept. 2002, 104:153-159.
147. He B., White B.D., Edwards G.L., Martin R.J. Neuropeptide Y antibody attenuates 2-deoxy-d-glucose induced feeding in rats. Brain Res. 1998, 781:348-350.
148. Henry M., Ghibaudi L., Gao J., Hwa J.J. Energy metabolic profile of mice after chronic activation of central NPY Y1, Y2, or Y5 receptors. Obes. Res 2005, 13:36-47.
149. Herve C., Fellmann D. Changes in rat melanin-concentrating hormone and dynorphin messenger ribonucleic acids induced by food deprivation. Neuropeptides 1997, 31:237-242.
150. Hervieu G.J., Cluderay J.E., Harrison D., Meakin J., Maycox P., Nasir S., Leslie R.A. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur. J. Neurosci. 2000, 12:1194-1216.
151. Hervieu G.J., Cluderay J.E., Harrison D.C., Roberts J.C., Leslie R.A. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 2001, 103:777-797.
152. Hilairet S., Bouaboula M., Carriere D., LeFur G., Casellas P. Hypersensitization of the orexin 1 receptor by the CB1 receptor-Evidence for crosstalk blocked by the specific CB1 antagonist, SR141716. J. Biol. Chem. 2003, 278:23731-23737.
153. Horvath T.L., Gao X.B. Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Cell Metab. 2005, 1:279-286.
154. Horvath T.L., Bechmann I., Naftolin F., Kalra S.P., Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res. 1997, 756:283-286.
155. Horvath T.L., Diano S., van den Pol A.N. Synaptic interaction between hypocretin (Orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 1999, 19:1072-1087.
156. Huang X.F., Han M., Storlien L.H. The level of NPY receptor mRNA expression in diet-induced obese and resistant mice. Mol. Brain Res. 2003, 115:21-28.
157. Hulsey M.G., Pless C.M., White B.D., Martin R.J. ICV administration of anti-NPY antisense oligonucleotide: effects on feeding behavior, body weight, peptide content and peptide release. Regul. Pept. 1995, 59:207-214.
158. Ida T., Nakahara K., Katayama T., Murakami N., Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res. 1999, 821:526-529.
159. Ida T., Nakahara K., Murakami T., Hanada R., Nakazato M., Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem. Biophys. Res. Commun. 2000, 270:318-323.
160. Ida T., Nakahara K., Kuroiwa T., Fukui K., Nakazato M., Murakami T., Murakami N. Both corticotropin releasing factor and neuropeptide Y are involved in the effect of orexin (hypocretin) on the food intake in rats. Neurosci. Lett. 2000, 293:119-122.
161. Iida M., Murakami T., Ishida K., Mizuno A., Kuwajima M., Shima K. Substitution at codon 269 (glutamine→proline) of the leptin receptor (OB-r) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem. Biophys. Res. Commun. 1996, 224:597-604.
162. Inui A. Neuropeptide Y feeding receptors: are multiple subtypes involved?. Trends Pharmacol. Sci. 1999, 20:43-46.
163. Ishii Y., Blundell J.E., Halford J.C.G., Upton N., Porter R., Johns A., Jeffrey P., Summerfield S., Rodgers R.J. Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867. Behav. Brain Res. 2005, 157:331-341.
164. Ishii Y., Blundell J.E., Halford J.C.G., Upton N., Porter R., Johns A., Rodgers R.J. Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S. Behav. Brain Res. 2005, 160:11-24.
165. Ishizaki K., Honma S., Katsuno Y., Abe H., Masubuchi S., Namihira M., Honma K. Gene expression of neuropeptide Y in the nucleus of the solitary tract is activated in rats under restricted daily feeding but not under 48-h food deprivation. Eur. J. Neurosci. 2003, 17:2097-2105.
166. Israel Y., Kandov Y., Khaimova E., Kest A., Lewis S.R., Pasternak G.W., Pan Y.X., Rossi G.C., Bodnar R.J. NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Peptides 2005, 26:1167-1175.
167. Ito M., Gomori A., Ishihara A., Oda Z., Mashiko S., Matsushita H., Yumoto M., Ito M., Sano H., Tokita S., Moriya M., Iwaasa H., Kanatani A. Characterization of MCH-mediated obesity in mice. Am. J. Physiol. 2003, 284:E940-E945.
168. Jain M.R., Horvath T.L., Kalra P.S., Kalra S.P. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul. Pept. 2000, 87:19-24.
169. Jang M.Y., Romsos D.R. Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding. J. Nutr. 1998, 128:2520-2525.
170. Jewett D.C., Cleary J., Levine A.S., Schaal D.W., Thompson T. Effects of neuropeptide-Y on food-reinforced behavior in satiated rats. Pharmacol Biochem. Behav. 1992, 42:207-212.
171. Jewett D.C., Cleary J., Levine A.S., Schaal D.W., Thompson T. Effects of neuropeptide Y, insulin, a 2-deoxyglucose, and food deprivation on food motivated behavior. Psychopharmacology (Berlin) 1995, 120:267-271.
172. Jhanwar-Uniyal M., Chua S.C. Critical effects of aging and nutritional state on hypothalamic neuropeptide-Y and galanin gene expression in lean and genetically obese Zucker rats. Mol. Brain Res. 1993, 19:195-202.
173. Jhanwar-Uniyal M., Beck B., Burlet C., Leibowitz S.F. Diurnal rhythm of neuropeptide Y-like immunoreactivity in the suprachiasmatic, arcuate and paraventricular nuclei and other hypothalamic sites. Brain Res. 1990, 536:331-334.
174. Jolicoeur E.B., Bouali S.M., Fournier A., St Pierre S. Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. Brain Res. Bull. 1995, 36:125-129.
175. Jones D.N.C., Gartlon J., Parker F., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., Hatcher J.P., Johns A., Porter R.A., Hagan J.J., Hunter A.J., Upton N. Effects of centrally administered orexin-1 and orexinA: a role for orexin-1 receptors in orexin-B-induced hyperactivity. Psychopharmacology (Berlin) 2001, 153:210-218.
176. Kogotani Y., Hashimoto T., Tsuruo Y., Kawano H., Daikoku S., Chihara K. Development of the neuronal system containing neuropeptide Y in the rat hypothalamus. Int. J. Dev. Neurosci. 1989, 7:359-374.
177. Kalra S.P., Kalra P.S. Neuropeptide Y-A physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine 2003, 22:49-55.
178. Kalra S.P., Dube M.G., Sahu A., Phelps C.P., Kalra P.S. Neuropeptide-Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:10931-10935.
179. Kanatani A., Ishihara A., Asahi S., Tanaka T., Ozaki S., Ihara M. Potent neuropeptide YY1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology 1996, 137:3177-3182.
180. Kanatani A., Kanno T., Ishihara A., Hata M., Sakuraba A., Tanaka T., Tsuchiya Y., Mase T., Fukuroda T., Fukami T., Ihara M. The novel neuropeptide YY1 receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochem. Biophys. Res. Commun. 1999, 266:88-91.
181. Kanatani A., Ishihara A., Iwaasa H., Nakamura K., Okamoto O., Hidaka M., Ito J., Fukuroda T., MacNeil D.J., VanderPloeg L.H.T., Ishii Y., Okabe T., Fukami T., Ihara M. L-152,804; orally active and selective neuropeptide YY5 receptor antagonist. Biochem. Biophys. Res. Commun. 2000, 272:169-173.
182. Kanatani A., Hata M., Mashiko S., Ishihara A., Okamoto O., Haga Y., Obe T., Kanno T., Murai N., Ishii Y., Fukuroda T., Fukami T., Ihara M. A typical y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814. Mol. Pharmacol. 2001, 59:501-505.
183. Kane J.K., Parker S.L., Matta S.G., Fu Y., Sharp B.M., Li M.D. Nicotine up-regulates expression of orexin and its receptors in rat brain. Endocrinology 2000, 141:3623-3629.
184. Karteris E., Machado R.J., Chen J., Zervou S., Hillhouse E.W., Randeva H.S. Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. Am. J. Physiol. 2005, 288:E1089-E1100.
185. Kask A., Rago L., Harro J. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y-1-selective antagonist BIBP3226. Br. J. Pharmacol. 1998, 124:1507-1515.
186. Kask A., Vasar E., Heidmets L.T., Allikmets L., Wikberg J.E.S. Neuropeptide YY5 receptor antagonist CGP71683A: the effects on food intake and anxiety-related behavior in the rat. Eur. J. Pharmacol. 2001, 414:215-224.
187. Kawauchi H., Kawazoe I., Tsubokawa M., Kishida M., Baker B.I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 1983, 305:321-323.
188. Keen-Rhinehart E., Kalra S.P., Kalra P.S. Leptin-receptor gene transfer into the arcuate nucleus of female fatty Zucker rats using, recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis. Biol. Reprod. 2004, 71:266-272.
189. Kennedy A.R., Todd J.F., Dhillo W.S., Seal L.J., Ghatei M.A., OToole C.P., Iones M., Witty D., Winborne K., Riley G., Hervieu G., Wilson S., Bloom S.R. Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1. J. Neuroendocrinol. 2003, 15:268-272.
190. Kerkerian L., Pelletier G. Effects of monosodium l-glutamate administration on neuropeptide Y-containing neurons in the rat hypothalamus. Brain Res. 1986, 369:388-390.
191. Kim E.M., Welch C.C., Grage M.K., Billington C.J., Levine A.S. Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus. Brain Res. 1998, 806:117-121.
192. Kiwaki K., Kotz C.M., Wang C.F., Lanningham-Foster L., Levine J.A. Orexin A (Hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats. Am. J. Physiol. 2004, 286:E551-E559.
193. Kojima M., Hosoda H., Kangawa K. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach. Best Pract. Res. Clin. Endocrinol. Metab. 2004, 18:517-530.
194. Kokkotou E.G., Tritos N.A., Mastaitis J.W., Slieker L., Maratos-Flier E. Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain. Endocrinology 2001, 142:680-686.
195. Kokkotou E., Jeon J.Y., Wang X.M., Marino F.E., Carlson M., Trombly D.J., Maratos-Flier E. Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am. J. Physiol. 2005, 289:R117-R124.
196. Korner J., Savontaus E., Chua S.C., Leibel R.L., Wardlaw S.L. Leptin regulation of Agrp and NPY mRNA in the rat hypothalamus. J. Neuroendocrinol. 2001, 13:959-966.
197. Kowalski T.J., Houpt T.A., Jahng J., Okada N., Liu S.M., Chua S.C., Smith G.P. Neuropeptide Y overexpression in the preweanling Zucker (fa/fa) rat. Physiol. Behav. 1999, 67:521-525.
198. Kowalski T.J., Farley C., Cohen-Williams M.E., Varty G., Spar B.D. Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size. Eur. J. Pharmacol. 2004, 497:41-47.
199. Kozak R., Mercer J.G., Burlet A., Moar K.M., Burlet C., Beck B. Hypothalamic neuropeptide Y content and mRNA expression in weanling rats subjected to dietary manipulations during fetal and neonatal life. Regul. Pept. 1998, 75-6:397-402.
200. Kozak R., Burlet A., Burlet C., Beck B. Dietary composition during fetal and neonatal life affects neuropeptide Y functioning in adult off-spring. Dev. Brain Res. 2000, 125:75-82.
201. Kozak R., Richy S., Beck B. Persistent alterations in neuropeptide Y release in the paraventricular nucleus of rats subjected to dietary manipulation during early life. Eur. J. Neurosci. 2005, 21:2887-2892.
202. Krief S., Bazin R. Genetic obesity-Is the defect in the sympathetic nervous system?-A review through developmental studies in the preobese Zucker rat. Proc. Soc. Exp. Biol. Med. 1991, 198:528-538.
203. Kuenzel W.J., Douglass L.W., Davison B.A. Robust feeding following central administration of neuropeptide Y or peptide YY in chicks. Gallus domesticus. Peptides 1987, 8:823-828.
204. Kunii K., Yamanaka A., Nambu T., Matsuzaki I., Goto K., Sakurai T. Orexins/hypocretins regulate drinking behavior. Brain Res. 1999, 842:256-261.
205. Kurose T., Ueta Y., Yamamoto Y., Serino R., Ozaki Y., Saito J., Nagata S., Yamashita H. Effects of restricted feeding on the activity of hypothalamic orexin (OX)-A containing neurons and OX2 receptor mRNA level in the paraventricular nucleus of rats. Regul. Pept. 2002, 104:145-151.
206. Kuru M., Ueta Y., Serino R., Nakazato M., Yamamoto Y., Shibuya L., Yamashita H. Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport 2000, 11:1977-1980.
207. Lambert P.D., Wilding J.P.H., Turton M.D., Ghatei M.A., Bloom S.R. Effect of food deprivation and streptozotocin-induced diabetes on hypothalamic, neuropeptide Y release as measured by a radioimmunoassay-linked microdialysis procedure. Brain Res. 1994, 656:135-140.
208. Langmead C.J., Jerman J.C., Brough S.J., Scott C., Porter R.A., Herdon H.J. Characterisation of the binding of [H-3]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br. J. Pharmacol. 2004, 141:340-346.
209. Larhammar D. Evolution of neuropeptide Y. peptide YY and pancreatic polypeptide. Regul. Pept. 1996, 62:1-11.
210. Larhammar D., Salaneck E. Molecular evolution of NPY receptor subtypes. Neuropeptides 2004, 38:141-151.
211. Lecklin A., Lundell I., Salmela S., Mannisto P.T., Beck-Sickinger A.G., Larhammar D. Agonists for neuropeptide Y receptors Y-1 and Y-5 stimulate different phases of feeding in guinea pigs. Br. J. Pharmacol. 2003, 139:1433-1440.
212. Leibowitz S.F., Alexander J.T. Analysis of neuropeptide Y-induced feeding-Dissociation of Y1-receptor and Y2-receptor effects on natural meal patterns. Peptides 1991, 12:1251-1260.
213. Levin B.E. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am. J. Physiol. 1999, 45:R382-R387.
214. Levin B.E., Dunn-Meynell A.A. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am. J. Physiol. 1997, 41:R1365-R1370.
215. Levin B.E., Dunn-Meynell A.A. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am. J. Physiol. 2002, 282:R46-R54.
216. Levin B.E., Dunn-Meynell A.A. Reduced central leptin sensitivity in rats with diet-induced obesity. Am. J. Physiol. 2002, 283:R941-R948.
217. Levin B.E., Govek E.K., Dunn-Meynell A.A. Reduced glucose-induced neuronal activation in the hypothalamus of diet-induced obese rats. Brain Res. 1998, 808:317-319.
218. Levin B.E., Dunn-Meynell A.A., Banks W.A. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am. J. Physiol. 2004, 286:R143-R150.
219. Levine A.S., Morley J.E. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 1984, 5:1025-1029.
220. Levine A.S., Winsky-Sommerer R., Huitron-Resendiz S., Grace M.K., de Lecea L. Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. Am. J. Physiol. 2005, 288:R1727-R1732.
221. Lewis D.E., Shellard L., Koeslag D.G., Boer D.E., McCarthy H.D., McKibbin P.E., Russell J.C., Williams G. Intense exercise and food restric- tion cause similar hypothalamic neuropeptide-Y increases in rats. Am. J. Physiol. 1993, 264:E279-E284.
222. Li A.J., Ritter S. Glucoprivation increases expression of neuropeptide Y mRNA in hindbrain neurons that innervate the hypothalamus. Eur. J. Neurosci. 2004, 19:2147-2154.
223. Lin S., Storlien L.H., Huang X.F. Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res. 2000, 875:89-95.
224. Lopez M., Seoane L., Garcia M.D., Lago F., Casanueva F.F., Senaris R., Dieguez C. Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus. Biochem. Biophys. Res. Commun. 2000, 269:41-45.
225. Lopez M., Seoane L.M., Garcia M.D., Dieguez C., Senaris R. Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology 2002, 75:34-44.
226. Louis-Sylvestre J., Giachetti I., Le magnen J. Sensory versus dietary factors in cafeteria-induced overweight. Physiol. Behav. 1984, 32:901-905.
227. Lu X.Y., Bagnol D., Burke S., Akil H., Watson S.J. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm. Behav. 2000, 37:335-344.
228. Lubkin M., Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem. Biophys. Res. Commun. 1998, 253:241-245.
229. Ludwig D.S., Mountjoy K.G., Tatro J.B., Gillette I.A., Frederich R.C., Flier J.S., Maratos-Flier E. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am. J. Physiol. 1998, 37:E627-E633.
230. Ludwig D.S., Tritos N.A., Mastaitis J.W., Kulkarni R., Kokkotou E., Elmquist J., Lowell B., Flier J.S., Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J. Clin. Invest. 2001, 107:379-386.
231. Lynch W.C., Grace M., Billington C.J., Levine A.S. Effects of neuropeptide-Y on ingestion of flavored solutions in nondeprived rats. Physiol. Behav. 1993, 54:877-880.
232. Lynch W.C., Hart P., Babcock A.M. Neuropeptide Y attenuates satiety-evidence from a detailed analysis of patterns of ingestion. Brain Res. 1994, 636:28-34.
233. Maitre M. The gamma-hydroxybutyrate signalling system in brain: organization and functional implications. Prog. Neurobiol. 1997, 51:337-361.
234. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 2001, 435:6-25.
235. Marks J.L., Li M., Schwartz M., Porte D., Baskin D.G. Effect of fasting on regional levels of neuropeptide-Y messenger RNA and insulin receptors in the rat hypothalamus-An autoradiographic study. Mol. Cell. Neurosci. 1992, 3:199-205.
236. Marsh D.J., Hollopeter G., Kafer K.E., Palmiter R.D. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat. Med. 1998, 4:718-721.
237. Marsh D.J., Weingarth D.T., Novi D.E., Chen H.Y., Trumbauer M.E., Chen A.S., Guan X.M., Jiang M.M., Feng Y., Camacho R.E., Shen Z., Frazier E.G., Yu H., Metzger J.M., Kuca S.J., Shearman L.P., Gopal-Truter S., MacNeil D.J., Strack A.M., MacIntyre D.E., VanderPloeg L.H.T., Qian S. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:3240-3245.
238. Mashiko S., Ishihara A., Iwaasa H., Sano H., Oda Z., Ito J., Yumoto M., Okawa M., Suzuki J., Fukuroda T., Jitsuoka M., Morin N.R., MacNeil D.J., VanderPloeg L.H.T., Ihara M., Fukami T., Kanatani A. Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: chronic intracerebroventricular infusion of d-Trp(34)NPY. Endocrinology 2003, 144:1793-1801.
239. Mashiko S., Ishihara A., Gomori A., Moriya R., Ito M., Iwaasa H., Matsuda M., Feng Y., Shen Z., Marsh D.J., Bednarek M.A., MacNeil D.J., Kanatani A. Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. Endocrinology 2005, 146:3080-3086.
240. Matthews J.E., Jansen M., Lyerly D., Cox R., Chen W.J., Koller K.J., Daniels A.J. Pharmacological characterization and selectivity of the NPY antagonist GR231118 (1229U91) for different NPY receptors. Regul. Pept. 1997, 72:113-119.
241. Maulon-Feraille L., Della Zuana O., Suply T., Rovere-Jovene C., Audinot V., Levens N., Boutin J.A., Duhault J., Nahon J.L. Appetite-boosting property of pro-melanin-concentrating hormone (131-165) (Neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance. J. Pharmacol. Exp. Ther. 2002, 302:766-773.
242. McCarthy H.D., McKibbin P.E., Holloway B., Mayers R., Williams G. Hypothalamic neuropeptide-Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci. 1991, 49:1491-1497.
243. McKibbin P.E., Cotton S.J., McMillan S., Holloway B., Mayers R., McCarthy H.D., Williams G. Altered neuropeptide-Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats-Possible relationship to obesity and neuroendocrine disturbances. Diabetes 1991, 40:1423-1429.
244. McMillen I.C., Robinson J.S. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol. Rev. 2005, 85:571-633.
245. McMinn J.E., Seeley R.J., Wilkinson C.W., Havel P.J., Woods S.C., Schwartz M.W. NPY-induced overfeeding suppresses hypothalamic NPY mRNA expression: potential roles of plasma insulin and leptin. Regul. Pept. 1998, 75-76:425-431.
246. McShane T.M., Petersen S.L., McCrone S., Keisler D.H. Influence of food restriction on neuropeptide-Y, proopiomelanocortin, and luteinizing hornone-releasing hormone gene expression in sheep hypothalami. Biol. Reprod. 1993, 49:831-839.
247. McShane T.M., Wilson M.E., Wise P.M. Effects of lifelong moderate caloric restriction on levels of neuropeptide Y, proopiomelanocortin, and galanin mRNA. J. Gerontol. A Biol. Sci. Med. Sci. 1999, 54:B14-B21.
248. Meguid M.M., Fetissov S.O., Varma M., Sato T., Zhang L.H., Laviano A., RossiFanelli F. Hypothalamic dopamine and serotonin in the regulation of food intake. Nutrition 2000, 16:843-857.
249. Menendez J.A., McGregor I.A., Healey P.A., Atrens D.M., Leibowitz S.F. Metabolic effects of neuropeptide Y injections into the paraventricular nucleus of the hypothalamus. Brain Res. 1990, 516:8-14.
250. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J., Trayhurn P. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 1996, 8:733-735.
251. Mercer J.G., Lawrence C.B., Atkinson T. Regulation of galanin gene expression in the hypothalamic paraventricular nucleus of the obese Zucker rat by manipulation of dietary macronutrients. Mol. Brain Res. 1996, 43:202-208.
252. Mercer J.G., Moar K.M., Rayner D.V., Trayhurn P., Hoggard N. Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett. 1997, 402:185-188.
253. Minami S., Kamegai J., Sugihara H., Suzuki N., Higuchi H., Wakabayashi I. Central glucoprivation evoked by administration of 2-deoxy-d-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide Y neurons in the rat hypothalamus. Mol. Brain Res. 1995, 33:305-310.
254. Miner J.L., Della-Fera M.A., Paterson J.A., Baile C.A. Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in the sheep. Am. J. Physiol. 1989, 257:R383-R387.
255. Mondal M.S., Nakazato M., Date Y., Murakami N., Hanada R., Sakata T., Matsukura S. Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models. Neurosci. Lett. 1999, 273:45-48.
256. Mondal M.S., Nakazato M., Matsukura S. Characterization of orexins (Hypocretins) and melanin-concentrating hormone in genetically obese mice. Regul. Pept. 2002, 104:21-25.
257. Moreno G., Perello M., Gaillard R.C., Spinedi E. Orexin A stimulates hypothalamic-pituitary-adrenal (HPA) axis function, but not food intake, in the absence of full hypothalamic NPY-ergic activity. Endocrine 2005, 26:99-106.
258. Morgan D.G.A., Small C.J., Abusnana S., Turton M., Gunn I., Heath M., Rossi M., Goldstone A.P., O'Shea D., Meeran K., Ghatei M., Smith D.M., Bloom S. The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism. Regul. Pept. 1998, 75-76:377-382.
259. Mori M., Harada M., Terao Y., Sugo T., Watanabe T., Shimomura Y., Abe M., Shintani Y., Onda H., Nishimura O., Fujino M. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem. Biophys. Res. Commun. 2001, 283:1013-1018.
260. Moriguchi T., Sakurai T., Nambu T., Yanagisawa M., Goto K. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci. Lett. 1999, 264:101-104.
261. Morley J.E., Levine A.S., Gosnell B.A., Kneip J., Grace M. Effect of neuropeptide Y on ingestive behaviors in the rat. Am. J. Physiol. 1987, 252:R599-R609.
262. Morley J.E., Hernandez E.N., Flood J.F. Neuropeptide Y increases food intake in mice. Am. J. Physiol. 1987, 253:R516-R522.
263. Morris Y.A., Crews D. The effects of exogenous neuropeptide-y on feeding and sexual behavior in the red-sided garter snake (Thamnophis sirtalis parietalis). Brain Res. 1990, 530:339-341.
264. Morton G.J., Mystkowski P., Matsumoto A.M., Schwartz M.W. Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanism. Peptides 2004, 25:667-674.
265. Mullett M.A., Billington C.J., Levine A.S., Kotz C.M. Hypocretin I in the lateral hypothalamus activates key feeding-regulatory brain sites. Neuroreport 2000, 11:103-108.
266. Muraki Y., Yamanaka A., Tsujino N., Kilduff T.S., Goto K., Sakurai T. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptors. J. Neurosci. 2004, 24:7159-7166.
267. Muroya S., Yada T., Shioda S., Takigawa M. Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y. Neurosci. Lett. 1999, 264:113-116.
268. 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur. J. Neurosci. 2004, 19:1524-1534.
269. Myers R.D., Wooten M.H., Ames C.D., Nyce J.W. Anorexic action of a new potential neuropeptide Y antagonist [d-tyr(27,36), d-thr(32)]-NPY (27-36) infused into the hypothalamus of the rat. Brain Res. Bull. 1995, 37:237-245.
270. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res. 1999, 827:243-260.
271. O'Shea R.D., Gundlach A.L. Preproneuropeptide-Y messenger ribonucleic acid in the hypothalamic arcuate nucleus of the rat is increased by food deprivation or dehydration. J. Neuroendocrinol. 1991, 3:11-14.
272. Olszewski P.K., Li D.H., Grace M.K., Billington C.J., Kotz C.M., Levine A.S. Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides 2003, 24:597-602.
273. Palani A., Shapiro S., McBriar M.D., Clader J.W., Greenlee W.J., Spar B., Kowalski T.J., Farley C., Cook J., vanHeek M., Weig B., ONeill K., Graziano M., Hawes B. Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity. J. Med. Chem. 2005, 48:4746-4749.
274. Parker E.M., Balasubramaniam A., Guzzi M., Mullins D.E., Salisbury B.G., Sheriff S., Witten M.B., Hwa J.J. d-Trp(34)] neuropeptide Y is a potent and selective neuropeptide YY5 receptor agonist with dramatic effects on food intake. Peptides 2000, 21:393-399.
275. Parrott, Heavens R.P., Baldwin B.A. Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y. Physiol. Behav. 1986, 36:523-525.
276. Pau M.Y.C., Pau K.Y.F., Spies H.G. Characterization of central actions of neuropeptide Y on food and water intake in rabbits. Physiol. Behav. 1988, 44:797-802.
277. Pesonen U., Huupponen R., Rouru J., Koulu M. Hypothalamic neuropeptide expression after food restriction in Zucker rats-evidence of persistent neuropeptide-Y gene activation. Mol. Brain Res 1992, 16:255-260.
278. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 1998, 18:9996-10015.
279. Phillips M.S., Liu Q.Y., Hammond H.A., Dugan V., Hey P.J., Caskey C.T., Hess J.F. Leptin receptor missense mutation in the fatty Zucker rat. Nat. Genet. 1996, 13:18-19.
280. Polidori C., Ciccocioppo R., Regoli D., Massi M. Neuropeptide Y receptor(s) mediating feeding in the rat: characterization with antagonists. Peptides 2000, 21:29-35.
281. Porte D., Baskin D.G., Schwartz M.W. Leptin and insulin action in the central nervous system. Nutr. Rev. 2002, 60:S20-S29.
282. Porter R.A., chan W.N., Coulton S., Johns A., Hadley M.S., Widdowson K., Jerman J.C., Brough S.J., Coldwell M., Smart D., jewitt F., Jeffrey P, Austin N. 1,3-Biarylureas as selective nonpeptide antagonists of the orexin-1 receptor. Bioorg Med. Chem. Lett. 2001, 11:1907-1910.
283. Presse F., Sorokovsky I., Max J.P., Nicolaidis S., Nahon J.L. Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat. Neuroscience 1996, 71:735-745.
284. Qian H., Azain M.J., Hartzell D.L., Baile C.A. Increased leptin resistance as rats grow to maturity. Proc. Soc. Exp. Biol. Med. 1998, 219:160-165.
285. Qu D.Q., Ludwig D.S., Gammeltoft S., Piper M., Pelley mounter M.A., Cullen M.J., Mathes W.F., Przypek J., Kanarek R., Maratos-Flier E. A role for melanin-concentrating hormone in the central regulation of feeding behavior. Nature 1996, 380:243-247.
286. Raposinho P.D., Pierroz D.D., Broqua P., White R.B., Pedrazzini T., Aubert M.L. Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. Mol. Cell. Endocrinol. 2001, 185:195-204.
287. Rehfeld J.F. Cholecystokinin. Best Pract. Res. Clin Endocrinol. Metab. 2004, 18:569-586.
288. Richard D., Lin Q., Timofeeva E. The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance. Eur. J. Pharmacol. 2002, 440:189-197.
289. Robinson S.W., Dinulescu D.M., Cone R.D. Genetic models of obesity and energy balance in the mouse. Annu. Rev. Genet. 2000, 34:687-745.
290. Rodgers R.J., Halford J.C.G., de Souza R.L.N., de Souza A.L.C., Piper D.C., Arch J.R.S., Blundell J.E. Dose-response effects of orexin-A on food intake and the behavioral satiety sequence in rats. Regul. Pept. 2000, 96:71-84.
291. Rodgers R.J., Halford J.C.G., de Souza R.L.N., de Souza A.L.C., Piper D.C., Arch J.R.S., Upton N., Porter R.A., Johns A., Blundell J.E. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioral satiety and blocks the hyperphagic effect of orexin-A in rats. Eur. J. Neurosci. 2001, 13:1444-1452.
292. Rossi M., Choi S.J., O'Shea D., Miyoshi T., Chatei M.A., Bloom S.R. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 1997, 138:351-355.
293. Rossi M., Beak S.A., Choi S.J., Small C.J., Morgan D.G.A., Ghatei M.A., Smith D.M., Bloom S.R. Investigation of the feeding effects of melanin concentrating hormone on food intake-action independent of galanin and the melanocortin receptors. Brain Res. 1999, 846:164-170.
294. Rothwell N., Stock M. Regulation of energy balance in two models of reversible obesity in the rat. Comp. Physiol. Psychol. 1979, 93:1024-1034.
295. Rovere C., Viale A., Nahon J.L., Kitabgi P. Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice. Endocrinology 1996, 137:2954-2958.
296. Rowland N.E. Peripheral and central satiety factors in neuropeptide Y-induced feeding in rats. Peptides 1988, 9:989-992.
297. Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin, (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 1998, 139:795-798.
298. Sahu A. Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology 1998, 139:4739-4742.
299. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front. Neuroendocrinol. 2003, 24:225-253.
300. Sahu A., Kalra S.P., Crowley W.R., Kalra P.S. Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Res. 1988, 457:376-378.
301. Sahu A., Kalra P.S., Kalra S.P. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 1988, 9:83-86.
302. Saito Y., Nothacker H.P., Wang Z.W., Lin S.H.S., Leslie F., Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 1999, 400:265-269.
303. Sakamaki R., Uemoto M., Inui A., Asakawa A., Ueno N., Ishibashi C., Hiron S., Yukioka H., Kato A., Shinfuku N., Kasuga M., Katsuura G. Melanin-concentrating, hormone enhances sucrose intake. Int. J. Mol. Med. 2005, 15:1033-1039.
304. Sakamoto F., Yamada S., Ueta Y. Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons. Regul. Pept. 2004, 118:183-191.
305. Sakurai T. Roles of orexins in regulation of feeding and wakefulness. Neuroreport 2002, 13:987-995.
306. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
307. Samson W.K., Taylor M.M., Follwell M., Ferguson A.V. Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates. Regul. Pept. 2002, 104:97-103.
308. Sanacora G., Kershaw M., Finkelstein J.A., White J.D. Increased hypothalamic content of preproneuropeptide Y messenger ribonculeic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 1990, 127:730-737.
309. Sanacora G., Finkelstein J.A., White J.D. Developmental aspects of differences in hypothalamic preproneuropeptide Y messenger ribonucleic acid content in lean and genetically obese Zucker rats. J. Neuroendocrinol. 1992, 4:353-357.
310. Sawchenko P.E., Swanson L.W., Grzanna R., Howe P.R.C., Bloom S.R., Polak J.M. Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic, neurons that project to the paraventricular nucleus of the hypothalamus. J. Comp. Neurol. 1985, 241:138-153.
311. Schaffhauser A.O., Madiehe A.M., Braymer H.D., Bray G.A., York D.A. Effects of a high-fat diet and strain on hypothalamic gene expression in rats. Obes. Res. 2002, 10:1188-1196.
312. Schlumberger S.E., Talke-Messerer C., Zumsteg U., Eberle A.N. Expression of receptors for melanin-concentrating hormone (MCH) in different tissues and cell lines. J. Recept. Signal. Transduct. Res. 2002, 22:509-531.
313. Schwartz M.W., Sipols A.J., Grubin C.E., Baskin D.G. Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide-Y, galanin, and glutamic acid decarboxylase. Brain Res. Bull. 1993, 31:361-367.
314. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte D., Woods S.C., Seeley R.J., Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 1996, 45:531-535.
315. Sclafani A. Carbohydrate-induced hyperphagia and obesity in the rat: effects of saccharide type, form, and taste. Neurosci. Biobehav. Rev. 1987, 11:155-162.
316. Seeley R.J., Payne C.J., Woods S.C. Neuropeptide Y fails to increase intraoral intake in rats. Am. J. Physiol. 1995, 37:R423-R427.
317. Seeley R.J., Drazen D.L., Clegg D.J. The critical role of the melanocortin system in the control of energy balance. Annu. Rev. Nutr. 2004, 24:133-149.
318. Segal-Lieberman G., Bradley R.L., Kokkotou E., Carlson M., Trombly D.J., Wang X.M., Bates S., Myers M.G., Flier J.S., Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:10085-10090.
319. Sergeyev V., Broberger C., Gorbatyuk O., Hokfelt T. Effect of 2-mercaptoacetate and 2-deoxy-d-glucose administration on the expression of NPY, AGRP, POMC, MCH and hypocretin/orexin in that rat hypothalamus. Neuroreport 2000, 11:117-121.
320. Serradeillegal C., Valette G., Rouby P.E., Pellet A., Ourydonat F., Brossard G., Lespy L., Marty E., Neliat G., Decointet P., Maffrand J.P., Lefur G. SR120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett 1995, 362:192-196.
321. Shearman L.P., Camacho R.E., Stribling D.S., Zhou D., Bednarek M.A., Hreniuk D.L., Feighner S.D., Tan C.P., Howard A.D., VanderPleog L.H.T., MacIntyre D.E., Hickey G.J., Strack A.M. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. Eur. J. Pharmacol 2003, 475:37-47.
322. Shibasaki T., Oda T., Imaki T., Ling N., Demura H. Injection of antineuropeptide-Y gammaglobulin into the hypothalamic paraventricular nucleus decreases food intake in rats. Brain Res 1993, 601:313-316.
323. Shimada M., Tritos N.A., Lowell B.B., Flier L.S., Maratos-Flier E. Mice lacking melaninconcentrating hormone are hypophagic and lean. Nature 1998, 396:670-674.
324. Shimomura Y., Mori M., Sugo T., Ishibashi Y., Abe M., Kurokawa T., Onda H., Nishimura O., Sumino Y., Fujino M. Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. Biochem. Biophys. Res. Commun. 1999, 261:622-626.
325. Shiraishi T., Oomura Y., Sasaki K., Wayner M.J. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol. Behav. 2000, 71:251-261.
326. Sindelar D.K., SteMarie L., Miura G.I., Palmiter R.D., McMinn J.E., Morton G.J., Schwartz M.W. Neuropeptide Y is required for hyperphagic feeding in response to neuroglucopenia. Endocrinology 2004, 145:3363-3368.
327. Sindelar D.K., Palmiter R.D., Woods S.C., Schwartz M.W. Attenuated feeding responses to circadian and palatability cues in mice lacking neuropeptide Y. Peptides 2005, 26:2597-2602.
328. Smart D., Sabido-David C., Brough S.J., Jewitt F., Johns A., Porter R.A., Jerman J.C. SB-334867-A: the first selective orexin-1 receptor antagonist. Br. J. Pharmacol. 2001, 132:1179-1182.
329. Smoller J.W., Truett G.E., Hirsch J., Leibel R.L. A molecular genetic method for genotyping fatty (fa/fa) rats. Am. J. Physiol. 1993, 264:R8-R11.
330. Souers A.J., Gao J., Wodka D., Judd A.S., Mulhern M.M., Napier J.J., Brune M.E., Bush E.N., Brodjian S.J., Dayton B.D., Shapiro R., Hernandez L.E., Marsh K.C., Sham H.L., Collins C.A., Kym P.R. Synthesis and evaluation of ureabased indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. Bioorg. Med. Chem. Lett. 2005, 15:2752-2757.
331. Stanley B.G., Leibowitz S.F. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci 1984, 35:2635-2642.
332. Stanley B.G., Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U.S.A. 1985, 82:3940-3943.
333. Stanley B.G., Thomas W.J. Feeding responses to perifornical hypothalamic injection of neuropeptide-Y in relation to circadian rhythms of eating behavior. Peptides 1993, 14:475-481.
334. Stanley B.G., Chin A.S., Leibowitz S.F. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res. Bull. 1985, 14:521-524.
335. Stanley B.G., Daniel D.R., Chin A.S., Leibowitz S.F. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 1985, 6:1205-1211.
336. Stanley B.G., Anderson K.C., Grayson M.H., Leibowitz S.F. Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats. Physiol. Behav. 1989, 46:173-177.
337. Stanley B.G., Magdalin W., Seirafi A., Thomas W.J., Leibowitz S.F. The perifornical area-the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s). Brain Res. 1993, 604:304-317.
338. Steininger T.L., Kilduff T.S., Behan M., Benca R.M., Landry C.F. Comparison of hypocretin/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain. J. Chem. Neuroanat. 2004, 27:165-181.
339. Steinman J.L., Gunion M.W., Morley J.E. Forebrain and hindbrain involvement of neuropeptide Y in ingestive behaviors of rats. Pharmacol. Biochem. Behav. 1994, 47:207-214.
340. Ster A.M., Kowalski T.J., Dube M.G., Kalra S.P., Smith G.P. Decreased hypothalamic concentration of neuropeptide Y correlates with onset of hyperphagia fa/fa rats on postnatal day 12. Physiol. Behav. 2003, 78:517-520.
341. Stricker-Krongrad A., Beck B. Modulation of hypothalamic hypocretin/orexin mRNA expression by glucocorticoids. Biochem. Biophys. Res. Commun. 2002, 296:129-133.
342. +-stimulated neuropeptide-Y release into the paraventricular nucleus and relation to feeding behavior in free-moving rats. Neuropeptides 1993, 24:307-312.
343. Stricker-Krongrad A., Max J.P., Musse N., Nicolas J.P., Burlet C., Beck B. Increased threshold concentrations of neuropeptide Y for a stimulatory effect on food intake in obese Zucker rats-changes in the microstructure of the feeding behavior. Brain Res. 1994, 660:162-166.
344. Stricker-Krongrad A., Kozak R., Burlet C., Nicolas J.P., Beck B. Physiological regulation of hypothalamic neuropeptide Y release in lean and obese rats. Am. J. Physiol. 1997, 42:R2112-R2116.
345. Stricker-Krongrad A., Dimitrov T., Beck B. Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats. Mol. Brain Res. 2001, 92:43-48.
346. Stricker-Krongrad A., Richy S., Beck B. Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects. Regul. Pept. 2002, 104:11-20.
347. Sunter D., Morgan I., Edwards C.M.B., Dakin C.L., Murphy K.G., Gardiner J., Taheri S., Rayes E., Bloom S.R. Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem. Brain Res. 2001, 907:27-34.
348. Suply T., Della Zuana O., Audinot V., Rodriguez M., Beauverger P., Duhault J., Canet E., Galizzi J.P., Nahon J.L., Levens N., Boutin J.A. SLC-1 receptor mediates effect of melaninconcentrating hormone on feeding behavior in rat: a structure-activity study. J. Pharmacol. Exp. Ther. 2001, 299:137-146.
349. Sutcliffe J.G., deLecea L. The hypocretins: setting the arousal threshold. Nat Rev. Neurosci. 2002, 3:339-349.
350. Suzuki R., Shimojima H., Funahashi H., Nakajo S., Yamada S., Guan J.L., Tsurugano S., Uehara K., Takeyama Y., Kikuyama S., Shioda S. Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus. Neurosci. Lett. 2002, 324:5-8.
351. Sweet D.C., Levine A.S., Kotz C.M. Functional opioid pathways are necessary for hypocretin-1 (Orexin-A)-induced feeding. Peptides 2004, 25:307-314.
352. Taheri S., Gardiner J., Hafizi S., Murphy K., Dakin C., Seal L., Small C., Ghatei M., Bloom S. Orexin A immunoreactivity and preproorexin mRNA in the brain of Zucker and WKY rats. Neuroreport 2001, 12:459-464.
353. Takekawa S., Asami A., Ishihara Y., Terauchi J., Kato K., Shimomura Y., Mori M., Murakoshi H., Kato K., Suzuki N., Nishimura O., Fujino M. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur. J. Pharmacol. 2002, 438:129-135.
354. Takenoya F., Hirayama M., Kageyama H., Funahashi H., Kita T., Matsumoto H., Ohtaki T., Katoh S., Takeuchi M., Shioda S. Neuronal interactions between galanin-like-peptide- and orexinor melanin-concentrating hormone-containing neurons. Regul. Pept. 2005, 126:79-83.
355. Tan C.P., Sano H., Iwaasa H., Pan J., Sailer A.W., Hreniuk D.L., Feighner S.D., Palyha O.C., Pong S.S., Figueroa D.J., Austin C.P., Jiang M.M., Yu H., Ito J., Ito M., Guan X.M., MacNeil D.J., Kanatani A., VanderPloeg L.H.T., Howard A.D. Melanin-concentrating hormone receptor subtypes 1 and 2: Species-specific gene expression. Genomics 2002, 79:785-792.
356. Tempel D.L., Leibowitz S.F. Diurnal variations in the feeding responses to norepinephrine, neuropeptide-Y and galanin in the PVN. Brain Res. Bull. 1990, 25:821-825.
357. Tempel D.L., Shor-Posner G., Dwyer D., Leibowitz S.F. Nocturnal patterns of macronutrient intake in freely feeding and food-deprived rats. Am. J. Physiol. 1989, 256:R541-R548.
358. Thompson R.H., Canteras N.S., Swanson L.W. Organization of projections from the dorsomedial nucleus of the hypothalamus: a PHA-I study in the rat. J. Comp. Neurol. 1996, 376:143-173.
359. Thorpe A.J., Kotz C.M. Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Res 2005, 1050:156-162.
360. Tortoriello D.V., McMinn J., Chua S.C. Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice. Endocrinology 2004, 145:1238-1247.
361. Tritos N.A., Elmquist J.K., Mastaitis J.W., Flier J.S., Maratos-Flier E. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoterdriven diphtheria toxin A) mice. Endocrinology 1998, 139:4634-4641.
362. Tritos N.A., Vicent D., Gillette J., Ludwig D.S., Flier E.S., Maratos-Flier E. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes 1998, 47:1687-1692.
363. Tritos N.A., Mastaitis J.W., Kokkotou E., Maratos-Flier E. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res. 2001, 895:160-166.
364. Trivedi P., Yu H., MacNeil D., VanderPloeg L.H.T., Guan X.M. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 1998, 438:71-75.
365. Truett G.E., Bahary N., Friedman J.M., Leibel R.L. Rat obesity gene fatty (fa)maps to chromosome 5-Evidence for homology with the mouse gene diabetes (db). Proc. Natl Acad. Sci. U.S.A. 1991, 88:7806-7809.
366. Turnbull A.V., Ellershaw L., Masters D.I., Birtles S., Boyer S., Carroll D., Clarkson P., Loxham S.J.G., McAulay P., Teague J.L., Foote K.M., Pease J.E., Block M.H. Selective antagonism of the NPYY5 receptor does not have a major effect on feeding in rats. Diabetes 2002, 51:2441-2449.
367. van den Pol A.N., Patrylo P.R., Ghosh P.K., Gao X.B. Lateral hypothalamus: Early developmental expression and response to hypocretin (Orexin). J. Comp. Neurol. 2001, 433:349-363.
368. van Houten M., Posner B., Kopriwa B., Brawer J.R. Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus. Science 1980, 207:1081-1083.
369. Velkoska E., Cole T.J., Morris M.J. Early dietary intervention: long-term effects on blood pressure, brain neuropeptide Y, and adiposity markers. Am. J. Physiol. 2005, 288:E1236-E1243.
370. Walter M.J., Scherrer J.E., Flood J.F., Morley J.E. Effects of localized injections of neuropeptide Y antibody on motor activity and other behaviors. Peptides 1994, 15:607-613.
371. Wang C.F., Kotz C.M. Urocortin in the lateral septal area modulates feeding induced by orexin A in the lateral hypothalamus. Am. J. Physiol. 2002, 283:R358-R367.
372. Wang S.K., Behan J., ONeill K., Weig B., Fried S., Laz T., Bayne M., Gustafson E., Hawes B.E. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. J. Biol. Chem. 2001, 276:34664-34670.
373. Warwick Z.S., Schiffman S.S. Role of dietary fat in calorie intake and weight gain. Neurosci. Biobehav. Rev. 1992, 16:585-596.
374. Welch C.C., Grace M.K., Billington C.J., Levine A.S. Preference and diet type affect macronutrient selection after morphine, NPY, norepinephrine, and deprivation. Am. J. Physiol. 1994, 266:R426-R433.
375. White B.D., He B., Dean R.G., Martin R.J. Low protein diets increase neuropeptide Y gene expression in the basomedial hypothalamus of rats. J. Nutr. 1994, 124:1152-1160.
376. White J.D., Kershaw M. Increased hypothalamic neuropeptide Y expression following food deprivation. Mol. Cell. Neurosci. 1990, 1:41-48.
377. Widdowson P.S. Quantitative receptor autoradiography demonstrates a differential distribution of neuropeptide-Y Y-1 and Y-2 receptor subtypes in human and rat brain. Brain Res. 1993, 631:27-38.
378. Widdowson P.S. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 "feeding" receptor. Brain Res. 1997, 758:17-25.
379. Widdowson P.S., Upton R., Henderson L., Buckingham R., Wilson S., Williams G. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res. 1997, 774:1-10.
380. Widdowson P.S., Henderson L., Pickavance L., Buckingham R., Tadayyon M., Arch J.R.S., Williams G. Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW1229U91, on the consumption of highly palatable energy-rich diet. Peptides 1999, 20:367-372.
381. Wieland H.A., Willim K.D., Entzeroth M., Wienen W., Rudolf K., Eberlein W., Engel W., Doods H.N. Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J. Pharmacol. Exp. Ther. 1995, 275:143-149.
382. Wieland H.A., Engel W., Eberlein W., Rudolf K., Doods H.N. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br. J. Pharmacol. 1998, 125:549-555.
383. Wilding J.P.H., Gilbey S.G., Bailey C.J., Batt R.A., Williams G., Ghatei M.A., Bloom S.R. Increased neuropeptide-Y messenger ribonucleic acid (messenger RNA) and decreased neurotensin messenger RNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 1993, 132:1939-1944.
384. Wyss P., Levens N., Stricker-Krongrad A. Stimulation of feeding in lean but not in obese Zucker rats by a selective neuropeptide Y Y5 receptor agonist. Neuroreport 1998, 9:2675-2677.
385. Wyss P., Stricker-Krongrad A., Brunner L., Miller J., Crossthwaite A., Whitebread S., Criscione L. The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regul. Pept. 1998, 75-6:363-371.
386. Xin X.G., Huang X.F. Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain. Neuroreport 1998, 9:737-741.
387. Xu B., Li B.H., Rowland N.E., Kalra S.P. Neuropeptide Y injection into the fourth cerebroventricle stimulates c-fos expression in the paraventricular nucleus and other nuclei in the forebrain: effect of food consumption. Brain Res. 1995, 698:227-231.
388. Yamamoto Y., Ueta Y., Date Y., Nakazato M., Hara Y., Serino R., Nomura M., Sibuya I., Matsukura S., Yamashita H. Down regulation of the prepro-orexin gene expression in genetically obese mice. Mol. Brain Res. 1999, 65:14-22.
389. Yamamoto Y., Ueta Y., Serino R., Nomura M., Shibuya I., Yamashita H. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice. Brain Res. Bull. 2000, 51:515-521.
390. Yamamoto Y., Ueta Y., Hara Y., Serino R., Nomura M., Shibuya I., Shirahata A., Yamashita H. Postnatal development of orexin/hypocretin in rats. Mol. Brain Res. 2000, 78:108-119.
391. Yamamoto Y., Ueta Y., Yamashita H., Asavama K., Shirahata A. Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat. Peptides 2002, 23:1689-1696.
392. Yamanaka A., Kunii K., Nambu T., Tsujino N., Sakai A., Matsuzaki I., Miwa Y., Goto K., Sakurai T. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res. 2000, 859:404-409.
393. Yang B., Samson W.K., Ferguson A.V. Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C. J. Neurosci 2003, 23:6215-6222.
394. Yokosuka M., Dube M.G., Kalra P.S., Kalra S.P. The mPVN mediates blockade of NPY-induced feeding by a Y5 receptor antagonist: a c-FOS analysis. Peptides 2001, 22:507-514.
395. Zhang J., Ren P., Avsian-Kretchmer O., Luo C., Rauch R., Klein C., Hsueh A. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 2005, 310:996-999.
396. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
397. Zheng H.Y., Corkern M., Stoyanova I., Patterson L.M., Tian R., Berthoud H.R. Peptides that regulate food intake-Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons. Am. J. Physiol. 2003, 284:R1436-R1444.
398. Zheng H.Y., Patterson L.M., Berthoud H.R. Orexin-A projections to the caudal medulla and orexin-induced c-fos expression, food intake, and autonomic function. J. Comp. Neurol. 2005, 485:127-142.
399. Zukowska Z., Pons J., Lee E., Li L.J. Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system?. Can J. Physiol. Pharmacol. 2003, 81:89-94.