Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 286, Issue 4 49-4, 2004, Pages

  Kiwaki, Kohji ^a   Kotz, Catherine M ^b,c,d   Wang, Chuanfeng ^b   Lanningham Foster, Lorraine ^a   Levine, James A ^a,c,e  

^a MAYO CLINIC   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c University of Minnesota   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e MAYO CLINIC ROCHESTER   (United States)

Author keywords

Energy expenditure; Hypothalamus; Nonexercise activity thermogenesis; Obesity

Indexed keywords

CARBON DIOXIDE; OREXIN A; OXYGEN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIMETRY; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FEEDING BEHAVIOR; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LIGHT DARK CYCLE; MALE; NIGHT VISION; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RAT; THERMOGENESIS; VIDEORECORDING;

ANIMALS; BENZOXAZOLES; CALORIMETRY, INDIRECT; CARBON DIOXIDE; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; MOTOR ACTIVITY; NEUROPEPTIDES; OXYGEN CONSUMPTION; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; THERMOGENESIS; UREA;

EID: 1642395090     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00126.2003     Document Type: Article

References (69)

1. Anonymous. Surgeon general's report on physical activity and health. From the Centers for Disease Control and Prevention. JAMA 276: 522, 1996.
2. Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, and Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord 26: 274-276, 2002.
3. Bertile F, Oudart H, Criscuolo F, Maho YL, and Raclot T. Hypothalamic gene expression in long-term fasted rats: relationship with body fat. Biochem Biophys Res Commun 303: 1106-13, 2003.
4. Bray GA, Bouchard C, and James WPT. Handbook of Obesity. New York: Dekker, 1998.
5. Brownlow BS, Petro A, Feinglos MN, and Surwit RS. The role of motor activity in diet-induced obesity in C57B1/6J mice. Physiol Behav 60: 37-41, 1996.
6. Cai XJ, Lister CA, Buckingham RE, Pickavance L, Wilding J, Arch JR, Wilson S, and Williams G. Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and Zucker diabetic fatty rats and effects of rosiglitazone. Brain Res Mol Brain Res 77: 131-137, 2000.
7. Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98: 437-451, 1999.
8. Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, and Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 96: 748-753, 1999.
9. Diano S, Horvath B, Urbanski HF, Sotonyi P, and Horvath TL. Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets. Endocrinology 144: 3774-3778, 2003.
10. Dube MG, Kalra SP, and Kalra PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842: 473-477, 1999.
11. Duxon MS, Stretton J, Starr K, Jones DN, Holland V, Riley G, Jerman J, Brough S, Smart D, Johns A, Chan W, Porter RA, and Upton N. Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology (Berl) 153: 203-209, 2001.
12. Edwards CM, Abusnana S, Sunter D, Murphy KG, Ghatei MA, and Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 160: R7-R12, 1999.
13. Espana RA, Baldo BA, Kelley AE, and Berridge CW. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 106: 699-715, 2001.
14. Espana RA, Plahn S, and Berridge CW. Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin. Brain Res 943: 224-236, 2002.
15. Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, and Scammell TE. Fos expression in orexin neurons varies with behavioral state. J Neurosci 21: 1656-1662, 2001.
16. Gispen WH and Isaacson RL. ACTH-induced excessive grooming in the rat. Pharmacol Ther 12: 209-246, 1981.
17. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, and Upton N. Orexin a activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96: 10911-10916, 1999.
18. Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, and Sakurai T. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30: 345-354, 2001.
19. Haynes AC, Jackson B, Chapman H, Tadayyon M, Johns A, Porter RA, and Arch JR. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96: 45-51, 2000.
20. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M, and Arch JR. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20: 1099-1105, 1999.
21. Ida T, Nakahara K, Katayama T, Murakami N, and Nakazato M. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res 821: 526-529, 1999.
22. Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, and Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 270: 318-323, 2000.
23. Jaszberenyi M, Bujdoso E, Pataki I, and Telegdy G. Effects of orexins on the hypothalamic-pituitary-adrenal system. J Neuroendocrinol 12: 1174-1178, 2000.
24. Jones DN, Gartlon J, Parker F, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Hatcher JP, Johns A, Porter RA, Hagan JJ, Hunter AJ, and Upton N. Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity. Psychopharmacology (Berl) 153: 210-218, 2001.
25. Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, and Kaira PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20: 68-100, 1999.
26. Kastin AJ and Akerstrom V. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J Pharmacol Exp Ther 289: 219-223, 1999.
27. Kiyashchenko LI, Mileykovskiy BY, Maidment N, Lam HA, Wu MF, John J, Peever J, and Siegel JM. Release of hypocretin (orexin) during waking and sleep states. J Neurosci 22: 5282-5286, 2002.
28. Kotz CM, Glass MJ, Levine AS, and Billington CJ. Regional effect of naltrexone in the nucleus of the solitary tract in blockade of NPY-induced feeding. Am J Physiol Regul Integr Comp Physiol 278: R499-R503, 2000.
29. Kotz CM, Teske JA, Levine JA, and Wang C. Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul Pept 104: 27-32, 2002.
30. Krahn DD, Gosnell BA, Levine AS, and Morley JE. Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 443: 63-69, 1988.
31. Kuru M, Ueta Y, Serino R, Nakazato M, Yamamoto Y, Shibuya I, and Yamashita H. Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport 11: 1977-1980, 2000.
32. Levine JA, Eberhardt NL, and Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283: 212-214, 1999.
33. Levine JA, Nygren J, Short KR, and Nair KS. Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats. J Appl Physiol 94: 165-170, 2003.
34. Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, de Jong PJ, Nishino S, and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-376, 1999.
35. Lubkin M and Stricker-Krongrad A. Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun 253: 241-245, 1998.
36. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, and Elmquist JK. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435: 6-25, 2001.
37. Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, and Goto K. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett 264: 101-104, 1999.
38. Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, and Sakurai T. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res 873: 181-187, 2000.
39. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, and Goto K. Distribution of orexin neurons in the adult rat brain. Brain Res 827: 243-260, 1999.
40. Nicholson C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res 333: 325-329, 1985.
41. Nishino S, Ripley B, Overeem S, Lammers GJ, and Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355: 39-40, 2000.
42. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates. Orlando, FL: Academic, 1997.
43. Peng MT and Kang M. Circadian rhythms and patterns of running-wheel activity, feeding and drinking behaviors of old male rats. Physiol Behav 33: 615-620, 1984.
44. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, and Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10015, 1998.
45. Phillips-Singh D, Li Q, Takeuchi S, Ohkubo T, Sharp PJ, and Boswell T. Fasting differentially regulates expression of agouti-related peptide, pro-opiomelanocortin, prepro-orexin, and vasoactive intestinal polypeptide mRNAs in the hypothalamus of Japanese quail. Cell Tissue Res 313: 217-225, 2003.
46. Picker MJ, Allen RM, Morgan D, Levine AS, O'Hare E, and Cleary JP. Effects of neuropeptide Y on the discriminative stimulus and antinociceptive properties of morphine. Pharmacol Biochem Behav 64: 161-164, 1999.
47. Piper DC, Upton N, Smith MI, and Hunter AJ. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur J Neurosci 12: 726-730, 2000.
48. Pu S, Jain MR, Kalra PS, and Kalra SP. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Regul Pept 78: 133-136, 1998.
49. Rising R, Harper IT, Fontvielle AM, Ferraro RT, Spraul M, and Ravussin E. Determinants of total daily energy expenditure: variability in physical activity. Am J Clin Nutr 59: 800-804, 1994.
50. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585, 1998.
51. Samson WK, Gosnell B, Chang JK, Resch ZT, and Murphy TC. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 831: 248-253, 1999.
52. Samson WK, Taylor MM, Follwell M, and Ferguson AV. Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates. Regul Pept 104: 97-103, 2002.
53. Siegel JM. Narcolepsy: a key role for hypocretins (orexins). Cell 98: 409-412, 1999.
54. Stricker-Krongrad A, Richy S, and Beck B. Orexins/hypocretins in the ob/ob mouse: hypothalamic gene expression, peptide content and metabolic effects. Regul Pept 104: 11-20, 2002.
55. Swanson LW, Sawchenko PE, and Lind RW. Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response. Prog Brain Res 68: 169-190, 1986.
56. Sweet DC, Levine AS, Billington CJ, and Kotz CM. Feeding response to central orexins. Brain Res 821: 535-538, 1999.
57. Taheri S, Gardiner J, Hafizi S, Murphy K, Dakin C, Seal L, Small C, Ghatei M, and Bloom S. Orexin A immunoreactivity and preproorexin mRNA in the brain of Zucker and WKY rats. Neuroreport 12: 459-464, 2001.
58. Takahashi N, Okumura T, Yamada H, and Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 254: 623-627, 1999.
59. Terao A, Apte-Deshpande A, Morairty S, Freund YR, and Kilduff TS. Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain. Neurosci Lett 332: 190-194, 2002.
60. Thorpe AJ, Mullet MA, Wang CF, and Kotz CM. Regional, metabolic and circadian specificity of lateral hypothalamus orexin A feeding stimulation. Am J Physiol Regul Integr Comp Physiol 284: R1409-R1417, 2003.
61. Tritos NA, Mastaitis JW, Kokkotou E, and Maratos-Flier E. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res 895: 160-166, 2001.
62. Trivedi P, Yu H, MacNeil DJ, Van der Ploeg LH, and Guan XM. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 438: 71-75, 1998.
63. Webb P, Annis JF, and Troutman SJ Jr. Energy balance in man measured by direct and indirect calorimetry. Am J Clin Nutr 33: 1287-1298, 1980.
64. Wortley KE, Chang GQ, Davydova Z, and Leibowitz SF. Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. Am J Physiol Regul Integr Comp Physiol 284: R1454-R1465, 2003.
65. Wu MF, John J, Maidment N, Lam HA, and Siegel JM. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol Regul Integr Comp Physiol 283: R1079-R1086, 2002.
66. Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, and Sakurai T. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38: 701-713, 2003.
67. Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, and Goto K. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 849: 248-252, 1999.
68. Yamamoto Y, Ueta Y, Date Y, Nakazato M, Hara Y, Serino R, Nomura M, Shibuya S, Matsukura S, and Yamashita H. Down regulation of the prepro-orexin gene expression in genetically obese mice. Brain Res Mol Brain Res 65: 14-22, 1999.
69. Yamamoto Y, Ueta Y, Serino R, Nomura M, Shibuya I, and Yamashita H. Effects of food restriction on the hypothalamic prepro-orexin gene expression in genetically obese mice. Brain Res Bull 51: 515-521, 2000.