Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons

Physiology and Behavior

Volumn 71, Issue 3-4, 2000, Pages 251-261

  Shiraishi, Takemasa ^a   Oomura, Yutaka ^b,d   Sasaki, Kazuo ^c   Wayner, Matthew J ^d  

^a TOKAI UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

Food intake; Glucoreceptor neurons; Glucose sensitive neurons; Leptin; LHA; Orexin; PVN; VMH

Indexed keywords

GLUCORECEPTOR; LEPTIN; LEPTIN RECEPTOR; OREXIN A; OREXIN RECEPTOR; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTERIOR HYPOTHALAMUS; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FOOD INTAKE; HORMONE ACTION; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY; THALAMUS VENTRAL NUCLEUS; TISSUE DISTRIBUTION;

EID: 0034319213     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(00)00341-3     Document Type: Article

References (74)

1. Effect of leptin on glucoreceptor neurons (GRNs) in the rat ventromedial hypothalamus (VMH)
2. The stomach is a source of leptin
3. The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism
4. The lateral hypothalamic area revisited: Ingestive behavior
5. The dorsomedial hypothalamic nucleus revisited: 1998 update
6. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells from distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
7. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
8. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
9. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
10. Corticotropin-releasing hormone decreases feeding, oxygen consumption and activity of genetically obese (ob/ob) and lean mice
11. Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action
12. Leptin activates hypothalamic CART neurons projecting to the spinal cord
13. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
14. Unraveling the central nervous system pathways underlying responses to leptin
15. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
16. Alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression
17. Independent glucose effects on rat hypothalamic neurons: An in vitro study
18. A novel endogenous sugar acid depolarizes ventromedial hypothalamic neurons in vitro
19. The effect of leptin on feeding-regulating neurons in the rat hypothalamus
20. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
21. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight
22. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
23. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
24. Central action of acidic fibroblast growth factor in feeding regulation
25. Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial
26. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
27. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
28. Central action of glucagon in the rat hypothalamus
29. Complex attributes of lateral hypothalamic neurons in the regulation of feeding of alert rhesus monkeys
30. Complex functional attributes of amygdaloid gustatory neurons in the rhesus monkey
31. An HRP study of the afferent connections to rat medial hypothalamic region
32. Hypothalamic CART is a new anorectic peptide regulated by leptin
33. ATP channels composed of Kir6.1 and SUR1 subunits
34. Influence of acetylcholine on neuronal activity of monkey amygdala during bar press feeding behavior
35. Fibroblast growth factor-1 in the lateral hypothalamic area regulates food intake
36. Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1
37. Neurotransmitters, neuropeptides and binding sites in the rat mediobasal hypothalamus: Effects of monosodium glutamate (MSG) lesions
38. Direct effects of 3,4-dihydroxybutanoic acid gamma-lactone and 2,4,5-trihydroxypentanoic acid gamma-lactone on lateral and ventromedial hypothalamic neurons
39. 17 β-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP
40. Electrophysiological properties and glucose responsiveness of guinea-pig ventromedial hypothalamic neurons in vitro
41. Gold-thioglucose (GTG) reduces hypothalamic proopiomelanocortin (POMC) mRNA correlated with body weight gain and impaired sensitivity
42. Congenital leptin deficiency is associated with severe early-onset obesity in humans
43. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia
44. Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y
45. Distribution of orexin neurons in the adult rat brain
46. Regulation of feeding by neural responses to endogenous factors
47. Endogenous chemical sense in control of feeding
48. Effect of free fatty acid on the rat lateral hypothalamic neurons
49. Taste and olfactory modulation of feeding related neurons in behaving monkey
50. Glucose inhibition of the glucose-sensitive neurone in the rat lateral hypothalamus
51. New brain glucosensory and its physiological significance
52. Neurons containing hypocretin (orexin) project to multiple neuronal systems
53. Leptin receptor missense mutation in the fatty Zucker rat
54. A role for melanin-concentrating hormone in the central regulation of feeding behaviour
55. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
56. Effects of leptin and orexin-A on the neuronal activity of the arcuate nucleus (ARC) in rats
57. Effects of leptin and neuropeptide-Y (NPY) on rat arcuate neurons
58. Effect of acidic fibroblast growth factor on neuronal activity of the parvocellular part in rat paraventricular nucleus
59. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
60. Melanocortin receptors in leptin effects
61. Modulation of feeding by endogenous sugar acids acting as hunger or satiety factors
62. Calcitonin-induced anorexia in rats: Evidence for its inhibitory action on lateral hypothalamic chemosensitive neurons
63. Immunohistochemical localization of leptin receptor in the rat brain
64. Gastric related properties of rat paraventricular neurons
65. Leptin effects on feeding-related hypothalamic and peripheral neuronal activities in normal and obese rats
66. Lateral hypothalamus neuron responses to electroosmotic 2-deoxy-D-glucose
67. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
68. Feeding response to central orexins
69. Distribution of orexin receptor mRNA in the rat brain
70. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
71. The relationship of tissue localization, distribution and turnover to feeding after intraperitoneal 125I-leptin administration in ob/ob and db/db mice
72. Localization of FGF receptor mRNA in the adult central nervous system by in situ hybridization
73. Specificity of behavioral regulation