Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight

Endocrinology

Volumn 138, Issue 1, 1997, Pages 351-355

  Rossi, M ^a   Choi, S J ^a   O'Shea, D ^a   Miyoshi, T ^a   Ghatei, M A ^a   Bloom, S R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIURESIS; FEEDING BEHAVIOR; FOOD INTAKE; GENE EXPRESSION; IMMUNOREACTIVITY; MALE; NEUROTRANSMISSION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

EID: 0031023301     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.1.4887     Document Type: Article

References (20)

1. Vaughan JM, Fischer WH, Hoeger C, Rivier J, Vale W 1989 Characterization of melanin-concentrating hormone from rat hypothalamus. Endocrinology 125:1660-1665
2. Presse F, Nahon JL, Fischer WH, Vale W 1990 Structure of the human melanin concentrating hormone mRNA. Mol Endocrinol 4:632-637
3. Kawauchi H, Kawazoe I, Tsubokawa M, Kishida M, Baker BI 1983 Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 305:321-323
4. Skofitsch G, Jacobowitz DM, Zamir N 1985 Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain. Brain Res Bull 15:635-649
5. Fellmann D, Bugnon C, Risold PY 1987 Unrelated peptide immunoreactivities coexist in neurons of the rat lateral dorsal hypothalamus: human growth hormone-releasing factor1-37-, salmon melanin-concentrating hormone- and alpha-melanotropin-like substances. Neurosci Lett 74:275-280
6. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE 1992 The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 319:218-245
7. Sekiya K, Ghatei MA, Lacoumenta S, Burnet PW, Zamir N, Burrin JM, Polak JM, Bloom SR 1988 The distribution of melanin-concentrating hormone-like immunoreactivity in the central nervous system of rat, guinea-pig, pig and man. Neuroscience 25:925-930
8. Nahon JL, Presse F, Bittencourt JC, Sawchenko PE, Vale W 1989 The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Endocrinology 125:2056-2065
9. Parkes D, Vale W 1992 Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells. Endocrinology 131:1826-1831
10. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes MF, Przypek J, Kanarek R, Maratos-Filer E 1996 A role for melanin-concentrating hormone in the regulation of feeding behaviour. Nature 380:243-246
11. Presse F, Sorokovsky I, Max JP, Nicoladis S, Nahon JL 1996 Melanin-concentrating hormone is a potent anorectic peptide regulated by food deprivation and glucopenia in the rat. Neuroscience 71:735-745
12. Jezova D, Bartanusz V, Westergren I, Johansson BB, Rivier J, Vale W, Rivier C 1992 Rat melanin-concentrating hormone stimulates adrenocorticotropin secretion: evidence for a site of action in brain regions protected by the blood-brain barrier. Endocrinology 130:1024-1029
13. Bluet Pajot MT, Presse F, Voko Z, Hoeger C, Mounier F, Epelbaum J, Nahon JL 1995 Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat. J Neuroendocrinol 7:297-303
14. Presse F, Nahon JL 1993 Differential regulation of melanin-concentrating hormone gene expression in distinct hypothalamic areas under osmotic stimulation in rat. Neuroscience 55:709-720
15. Zamir N, Skofitsch G, Bannon MJ, Jacobowitz DM 1986 Melanin-concentrating hormone: unique peptide neuronal system in the rat brain and pituitary gland. Proc Natl Acad Sci USA 83:1528-1531
16. Parkes DG 1996 Diuretic and natriuretic actions of melanin concentating hormone in conscious sheep. J Endocrinol 8:57-63
17. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides 7:1189-1192
18. Smith BK, York DA, Bray GA 1994 Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 15:1267-1272
19. Akabayashi A, Koenig JI, Watanabe Y, Alexander JT, Leibowitz SF 1994 Galanin-containing neurons in the paraventricular nucleus: a neurochemical marker for fat ingestion and body weight gain. Proc Natl Acad Sci USA 91:10375-10379
20. Drozdz R, Siegrist W, Baker BI, Chluba de Tapia J, Eberle AN 1995 Melanin-concentrating hormone binding to mouse melanoma cells in vitro. FEBS Lett 359:199-202