T-226296: A novel, orally active and selective melanin-concentrating hormone receptor antagonist

European Journal of Pharmacology

Volumn 438, Issue 3, 2002, Pages 129-135

  Takekawa, Shiro ^a   Asami, Asano ^a   Ishihara, Yuji ^b   Terauchi, Jun ^b   Kato, Kaneyoshi ^b   Shimomura, Yukio ^a   Mori, Masaaki ^a   Murakoshi, Hitomi ^c   Kato, Koki ^c   Suzuki, Nobuhiro ^a   Nishimura, Osamu ^a   Fujino, Masahiko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Medicinal Chemistry Research Laboratories II   (Japan)

^c Pharmaceutical Research Laboratories II   (Japan)

Author keywords

(MCH) melanin concentrating hormone; Food intake; Obesity; Receptor antagonist; SLC 1 receptor

Indexed keywords

ARACHIDONIC ACID; CALCIUM ION; CARRIER PROTEIN; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; ION CHANNEL; MELANIN CONCENTRATING HORMONE; N (6 DIMETHYLAMINOMETHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHYL) 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; N [6 (DIMETHYLAMINO)METHYL 5,6,7,8 TETRAHYDRO 2 NAPHTHALENYL] 4' FLUORO 1,1' BIPHENYL 4 CARBOXAMIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FOOD INTAKE; HUMAN; MALE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY;

ADMINISTRATION, ORAL; ANIMALS; ARACHIDONIC ACID; BIPHENYL COMPOUNDS; CALCIUM; CHO CELLS; CRICETINAE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; HYPOTHALAMIC HORMONES; INJECTIONS, INTRAVENTRICULAR; IODINE RADIOISOTOPES; MALE; MELANINS; NAPHTHALENES; PEPTIDE FRAGMENTS; PITUITARY HORMONES; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PITUITARY HORMONE;

EID: 18344363180     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01314-6     Document Type: Article

References (30)

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