Characterisation of the binding of [ 3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

British Journal of Pharmacology

Volumn 141, Issue 2, 2004, Pages 340-346

  Langmead, Christopher J ^a   Jerman, Jeffrey C ^a   Brough, Stephen J ^a   Scott, Claire ^a   Porter, Rod A ^a   Herdon, Hugh J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

3H SB 674042; Hypocretin; Orexin; Radioligand binding; SB 334867; SB 408124; SB 410220

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 1 (5,8 DIFLUOROQUINOLIN 4 YL) 3 (4 DIMETHYLAMINOPHENYL)UREA; 1 (6,8 DIFLUORO 2 METHYL 4 QUINOLINYL) 3 (4 DIMETHYLAMINOPHENYL)UREA; 1 (6,8 DIFLUORO 2 METHYLQUINOLIN 4 YL) 3 (4 DIMETHYLAMINOPHENYL)UREA; 1 [5 (2 FLUOROPHENYL) 2 METHYLTHIAZOL 4 YL] 1 [2 (5 PHENYL(1,3,4)OXADIAZOL 2 YLMETHYL)PYRROLIDIN 1 YL]METHANONE; BLOCKING AGENT; NONPEPTIDE BLOCKING AGENT; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; RECEPTOR PROTEIN; SB 410220; SB 674042; UNCLASSIFIED DRUG; 1 (2 METHYLBENZOXAZOL 6 YL) 3 (1,5)NAPHTHYRIDIN 4 YL UREA; 1-(2-METHYLBENZOXAZOL-6-YL)-3-(1,5)NAPHTHYRIDIN-4-YL UREA; BENZOXAZOLE DERIVATIVE; DRUG DERIVATIVE; G PROTEIN COUPLED RECEPTOR; NEUROPEPTIDE RECEPTOR; OREXIN RECEPTORS; PYRROLIDINE DERIVATIVE; SB674042; THIAZOLE DERIVATIVE; TRITIUM; UREA;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM MOBILIZATION; CELL ASSAY; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BLOCKING; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

ANIMALS; BENZOXAZOLES; CHO CELLS; CRICETINAE; HUMANS; PROTEIN BINDING; PYRROLIDINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; THIAZOLES; TRITIUM; UREA;

EID: 1342322672     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705610     Document Type: Article

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