Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4746-4749

  Palani, Anandan ^a   Shapiro, Sherry ^a   McBriar, Mark D ^a   Clader, John W ^a   Greenlee, William J ^a   Spar, Brian ^a   Kowalski, Timothy J ^a   Farley, Constance ^a   Cook, John ^a   Van Heek, Margaret ^a   Weig, Blair ^a   O'Neill, Kim ^a   Graziano, Michael ^a   Hawes, Brian ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE; MELANIN CONCENTRATING HORMONE RECEPTOR BLOCKING AGENT; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FEMALE; FOOD INTAKE; MOUSE; NONHUMAN; OBESITY; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CALCIUM; CELLS, CULTURED; CHRONIC DISEASE; HUMANS; OBESITY; RATS; RECEPTORS, SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 22744433849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0503852     Document Type: Article

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