NPY-induced feeding: Pharmacological characterization using selective opioid antagonists and antisense probes in rats

Peptides

Volumn 26, Issue 7, 2005, Pages 1167-1175

  Israel, Y ^a   Kandov, Y ^a   Khaimova, E ^a   Kest, A ^a   Lewis, S R ^a   Pasternak, G W ^b   Pan, Y X ^b   Rossi, G C ^c   Bodnar, R J ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c LONG ISLAND UNIVERSITY   (United States)

Author keywords

Funaltrexamine; opioid receptor; opioid receptor; opioid receptor; Naltrexone; Naltrindole; Nor binaltorphamine

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; BETA FUNALTREXAMINE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALTREXONE; NALTRINDOLE; NEUROPEPTIDE Y; NORBINALTORPHIMINE; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EXON; FEEDING BEHAVIOR; MALE; NONHUMAN; NUCLEIC ACID PROBE; PRIORITY JOURNAL; RAT;

ANIMALS; APPETITE REGULATION; BEHAVIOR, ANIMAL; FEEDING BEHAVIOR; MALE; NARCOTIC ANTAGONISTS; NEUROPEPTIDE Y; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 20444428364     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.01.017     Document Type: Article

References (71)

1. A. Akabayashi, C. Wahlestedt, J.T. Alexander, and S.F. Leibowitz Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion Mol Brain Res 21 1994 55 61
2. A. Akabayashi, C.T. Zaia, I. Silva, H.J. Chae, and S.F. Leibowitz Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose utilization Brain Res 621 1993 343 348
3. D. Arjune, and R.J. Bodnar Suppression of nocturnal, palatable and glucoprivic intake in rats by the kappa opioid antagonist, nor-binaltorphamine Brain Res 534 1990 313 316
4. D. Arjune, W.D. Bowen, and R.J. Bodnar Ingestive behavior following central [D-Ala2,Leu5,Cys6]-enkephalin (DALCE), a short-acting agonist and long-acting antagonist at the delta opioid receptor Pharmacol Biochem Behav 39 1991 429 436
5. D. Arjune, K.M. Standifer, G.W. Pasternak, and R.J. Bodnar Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions Brain Res 535 1990 101 109
6. F.L. Bai, M. Yamano, Y. Shiotani, P.C. Emson, A.D. Smith, and J.F. Powell An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat Brain Res 331 1985 172 175
7. C.J. Billington, J.E. Briggs, S. Harker, M. Grace, and A.S. Levine Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism Am J Physiol 266 1994 R1765 R1770
8. R.J. Bodnar Endogenous opioids and feeding behavior: a thirty-year historical perspective Peptides 25 2004 697 725
9. C. Broberger, J. Johansen, C. Johansson, M. Schalling, and T. Hokfelt The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice Proc Natl Acad Sci USA 95 1998 15043 15048
10. K.S. Brown, R.M. Gentry, and N.E. Rowland Central injection in rats of alpha-melanocyte stimulating hormone analog: effects on food intake and brain Fos Regul Pept 78 1998 89 94
11. S. Brugman, D.J. Clegg, S.C. Woods, and R.J. Seeley Combined blockade of both micro- and kappa-opioid receptors prevents the acute orexigenic action of Agouti-related protein Endocrinology 143 11 2002 4265 4270
12. K. Burdick, W.-Z. Yu, A. Ragnauth, M. Moroz, Y.X. Pan, and G.C. Rossi Antisense mapping of opioid receptor clones: effects upon 2-deoxy-d-glucose- induced hyperphagia Brain Res 794 1998 359 363
13. J.T. Clark, P.S. Kalra, W.R. Crowley, and S.P. Kalra Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats Endocrine 115 1984 427 429
14. M.A. Cowley, J.L. Smart, M. Rubinstein, M.G. Cerdan, S. Diano, and T.L. Horvath Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 411 2001 480 484
15. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385 1997 165 168
16. S.Q. Giraudo, C.J. Billington, and A.S. Levine Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the central nucleus of the amygdala and in the paraventricular nucleus in the rat Brain Res 782 1998 18 23
17. S.Q. Giraudo, C.J. Billington, and A.S. Levine Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands Brain Res 809 1998 302 306
18. S.Q. Giraudo, M.K. Grace, C.J. Billington, and A.S. Levine Differential effects of neuropeptide Y and the mu-agonist DAMGO on 'palatability' vs. 'energy' Brain Res 834 1999 160 163
19. L. Grandison, and A. Guidotti Stimulation of food intake by muscimol and beta-endorphin Neuropharmacology 16 1977 533 536
20. H.J. Grill, A.B. Ginsberg, R.J. Seeley, and J.M. Kaplan Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight J Neurosci 18 1998 10128 10135
21. H.C. Grossman, M.M. Hadjimarkou, R.M. Silva, S.Q. Giraudo, and R.J. Bodnar Interrelationships between mu opioid and melanocortin receptors in mediating food intake in rats Brain Res 991 2003 240 244
22. M.M. Hadjimarkou, E. Khaimova, Y.-X. Pan, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Feeding induced by food deprivation is differentially reduced by opioid receptor antisense oligodeoxynucleotide probes in rats Brain Res 987 2003 223 232
23. M.M. Hadjimarkou, A. Singh, Y. Kandov, Y. Israel, Y.-X. Pan, and G.C. Rossi Opioid receptor involvement in food deprivation-induced feeding: evaluation of selective antagonist and antisense oligodeoxynucleotides probe effects in mice and rats J Pharmacol Exp Ther 311 2004 1188 1202
24. M.M. Hagan, S.C. Benoit, P.A. Rushing, L.M. Pritchard, S.C. Woods, and R.J. Seeley Immediate and prolonged patterns of agouti-related peptide (83-132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites Endocrinology 142 2000 1050 1056
25. M.M. Hagan, P.A. Rushing, S.C. Benoit, S.C. Woods, and R.A. Seeley Opioid receptor involvement in the effect of AGRP (83-132) on food intake and food selection Am J Physiol 280 2001 R814 R821
26. T.M. Hahn, J.F. Breininger, D.G. Baskin, and M.W. Schwartz Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons Nat Neurosci 1 1998 271 272
27. D.C. Jewett, J. Cleary, A.S. Levine, D.W. Schaal, and T. Thompson Effects of neuropeptide Y, insulin, 2-deoxyglucose, and food deprivation on food-motivated behavior Psychopharmacology (Berl) 20 1995 267 271
28. D.C. Jewett, M.K. Grace, R.M. Jones, C.J. Billington, P.S. Portoghese, and A.S. Levine The kappa-opioid antagonist GNTI reduces U50,488-, DAMGO-, and deprivation-induced feeding, but not butorphanol- and neuropeptide Y-induced feeding in rats Brain Res 909 2001 75 80
29. S.P. Kalra, M.G. Dube, S. Pu, B. Xu, T.L. Horvath, and P.S. Kalra Interacting appetite-regulating pathways in the hypothalamic regulation of body weight Endocr Rev 20 1999 68 100
30. S.P. Kalra, and P.S. Kalra NPY - an endearing journey in search of a neurochemical on/off switch for appetite, sex and reproduction Peptides 25 2004 465 471
31. J.E. Koch, and R.J. Bodnar Selective alterations in macronutrient intake of food-deprived or glucoprivic rats by centrally-administered opioid receptor subtype antagonists in rats Brain Res 657 1994 191 201
32. C.M. Kotz, M.J. Glass, A.S. Levine, and C.J. Billington Regional effect of naltrexone in the nucleus of the solitary tract in blockade of NPY-induced feeding Am J Physiol 278 2000 R499 R503
33. C.M. Kotz, M.K. Grace, C.J. Billington, and A.S. Levine The effect of nor-binaltorphamine, beta-funaltrexamine and naltrindole on NPY-induced feeding Brain Res 631 1993 325 328
34. C.M. Kotz, M.K. Grace, J. Briggs, A.S. Levine, and C.J. Billington Effects of opioid antagonists naloxone and naltrexone on neuropeptide Y-induced feeding and brown fat thermogenesis in the rat J Clin Invest 96 1995 163 170
35. S.F. Leibowitz, and L. Hor Endorphinergic and alpha-noradrenergic systems in the paraventricular nucleus: effects on eating behavior Peptides 3 1982 421 428
36. S.F. Leibowitz, M. Xuereb, and T. Kim Blockade of natural and neuropeptide Y-induced carbohydrate feeding by a receptor antagonist PYX-2 Neuroreport 3 1992 1023 1026
37. S.F. Leibowitz, and K.E. Wortley Hypothalamic control of energy balance: different peptides, different functions Peptides 25 2004 473 504
38. L. Leventhal, J.L. Cole, G.C. Rossi, Y.X. Pan, G.W. Pasternak, and R.J. Bodnar Antisense oligodeoxynucleotides against the MOR-1 clone alter weight and ingestive responses in rats Brain Res 719 1996 78 84
39. L. Leventhal, J.P. Mathis, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia Eur J Pharmacol 349 1998 R1 R3
40. L. Leventhal, R.M. Silva, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats J Pharmacol Exp Ther 287 1998 538 544
41. L. Leventhal, L.B. Stevens, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Antisense mapping of the MOR-1 opioid receptor clone: modulation of hyperphagia induced by DAMGO J Pharmacol Exp Ther 282 1997 1402 1407
42. A.S. Levine, M. Grace, and C.J. Billington The effect of centrally administered naloxone on deprivation and drug-induced feeding Pharmacol Biochem Behav 36 1990 409 412
43. A.S. Levine, D.C. Jewett, J.P. Cleary, C.M. Kotz, and C.J. Billington Our journey with neuropeptide Y: effects on ingestive behavior and energy expenditure Peptides 25 2004 505 510
44. A.S. Levine, and J.E. Morley Neuropeptide Y: a potent inducer of consummatory behavior in rats Peptides 5 1984 1025 1029
45. P.K. Olszewski, M.M. Wirth, M.K. Grace, A.S. Levine, and S.Q. Giraudo Evidence of interactions between melanocortin and opioid systems in regulation of feeding Neuroreport 12 2001 1727 1730
46. G.W. Pasternak Incomplete cross tolerance and multiple mu opioid peptide receptors Trends Pharmacol Sci 22 2001 67 70
47. G.W. Pasternak, and Y.X. Pan Antisense mapping: assessing functional significance of genes and splice variants Methods Enzymol 314 2000 51 60
48. G.W. Pasternak, and K.M. Standifer Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology Trends Pharmacol Sci 16 1995 344 350
49. J.D. Pomonis, A.S. Levine, and C.J. Billington Interaction of the hypothalamic paraventricular nucleus and central nucleus of the amygdala in naloxone blockade of neuropeptide Y-induced feeding revealed by c-fos expression J Neurosci 17 1997 5175 5182
50. P.S. Portoghese, D.L. Larson, L.M. Sayre, D.S. Fries, and A.E. Takemori A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities J Med Chem 23 1980 233 234
51. P.S. Portoghese, A.W. Lipkowski, and A.E. Takemori Binaltorphamine and nor-binaltorphamine, potent and selective K-opioid receptor antagonists Life Sci 40 1987 1287 1292
52. P.S. Portoghese, M. Sultana, and A.E. Takemori Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist Eur J Pharmacol 146 1988 185 186
53. P.D. Raposinho, D.D. Pierroz, P. Broqua, R.B. White, T. Pedrazzini, and M.L. Aubert Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism Mol Cell Endocrinol 185 2001 195 204
54. G.C. Rossi, and G.W. Pasternak Establishing the molecular biology of opioid behavior through antisense approaches B. Weiss Antisense oligodeoxynucleotides and antisense RNA 1997 CRC Press Boca Raton, FL 115 130
55. M. Rossi, M.S. Kim, D.J.A. Morgan, C.J. Small, C.M.B. Edwards, and D. Sunter A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo Endocrinology 139 1998 4428 4431
56. J.M. Rudski, M. Grace, M.A. Kuskowski, C.J. Billington, and A.S. Levine Behavioral effects of naloxone on neuropeptide Y-induced feeding Pharmacol Biochem Behav 54 1996 771 777
57. V. Sergeyev, C. Broberger, O. Gorbatyuk, and T. Hokfelt Effect of 2-mercaptoacetate and 2-deoxy-d-glucose administration on the expression of NPY, AGRP, POMC MCH and hypocretin/orexin in the rat hypothalamus Neuroreport 11 2000 117 121
58. R.M. Silva, H.C. Grossman, M.M. Hadjimarkou, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Dynorphin A1-17-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats J Pharmacol Exp Ther 301 2002 513 518
59. R.M. Silva, M.M. Hadjimarkou, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Beta-endorphin-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats J Pharmacol Exp Ther 297 2001 590 596
60. B.G. Stanley, K.C. Anderson, M.H. Grayson, and S.F. Leibowitz Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats Physiol Behav 46 1989 173 177
61. B.G. Stanley, S.E. Kyrkouli, S. Lampert, and S.F. Leibowitz Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity Peptides 7 1986 1189 1192
62. B.G. Stanley, and S.F. Leibowitz Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus Life Sci 35 1984 2635 2642
63. B.G. Stanley, W. Magdalin, A. Seirafi, M.M. Nguyen, and S.F. Leibowitz Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect Peptides 13 1992 581 587
64. J.A. Stein, V. Znamensky, F. Baumer, G.C. Rossi, G.W. Pasternak, and R.J. Bodnar Mercaptoacetate induces feeding through central opioid-mediated mechanisms in rats Brain Res 864 2000 240 251
65. T.E. Thiele, G. van Dijk, K.A. Yagaloff, S.L. Fisher, M. Schwartz, and P. Burn Central infusion of melanocortin agonist MTII in rats: assessment of c-fos expression and taste aversion Am J Physiol 274 1998 R248 R254
66. S. Tsujii, and G.A. Bray Acetylation alters the feeding response to MSH and beta-endorphin Brain Res Bull 23 1989 165 169
67. M. Ukai, and S.G. Holtzman Effects of beta-funaltrexamine on ingestive behaviors in the rat Eur J Pharmacol 153 1988 161 165
68. J. Wang, J. Dourmashkin, R. Yun, and S.F. Leibowitz Rapid changes in hypothalamic neuropeptide Y produced by carbohydrate-rich meals that enhance corticosterone and glucose levels Brain Res 848 1999 124 136
69. G. Williams, J.A. Harrold, and D.J. Cutler The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box Proc Nutr Soc 59 2000 385 396
70. M.M. Wirth, and S.Q. Giraudo Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding Peptides 21 2000 1369 1375
71. M.M. Wirth, P.K. Olszewski, C. Yu, A.S. Levine, and S.Q. Giraudo Paraventricular hypothalamic alpha-melanocyte-stimulating hormone and MTII reduce feeding without causing aversive effects Peptides 22 2001 129 134