Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus

Neuroendocrinology

Volumn 75, Issue 1, 2002, Pages 34-44

  López, Miguel ^a   Seoane, Luisa María ^a   García, María Del Carmen ^a   Diéguez, Carlos ^a   Señarís, Rosa ^a,b  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Agouti related peptide; Feeding behavior; Melanin concentrating hormone; Neuropeptide Y; Orexin receptors; Orexins

Indexed keywords

AGOUTI RELATED PROTEIN; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; NEUROPEPTIDE Y; OREXIN A; OREXIN RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LOCOMOTION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPATHETIC FUNCTION;

ANIMALS; ARCUATE NUCLEUS; CARRIER PROTEINS; FEEDING BEHAVIOR; GENE EXPRESSION; HYPOTHALAMIC AREA, LATERAL; HYPOTHALAMIC HORMONES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANINS; NEUROPEPTIDE Y; NEUROPEPTIDES; PITUITARY HORMONES; PROTEIN PRECURSORS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER;

EID: 0036161931     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048219     Document Type: Article

References (56)

1. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
2. Control of food intake via leptin receptors in the hypothalamus
3. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats
4. A role for melanin-concentrating hormone in the central regulation of feeding behaviour
5. Orexins and orexins receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour
6. Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling
7. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo
8. The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
9. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
10. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
11. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
12. Hypocretin (orexin) deficiency in human narcolepsy
13. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
14. Orexin A activates locus coeruleus cell firing and increases arousal in the rat
15. Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats
16. Possible involvement of orexin in the stress reaction in rats
17. Effects of centrally administered orexin-B and orexin-A: A role for orexin-1 receptors in orexin-B-induced hyperactivity
18. Cardiovascular regulatory actions of the hypocretins in brain
19. Sympathetic and cardiovascular actions of orexins in conscious rats
20. Orexin-A, an hypothalamic peptide with analgesic properties
21. Hypothalamic hypocretin (orexin): Robust innervation of the spinal cord
22. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
23. Orexins, a novel family of hypothalamic neuropeptides, modulate pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner
24. Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus
25. Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia
26. Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area
27. Hypothalamic orexin expression: Modulation by blood glucose and feeding
28. Prepro-orexin mRNA levels in the rat hypothalamus, and orexin mRNA levels in the rat hypothalamus and adrenal gland are not influence by thyroid status
29. Distribution of orexin receptor mRNA in the rat brain
30. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord
31. Orexin receptors are expressed in the adrenal medulla of the rat
32. Orexin synthesis and response in the gut
33. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
34. Hypocretin/orexin and melanin concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene related protein systems
35. Neurons containing hypocretin (orexin) project to multiple neuronal systems
36. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
37. Orexin-induced food intake involves neuropeptide Y pathway
38. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
39. Both corticotropin releasing factor and neuropeptide Y are involved in the effect of orexin (hypocretin) on the food intake in rats
40. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
41. Behavioral characterization of neuropeptide Y knockout mice
42. Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats
43. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting
44. Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH Secretion
45. Regulation of hypothalamic somatostatin, growth hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids
46. Hypothalamic neuropeptide Y and its gene expression: Relation to light/dark cycle and circulating corticosterone
47. Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat
48. Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system
49. Inhibition of food intake by central injection of anti-orexin antibody in fasted rats
50. The acute suckling stimulus induces expression of neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and increases NPY expression in the arcuate nucleus
51. Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor
52. Coexpression of AgRP and NPY in fasting-activated hypothalamic neurons
53. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
54. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade
55. Mice lacking melanin-concentrating hormone are hypophagic and lean