Chronic intracerebroventricular infusion of MCH causes obesity in mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 3 47-3, 2003, Pages

  Gomori, Akira ^a   Ishihara, Akane ^a   Ito, Masahiko ^a   Mashiko, Satoshi ^a   Matsushita, Hiroko ^a   Yumoto, Mariko ^a   Ito, Makoto ^a   Tanaka, Takeshi ^a   Tokita, Shigeru ^a   Moriya, Minoru ^a   Iwaasa, Hisashi ^a   Kanatani, Akio ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Body weight; Fat weight; Food intake; Melanin concentrating hormone

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; DIET; ENERGY; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HORMONE ACTION; HYPERPHAGIA; INSULIN BLOOD LEVEL; LATERAL HYPOTHALAMUS; LIPID DIET; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0037369253     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00350.2002     Document Type: Article

References (34)

1. An S, Cutler G, Zhao JJ, Huang SG, Tian H, Li W, Liang L, Rich M, Bakleh A, Du J, Chen JL, and Dai K. Identification and characterization of a melanin-concentrating hormone receptor. Proc Natl Acad Sci USA 98: 7576-7581, 2001.
2. Bachner D, Kreienkamp HJ, Weise C, Buck F, and Richter D. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Lett 457: 522-524, 1999.
3. Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, and Hervieu G. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400: 261-265, 1999.
4. a.Chen YY, Hu C, Hsu CK, Zhang Q, Bi C, Asnicar M, Hsiung HM, Fox N, Slieker LJ, Yang DD, Heiman ML, and Shi Y. Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology 143: 2469-2477, 2002.
5. Hanada R, Nakazato M, Matsukura S, Murakami N, Yoshimatsu H, and Sakata T. Differential regulation of melaninconcentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system. Biochem Biophys Res Commun 268: 88-91, 2000.
6. Hill J, Duckworth M, Rennie G, David CS, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, and Muir AI. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J Biol Chem 276: 20125-20129, 2001.
7. Jump DB, Clarke SD, Thelen A, and Liimatta M. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 35: 1076-1084, 1994.
8. Kawaguchi H, Kawazoe I, Tsubokawa M, Kishida M, and Baker BI. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 305: 321-323, 1983.
9. Kennedy AR, Todd JF, Stanley SA, Abbot CR, Small CJ, Ghatei MA, and Bloom SR. Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vitro and in vivo, via the hypothalamus and the pituitary. Endocrinology 142: 3265-3268, 2001.
10. Krongrad AS, Dimitrov T, and Beck B. Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats. Mol Brain Res 92: 43-48, 2001.
11. Lauterio TJ, Bond JP, and Ulman EA. Development and characterization of a purified diet to identify obesity-susceptible and resistant rat populations. J Nutr 124: 2172-2178, 1994.
12. Lembo PMC, Grazzini E, Cao J, Hubatsch DA, Pelletier M, Hoffert C, St-Onge S, Pou C, Labrecque J, Groblewski T, O'Donnell D, Payza K, Ahmad S, and Walker P. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat Cell Biol 1: 267-271, 1999.
13. Ludwig DS, Tritos NA, Mastatris JW, Kulkarni R, and Flier EM. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest 107: 379-386, 2001.
14. Marsh DJ, Weingarth DT, Novi DE, Chen HY, Trumbauer ME, Chen AS, Guan XM, Jiang MM, Feng Y, and Camacho RE. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA 99: 3240-3245, 2002.
15. Mizuno T, Kleopoulos ST, Bergen HT, Roberts JL, Priest CA, and Mobbs CV. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47: 294-297, 1997.
16. Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, and Fujino M. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor. Biochem Biophys Res Commun 283: 1013-1018, 2001.
17. Mori T, Baba J, Ichimaru Y, and Suzuki T. Effects of Rolipram, a selective inhibitor of phosphodiesterase 4, on hyperlocomotion induced by several abused drugs in mice. Jpn J Pharmacol 83: 113-118, 2000.
18. Mystkowski P, Seeley RJ, Hahn TM, Baskin DG, Havel PJ, Matsumoto AM, Wilkinson W, Kinzig KP, Blake KA, and Schwartz MW. Hypothalamic melanin-concentrating hormone and estrogen-induced weight loss. J Neurosci 20: 8637-8642, 2000.
19. Nahon JL. The melanin-concentrating hormone: from the peptide to the gene. Crit Rev Neurobiol 8: 221-262, 1994.
20. Narita M, Mizuo K, Shibasaki M, and Suzuki T. Upregulation of the Gq/11α protein kinase C during the development of sensitization to morphine-induced hyperlocomotion. Neuroscience 111: 127-132, 2002.
21. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, and Mckinley MJ. The neurochemical characterization of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110: 515-526, 2002.
22. Qu D, Ludwig DS, Gammeltoft S, Piper M, and Pelleymounter MA. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380: 243-247, 1996.
23. Rodriguez M, Beauverger P, Naime I, Rique H, Ouvry C, Souchaud S, Dromaint S, Nagel N, Suply T, Audinot V, Boutin JA, and Galizzi JP. Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor 2. Mol Pharmacol 60: 632-639, 2001.
24. Rossi M, Beak SA, Choi SJ, Small CJ, and Morgan DGA. Investigation of the feeding effects of melanin concentrating hormone on food intake-action independent of galanin and the melanocortin receptors. Brain Res 846: 164-170, 1999.
25. Rossi M, Choi SJ, Miyoshi T, Ghatei MA, and Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138: 351-355, 1997.
26. Sahu A. Leptin decreases food intake induced by melaninconcentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat. Endocrinology 139: 4739-4742, 1998.
27. Sailer AW, Sano H, Zeng Z, Mcdonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, and Bansal A. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci USA 98: 7564-7569, 2001.
28. Saitou Y, Nothcker HP, Wang Z, Lin SHS, Leslie F, and Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400: 265-269, 1999.
29. Shimada M, Tritos NA, Lowell BB, Flier JS, and Flier EL. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396: 670-674, 1998.
30. Shimomura Y, Mori M, Sugo T, Ishibashi Y, Abe M, Kurokawa T, Onda H, Nishimura O, Sumino Y, and Fujino M. Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor. Biochem Biophys Res Commun 261: 622-626, 1999.
31. Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Ito M, Guan X, Kanatani A, Van der Ploeg LH, and Thoward AD. Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 79: 785-792, 2002.
32. Touzani K, Traumu G, Nahon JL, and Velley L. Hypothalamic melanin-concentrating hormone and α-neoendorphin-immunoreactive neurons project to the medial part of the rat parabrachial area. Neuroscience 53: 865-876, 1993.
33. Wang S, Behan J, O'Neill K, Weig B, Fried S, Laz T, Bayne M, Gustafson E, and Hawes BE. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, MCH-R2. J Biol Chem 276: 34664-34670, 2001.
34. Xu J, Nakamura M, Cho HP, and Clarke SD. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. J Biol Chem 274: 23577-23583, 1999.