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Volumn 20, Issue 3, 1999, Pages 367-372

Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW1229U91, on the consumption of highly palatable energy-rich diet

Author keywords

BW1229U91; Energy balance; Hypothalamus; Neuropeptide Y; Obesity

Indexed keywords

GR 231118; INSULIN; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

EID: 0032853212     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00044-3     Document Type: Article
Times cited : (34)

References (32)
  • 1
    • 0027194241 scopus 로고
    • Hypothalamic neuropeptide Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats: Potential regulation thereof by corticotrophin-releasing factor
    • Bchini-Hooft Van Huisduijnen O., Roher-Jeanrenaud F., Jeanrenaud B. Hypothalamic neuropeptide Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats potential regulation thereof by corticotrophin-releasing factor . J Neuroendocrinol. 5:1993;381-386.
    • (1993) J Neuroendocrinol , vol.5 , pp. 381-386
    • Bchini-Hooft Van Huisduijnen, O.1    Roher-Jeanrenaud, F.2    Jeanrenaud, B.3
  • 2
    • 0029092010 scopus 로고
    • Diet- And diabetes-induced changes of ob gene expression in rat adipose tissue
    • Becker D.J., Ongemba L.N., Brichard V., Henquin J.-C., Brichard S.M. Diet- and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett. 371:1995;324-328.
    • (1995) FEBS Lett , vol.371 , pp. 324-328
    • Becker, D.J.1    Ongemba, L.N.2    Brichard, V.3    Henquin, J.-C.4    Brichard, S.M.5
  • 3
    • 0026022088 scopus 로고
    • Effects of intracerebroventricular injection of NPY on energy metabolism
    • Billington C.J., Briggs J., Grace M., Levine A.S. Effects of intracerebroventricular injection of NPY on energy metabolism. Am J Physiol. 260:1991;R321-R327.
    • (1991) Am J Physiol , vol.260
    • Billington, C.J.1    Briggs, J.2    Grace, M.3    Levine, A.S.4
  • 4
    • 0029001753 scopus 로고
    • Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus
    • Currie P.J., Coscina D.V. Dissociated feeding and hypothermic effects of neuropeptide Y in the paraventricular and perifornical hypothalamus. Peptides. 16:1995;599-604.
    • (1995) Peptides , vol.16 , pp. 599-604
    • Currie, P.J.1    Coscina, D.V.2
  • 5
    • 0028228615 scopus 로고
    • Neuropeptide Y and energy balance: One way ahead for the treatment of obesity?
    • Dryden S., Frankish H., Wang Q., Williams G. Neuropeptide Y and energy balance one way ahead for the treatment of obesity? Eur J Clin Invest. 24:1994;293-308.
    • (1994) Eur J Clin Invest , vol.24 , pp. 293-308
    • Dryden, S.1    Frankish, H.2    Wang, Q.3    Williams, G.4
  • 6
    • 0029122302 scopus 로고
    • Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats
    • Dryden S., Pickavance L., Frankish H.M., Williams G. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats. Brain Res. 690:1995;185-188.
    • (1995) Brain Res , vol.690 , pp. 185-188
    • Dryden, S.1    Pickavance, L.2    Frankish, H.M.3    Williams, G.4
  • 7
    • 0026061245 scopus 로고
    • Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue
    • Egawa M., Yoshimatsu H., Bray G.A. Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue. Am J Physiol. 260:1991;R328-R334.
    • (1991) Am J Physiol , vol.260
    • Egawa, M.1    Yoshimatsu, H.2    Bray, G.A.3
  • 9
    • 0028277938 scopus 로고
    • Neuropeptide Y effector system: Perspectives for drug development
    • Grundemar L., Håkanson R. Neuropeptide Y effector system perspectives for drug development . TIPS. 15:1994;153-159.
    • (1994) TIPS , vol.15 , pp. 153-159
    • Grundemar, L.1    Håkanson, R.2
  • 10
    • 0030481802 scopus 로고    scopus 로고
    • Expression of leptin receptor mRNA in hypothalamic arcuate nucleus - relationship with NPY neurones
    • Håkanson M.-L., Hulting A.-L., Meister B. Expression of leptin receptor mRNA in hypothalamic arcuate nucleus - relationship with NPY neurones. NeuroReport. 7:1996;3087-3092.
    • (1996) NeuroReport , vol.7 , pp. 3087-3092
    • Håkanson, M.-L.1    Hulting, A.-L.2    Meister, B.3
  • 12
    • 0028506528 scopus 로고
    • Central nervous system and peripheral abnormalities: Clues to the understanding of obesity and NIDDM
    • Jeanrenaud B. Central nervous system and peripheral abnormalities clues to the understanding of obesity and NIDDM . Diabetologia. 37:(suppl 2):1994;S170-S178.
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 2
    • Jeanrenaud, B.1
  • 13
    • 0344757592 scopus 로고    scopus 로고
    • Two distinct leptin-NPY signaling modalities underlie hyperphagia in CNS-dependent obesity models
    • Kalra P.S., Xu B., Duke M.G. Two distinct leptin-NPY signaling modalities underlie hyperphagia in CNS-dependent obesity models. Peptides. 71:1997;218.
    • (1997) Peptides , vol.71 , pp. 218
    • Kalra, P.S.1    Xu, B.2    Duke, M.G.3
  • 14
    • 85047679082 scopus 로고    scopus 로고
    • Potent neuropeptide Y Y1 receptor antagonist, 1229U91: Blockade of neuropeptide Y-induced and physiological food intake
    • Kanatani A., Ishihara A., Asahi A., Tanaka T., Ozaki S., Ihara M.L. Potent neuropeptide Y Y1 receptor antagonist, 1229U91 blockade of neuropeptide Y-induced and physiological food intake . Endocrinology. 137:1996;3177-3182.
    • (1996) Endocrinology , vol.137 , pp. 3177-3182
    • Kanatani, A.1    Ishihara, A.2    Asahi, A.3    Tanaka, T.4    Ozaki, S.5    Ihara, M.L.6
  • 16
    • 0031890721 scopus 로고    scopus 로고
    • Severe leptin resistance in brown fat-deficient uncoupling protein promotor-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations
    • Mantzoros C.S., Frederich R.-C., Qu D., Lowell B.B., Maratos-Flier J.S. Severe leptin resistance in brown fat-deficient uncoupling protein promotor-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. 47:1998;230-238.
    • (1998) Diabetes , vol.47 , pp. 230-238
    • Mantzoros, C.S.1    Frederich, R.-C.2    Qu, D.3    Lowell, B.B.4    Maratos-Flier, J.S.5
  • 17
    • 0031592872 scopus 로고    scopus 로고
    • Pharmacological characterization and selectivity of the NPY antagonist GR2331118 (1229U91) for different NPY receptors
    • Matthews J.E., Jansen M., Lyerly D., Cox R., Chen W.-J., Koller K.K., Daniels A.J. Pharmacological characterization and selectivity of the NPY antagonist GR2331118 (1229U91) for different NPY receptors. Regul Pept. 72:1997;113-119.
    • (1997) Regul Pept , vol.72 , pp. 113-119
    • Matthews, J.E.1    Jansen, M.2    Lyerly, D.3    Cox, R.4    Chen, W.-J.5    Koller, K.K.6    Daniels, A.J.7
  • 18
    • 0031040784 scopus 로고    scopus 로고
    • Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice
    • Mercer J.G., Moar K.M., Rayner D.V., Trayhurn P., Hoggard N. Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett. 402:1997;185-188.
    • (1997) FEBS Lett , vol.402 , pp. 185-188
    • Mercer, J.G.1    Moar, K.M.2    Rayner, D.V.3    Trayhurn, P.4    Hoggard, N.5
  • 19
    • 0025988223 scopus 로고
    • Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats
    • McCarthy H.D., McKibbin P.E., Holloway B., Mayers R., Williams G. Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats. Life Sci. 49:1991;1491-1497.
    • (1991) Life Sci , vol.49 , pp. 1491-1497
    • McCarthy, H.D.1    McKibbin, P.E.2    Holloway, B.3    Mayers, R.4    Williams, G.5
  • 22
    • 0025072899 scopus 로고    scopus 로고
    • Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
    • Sancora G., Kershaw M., Finkelstein J.A., White J.D. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology. 127:1996;730-737.
    • (1996) Endocrinology , vol.127 , pp. 730-737
    • Sancora, G.1    Kershaw, M.2    Finkelstein, J.A.3    White, J.D.4
  • 24
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • Stanley B.G., Kyhouli S.E., Lampert S., Leibowitz S.F. Neuropeptide Y chronically injected into the hypothalamus a powerful neurochemical inducer of hyperphagia and obesity . Peptides. 7:1986;1189-1192.
    • (1986) Peptides , vol.7 , pp. 1189-1192
    • Stanley, B.G.1    Kyhouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 25
    • 0027450918 scopus 로고
    • The perifornical area: The major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)
    • Stanley B.G., Magdalin W., Seifari A., Thomas W.J., Leibowitz S.F. The perifornical area the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s) . Brain Res. 604:1993;304-317.
    • (1993) Brain Res , vol.604 , pp. 304-317
    • Stanley, B.G.1    Magdalin, W.2    Seifari, A.3    Thomas, W.J.4    Leibowitz, S.F.5
  • 27
    • 85050956429 scopus 로고
    • Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats
    • Vettor R., Zarjevski N., Cusin I., Rohner-Jeanrenaud F., Jeanrenaud B. Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats. Diabetologia. 37:1994;1202-1208.
    • (1994) Diabetologia , vol.37 , pp. 1202-1208
    • Vettor, R.1    Zarjevski, N.2    Cusin, I.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 29
    • 0030758749 scopus 로고    scopus 로고
    • Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat: Relationship to the Y5 'feeding' receptor
    • Widdowson P.S. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat relationship to the Y5 'feeding' receptor . Brain Res. 758:1997;17-25.
    • (1997) Brain Res , vol.758 , pp. 17-25
    • Widdowson, P.S.1
  • 30
    • 0030669288 scopus 로고    scopus 로고
    • Attenuated response in the rat to intracerebroventricular injections of leptin on food consumption in diet-induced obesity
    • Widdowson P.S., Upton R., Buckingham R., Arch J., Williams G. Attenuated response in the rat to intracerebroventricular injections of leptin on food consumption in diet-induced obesity. Diabetes. 46:1997;1782-1785.
    • (1997) Diabetes , vol.46 , pp. 1782-1785
    • Widdowson, P.S.1    Upton, R.2    Buckingham, R.3    Arch, J.4    Williams, G.5
  • 31
    • 0031558626 scopus 로고    scopus 로고
    • Diametric regional changes in NPY receptor density during dietary restriction and dietary-induced obesity in the rat brain
    • Widdowson P.S., Upton R., Henderson L., Buckingham R., Wilson S., Williams G. Diametric regional changes in NPY receptor density during dietary restriction and dietary-induced obesity in the rat brain. Brain Res. 774:1997;1-10.
    • (1997) Brain Res , vol.774 , pp. 1-10
    • Widdowson, P.S.1    Upton, R.2    Henderson, L.3    Buckingham, R.4    Wilson, S.5    Williams, G.6
  • 32
    • 0026537083 scopus 로고
    • Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats
    • Wilding J.P.H., Gilbey S.G., Mannan M., Aslam N., Ghatei M.A., Bloom S.R. Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats. J Endocrinol. 132:1992;299-304.
    • (1992) J Endocrinol , vol.132 , pp. 299-304
    • Wilding, J.P.H.1    Gilbey, S.G.2    Mannan, M.3    Aslam, N.4    Ghatei, M.A.5    Bloom, S.R.6


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