메뉴 건너뛰기




Volumn 71, Issue 1, 2004, Pages 266-272

Leptin-receptor gene transfer into the arcuate nucleus of female fatty Zucker rats using recombinant adeno-associated viral vectors stimulates the hypothalamo-pituitary-gonadal axis

Author keywords

Gonadotropin releasing hormone; Hypothalamic hormones; Leptin; Leptin receptor; Neuropeptide Y

Indexed keywords

BETA ENDORPHIN; DOXYCYCLINE; GONADORELIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y;

EID: 3142767549     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.103.025858     Document Type: Conference Paper
Times cited : (18)

References (67)
  • 2
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments]. Science 1995; 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 5
    • 0031814986 scopus 로고    scopus 로고
    • Leptin indirectly affects estrous cycles by increasing metabolic fuel oxidation
    • Schneider JE, Goldman MD, Tang S, Bean B, Ji H, Friedman MI. Leptin indirectly affects estrous cycles by increasing metabolic fuel oxidation. Horm Behav 1998; 33:217-228.
    • (1998) Horm Behav , vol.33 , pp. 217-228
    • Schneider, J.E.1    Goldman, M.D.2    Tang, S.3    Bean, B.4    Ji, H.5    Friedman, M.I.6
  • 6
    • 0033935226 scopus 로고    scopus 로고
    • Leptin and metabolic control of reproduction
    • Schneider JE, Zhou D, Blum RM. Leptin and metabolic control of reproduction. Horm Behav 2000; 37:306-326.
    • (2000) Horm Behav , vol.37 , pp. 306-326
    • Schneider, J.E.1    Zhou, D.2    Blum, R.M.3
  • 7
    • 0031813699 scopus 로고    scopus 로고
    • Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting
    • Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 1998; 67:370-376.
    • (1998) Neuroendocrinology , vol.67 , pp. 370-376
    • Nagatani, S.1    Guthikonda, P.2    Thompson, R.C.3    Tsukamura, H.4    Maeda, K.I.5    Foster, D.L.6
  • 8
    • 0033679813 scopus 로고    scopus 로고
    • Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep
    • Nagatani S Zeng Y, Keisler DH, Foster DL, Jaffe CA. Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinology 2000; 141:3695-3975.
    • (2000) Endocrinology , vol.141 , pp. 3695-3975
    • Nagatani, S.1    Zeng, Y.2    Keisler, D.H.3    Foster, D.L.4    Jaffe, C.A.5
  • 9
    • 0032472251 scopus 로고    scopus 로고
    • Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: Role of neuropeptide Y
    • Kalra SP, Xu B, Dube MG, Moldawer LL, Martin D, Kalra PS. Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: Role of neuropeptide Y. Neurosci Lett 1998; 240:45-49.
    • (1998) Neurosci Lett , vol.240 , pp. 45-49
    • Kalra, S.P.1    Xu, B.2    Dube, M.G.3    Moldawer, L.L.4    Martin, D.5    Kalra, P.S.6
  • 12
    • 0008903010 scopus 로고    scopus 로고
    • Leptin and NPY regulation of GnRH secretion and energy homeostasis
    • Bourguignon JP, Plant TM (eds). Pittsburgh: Elsevier Science
    • Kalra SP, Pu S, Horvath TL, Kalra PS. Leptin and NPY regulation of GnRH secretion and energy homeostasis. In: Bourguignon JP, Plant TM (eds), The Onset of Puberty in Perspective. Pittsburgh: Elsevier Science; 2000:317-327.
    • (2000) The Onset of Puberty in Perspective , pp. 317-327
    • Kalra, S.P.1    Pu, S.2    Horvath, T.L.3    Kalra, P.S.4
  • 13
    • 0034455630 scopus 로고    scopus 로고
    • In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms
    • Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, Bourguignon JP. In vitro stimulation of the prepubertal rat gonadotropin- releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 2000; 141:1464-1469.
    • (2000) Endocrinology , vol.141 , pp. 1464-1469
    • Lebrethon, M.C.1    Vandersmissen, E.2    Gerard, A.3    Parent, A.S.4    Junien, J.L.5    Bourguignon, J.P.6
  • 14
    • 77957216320 scopus 로고
    • Fatty, a new mutation in the rat
    • Zucker LM, Zucker TF. Fatty, a new mutation in the rat. J Hered 1961; 52:275-278.
    • (1961) J Hered , vol.52 , pp. 275-278
    • Zucker, L.M.1    Zucker, T.F.2
  • 15
    • 0031031627 scopus 로고    scopus 로고
    • Abnormal estrous cyclicity and behavioral hyporesponsiveness to ovarian hormones in genetically obese Zucker female rats
    • Bivens CL, Olster DH. Abnormal estrous cyclicity and behavioral hyporesponsiveness to ovarian hormones in genetically obese Zucker female rats. Endocrinology 1997; 138:143-148.
    • (1997) Endocrinology , vol.138 , pp. 143-148
    • Bivens, C.L.1    Olster, D.H.2
  • 17
    • 0032566826 scopus 로고    scopus 로고
    • Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats
    • Marin-Bivens CL, Kalra SP, Olster DH. Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats. Regul Pept 1998; 75-76:327-334.
    • (1998) Regul Pept , vol.75-76 , pp. 327-334
    • Marin-Bivens, C.L.1    Kalra, S.P.2    Olster, D.H.3
  • 18
    • 0344417858 scopus 로고    scopus 로고
    • Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats
    • Marin-Bivens CL, Olster DH, Food restriction neither improves nor exacerbates reproduction in obese female Zucker rats. Physiol Behav 1999; 66:893-897.
    • (1999) Physiol Behav , vol.66 , pp. 893-897
    • Marin-Bivens, C.L.1    Olster, D.H.2
  • 19
  • 20
    • 0024500021 scopus 로고
    • Circulating reproductive hormones and hypothalamic estradiol and progestin receptors in infertile Zucker rats
    • Whitaker EM, Robinson AC. Circulating reproductive hormones and hypothalamic estradiol and progestin receptors in infertile Zucker rats. J Endocrinol 1989; 120:331-336.
    • (1989) J Endocrinol , vol.120 , pp. 331-336
    • Whitaker, E.M.1    Robinson, A.C.2
  • 21
    • 0032559570 scopus 로고    scopus 로고
    • Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain
    • Yarnell DO, Knight DS, Hamilton K, Tulp O, Tso P. Localization of leptin receptor immunoreactivity in the lean and obese Zucker rat brain. Brain Res 1998; 785:80-90.
    • (1998) Brain Res , vol.785 , pp. 80-90
    • Yarnell, D.O.1    Knight, D.S.2    Hamilton, K.3    Tulp, O.4    Tso, P.5
  • 24
    • 0029895233 scopus 로고    scopus 로고
    • Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
    • Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996; 387:113-116.
    • (1996) FEBS Lett , vol.387 , pp. 113-116
    • Mercer, J.G.1    Hoggard, N.2    Williams, L.M.3    Lawrence, C.B.4    Hannah, L.T.5    Trayhurn, P.6
  • 25
    • 85011452023 scopus 로고    scopus 로고
    • Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain
    • Mercer JG, Moar KM, Hoggard N. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 1998; 139:29-34.
    • (1998) Endocrinology , vol.139 , pp. 29-34
    • Mercer, J.G.1    Moar, K.M.2    Hoggard, N.3
  • 27
    • 0032998652 scopus 로고    scopus 로고
    • Leptin-receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
    • Baskin DG, Breininger JF, Schwartz MW. Leptin-receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 1999; 48:828-833.
    • (1999) Diabetes , vol.48 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 28
    • 0031963436 scopus 로고    scopus 로고
    • Leptin-receptor immunoreactivity in chemically defined target neurons of the hypothalamus
    • Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin-receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 1998; 18:559-572.
    • (1998) J Neurosci , vol.18 , pp. 559-572
    • Hakansson, M.L.1    Brown, H.2    Ghilardi, N.3    Skoda, R.C.4    Meister, B.5
  • 29
    • 0030481802 scopus 로고    scopus 로고
    • Expression of leptin-receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones
    • Hakansson ML, Hulting AL, Meister B. Expression of leptin-receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones. Neuroreport 1996; 7:3087-3092.
    • (1996) Neuroreport , vol.7 , pp. 3087-3092
    • Hakansson, M.L.1    Hulting, A.L.2    Meister, B.3
  • 31
    • 0031764893 scopus 로고    scopus 로고
    • Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), pro-opiomelanocortin (POMC), and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus
    • Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), pro-opiomelanocortin (POMC), and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 1998; 139:795-798.
    • (1998) Endocrinology , vol.139 , pp. 795-798
    • Sahu, A.1
  • 34
    • 0021811922 scopus 로고
    • Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats
    • Allen LG, Kalra PS, Crowley WR, Kalra SP. Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats. Life Sci 1985; 37:617-623.
    • (1985) Life Sci , vol.37 , pp. 617-623
    • Allen, L.G.1    Kalra, P.S.2    Crowley, W.R.3    Kalra, S.P.4
  • 35
    • 0022861639 scopus 로고
    • Steroidal modulation of the regulatory neuropeptides: Luteinizing hormone releasing hormone, neuropeptide Y, and endogenous opioid peptides
    • Kalra PS, Kalra SP. Steroidal modulation of the regulatory neuropeptides: luteinizing hormone releasing hormone, neuropeptide Y, and endogenous opioid peptides. J Steroid Biochem 1986; 25:733-740.
    • (1986) J Steroid Biochem , vol.25 , pp. 733-740
    • Kalra, P.S.1    Kalra, S.P.2
  • 37
    • 0023114303 scopus 로고
    • Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits
    • Khorram O, Pau KY, Spies HG. Bimodal effects of neuropeptide Y on hypothalamic release of gonadotropin-releasing hormone in conscious rabbits. Neuroendocrinology 1987; 45:290-297.
    • (1987) Neuroendocrinology , vol.45 , pp. 290-297
    • Khorram, O.1    Pau, K.Y.2    Spies, H.G.3
  • 38
    • 0030272305 scopus 로고    scopus 로고
    • Nutritional infertility: The role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network
    • Kalra SP, Kalra PS. Nutritional infertility: the role of the interconnected hypothalamic neuropeptide Y-galanin-opioid network. Front Neuroendocrinol 1996; 17:371-401.
    • (1996) Front Neuroendocrinol , vol.17 , pp. 371-401
    • Kalra, S.P.1    Kalra, P.S.2
  • 39
    • 0026463547 scopus 로고
    • Neuropeptide-Y innervation of β-endorphin-containing cells in the rat mediobasal hypothalamus: A light and electron microscopic double immunostaining analysis
    • Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of β-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology 1992; 131:2461-2467.
    • (1992) Endocrinology , vol.131 , pp. 2461-2467
    • Horvath, T.L.1    Naftolin, F.2    Kalra, S.P.3    Leranth, C.4
  • 40
    • 0026094772 scopus 로고
    • Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances
    • McKibbin PE, Cotton SJ, McMillan S, Holloway B, Mayers R, McCarthy HD, Williams G. Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances. Diabetes 1991; 40:1423-1429.
    • (1991) Diabetes , vol.40 , pp. 1423-1429
    • McKibbin, P.E.1    Cotton, S.J.2    McMillan, S.3    Holloway, B.4    Mayers, R.5    McCarthy, H.D.6    Williams, G.7
  • 41
    • 0031769587 scopus 로고    scopus 로고
    • Ontogeny of hyperphagia in the Zucker (fa/fa) rat
    • Kowalski TJ, Ster AM, Smith GP. Ontogeny of hyperphagia in the Zucker (fa/fa) rat. Am J Physiol 1998; 275:R1106-R1109.
    • (1998) Am J Physiol , vol.275
    • Kowalski, T.J.1    Ster, A.M.2    Smith, G.P.3
  • 43
    • 0031960554 scopus 로고    scopus 로고
    • Neuropeptide Y in the magnocellular hypothalamic neurons of obese Zucker rats
    • Fetissov S, Nicolaidis S. Neuropeptide Y in the magnocellular hypothalamic neurons of obese Zucker rats. Neuropeptides 1998; 32:63-66.
    • (1998) Neuropeptides , vol.32 , pp. 63-66
    • Fetissov, S.1    Nicolaidis, S.2
  • 44
    • 0025342930 scopus 로고
    • Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: Implications in feeding and sexual behaviors
    • Beck B, Burlet A, Nicolas JP, Burlet C. Hypothalamic neuropeptide Y (NPY) in obese Zucker rats: implications in feeding and sexual behaviors. Physiol Behav 1990; 47:449-453.
    • (1990) Physiol Behav , vol.47 , pp. 449-453
    • Beck, B.1    Burlet, A.2    Nicolas, J.P.3    Burlet, C.4
  • 45
    • 0029583489 scopus 로고
    • Neuropeptide Y stimulates beta-endorphin release in the basal hypothalamus: Role of gonadal steroids
    • Kalra PS, Norlin M, Kalra SP. Neuropeptide Y stimulates beta-endorphin release in the basal hypothalamus: role of gonadal steroids. Brain Res 1995; 705:353-356.
    • (1995) Brain Res , vol.705 , pp. 353-356
    • Kalra, P.S.1    Norlin, M.2    Kalra, S.P.3
  • 46
    • 0025008866 scopus 로고
    • An opioid-neuropeptide-Y transmission line to luteinizing hormone (LH)-releasing hormone neurons: A role in the induction of LH surge
    • Sahu A, Crowley WR, Kalra SP. An opioid-neuropeptide-Y transmission line to luteinizing hormone (LH)-releasing hormone neurons: a role in the induction of LH surge. Endocrinology 1990; 126:876-883.
    • (1990) Endocrinology , vol.126 , pp. 876-883
    • Sahu, A.1    Crowley, W.R.2    Kalra, S.P.3
  • 47
    • 0032550793 scopus 로고    scopus 로고
    • Selective and rapid uptake of adeno-associated virus type 2 in brain
    • Bartlett JS, Samulski RJ, McCown TJ. Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum Gene Ther 1998; 9:1181-1186.
    • (1998) Hum Gene Ther , vol.9 , pp. 1181-1186
    • Bartlett, J.S.1    Samulski, R.J.2    McCown, T.J.3
  • 48
    • 0028169741 scopus 로고
    • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
    • Kaplitt MG, Leone P, Samulski RJ, Xiao X, Pfaff DW, O'Malley KL, During MJ. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet 1994; 8:148-154.
    • (1994) Nat Genet , vol.8 , pp. 148-154
    • Kaplitt, M.G.1    Leone, P.2    Samulski, R.J.3    Xiao, X.4    Pfaff, D.W.5    O'Malley, K.L.6    During, M.J.7
  • 49
    • 0026525713 scopus 로고
    • Use of adeno-associated virus as a general transduction vector for mammalian cells
    • Muzyczka N. Use of adeno-associated virus as a general transduction vector for mammalian cells. Curr Top Microbiol Immunol 1992; 158: 97-129.
    • (1992) Curr Top Microbiol Immunol , vol.158 , pp. 97-129
    • Muzyczka, N.1
  • 50
    • 0035876708 scopus 로고    scopus 로고
    • Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: A long-term study
    • Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS. Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept 2001; 99: 69-77.
    • (2001) Regul Pept , vol.99 , pp. 69-77
    • Dhillon, H.1    Kalra, S.P.2    Prima, V.3    Zolotukhin, S.4    Scarpace, P.J.5    Moldawer, L.L.6    Muzyczka, N.7    Kalra, P.S.8
  • 51
    • 0034882656 scopus 로고    scopus 로고
    • Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus
    • Dhillon H, Kalra SP, Kalra PS. Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol Ther 2001; 4:139-145.
    • (2001) Mol Ther , vol.4 , pp. 139-145
    • Dhillon, H.1    Kalra, S.P.2    Kalra, P.S.3
  • 55
    • 0027143823 scopus 로고
    • Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids
    • Bonavera JJ, Sahu A, Kalra PS, Kalra SP. Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids. Endocrinology 1993; 133: 2481-2487.
    • (1993) Endocrinology , vol.133 , pp. 2481-2487
    • Bonavera, J.J.1    Sahu, A.2    Kalra, P.S.3    Kalra, S.P.4
  • 57
    • 0022517599 scopus 로고
    • Morphine or capsaicin administration alters the secretion of β-endorphin into the hypophysial portal vasculature of the rat
    • Koenig JI, Meltzer HY, Gudelsky GA. Morphine or capsaicin administration alters the secretion of β-endorphin into the hypophysial portal vasculature of the rat. Neuroendocrinology 1986; 43:611-617.
    • (1986) Neuroendocrinology , vol.43 , pp. 611-617
    • Koenig, J.I.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 59
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M, Nikkhah G, Bentlage C, Bjorklund A. 1995 Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 1995; 15:3863-3872.
    • (1995) J Neurosci , vol.15 , pp. 3863-3872
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Bjorklund, A.4
  • 60
    • 0031821377 scopus 로고    scopus 로고
    • Leptin-receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells
    • Diano S, Kalra SP, Horvath TL. Leptin-receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells. J Neuroendocrinol 1998; 10:647-650.
    • (1998) J Neuroendocrinol , vol.10 , pp. 647-650
    • Diano, S.1    Kalra, S.P.2    Horvath, T.L.3
  • 61
    • 0033937063 scopus 로고    scopus 로고
    • Effects of intracerebroventricular leptin administration on feeding and sexual behaviors in lean and obese female Zucker rats
    • 200
    • Fox AS, Olster DH. Effects of intracerebroventricular leptin administration on feeding and sexual behaviors in lean and obese female Zucker rats. Horm Behav 200; 37:377-387.
    • Horm Behav , vol.37 , pp. 377-387
    • Fox, A.S.1    Olster, D.H.2
  • 62
    • 0030776182 scopus 로고    scopus 로고
    • Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland
    • Yu WH, Walczewska A, Karanth S, McCann SM. Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. Endocrinology 1997; 138:5055-5058.
    • (1997) Endocrinology , vol.138 , pp. 5055-5058
    • Yu, W.H.1    Walczewska, A.2    Karanth, S.3    McCann, S.M.4
  • 64
    • 0022730034 scopus 로고
    • Pseudopregnancy and decidual response in the obese Zucker rat: A re-examination
    • Chelich AM, Edmonds ES. 1986 Pseudopregnancy and decidual response in the obese Zucker rat: a re-examination. Biol Reprod 1986; 34:805-808.
    • (1986) Biol Reprod , vol.34 , pp. 805-808
    • Chelich, A.M.1    Edmonds, E.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.