Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat

Biochemical and Biophysical Research Communications

Volumn 224, Issue 2, 1996, Pages 597-604

  Iida, Mitsuru ^a,b   Murakami, Takashi ^a   Ishida, Kaori ^a   Mizuno, Akira ^a   Kuwajima, Masamichi ^a   Shima, Kenji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HORMONE RECEPTOR; LEPTIN; MUTANT PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO ACID SUBSTITUTION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; GENE EXPRESSION; MALE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0030590070     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.1070     Document Type: Article

References (29)

1. 1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432.
2. 2. Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., and Collins, F. (1995) Science 269, 540-543.
3. 3. Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995) Science 269, 543-546.
4. 4. Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995) Science 269, 546-549.
5. 5. Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., MacKellar, W., Rosteck Jr., P. R., Schoner, B., Smith, D., Tinsley, F. C., Zhang, X.-Y., and Heiman, M. (1995) Nature 377, 530-532.
6. 6. Hummel, K. P., Dickie, M. M., and Coleman, D. L. (1966) Science 153, 1127-1128.
7. 7. Coleman, D. L. (1978) Diabetologia 14, 141-148.
8. 8. Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A., and Tepper, R. I. (1995) Cell 83, 1263-1271.
9. 9. Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., Moore, K. J., Breitbart, R. E., Duyk, G. M., Tepper, R. I., and Morgenstern, J. P. (1996) Cell 84, 491-495.
10. 10. Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., and Friedman, J. M. (1996) Nature 379, 632-635.
11. 11. Murakami, T., and Shima, K. (1995) Biochem. Biophys. Res. Commun. 209, 944-952.
12. 12. Chua Jr., S. C., Chung, W. K., Wu-Peng, S., Zhang, Y., Liu, S.-M., Tartaglia, L., and Leibel, R. L. (1996) Science 271, 994-996.
13. 13. Iida, M., Murakami, T., Ishida, K., Mizuno, A., Kuwajima, M., and Shima, K. Biochem. Biophys. Res. Commun., in press
14. 14. Kawasaki, E. S., Clark, S. S., Coyne, M. Y., Smith, S. D., Champlin, R., Witte, O. N., and McCormick, F. P. (1988) Proc. Natl. Acad. Sci. USA 85, 5698-5702.
15. 15. Rappolee, D. A., Mark, D., Banda, M. J., and Werb, Z. (1988) Science 241, 708-712.
16. 16. Rappolee, D. A., Brenner, C. A., Schultz, R., Mark, D., and Werb, Z. (1988) Science 241, 1823-1825.
17. 17. Zucker, L. M., and Zucker, T. F. (1961) J. Hered. 52, 275-278.
18. 18. Blin, N., and Stafford, D. W. (1976) Nucleic Acids Res. 3, 2303-2308.
19. 19. Southern, E. M. (1975) J. Mol. Biol. 98, 503-517.
20. 20. Feinberg, A. P., and Vogelstein, B. (1983) Anal. Biochem. 132, 6-13.
21. 21. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
22. 22. Ullrich, A., Shine, J., Chirgwin, J., Pictet, R., Tischer, E., Rutter, W. J., and Goodman, H. M. (1977) Science 196, 1313-1319.
23. 23. Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., and Rutter, W. J. (1979) Biochemistry 18, 5294-5299.
24. 24. Amemiya, Y., and Miyahara, J. (1988) Nature 336, 89-90.
25. 25. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. USA 74, 5463-5467.
26. 26. Adams, M. D., Fields, C., and Venter, J. C. (1994) Automated DNA Sequencing and Analysis, Academic Press, London.
27. 27. Narazaki, M., Witthuhn, B. A., Yoshida, K., Silvennoinen, O., Yasukawa, K., Ihle, J. N., Kishimoto, T., and Taga, T. (1994) Proc. Natl. Acad. Sci, USA 91, 2285-2289.
28. 28. Baumann, H., Symes, A. J., Comeau, M. R., Morella, K. K., Wang, Y., Friend, D., Ziegler, S. F., Fink, J. S., and Gearing, D. P. (1994) Mol. Cell. Biol. 14, 138-146.
29. 29. Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell Jr., J. E., and Yancopoulos, G. D. (1995) Science 267, 1349-1353.