Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: Focus on orexin targets involved in control of food and water intake

European Journal of Neuroscience

Volumn 15, Issue 2, 2002, Pages 315-328

  Bäckberg, Matilda ^a   Hervieu, Guillaume ^b   Wilson, Shelagh ^b   Meister, Björn ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antiserum; Body weight; Feeding; Hypocretin; Immunohistochemistry; Rat

Indexed keywords

AGOUTI RELATED PROTEIN; AMPHETAMINE; COCAINE; CORTICOTROPIN RELEASING FACTOR; HISTAMINE; NEUROPEPTIDE; NEUROPEPTIDE Y; OREXIN; OREXIN 1 RECEPTOR; OXYTOCIN; POLYCLONAL ANTISERUM; PROOPIOMELANOCORTIN; RECEPTOR; SOMATOSTATIN; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOPRESSIN; WATER;

ANIMAL BEHAVIOR; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARCUATE NUCLEUS; ARTICLE; BRAIN REGION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLUID BALANCE; FLUID INTAKE; FOOD INTAKE; GIANT CELL; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL; NEUROENDOCRINE SYSTEM; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; RAT; SUPRACHIASMATIC NUCLEUS; SUPRAOPTIC NUCLEUS; THALAMUS VENTRAL NUCLEUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; DRINKING; EATING; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR SEQUENCE DATA; NEURONS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 0036460171     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816x.2001.01859.x     Document Type: Article

References (65)

1. Bourque, C.W. & Oliet, S.H. (1997) Osmoreceptors in the central nervous system. Annu. Rev. Physiol., 59, 601-619.
2. Broberger, C., de Lecea, L., Sutcliffe, J.G. & Hökfelt, T. (1998a) Hypocretin/ orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems. J. Comp. Neurol., 402, 460-474.
3. Broberger, C., Johansen, J., Johansson, C., Schalling, M. & Hökfelt, T. (1998b) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. USA, 95, 15043-15048.
4. Brown, R.E., Stevens, D.R. & Haas, H.L. (2001) The physiology of brain histamine. Prog. Neurobiol., 63, 637-672.
5. Buchan, A.M., Sikora, L.K., Levy, J.G., McIntosh, C.H., Dyck, I. & Brown, J.C. (1985) An immunocytochemical investigation with monoclonal antibodies to somatostatin. Histochemistry, 83, 175-180.
6. Cai, X.J., Widdowson, P.S., Harrold, J., Wilson, S., Buckingham, R.E., Arch., J.R., Tadayyon, M., Clapham, J.C., Wilding, J. & Williams, G. (1999) Hypothalamic orexin expression: Modulation by blood glucose and feeding. Diabetes, 48, 2132-2137.
7. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B. & Yanagisawa, M. (1999) Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation. Cell, 98, 437-451.
8. Clark, J.T., Kalra, P.S., Crowley, W.R. & Kalra, S.P. (1984) Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology, 115, 427-429.
9. Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. & Nakazato, M. (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. USA, 96, 748-753.
10. Dube, M.G., Horvath, T.L., Kalra, P.S. & Kalra, S.P. (2000) Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides, 21, 1557-1560.
11. Dube, M.G., Kalra, S.P. & Kalra, P.S. (1999) Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action. Brain Res., 842, 473-477.
12. Edwards, C.M., Abusnana, S., Sunter, D., Murphy, K.G., Ghatei, M.A. & Bloom, S.R. (1999) The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol., 160, R7-R12.
13. Elde, R.P. & Hökfelt, T. (1978) Distribution of hypothalamic hormones and other peptides in the brain. In Ganong, W.F. & Martini, L. (eds), Frontiers in Neuroendocrinology. Raven Press, New York, pp. 1-33.
14. Elias, C.F., Saper, C.B., Maratos-Flier, E., Tritos, N.A., Lee, C., Kelly, J., Tatro, J.B., Hoffman, G.E., Ollmann, M.M., Barsh, G.S., Sakurai, T., Yanagisawa, M. & Elmquist, J.K. (1998) Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol., 402, 442-459.
15. Ericson, H., Watanabe, T. & Köhler, C. (1987) Morphological analysis of the tuberomammillary nucleus in the rat brain: Delineation of subgroups with antibody against L-histidine decarboxylase as a marker. J. Comp. Neurol., 263, 1-24.
16. Estabrooke, I., McCarthy, M.T., Ko, E., Chou, T.C., Chemelli, R.M., Yanagisawa, M., Saper, C.B. & Scammell, T.E. (2001) Fos expression in orexin neurons varies with behavioral state. J. Neurosci., 21, 1656-1662.
17. Gautvik, K.M., de Lecea, L., Gautvik, V.T., Danielson, P.E., Tranque, P., Dopazo, A., Bloom, F.E. & Sutcliffe, J.G. (1996) Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc. Natl. Acad. Sci. USA, 93, 8733-8738.
18. Ghandour, M.S., Langley, O.K. & Keller, A. (1981) A comparative immunohistological study of cerebellar enolases. Double labelling technique and immunoelectronmicroscopy. Exp. Brain Res., 41, 271-279.
19. Grossman, S.P. (1997) Eating or drinking elicited by direct adrenergic or cholinergic stimulation of hypothalamus, 1960. Obes. Res., 5, 291-293.
20. Grouzmann, E., Comoy, E., Walker, P., Burnier, M., Bohuon, C., Waeber, B. & Brunner, H. (1992) Production and characterization of four anti-neuropeptide Y monoclonal antibodies. Hybridoma, 11, 409-424.
21. Hahn, T.M., Breininger, J.F., Baskin, D.G. & Schwartz, M.W. (1998) Coexpression of AGRP and NPY in fasting-activated hypothalamic neurons. Nature Neurosci., 1, 271-272.
22. Hervieu, G.J., Cludery, J.E., Harrison, D.C., Roberts, J.C. & Leslie, R.A. (2001) Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience, 103, 777-797.
23. Horvath, T.L., Diano, S. & van den Pol, A.N. (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations. J. Neurosci, 19, 1072-1087.
24. Huang, Z.L., Qu, W.M., Li, W.D., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y. & Hayaishi, O. (2001) Arousal effect of orexin A depends on activation of the histaminergic system. Proc. Natl. Acad. Sci. USA, 98, 9965-9970.
25. Ida, T., Nakahara, K., Katayama, T., Murakami, N. & Nakazato, M. (1999) Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res., 821, 526-529.
26. Jain, M.R., Horvath, T.L., Kalra, P.S. & Kalra, S.P. (2000) Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul. Pept., 87, 19-24.
27. Kalra, S.P., Dube, M.G., Pu, S., Xu, B., Horvath, T.L. & Kalra, P.S. (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev., 20, 68-100.
28. Kilduff, T.S. & Peyron, C. (2000) The hypocretin/orexin ligand-receptor system: Implications for sleep and sleep disorders. Trends Neurosci., 23, 359-365.
29. Köhler, C., Swanson, L.W., Haglund, L. & Wu, J.Y. (1985) The cytoarchitecture, histochemistry and projections of the tuberomammillary nucleus in the rat. Neuroscience, 16, 85-110.
30. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christjansen, K.N., Wulff, B.S., Clausen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J. & Hastrup, S. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 393, 72-76.
31. Kunii, K., Yamanaka, A., Nambu, T., Matsuzaki, I., Goto, K. & Sakurai, T. (1999) Orexins/hypocretins regulate drinking behaviour. Brain Res., 842, 256-261.
32. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. & Sutcliffe, J.G. (1998) The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA, 95, 322-327.
33. Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. & Mignot, E. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell, 98, 365-376.
34. Lu, X.Y., Bagnol, D., Burke, S., Akil, H. & Watson, S.J. (2000) Differential distribution and regulation of OX1 and OX2 Orexin/Hypocretin receptor messenger RNA in the brain upon fasting. Horm. Behav., 37, 335-344.
35. Marcus, J.N., Aschkenasi, C.J., Lee, C.E., Chemelli, R.M., Saper, C.B., Yanagisawa, M. & Elmquist, J.K. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol., 435, 6-25.
36. Marshall, J.F. & Teitelbaum, P. (1974) Further analysis of sensory inattention following lateral hypothalamic damage in rats. J. Comp. Physiol. Psychol., 86, 375-395.
37. Meister, B., Cortés, R., Villar, M.J., Schalling, M. & Hökfelt, T. (1990) Peptides and transmitter enzymes in hypothalamic magnocellular neurons after administration of hyperosmotic stimuli: Comparison between messenger RNA and peptide/protein levels. Cell Tissue Res., 260, 279-297.
38. Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M. & Goto, K. (1999) Distribution of orexin neurons in the adult rat brain. Brain Res., 827, 243-260.
39. Nisbett, R.E. (1972) Hunger, obesity, and the ventromedial hypothalamus. Psychol. Rev., 79, 433-453.
40. Nishino, S., Ripley, B., Overeem, S., Lammers, G.J. & Mignot, E. (2000) Hypocretin (orexin) deficiency in human narcolepsy. Lancet, 355, 39-40.
41. Oltmans, G.A. & Harvey, J.A. (1976) Lateral hypothalamic syndrome in rats: A comparison of the behavioral and neurochemical effects of lesions placed in the lateral hypothalamus and nigrostriatal bundle. J. Comp. Physiol. Psychol., 90, 1051-1062.
42. Oomura, Y., Ono, T., Ooyama, H. & Wayner, M.J. (1969) Glucose and osmosensitive neurones of the rat hypothalamus. Nature, 222, 282-284.
43. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., Li, R., Hungs, M., Pedrazzoli, M., Padigaru, M., Kucherlapati, M., Fan, J., Maki, R., Lammers, G.J., Bouras, C., Kucherlapati, R., Nishino, S. & Mignot, E. (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nature Med., 6, 991-997.
44. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. & Kilduff, T.S. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci., 18, 9996-10015.
45. Poggioli, R., Vergoni, A.V. & Bertolini, A. (1986) ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides, 7, 843-848.
46. van den Pol, A.N. (1999) Hypothalamic hypocretin (orexin): Robust innervation of the spinal cord. J. Neurosci., 19, 3171-3182.
47. van den Pol, A.N., Gao, X.B., Obrietan, K., Kilduff, T.S. & Belousov, A.B. (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci., 18, 7962-7971.
48. Rauch, M., Riediger, T., Schmid, H.A. & Simon, E. (2000) Orexin A activates leptin-responsive neurons in the arcuate nucleus. Pflügers Arch., 440, 699-703.
49. Risold, P.Y., Griffond, B., Kilduff, T.S., Sutcliffe, J.G. & Fellmann, D. (1999) Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area. Neurosci. Lett., 259, 153-156.
50. Rossi, M., Kim, M.S., Morgan, D.G., Small, C.J., Edwards, C.M., Sunter, D., Abusnana, S., Goldstone, A.P., Russell, S.H., Stanley, S.A., Smith, D.M., Yagaloff, K., Ghatei, M.A. & Bloom, S.R. (1998) A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology, 139, 4428-4431.
51. Sakurai, T. (1999) Orexins and orexin receptors: Implication in feeding behavior. Regul. Pept., 85, 25-30.
52. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch., J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. & Yanagisawa, M. (1998) Orexins and orexin receptors: A family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior. Cell, 92, 573-585.
53. Schwartz, M.W., Woods, S.C., Porte, D. Jr, Seeley, R.J. & Baskin, D.G. (2000) Central nervous system control of food intake. Nature, 404, 661-671.
54. Shiraishi, T., Oomura, Y., Sasaki, K. & Wayner, M.J. (2000) Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol. Behav., 71, 251-261.
55. Stanley, B.G. & Leibowitz, S.F. (1985) Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. USA, 82, 3940-3943.
56. Stanley, B.G., Magdalin, W., Seirafi, A., Thomas, W.J. & Leibowitz, S.F. (1993) The perifornical area: The major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system (s). Brain Res., 604, 304-317.
57. Sutcliffe, J.G. & de Lecea, L. (2000) The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. J. Neurosci. Res., 62, 161-168.
58. Sweet, D.C., Levine, A.S., Billington, C.J. & Kotz, C.M. (1999) Feeding response to central orexins. Brain Res., 821, 535-538.
59. Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M. & Siegel, J.M. (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron, 27, 469-474.
60. Trivedi, P., Yu, H., MacNeil, D.J., Van der Ploeg, L.H. & Guan, X.M. (1998) Distribution of orexin receptor mRNA in the rat brain. FEBS Lett., 438, 71- 75.
61. Volkoff, H., Bjorklund, J.M. & Peter, R.E. (1999) Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B. Brain Res., 846, 204-209.
62. Warnke, R. & Levy, R. (1980) Detection of T and B cell antigens hybridoma monoclonal antibodies: A biotin-avidin-horseradish peroxidase method. J. Histochem. Cytochem., 28, 771-776.
63. Watanabe, T., Taguchi, Y., Shiosaka, S., Tanaka, J., Kubota, H., Terano, Y., Tohyama, M. & Wada, H. (1984) Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res., 295, 13-25.
64. Yamanaka, A., Kunii, K., Nambu, T., Tsujino, N., Sakai, A., Matsuzaki, I., Miwa, Y., Katsutoshi, G. & Sakurai, T. (2000) Orexin-induced food intake involves neuropeptide Y pathway. Brain Res., 859, 404-409.
65. Yamanaka, A., Sakurai, T., Katsumoto, T., Yanagisawa, M. & Goto, K. (1999) Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res., 849, 248-252.