The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin

Journal of Endocrinology

Volumn 160, Issue 3, 1999, Pages

  Edwards, C M B ^a   Abusnana, S ^a   Sunter, D ^a   Murphy, K G ^a   Ghatei, M A ^a   Bloom, S R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GALANIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE; NEUROPEPTIDE Y;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CELL ACTIVATION; CONTROLLED STUDY; FOOD INTAKE; GENE EXPRESSION; MALE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; WEIGHT REDUCTION;

EID: 0032940785     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.160r007     Document Type: Article

References (19)

1. Arnold FJL, deLucas Bueno M, Shiers HM, Hancock DE, Evans GI & Herbert J 1992 Expression of c-fos in regions of the basal limbic forebrain following intra-cerebroventricular corticotropin-releasing factor (CRF) in unstressed or stressed male rats. Neuroscience 51 377-390.
2. Bray GA 1984 Hypothalamic and genetic obesity: an appraisal of the autonomic hypothesis and the endocrine hypothesis. International Journal of Obesity 9 119-137.
3. Chronwall BM, DiMaggio DA, Massari VJ, Pickel VM, Ruggiero DA & O'Donohue TL 1985 The anatomy of neuropeptide-Y-containing neurons in rat brain. Neuroscience 15 1159-1181.
4. De-Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett II FS, Frankel WN, van-den-Pol AN, Bloom FE, Gautvik KM & Sutcliffe JG 1998 The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the USA 95 322-327.
5. Herbert J 1993 Peptides in the limbic system: neurochemical codes for co-ordinated adaptive responses to behavioural and physiological demand. Progress in Neurobiology 41 723-791.
6. Kyrkouli SE, Stanley BG & Leibowitz SF 1986 Galanin: stimulation of feeding by medial hypothalamic injection of this novel peptide. European Journal of Pharmacology 122 159-160.
7. Lambert PD, Phillips PJ, Wilding JPH, Bloom SR & Herbert J 1995 c-fos expression in the paraventricular nucleus of the hypothalamus following intracerebroventricular infusions of neuropeptide Y. Brain Research 670 59-65.
8. McMahon LR & Wellman PJ 1998 PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats. American Journal of Physiology 274 R23-R29.
9. O'Shea D, Morgan DG, Meeran K, Edwards CMB, Turton MD, Choi SJ, Heath MM, Gunn I, Taylor GM, Howard JK, Bloom CI, Small CJ, Haddo O, Ma JJ, Callinan W, Smith DM, Ghatei MA & Bloom SR 1997 Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology 138 196-202.
10. Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, Mathes WF, Przypek R, Kanarek R & Maratos-Flier E 1996 A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380 243-247.
11. Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA & Bloom SR 1997 Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138 351-355.
12. Sagar SM, Sharp FR & Curran T 1988 Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240 1328-1331.
13. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ & Yanagisawa M 1998 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 573-585.
14. Shimada M, Tritos NA, Lowell BB, Flier JS & Maratos-Flier E 1998 Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396 670-674.
15. Stanley BG & Leibowitz SF 1984 Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sciences 35 2635-2642.
16. Stanley BG, Kyrkouli SE, Lamport S & Leibowitz SF 1986 Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptidesl 1189-1192.
17. Tacha DE & McKinney LA 1992 Casein reduces nonspecific background staining in immunolabeling techniques. Journal of Histotechnology 15 127-132.
18. Tempel DL, Leibowitz KJ & Leibowitz SF 1988 Effects of PVN galanin on macronutrient selection. Peptides 9 309-314.
19. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghatei MA, Herbert J & Bloom SR 1996 A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69-72