Melanin-concentrating hormone is the cognate ligand for the orphan G- protein-coupled receptor SLC-1

Nature

Volumn 400, Issue 6741, 1999, Pages 261-265

  Chambers, Jon ^a   Ames, Robert S ^a   Bergsma, Derk ^a   Muir, Alison ^a   Fitzgerald, Laura R ^a   Hervieu, Guillaume ^a   Dytko, George M ^a   Foley, James J ^a   Martin, John ^a   Liu, Wu Schyong ^a   Park, Janet ^a   Ellis, Catherine ^a   Ganguly, Subinay ^a   Konchar, Susan ^a   Cluderay, Jane ^a   Leslie, Ron ^a   Wilson, Shelagh ^a   Sarau, Henry M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIC AMP; FORSKOLIN; LIGAND; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; NEUROPEPTIDE; NEUROTRANSMITTER;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENERGY BALANCE; FEEDING BEHAVIOR; FOOD INTAKE; HUMAN; HUMAN CELL; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMUS VENTRAL NUCLEUS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP; FEEDING BEHAVIOR; GTP-BINDING PROTEINS; HUMANS; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LIGANDS; MELANINS; MICE; MOLECULAR SEQUENCE DATA; PITUITARY HORMONES; RATS; RECEPTORS, SOMATOSTATIN; RECOMBINANT PROTEINS; RNA, MESSENGER;

ANIMALIA;

EID: 0033566128     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/22313     Document Type: Article

References (25)

1. Qu, D. et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243-247 (1996).
2. Rossi, M. et al. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138, 351-355 (1997).
3. Shimada, M., Tritos, N., Lowell, B., Flier, J. & Maratos-Flier, E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature 396, 670-674 (1998).
4. Lakaye, B., Minet, A., Zorzi, W. & Grisar, T. Cloning of the rat brain cDNA encoding for the SLC-1 G protein coupled receptor reveals the presence of an intron in the gene. Biochim. Biophys. Acta 1401, 216-220 (1998).
5. Kolakowski, L. F. Jr. et al. Characterization of a human gene related to genes encoding somatostatin receptors. FEBS Lett. 398, 253-258 (1996).
6. Moro, O., Lameh, J., Hogger, P. & Sadee, W. Hydrophobic amino acid in the i2 loop plays a key role in receptor-G-protein coupling. J. Biol. Chem. 268, 22273-22276 (1993).
7. Stadel, J. M., Wilson, S. & Bergsma, D. J. Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery. Trends Pharmacol. Sci. 18, 430-437 (1997).
8. Sakurai, T. et al. Orexins and Orexin receptors: A family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behaviour. Cell 92, 573-585 (1998).
9. Breton, C., Schorpp, M. & Nahon, J. L. Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene. Mol. Brain Res. 18, 297-310 (1993).
10. Miller, C. L., Burmeister, M. & Thompson, R. C. Antisense expression of the human pro-melanin concentrating hormone genes. Brain Res. 803, 86-94 (1998).
11. Presse, F., Nahon, J. L., Fischer, W. H. & Vale, W. Structure of the human melanin concentrating hormone mRNA. Mol. Endocrinol. 4, 632-637 (1990).
12. Toumaniantz, G., Bittencourt, J. C. & Nahon, J. L. The rat melanin-concentrating hormone gene encodes an additional putative protein in a different reading frame. Endocrinology 137, 4518-4521 (1996).
13. Burgaud, J-L., Poosti, R., Fehrentz, J-A., Martinez, J. & Nahon, J-L. Melanin-concentrating hormone binding sites in human SVK14 keratinocytes. Biochem. Biophys. Res. Commun. 241, 622-629 (1997).
14. Drozdz, R., Siegrist, W., Baker, B. I., Chluba-de Tapia, J. & Eberle, A. N. Melanin-concentrating hormone binding to mouse melanoma cells in vitro. FEBS Lett. 359, 199-202 (1995).
15. Kawauchi, H., Kawazoe, I., Tsubokawa, M., Kishida, M. & Baker, B. I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 305, 321-323 (1983).
16. Ludwig, D. S. et al. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. Am. J. Physiol. 247, E627-E633 (1998).
17. Tritos, N. A. et al. Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. Diabetes 47, 1687-1692 (1998).
18. Bittencourt, J. C. et al. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 319, 218-245 (1992).
19. Bergsma, D. J. et al. Cloning and expression of an angiotensin II type 1 teceptor. Biochem. Biophys. Res. Commun. 183, 989-995 (1992).
20. Bergsma, D. J. et al. The cyclophilin multigene family of peptidy-prolyl isomerases. J. Biol. Chem. 266, 23204-23214 (1991).
21. Aiyar, N. et al. Human AT1 receptor is a single copy gene: characterization in a stable cell line. Mol. Cell. Biochem. 131, 75-86 (1994).
22. Tam, J. P., Wu, C.-R., Liu, W. & Zhang, J.-W. Disulfide bond formation in peptides by dimethyl sulfoxide: scope and applications. J. Am. Chem. Soc. 113, 6657-6662 (1991).
23. Fitzgerald, L. W., Patterson, J. P., Conklin, D. S., Horlick, R. & Largent, B. L. Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: Agonist character of chimeric galanin peptides. J. Pharmacol. Exp. Ther. 287, 448-456 (1998).
24. Hervieu, G. & Nahon, J. L. Pro-melanin-concentrating hormone messenger RNA and peptide expression in peripheral tissues of the rat. Neuroendocrinology 61, 348-364 (1995).
25. 1 immunoreactivity in the rat brain using an N-terminal specific antibody. Neuroscience 85, 1263-1284 (1998).