The endogenous cennabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Journal of Clinical Investigation

Volumn 112, Issue 3, 2003, Pages 423-431

  Cota, Daniela ^a   Marsicano, Giovanni ^a   Tschöp, Matthias ^b   Grübler, Yvonne ^a   Flachskamm, Cornelia ^a   Schubert, Mirjam ^a   Auer, Dorothee ^a   Yassouridis, Alexander ^a   Thöne Reineke, Christa ^b   Ortmann, Sylvia ^c   Tomassoni, Federica ^d   Cervino, Cristina ^d   Nisoli, Enzo ^e   Linthorst, Astrid C E ^a   Pasquali, Renato ^d   Lutz, Beat ^a   Stalla, Günter K ^a   Pagotto, Uberto ^d  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c LEIBNIZ INSTITUTE FOR ZOO AND WILDLIFE RESEARCH   (Germany)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; CANNABINOID; CANNABINOID 1 RECEPTOR; COCAINE; CORTICOTROPIN RELEASING FACTOR; LIGAND; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; CANNABINOID RECEPTOR; DRUG RECEPTOR; ENDOCANNABINOID; LIPID; NEUROPEPTIDE; UNSATURATED FATTY ACID;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; BODY FAT; BRAIN NUCLEUS; BRAIN VENTRICLE; CALORIC INTAKE; CELL CULTURE; CONTROLLED STUDY; DRUG TARGETING; ENERGY BALANCE; ENERGY EXPENDITURE; EPIDIDYMIS FAT; FOOD INTAKE; GENOTYPE; HYPOPHAGIA; HYPOTHALAMUS; LEAN BODY WEIGHT; LIPOGENESIS; LOCOMOTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; WILD TYPE; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; C57BL MOUSE; EATING; ENERGY METABOLISM; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE MUTANT; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPOCYTES; ANIMALS; APPETITE; CANNABINOIDS; CORTICOTROPIN-RELEASING HORMONE; EATING; ENDOCANNABINOIDS; ENERGY METABOLISM; FATTY ACIDS, UNSATURATED; GENE EXPRESSION; HYPOTHALAMUS; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPEPTIDES; OBESITY; PHENOTYPE; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RNA, MESSENGER; THINNESS;

EID: 85047690626     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17725     Document Type: Article

References (49)

1. Flegal, K.M., Carroll, M.D., Ogden, C.L., and Johnson, C.L. 2002. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 288:1723-1727.
2. Yanovski, S.Z., and Yanovski, J.A. 2002. Obesity. N. Engl. J. Med. 346:591-602.
3. Zhang, Y., et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
4. Howlett, A.C., et al. 2002. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54:161-202.
5. Lutz, B. 2002. Molecular biology of cannabinoid receptors. Prostaglandins Leukot. Essent. Fatty Acids. 66:123-142.
6. Abet, E.L. 1975. Cannabis: effects on hunger and thirst. Behav. Biol. 15:255-281.
7. Williams, C.M., Rogers, P.J., and Kirkham, T.C. 1998. Hyperphagia in pre-fed rats following oral delta9-THC. Physiol Behav. 65:343-346.
8. Koch, J.E. 2001. Delta(9)-THC stimulates food intake in Lewis rats: effects on chow, high-fat and sweet high-far diets. Pharmacol. Biochem. Behav. 68:539-543.
9. Williams, C.M., and Kirkham, T.C. 1999. Anandamide induces overeating: mediation by central cannabinoid (CBI) receptors. Psychopharmacology (Berl). 143:315-317.
10. Jamshich, N., and Taylor, D.A. 2001. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br. J. Pharmacol. 134:1151-1154.
11. Hao, S., Avraham, Y., Mechoulam, R., and Berry, E.M. 2000. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. Eur. J. Pharmacol. 392:147-156.
12. Mechoulam, R., and Fride, E. 2001. A hunger for cannabinoids, Nature. 410:763-765,
13. Cota, D., et al. 2003. The endogenous cannabinoicl system as a modulator of food intake. Int. J. Obes. Relat. Metab. Disord. 27:289-301.
14. Simiand, J., Keane, M., Keane, P.E., and Soubrie, P. 1998. SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Behav. Pharmacol. 9:179-181.
15. Colombo, G., et al. 1998. Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 63:L113-L117.
16. Freedland, C.S., Poston, J.S., and Porrino, LJ. 2000. Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding. Pharmacol. Biochem. Behav. 67:265-270.
17. Di Marzo, V., et al, 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature, 410:822-825.
18. Gomez, R., et al. 2002. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J. Neurosci. 22:9612-9617.
19. Marsicano, G., et al. 2002. The endogenous cannabinoid system controls extinction of aversive memories. Nature. 418:530-534.
20. Klaus, S., Munzberg, H., Truloff, C., and Heldmaier, G. 1998. Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature. Am. J. Physiol. 274:R287-R293.
21. Linthorst, A.C.E., Karanth, S., Barden, N., Holsboer, F., and Reul, J.M.H.M. 1999. Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin. Eur. J. Neurosci. 66:143-151.
22. Marsicano, G., and Lutz, B. 1999. Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain. Eur. J. Neurosci. 11:4213-4225.
23. Seasholtz, A., Bourbonais, F.J., Harnden, C.E., and Camper, S.A. 1991. Nucleotide sequence and expression of the mouse corticotropin-releasing hormone gene. Mol. Cell. Neurosci. 2:266-273.
24. Hermann, H., Marsicano, G., and Lutz, B. 2002. Coexpression of the cannabinoid receptor type I with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Neuroscience. 109:451-460.
25. Ailhaud, G. 2001. Adipose tissue protocols. Humana Press. Totowa, New Jersey, USA. 334 pp.
26. Pagotro, U., et al. 1995. Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth. J. Clin. Invest. 96:2017-2025.
27. Matsumoto, F., et al. 2002. Effects of nutrition on the cell survival and gene expression of transplanted far tissues in mice. Biochem. Biophys. Res. Commun. 295:630-635.
28. Olschowka, JA., O'Donohue, T.L., Mueller, G.P., and Jacobowitz, D.M. 1982. The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain. Peptides. 3:995-1015.
29. Allen, Y.S., et al. 1983. Neuropeptide Y distribution in the rat brain. Science, 221:877-879.
30. Couceyro, P.R., Koylu, E.O., and Kuhar, MJ. 1997. Further studies on the anatomical distribution of CART by in situ hybridization. J. Chem. Neuroanat. 12:229-241.
31. de Lecea, L., et al. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 95:322-327.
32. Bittencourt, J.C., et al. 1992. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J. Comp. Neurol. 319:218-245.
33. Farooqi, I.S., et al. 1999. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341:879-884.
34. Dhillo, WS., and Bloom, S.R. 2001. Hypothalamic peptides as drug targets for obesity. Curr. Opin. Pharmacol. 1:651-655.
35. Berry, E.M., and Mechoulam, R. 2002. Tetrahydrocannabinol and endocannabinoids in feeding and appetite. Pharmacol. Ther. 95:185-190.
36. Qian, S., et al. 2002. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol. Cell Biol. 22:5027-5035.
37. Kreuz, D.S., and Axelrod, J. 1973. Delta-9-tetrahydrocannabinol: localization in body fat. Science. 179:391-393.
38. Karlsson, M., Contreras, J.A., Hellman, U., Tornqvist, H., and Holm, C. 1997. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J. Biol. Chem. 272:27218-27223.
39. Dinh, T.P., et al. 2002. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Natl. Acad. Sci. U. S. A. 99:10819-10824.
40. Ravinet, T.C., et al. 2003. Anti-obesin, effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:R345-R353.
41. Inui, A. 1999. Feeding and body-weight regulation by hypothalamic neuropeptides-mediation of the actions of leptin. Trends Neurosci. 22:62-67.
42. Li, C., Chen, P., and Smith, M.S. 2000. Corticotropin releasing hormone neurons in the paraventricular nucleus are direct targets for neuropeptide Y neurons in the arcuate nucleus: an anterograde tracing study. Brain Res. 854:122-129.
43. Kristensen, P., et al. 1998. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:72-76.
44. Abbott, C.R., et al. 2001. Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology. 142:3457-3463.
45. Kunos, G., et al. 2002. Endocannabinoids and appetite: possible interactions with other neurotransmitter systems. Symposium on the Cannabinoids. Burlington, Vermont, USA, International Cannabinoid Research Society. (Abstr.)
46. Zimmer, A., Zimmer, A.M., Hohmann, A.G., Herkenham, M., and Bonner, T.I. 1999. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc. Natl. Acad. Sci. U. S. A. 96:5780-5785.
47. Ledent, C., et al. 1999. Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science. 283:401-404.
48. Chen, A.S., et al. 2000. Inactivation of the mouse melanocortin-3 receptor results in increased far mass and reduced lean body mass. Nat. Genet. 26:97-102,
49. Asnicar, M.A., et al. 2001. Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology. 142:4394-4400.