1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 14, 2001, Pages 1907-1910

  Porter, Roderick A ^a   Chan, Wai N ^a   Coulton, Steven ^a   Johns, Amanda ^a   Hadley, Michael S ^a   Widdowson, Katherine ^b   Jerman, Jeffrey C ^a   Brough, Stephen J ^a   Coldwell, Martyn ^a   Smart, Darren ^a   Jewitt, Frances ^a   Jeffrey, Phillip ^a   Austin, Nigel ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 3 NAPHTHYRIDIN 4 YLUREA DERIVATIVE; 3 QUINOLIN 4 YLUREA DERIVATIVE; G PROTEIN COUPLED RECEPTOR; OREXIN 1 RECEPTOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; BLOOD BRAIN BARRIER; DOSE RESPONSE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; IN VIVO STUDY; NONHUMAN; PERMEABILITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOXAZOLES; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHO CELLS; CRICETINAE; HUMANS; INDOLES; INFUSIONS, INTRAVENOUS; NAPHTHYRIDINES; PERMEABILITY; QUINOLINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0035939299     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00343-2     Document Type: Article

References (19)