-
1
-
-
84865411454
-
Discovery of Purinergic Signalling, the Initial Resistance and Current Explosion of Interest
-
Burnstock G. Discovery of Purinergic Signalling, the Initial Resistance and Current Explosion of Interest. Br J Pharmacol. 2012;2:238-255.
-
(2012)
Br J Pharmacol.
, vol.2
, pp. 238-255
-
-
Burnstock, G.1
-
2
-
-
58149481772
-
Purinergic signalling in the nervous system: An overview
-
Abbracchio MP, Burnstock G, Verkhratsky A, Zimmermann H. Purinergic signalling in the nervous system: an overview. Trends Neurosci. 2009;32(1):19-29.
-
(2009)
Trends Neurosci.
, vol.32
, Issue.1
, pp. 19-29
-
-
Abbracchio, M.P.1
Burnstock, G.2
Verkhratsky, A.3
Zimmermann, H.4
-
3
-
-
67649639047
-
Signaling at purinergic P2X receptors
-
Surprenant A, North RA. Signaling at purinergic P2X receptors. Annu Rev Physiol. 2009;71:333-359.
-
(2009)
Annu Rev Physiol.
, vol.71
, pp. 333-359
-
-
Surprenant, A.1
North, R.A.2
-
4
-
-
77951237274
-
The birth and postnatal development of purinergic signalling
-
Burnstock G, Fredholm BB, North RA, Verkhratsky A. The birth and postnatal development of purinergic signalling. Acta Physiol (Oxf). 2010;199(2):93-147.
-
(2010)
Acta Physiol (Oxf).
, vol.199
, Issue.2
, pp. 93-147
-
-
Burnstock, G.1
Fredholm, B.B.2
North, R.A.3
Verkhratsky, A.4
-
5
-
-
33746701380
-
P2X receptors as cell-surface ATP sensors in health and disease
-
Khakh BS, North RA. P2X receptors as cell-surface ATP sensors in health and disease. Nature. 2006;442(7102):527-532.
-
(2006)
Nature.
, vol.442
, Issue.7102
, pp. 527-532
-
-
Khakh, B.S.1
North, R.A.2
-
6
-
-
0036788971
-
Molecular physiology of P2X receptors
-
North RA. Molecular physiology of P2X receptors. Physiol Rev. 2002;82(4):1013-1067.
-
(2002)
Physiol Rev.
, vol.82
, Issue.4
, pp. 1013-1067
-
-
North, R.A.1
-
7
-
-
77956626757
-
Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
-
Adinolfi E, Cirillo M, Woltersdorf R, etal. Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor. FASEB J. 2010;24(9):3393-3404.
-
(2010)
FASEB J.
, vol.24
, Issue.9
, pp. 3393-3404
-
-
Adinolfi, E.1
Cirillo, M.2
Woltersdorf, R.3
-
8
-
-
70350012258
-
A functional P2X7splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
-
Nicke A, Kuan YH, Masin M, etal. A functional P2X7splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice. J Biol Chem. 2009;284(38):25813-25822.
-
(2009)
J Biol Chem.
, vol.284
, Issue.38
, pp. 25813-25822
-
-
Nicke, A.1
Kuan, Y.H.2
Masin, M.3
-
9
-
-
19344369446
-
Identification and characterization of splice variants of the human P2X7 ATP channel
-
Cheewatrakoolpong B, Gilchrest H, Anthes JC, Greenfeder S. Identification and characterization of splice variants of the human P2X7 ATP channel. Biochem Biophys Res Commun. 2005;332(1):17-27.
-
(2005)
Biochem Biophys Res Commun.
, vol.332
, Issue.1
, pp. 17-27
-
-
Cheewatrakoolpong, B.1
Gilchrest, H.2
Anthes, J.C.3
Greenfeder, S.4
-
10
-
-
33745188916
-
A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization
-
Feng YH, Li X, Wang L, Zhou L, Gorodeski GI. A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization. J Biol Chem. 2006;281(25):17228-17237.
-
(2006)
J Biol Chem.
, vol.281
, Issue.25
, pp. 17228-17237
-
-
Feng, Y.H.1
Li, X.2
Wang, L.3
Zhou, L.4
Gorodeski, G.I.5
-
11
-
-
84863011694
-
Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: Re-evaluation of P2X7 knockouts
-
Masin M, Young C, Lim K, etal. Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts. Br J Pharmacol. 2012;165(4):978-993.
-
(2012)
Br J Pharmacol.
, vol.165
, Issue.4
, pp. 978-993
-
-
Masin, M.1
Young, C.2
Lim, K.3
-
12
-
-
0038441333
-
Pharmacological and biophysical properties of the human P2X5 receptor
-
Bo X, Jiang LH, Wilson HL, etal. Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol. 2003;63(6):1407-1416.
-
(2003)
Mol Pharmacol.
, vol.63
, Issue.6
, pp. 1407-1416
-
-
Bo, X.1
Jiang, L.H.2
Wilson, H.L.3
-
13
-
-
15444372454
-
Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize
-
Barrera NP, Ormond SJ, Henderson RM, Murrell-Lagnado RD, Edwardson JM. Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J Biol Chem. 2005;280(11):10759-10765.
-
(2005)
J Biol Chem.
, vol.280
, Issue.11
, pp. 10759-10765
-
-
Barrera, N.P.1
Ormond, S.J.2
Henderson, R.M.3
Murrell-Lagnado, R.D.4
Edwardson, J.M.5
-
14
-
-
33645837836
-
An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum
-
Ormond SJ, Barrera NP, Qureshi OS, Henderson RM, Edwardson JM, Murrell-Lagnado RD. An uncharged region within the N terminus of the P2X6 receptor inhibits its assembly and exit from the endoplasmic reticulum. Mol Pharmacol. 2006;69(5):1692-1700.
-
(2006)
Mol Pharmacol.
, vol.69
, Issue.5
, pp. 1692-1700
-
-
Ormond, S.J.1
Barrera, N.P.2
Qureshi, O.S.3
Henderson, R.M.4
Edwardson, J.M.5
Murrell-Lagnado, R.D.6
-
15
-
-
84858408591
-
P2X2 and P2X5subunits define a new heteromeric receptor with P2X7-like properties
-
Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F. P2X2 and P2X5subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci. 2012;32(12):4284-4296.
-
(2012)
J Neurosci.
, vol.32
, Issue.12
, pp. 4284-4296
-
-
Compan, V.1
Ulmann, L.2
Stelmashenko, O.3
Chemin, J.4
Chaumont, S.5
Rassendren, F.6
-
16
-
-
0032089620
-
P2X1 and P2X3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels
-
Nicke A, Baumert HG, Rettinger J, etal. P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J. 1998;17(11):3016-3028.
-
(1998)
EMBO J.
, vol.17
, Issue.11
, pp. 3016-3028
-
-
Nicke, A.1
Baumert, H.G.2
Rettinger, J.3
-
17
-
-
0141864571
-
Subunit arrangement in P2X receptors
-
Jiang LH, Kim M, Spelta V, Bo X, Surprenant A, North RA. Subunit arrangement in P2X receptors. J Neurosci. 2003;23(26):8903-8910.
-
(2003)
J Neurosci.
, vol.23
, Issue.26
, pp. 8903-8910
-
-
Jiang, L.H.1
Kim, M.2
Spelta, V.3
Bo, X.4
Surprenant, A.5
North, R.A.6
-
18
-
-
33748944331
-
Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor
-
Wilkinson WJ, Jiang LH, Surprenant A, North RA. Role of ectodomain lysines in the subunits of the heteromeric P2X2/3 receptor. Mol Pharmacol. 2006;70(4):1159-1163.
-
(2006)
Mol Pharmacol.
, vol.70
, Issue.4
, pp. 1159-1163
-
-
Wilkinson, W.J.1
Jiang, L.H.2
Surprenant, A.3
North, R.A.4
-
19
-
-
33846968794
-
Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor
-
Marquez-Klaka B, Rettinger J, Bhargava Y, Eisele T, Nicke A. Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor. J Neurosci. 2007;27(6):1456-1466.
-
(2007)
J Neurosci.
, vol.27
, Issue.6
, pp. 1456-1466
-
-
Marquez-Klaka, B.1
Rettinger, J.2
Bhargava, Y.3
Eisele, T.4
Nicke, A.5
-
20
-
-
60549095934
-
Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors
-
Marquez-Klaka B, Rettinger J, Nicke A. Inter-subunit disulfide cross-linking in homomeric and heteromeric P2X receptors. Eur Biophys J. 2009;38(3):329-338.
-
(2009)
Eur Biophys J.
, vol.38
, Issue.3
, pp. 329-338
-
-
Marquez-Klaka, B.1
Rettinger, J.2
Nicke, A.3
-
21
-
-
67949117176
-
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
-
Kawate T, Michel JC, Birdsong WT, Gouaux E. Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature. 2009;460(7255):592-598.
-
(2009)
Nature.
, vol.460
, Issue.7255
, pp. 592-598
-
-
Kawate, T.1
Michel, J.C.2
Birdsong, W.T.3
Gouaux, E.4
-
22
-
-
84860785529
-
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
-
Hattori M, Gouaux E. Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature. 2012;485(7397):207-212.
-
(2012)
Nature.
, vol.485
, Issue.7397
, pp. 207-212
-
-
Hattori, M.1
Gouaux, E.2
-
24
-
-
77958610109
-
Structural interpretation of P2X receptor mutagenesis studies on drug action
-
Evans RJ. Structural interpretation of P2X receptor mutagenesis studies on drug action. Br J Pharmacol. 2010;161(5):961-971.
-
(2010)
Br J Pharmacol.
, vol.161
, Issue.5
, pp. 961-971
-
-
Evans, R.J.1
-
25
-
-
77950941000
-
Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions
-
Roger S, Mei ZZ, Baldwin JM, etal. Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. J Psychiatr Res. 2010;44(6):347-355.
-
(2010)
J Psychiatr Res.
, vol.44
, Issue.6
, pp. 347-355
-
-
Roger, S.1
Mei, Z.Z.2
Baldwin, J.M.3
-
26
-
-
79953157461
-
Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms
-
Bradley HJ, Baldwin JM, Goli GR, etal. Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms. J Biol Chem. 2011;286(10):8176-8187.
-
(2011)
J Biol Chem.
, vol.286
, Issue.10
, pp. 8176-8187
-
-
Bradley, H.J.1
Baldwin, J.M.2
Goli, G.R.3
-
27
-
-
67949092829
-
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
-
Gonzales EB, Kawate T, Gouaux E. Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature. 2009;460(7255):599-604.
-
(2009)
Nature.
, vol.460
, Issue.7255
, pp. 599-604
-
-
Gonzales, E.B.1
Kawate, T.2
Gouaux, E.3
-
28
-
-
1842558753
-
Contribution of calcium ions to P2X channel responses
-
Egan TM, Khakh BS. Contribution of calcium ions to P2X channel responses. J Neurosci. 2004;24(13):3413-3420.
-
(2004)
J Neurosci.
, vol.24
, Issue.13
, pp. 3413-3420
-
-
Egan, T.M.1
Khakh, B.S.2
-
29
-
-
0033625619
-
Activation of purinergic P2X receptors inhibits P2Y-mediated Ca2+ influx in human microglia
-
Wang X, Kim SU, van Breemen C, McLarnon JG. Activation of purinergic P2X receptors inhibits P2Y-mediated Ca2+ influx in human microglia. Cell Calcium. 2000;27(4):205-212.
-
(2000)
Cell Calcium.
, vol.27
, Issue.4
, pp. 205-212
-
-
Wang, X.1
Kim, S.U.2
van Breemen, C.3
McLarnon, J.G.4
-
30
-
-
79960426653
-
Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons
-
Baxter AW, Choi SJ, Sim JA, North RA. Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons. Eur J Neurosci. 2011;34(2):213-220.
-
(2011)
Eur J Neurosci.
, vol.34
, Issue.2
, pp. 213-220
-
-
Baxter, A.W.1
Choi, S.J.2
Sim, J.A.3
North, R.A.4
-
31
-
-
0042738937
-
ATP modulation of excitatory synapses onto interneurons
-
Khakh BS, Gittermann D, Cockayne DA, Jones A. ATP modulation of excitatory synapses onto interneurons. J Neurosci. 2003;23(19):7426-7437.
-
(2003)
J Neurosci.
, vol.23
, Issue.19
, pp. 7426-7437
-
-
Khakh, B.S.1
Gittermann, D.2
Cockayne, D.A.3
Jones, A.4
-
32
-
-
34547483582
-
Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia
-
Zhang X, Chen Y, Wang C, Huang LY. Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci U S A. 2007;104(23):9864-9869.
-
(2007)
Proc Natl Acad Sci U S A.
, vol.104
, Issue.23
, pp. 9864-9869
-
-
Zhang, X.1
Chen, Y.2
Wang, C.3
Huang, L.Y.4
-
33
-
-
70450170577
-
Ca2+-dependent modulation of GABAA and NMDA receptors by extracellular ATP: Implication for function of tripartite synapse
-
Lalo U, Andrew J, Palygin O, Pankratov Y. Ca2+-dependent modulation of GABAA and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. Biochem Soc Trans. 2009;37(Pt 6):1407-1411.
-
(2009)
Biochem Soc Trans.
, vol.37
, Issue.PART 6
, pp. 1407-1411
-
-
Lalo, U.1
Andrew, J.2
Palygin, O.3
Pankratov, Y.4
-
34
-
-
58149465599
-
P2X receptors and synaptic plasticity
-
Pankratov Y, Lalo U, Krishtal OA, Verkhratsky A. P2X receptors and synaptic plasticity. Neuroscience. 2009;158(1):137-148.
-
(2009)
Neuroscience.
, vol.158
, Issue.1
, pp. 137-148
-
-
Pankratov, Y.1
Lalo, U.2
Krishtal, O.A.3
Verkhratsky, A.4
-
35
-
-
0034610742
-
Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors
-
Mulryan K, Gitterman DP, Lewis CJ, etal. Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. Nature. 2000;403(6765):86-89.
-
(2000)
Nature.
, vol.403
, Issue.6765
, pp. 86-89
-
-
Mulryan, K.1
Gitterman, D.P.2
Lewis, C.J.3
-
36
-
-
79952424032
-
Ca2+ entry following P2X receptor activation induces IP3 receptor-mediated Ca2+ release in myocytes from small renal arteries
-
Povstyan OV, Harhun MI, Gordienko DV. Ca2+ entry following P2X receptor activation induces IP3 receptor-mediated Ca2+ release in myocytes from small renal arteries. Br J Pharmacol. 2011;162(7):1618-1638.
-
(2011)
Br J Pharmacol.
, vol.162
, Issue.7
, pp. 1618-1638
-
-
Povstyan, O.V.1
Harhun, M.I.2
Gordienko, D.V.3
-
37
-
-
84860343595
-
Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility
-
Amobi NI, Guillebaud J, Smith IC. Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility. Exp Physiol. 2012;97(5):583-602.
-
(2012)
Exp Physiol.
, vol.97
, Issue.5
, pp. 583-602
-
-
Amobi, N.I.1
Guillebaud, J.2
Smith, I.C.3
-
38
-
-
30044434110
-
Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice
-
Yamamoto K, Sokabe T, Matsumoto T, etal. Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med. 2006;12(1):133-137.
-
(2006)
Nat Med.
, vol.12
, Issue.1
, pp. 133-137
-
-
Yamamoto, K.1
Sokabe, T.2
Matsumoto, T.3
-
39
-
-
65649141604
-
Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis
-
Adinolfi E, Callegari MG, Cirillo M, etal. Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 2009;284(15):10120-10128.
-
(2009)
J Biol Chem.
, vol.284
, Issue.15
, pp. 10120-10128
-
-
Adinolfi, E.1
Callegari, M.G.2
Cirillo, M.3
-
40
-
-
78049404838
-
Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes
-
Hill LM, Gavala ML, Lenertz LY, Bertics PJ. Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes. J Immunol. 2010;185(5):3028-3034.
-
(2010)
J Immunol.
, vol.185
, Issue.5
, pp. 3028-3034
-
-
Hill, L.M.1
Gavala, M.L.2
Lenertz, L.Y.3
Bertics, P.J.4
-
41
-
-
55949099672
-
Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons
-
Chen Y, Zhang X, Wang C, Li G, Gu Y, Huang LY. Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons. Proc Natl Acad Sci U S A. 2008;105(43):16773-16778.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, Issue.43
, pp. 16773-16778
-
-
Chen, Y.1
Zhang, X.2
Wang, C.3
Li, G.4
Gu, Y.5
Huang, L.Y.6
-
42
-
-
0037096207
-
Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
-
Labasi JM, Petrushova N, Donovan C, etal. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol. 2002;168(12):6436-6445.
-
(2002)
J Immunol.
, vol.168
, Issue.12
, pp. 6436-6445
-
-
Labasi, J.M.1
Petrushova, N.2
Donovan, C.3
-
43
-
-
0029665112
-
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
-
Surprenant A, Rassendren F, Kawashima E, North RA, Buell G. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science. 1996;272(5262):735-738.
-
(1996)
Science.
, vol.272
, Issue.5262
, pp. 735-738
-
-
Surprenant, A.1
Rassendren, F.2
Kawashima, E.3
North, R.A.4
Buell, G.5
-
44
-
-
0033366463
-
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds
-
Khakh BS, Bao XR, Labarca C, Lester HA. Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci. 1999;2(4):322-330.
-
(1999)
Nat Neurosci.
, vol.2
, Issue.4
, pp. 322-330
-
-
Khakh, B.S.1
Bao, X.R.2
Labarca, C.3
Lester, H.A.4
-
45
-
-
0033360313
-
Pore dilation of neuronal P2X receptor channels
-
Virginio C, MacKenzie A, Rassendren FA, North RA, Surprenant A. Pore dilation of neuronal P2X receptor channels. Nat Neurosci. 1999;2(4):315-321.
-
(1999)
Nat Neurosci.
, vol.2
, Issue.4
, pp. 315-321
-
-
Virginio, C.1
McKenzie, A.2
Rassendren, F.A.3
North, R.A.4
Surprenant, A.5
-
46
-
-
0036023394
-
Control of P2X(2) channel permeability by the cytosolic domain
-
Eickhorst AN, Berson A, Cockayne D, Lester HA, Khakh BS. Control of P2X(2) channel permeability by the cytosolic domain. J Gen Physiol. 2002;120(2):119-131.
-
(2002)
J Gen Physiol.
, vol.120
, Issue.2
, pp. 119-131
-
-
Eickhorst, A.N.1
Berson, A.2
Cockayne, D.3
Lester, H.A.4
Khakh, B.S.5
-
47
-
-
33750473352
-
Pannexin-1mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
-
Pelegrin P, Surprenant A. Pannexin-1mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 2006;25(21):5071-5082.
-
(2006)
EMBO J.
, vol.25
, Issue.21
, pp. 5071-5082
-
-
Pelegrin, P.1
Surprenant, A.2
-
48
-
-
84862777282
-
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
-
Sorge RE, Trang T, Dorfman R, etal. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012;18(4):595-599.
-
(2012)
Nat Med.
, vol.18
, Issue.4
, pp. 595-599
-
-
Sorge, R.E.1
Trang, T.2
Dorfman, R.3
-
49
-
-
84871458711
-
Extracellular K(+) and Astrocyte Signaling via Connexin and Pannexin Channels
-
[Epub ahead of print]
-
Scemes E, Spray DC. Extracellular K(+) and Astrocyte Signaling via Connexin and Pannexin Channels. Neurochem Res. 2012. [Epub ahead of print].
-
(2012)
Neurochem Res.
-
-
Scemes, E.1
Spray, D.C.2
-
50
-
-
79958034097
-
Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation
-
Qu Y, Misaghi S, Newton K, etal. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol. 2011;186(11):6553-6561.
-
(2011)
J Immunol.
, vol.186
, Issue.11
, pp. 6553-6561
-
-
Qu, Y.1
Misaghi, S.2
Newton, K.3
-
51
-
-
84867112397
-
Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1
-
[Epub ahead of print]
-
Xu XJ, Boumechache M, Robinson LE, etal. Splice-variants of the P2X7 receptor reveal differential agonist-dependence and functional coupling with pannexin-1. J Cell Sci. 2012. [Epub ahead of print].
-
(2012)
J Cell Sci.
-
-
Xu, X.J.1
Boumechache, M.2
Robinson, L.E.3
-
52
-
-
50149118145
-
Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels
-
Chaumont S, Khakh BS. Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels. Proc Natl Acad Sci U S A. 2008;105(33):12063-12068.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, Issue.33
, pp. 12063-12068
-
-
Chaumont, S.1
Khakh, B.S.2
-
53
-
-
84858070953
-
P2X4 receptor channels form large noncytolytic pores in resting and activated microglia
-
Bernier LP, Ase AR, Boue-Grabot E, Seguela P. P2X4 receptor channels form large noncytolytic pores in resting and activated microglia. Glia. 2012;60(5):728-737.
-
(2012)
Glia.
, vol.60
, Issue.5
, pp. 728-737
-
-
Bernier, L.P.1
Ase, A.R.2
Boue-Grabot, E.3
Seguela, P.4
-
54
-
-
64849087753
-
The P2X7 receptor drives microglial activation and proliferation: A trophic role for P2X7R pore
-
Monif M, Reid CA, Powell KL, Smart ML, Williams DA. The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci. 2009;29(12):3781-3791.
-
(2009)
J Neurosci.
, vol.29
, Issue.12
, pp. 3781-3791
-
-
Monif, M.1
Reid, C.A.2
Powell, K.L.3
Smart, M.L.4
Williams, D.A.5
-
55
-
-
59649098673
-
Voltage-and [ATP]-dependent gating of the P2X(2) ATP receptor channel
-
Fujiwara Y, Keceli B, Nakajo K, Kubo Y. Voltage-and [ATP]-dependent gating of the P2X(2) ATP receptor channel. J Gen Physiol. 2009;133(1):93-109.
-
(2009)
J Gen Physiol.
, vol.133
, Issue.1
, pp. 93-109
-
-
Fujiwara, Y.1
Keceli, B.2
Nakajo, K.3
Kubo, Y.4
-
56
-
-
2342423633
-
The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes
-
Le Stunff H, Auger R, Kanellopoulos J, Raymond MN. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem. 2004;279(17):16918-16926.
-
(2004)
J Biol Chem.
, vol.279
, Issue.17
, pp. 16918-16926
-
-
Le Stunff, H.1
Auger, R.2
Kanellopoulos, J.3
Raymond, M.N.4
-
57
-
-
33750085298
-
A role for P2X7in microglial proliferation
-
Bianco F, Ceruti S, Colombo A, etal. A role for P2X7in microglial proliferation. J Neurochem. 2006;99(3):745-758.
-
(2006)
J Neurochem.
, vol.99
, Issue.3
, pp. 745-758
-
-
Bianco, F.1
Ceruti, S.2
Colombo, A.3
-
58
-
-
0033198510
-
Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor
-
Virginio C, MacKenzie A, North RA, Surprenant A. Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. J Physiol. 1999;519 Pt 2:335-346.
-
(1999)
J Physiol.
, vol.519
, Issue.PART 2
, pp. 335-346
-
-
Virginio, C.1
McKenzie, A.2
North, R.A.3
Surprenant, A.4
-
59
-
-
0035655395
-
Rapid secretion of interleukin-1beta by microvesicle shedding
-
MacKenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity. 2001;15(5):825-835.
-
(2001)
Immunity.
, vol.15
, Issue.5
, pp. 825-835
-
-
McKenzie, A.1
Wilson, H.L.2
Kiss-Toth, E.3
Dower, S.K.4
North, R.A.5
Surprenant, A.6
-
60
-
-
25844484867
-
Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors
-
Mackenzie AB, Young MT, Adinolfi E, Surprenant A. Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors. J Biol Chem. 2005;280(40):33968-33976.
-
(2005)
J Biol Chem.
, vol.280
, Issue.40
, pp. 33968-33976
-
-
McKenzie, A.B.1
Young, M.T.2
Adinolfi, E.3
Surprenant, A.4
-
61
-
-
34548614009
-
Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
-
Qu Y, Franchi L, Nunez G, Dubyak GR. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol. 2007;179(3):1913-1925.
-
(2007)
J Immunol.
, vol.179
, Issue.3
, pp. 1913-1925
-
-
Qu, Y.1
Franchi, L.2
Nunez, G.3
Dubyak, G.R.4
-
62
-
-
70350782373
-
Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X receptor action
-
Fang KM, Yang CS, Sun SH, Tzeng SF. Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X receptor action. J Neurochem. 2009;111(5):1225-1237.
-
(2009)
J Neurochem.
, vol.111
, Issue.5
, pp. 1225-1237
-
-
Fang, K.M.1
Yang, C.S.2
Sun, S.H.3
Tzeng, S.F.4
-
63
-
-
84863393008
-
Activation of neuronal P2X7 receptor-pannexin-1mediates death of enteric neurons during colitis
-
Gulbransen BD, Bashashati M, Hirota SA, etal. Activation of neuronal P2X7 receptor-pannexin-1mediates death of enteric neurons during colitis. Nat Med. 2012;18(4):600-604.
-
(2012)
Nat Med.
, vol.18
, Issue.4
, pp. 600-604
-
-
Gulbransen, B.D.1
Bashashati, M.2
Hirota, S.A.3
-
64
-
-
0035890154
-
Proteomic and functional evidence for a P2X7 receptor signalling complex
-
Kim M, Jiang LH, Wilson HL, North RA, Surprenant A. Proteomic and functional evidence for a P2X7 receptor signalling complex. EMBO J. 2001;20(22):6347-6358.
-
(2001)
EMBO J.
, vol.20
, Issue.22
, pp. 6347-6358
-
-
Kim, M.1
Jiang, L.H.2
Wilson, H.L.3
North, R.A.4
Surprenant, A.5
-
65
-
-
0037072748
-
Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus
-
Wilson HL, Wilson SA, Surprenant A, North RA. Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J Biol Chem. 2002;277(37):34017-34023.
-
(2002)
J Biol Chem.
, vol.277
, Issue.37
, pp. 34017-34023
-
-
Wilson, H.L.1
Wilson, S.A.2
Surprenant, A.3
North, R.A.4
-
66
-
-
46749144924
-
Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding
-
Roger S, Pelegrin P, Surprenant A. Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding. J Neurosci. 2008;28(25):6393-6401.
-
(2008)
J Neurosci.
, vol.28
, Issue.25
, pp. 6393-6401
-
-
Roger, S.1
Pelegrin, P.2
Surprenant, A.3
-
67
-
-
35348909573
-
Agonist potency at P2X7 receptors is modulated by structurally diverse lipids
-
Michel AD, Fonfria E. Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. Br J Pharmacol. 2007;152(4):523-537.
-
(2007)
Br J Pharmacol.
, vol.152
, Issue.4
, pp. 523-537
-
-
Michel, A.D.1
Fonfria, E.2
-
68
-
-
24744448897
-
Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction
-
Vial C, Evans RJ. Disruption of lipid rafts inhibits P2X1 receptor-mediated currents and arterial vasoconstriction. J Biol Chem. 2005;280(35):30705-30711.
-
(2005)
J Biol Chem.
, vol.280
, Issue.35
, pp. 30705-30711
-
-
Vial, C.1
Evans, R.J.2
-
69
-
-
77958471651
-
Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: Chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors
-
Allsopp RC, Lalo U, Evans RJ. Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors. J Biol Chem. 2010;285(43):32770-32777.
-
(2010)
J Biol Chem.
, vol.285
, Issue.43
, pp. 32770-32777
-
-
Allsopp, R.C.1
Lalo, U.2
Evans, R.J.3
-
70
-
-
80052197134
-
Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation
-
Lalo U, Roberts JA, Evans RJ. Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation. J Biol Chem. 2011;286(35):30591-30599.
-
(2011)
J Biol Chem.
, vol.286
, Issue.35
, pp. 30591-30599
-
-
Lalo, U.1
Roberts, J.A.2
Evans, R.J.3
-
71
-
-
58149237912
-
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1
-
Chaumont S, Compan V, Toulme E, etal. Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Sci Signal. 2008;1(41):ra8.
-
(2008)
Sci Signal.
, vol.1
, Issue.41
-
-
Chaumont, S.1
Compan, V.2
Toulme, E.3
-
72
-
-
50149099412
-
Inhibitory interaction between P2X4 and GABA(C) rho1 receptors
-
Xia R, Mei ZZ, Milligan C, Jiang LH. Inhibitory interaction between P2X4 and GABA(C) rho1 receptors. Biochem Biophys Res Commun. 2008;375(1):38-43.
-
(2008)
Biochem Biophys Res Commun.
, vol.375
, Issue.1
, pp. 38-43
-
-
Xia, R.1
Mei, Z.Z.2
Milligan, C.3
Jiang, L.H.4
-
73
-
-
0034721119
-
State-dependent cross-inhibition between transmitter-gated cation channels
-
Khakh BS, Zhou X, Sydes J, Galligan JJ, Lester HA. State-dependent cross-inhibition between transmitter-gated cation channels. Nature. 2000;406(6794):405-410.
-
(2000)
Nature.
, vol.406
, Issue.6794
, pp. 405-410
-
-
Khakh, B.S.1
Zhou, X.2
Sydes, J.3
Galligan, J.J.4
Lester, H.A.5
-
74
-
-
1342346558
-
Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels
-
Boue-Grabot E, Emerit MB, Toulme E, Seguela P, Garret M. Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. J Biol Chem. 2004;279(8):6967-6975.
-
(2004)
J Biol Chem.
, vol.279
, Issue.8
, pp. 6967-6975
-
-
Boue-Grabot, E.1
Emerit, M.B.2
Toulme, E.3
Seguela, P.4
Garret, M.5
-
75
-
-
10644270596
-
Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels
-
Boue-Grabot E, Toulme E, Emerit MB, Garret M. Subunit-specific coupling between gamma-aminobutyric acid type A and P2X2 receptor channels. J Biol Chem. 2004;279(50):52517-52525.
-
(2004)
J Biol Chem.
, vol.279
, Issue.50
, pp. 52517-52525
-
-
Boue-Grabot, E.1
Toulme, E.2
Emerit, M.B.3
Garret, M.4
-
76
-
-
34547405241
-
An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons
-
Toulme E, Blais D, Leger C, etal. An intracellular motif of P2X(3) receptors is required for functional cross-talk with GABA(A) receptors in nociceptive DRG neurons. J Neurochem. 2007;102(4):1357-1368.
-
(2007)
J Neurochem.
, vol.102
, Issue.4
, pp. 1357-1368
-
-
Toulme, E.1
Blais, D.2
Leger, C.3
-
77
-
-
79957615177
-
Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse
-
Jo YH, Donier E, Martinez A, Garret M, Toulme E, Boue-Grabot E. Cross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse. J Biol Chem. 2011;286(22):19993-20004.
-
(2011)
J Biol Chem.
, vol.286
, Issue.22
, pp. 19993-20004
-
-
Jo, Y.H.1
Donier, E.2
Martinez, A.3
Garret, M.4
Toulme, E.5
Boue-Grabot, E.6
-
78
-
-
84874777986
-
Interplay between ionotropic receptors modulates inhibitory synaptic strength
-
Jo YH, Boue-Grabot E. Interplay between ionotropic receptors modulates inhibitory synaptic strength. Commun Integr Biol. 2011;4(6):706-709.
-
(2011)
Commun Integr Biol.
, vol.4
, Issue.6
, pp. 706-709
-
-
Jo, Y.H.1
Boue-Grabot, E.2
-
79
-
-
58149379608
-
Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions
-
Bernier LP, Ase AR, Chevallier S, etal. Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions. J Neurosci. 2008;28(48):12938-12945.
-
(2008)
J Neurosci.
, vol.28
, Issue.48
, pp. 12938-12945
-
-
Bernier, L.P.1
Ase, A.R.2
Chevallier, S.3
-
80
-
-
0026771094
-
ATP mediates fast synaptic transmission in mammalian neurons
-
Evans RJ, Derkach V, Surprenant A. ATP mediates fast synaptic transmission in mammalian neurons. Nature. 1992;357(6378):503-505.
-
(1992)
Nature.
, vol.357
, Issue.6378
, pp. 503-505
-
-
Evans, R.J.1
Derkach, V.2
Surprenant, A.3
-
81
-
-
0026648857
-
ATP receptor-mediated synaptic currents in the central nervous system
-
Edwards FA, Gibb AJ, Colquhoun D. ATP receptor-mediated synaptic currents in the central nervous system. Nature. 1992;359(6391):144-147.
-
(1992)
Nature.
, vol.359
, Issue.6391
, pp. 144-147
-
-
Edwards, F.A.1
Gibb, A.J.2
Colquhoun, D.3
-
82
-
-
0034718839
-
Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
-
Cockayne DA, Hamilton SG, Zhu QM, etal. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 2000;407(6807):1011-1015.
-
(2000)
Nature.
, vol.407
, Issue.6807
, pp. 1011-1015
-
-
Cockayne, D.A.1
Hamilton, S.G.2
Zhu, Q.M.3
-
83
-
-
24944564718
-
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP
-
Cockayne DA, Dunn PM, Zhong Y, etal. P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol. 2005;567(Pt 2):621-639.
-
(2005)
J Physiol.
, vol.567
, Issue.PART 2
, pp. 621-639
-
-
Cockayne, D.A.1
Dunn, P.M.2
Zhong, Y.3
-
84
-
-
0035808396
-
Altered cytokine production in mice lacking P2X(7) receptors
-
Solle M, Labasi J, Perregaux DG, etal. Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem. 2001;276(1):125-132.
-
(2001)
J Biol Chem.
, vol.276
, Issue.1
, pp. 125-132
-
-
Solle, M.1
Labasi, J.2
Perregaux, D.G.3
-
85
-
-
28544448048
-
ATP signaling is crucial for communication from taste buds to gustatory nerves
-
Finger TE, Danilova V, Barrows J, etal. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 2005;310(5753):1495-1499.
-
(2005)
Science.
, vol.310
, Issue.5753
, pp. 1495-1499
-
-
Finger, T.E.1
Danilova, V.2
Barrows, J.3
-
86
-
-
77956936562
-
P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
-
Lopez-Castejon G, Theaker J, Pelegrin P, Clifton AD, Braddock M, Surprenant A. P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases. J Immunol. 2010;185(4):2611-2619.
-
(2010)
J Immunol.
, vol.185
, Issue.4
, pp. 2611-2619
-
-
Lopez-Castejon, G.1
Theaker, J.2
Pelegrin, P.3
Clifton, A.D.4
Braddock, M.5
Surprenant, A.6
-
87
-
-
0142188258
-
NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor
-
Seman M, Adriouch S, Scheuplein F, etal. NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Immunity. 2003;19(4):571-582.
-
(2003)
Immunity.
, vol.19
, Issue.4
, pp. 571-582
-
-
Seman, M.1
Adriouch, S.2
Scheuplein, F.3
-
88
-
-
68949144919
-
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells
-
Hong S, Schwarz N, Brass A, etal. Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells. J Immunol. 2009;183(1):578-592.
-
(2009)
J Immunol.
, vol.183
, Issue.1
, pp. 578-592
-
-
Hong, S.1
Schwarz, N.2
Brass, A.3
-
89
-
-
20144375454
-
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
-
Chessell IP, Hatcher JP, Bountra C, etal. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005;114(3):386-396.
-
(2005)
Pain.
, vol.114
, Issue.3
, pp. 386-396
-
-
Chessell, I.P.1
Hatcher, J.P.2
Bountra, C.3
-
90
-
-
67149096558
-
Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses
-
Taylor SR, Gonzalez-Begne M, Sojka DK, etal. Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses. J Leukoc Biol. 2009;85(6):978-986.
-
(2009)
J Leukoc Biol.
, vol.85
, Issue.6
, pp. 978-986
-
-
Taylor, S.R.1
Gonzalez-Begne, M.2
Sojka, D.K.3
-
91
-
-
21244497838
-
Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice
-
Sanchez-Nogueiro J, Marin-Garcia P, Miras-Portugal MT. Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice. FEBS Lett. 2005;579(17):3783-3788.
-
(2005)
FEBS Lett.
, vol.579
, Issue.17
, pp. 3783-3788
-
-
Sanchez-Nogueiro, J.1
Marin-Garcia, P.2
Miras-Portugal, M.T.3
-
92
-
-
33646124242
-
Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
-
Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends Neurosci. 2006;29(5):257-262.
-
(2006)
Trends Neurosci.
, vol.29
, Issue.5
, pp. 257-262
-
-
Anderson, C.M.1
Nedergaard, M.2
-
93
-
-
0017682312
-
Observations on the algogenic actions of adenosine compounds on the human blister base preparation
-
Bleehen T, Keele CA. Observations on the algogenic actions of adenosine compounds on the human blister base preparation. Pain. 1977;3(4):367-377.
-
(1977)
Pain.
, vol.3
, Issue.4
, pp. 367-377
-
-
Bleehen, T.1
Keele, C.A.2
-
94
-
-
0029102288
-
A P2X purinoceptor expressed by a subset of sensory neurons
-
Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature. 1995;377(6548):428-431.
-
(1995)
Nature.
, vol.377
, Issue.6548
, pp. 428-431
-
-
Chen, C.C.1
Akopian, A.N.2
Sivilotti, L.3
Colquhoun, D.4
Burnstock, G.5
Wood, J.N.6
-
95
-
-
0028982205
-
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons
-
Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature. 1995;377(6548):432-435.
-
(1995)
Nature.
, vol.377
, Issue.6548
, pp. 432-435
-
-
Lewis, C.1
Neidhart, S.2
Holy, C.3
North, R.A.4
Buell, G.5
Surprenant, A.6
-
96
-
-
0034718892
-
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
-
Souslova V, Cesare P, Ding Y, etal. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature. 2000;407(6807):1015-1017.
-
(2000)
Nature.
, vol.407
, Issue.6807
, pp. 1015-1017
-
-
Souslova, V.1
Cesare, P.2
Ding, Y.3
-
97
-
-
33748281147
-
Altered hippocampal synaptic potentiation in P2X4 knock-out mice
-
Sim JA, Chaumont S, Jo J, etal. Altered hippocampal synaptic potentiation in P2X4 knock-out mice. J Neurosci. 2006;26(35):9006-9009.
-
(2006)
J Neurosci.
, vol.26
, Issue.35
, pp. 9006-9009
-
-
Sim, J.A.1
Chaumont, S.2
Jo, J.3
-
98
-
-
0042968804
-
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
-
Tsuda M, Shigemoto-Mogami Y, Koizumi S, etal. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003;424(6950):778-783.
-
(2003)
Nature.
, vol.424
, Issue.6950
, pp. 778-783
-
-
Tsuda, M.1
Shigemoto-Mogami, Y.2
Koizumi, S.3
-
99
-
-
56149096976
-
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain
-
Ulmann L, Hatcher JP, Hughes JP, etal. Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci. 2008;28(44):11263-11268.
-
(2008)
J Neurosci.
, vol.28
, Issue.44
, pp. 11263-11268
-
-
Ulmann, L.1
Hatcher, J.P.2
Hughes, J.P.3
-
100
-
-
67650222417
-
Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays
-
Tsuda M, Kuboyama K, Inoue T, Nagata K, Tozaki-Saitoh H, Inoue K. Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays. Mol Pain. 2009;5:28.
-
(2009)
Mol Pain.
, vol.5
, pp. 28
-
-
Tsuda, M.1
Kuboyama, K.2
Inoue, T.3
Nagata, K.4
Tozaki-Saitoh, H.5
Inoue, K.6
-
101
-
-
77954886436
-
P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain
-
Ulmann L, Hirbec H, Rassendren F. P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain. EMBO J. 2010;29(14):2290-2300.
-
(2010)
EMBO J.
, vol.29
, Issue.14
, pp. 2290-2300
-
-
Ulmann, L.1
Hirbec, H.2
Rassendren, F.3
-
102
-
-
0036316688
-
Prostanoids and pain: Unraveling mechanisms and revealing therapeutic targets
-
Samad TA, Sapirstein A, Woolf CJ. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med. 2002;8(8):390-396.
-
(2002)
Trends Mol Med.
, vol.8
, Issue.8
, pp. 390-396
-
-
Samad, T.A.1
Sapirstein, A.2
Woolf, C.J.3
-
103
-
-
0036200917
-
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism
-
Brough D, Le Feuvre RA, Iwakura Y, Rothwell NJ. Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism. Mol Cell Neurosci. 2002;19(2):272-280.
-
(2002)
Mol Cell Neurosci.
, vol.19
, Issue.2
, pp. 272-280
-
-
Brough, D.1
Le Feuvre, R.A.2
Iwakura, Y.3
Rothwell, N.J.4
-
104
-
-
0036479134
-
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production
-
Le Feuvre RA, Brough D, Iwakura Y, Takeda K, Rothwell NJ. Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J Biol Chem. 2002;277(5):3210-3218.
-
(2002)
J Biol Chem.
, vol.277
, Issue.5
, pp. 3210-3218
-
-
Le Feuvre, R.A.1
Brough, D.2
Iwakura, Y.3
Takeda, K.4
Rothwell, N.J.5
-
105
-
-
77957101431
-
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis
-
Riteau N, Gasse P, Fauconnier L, etal. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med. 2010;182(6):774-783.
-
(2010)
Am J Respir Crit Care Med.
, vol.182
, Issue.6
, pp. 774-783
-
-
Riteau, N.1
Gasse, P.2
Fauconnier, L.3
-
106
-
-
78149263196
-
The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice
-
Chong JH, Zheng GG, Ma YY, etal. The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice. J Biol Chem. 2010;285(46):36179-36187.
-
(2010)
J Biol Chem.
, vol.285
, Issue.46
, pp. 36179-36187
-
-
Chong, J.H.1
Zheng, G.G.2
Ma, Y.Y.3
-
107
-
-
0037079543
-
P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia
-
Adinolfi E, Melchiorri L, Falzoni S, etal. P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood. 2002;99(2):706-708.
-
(2002)
Blood.
, vol.99
, Issue.2
, pp. 706-708
-
-
Adinolfi, E.1
Melchiorri, L.2
Falzoni, S.3
-
108
-
-
0037196958
-
A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: A molecular study
-
Wiley JS, Dao-Ung LP, Gu BJ, etal. A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. Lancet. 2002;359(9312):1114-1119.
-
(2002)
Lancet.
, vol.359
, Issue.9312
, pp. 1114-1119
-
-
Wiley, J.S.1
Dao-Ung, L.P.2
Gu, B.J.3
-
109
-
-
0042623513
-
Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431cells
-
Greig AV, Linge C, Healy V, etal. Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431cells. J Invest Dermatol. 2003;121(2):315-327.
-
(2003)
J Invest Dermatol.
, vol.121
, Issue.2
, pp. 315-327
-
-
Greig, A.V.1
Linge, C.2
Healy, V.3
-
110
-
-
6044228204
-
P2X7 receptor-mediated apoptosis of human cervical epithelial cells
-
Wang Q, Wang L, Feng YH, Li X, Zeng R, Gorodeski GI. P2X7 receptor-mediated apoptosis of human cervical epithelial cells. Am J Physiol Cell Physiol. 2004;287(5):C1349-C1358.
-
(2004)
Am J Physiol Cell Physiol.
, vol.287
, Issue.5
-
-
Wang, Q.1
Wang, L.2
Feng, Y.H.3
Li, X.4
Zeng, R.5
Gorodeski, G.I.6
-
111
-
-
17644381601
-
P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: Effects of extracellular nucleotides on apoptosis and cell proliferation
-
Coutinho-Silva R, Stahl L, Cheung KK, etal. P2X and P2Y purinergic receptors on human intestinal epithelial carcinoma cells: effects of extracellular nucleotides on apoptosis and cell proliferation. Am J Physiol Gastrointest Liver Physiol. 2005;288(5):G1024-G1035.
-
(2005)
Am J Physiol Gastrointest Liver Physiol.
, vol.288
, Issue.5
-
-
Coutinho-Silva, R.1
Stahl, L.2
Cheung, K.K.3
-
112
-
-
59749093364
-
1513A. >C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: Correlation with histological variants and clinical parameters
-
Dardano A, Falzoni S, Caraccio N, etal. 1513A. >C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: correlation with histological variants and clinical parameters. J Clin Endocrinol Metab. 2009;94(2):695-698.
-
(2009)
J Clin Endocrinol Metab.
, vol.94
, Issue.2
, pp. 695-698
-
-
Dardano, A.1
Falzoni, S.2
Caraccio, N.3
-
113
-
-
78149416375
-
Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma
-
Gu LQ, Li FY, Zhao L, etal. Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma. Endocrine. 2010;38(2):276-282.
-
(2010)
Endocrine.
, vol.38
, Issue.2
, pp. 276-282
-
-
Gu, L.Q.1
Li, F.Y.2
Zhao, L.3
-
114
-
-
84862557061
-
Expression of P2X7 receptor increases in vivo tumor growth
-
Adinolfi E, Raffaghello L, Giuliani AL, etal. Expression of P2X7 receptor increases in vivo tumor growth. Cancer Res. 2012;72(12):2957-2969.
-
(2012)
Cancer Res.
, vol.72
, Issue.12
, pp. 2957-2969
-
-
Adinolfi, E.1
Raffaghello, L.2
Giuliani, A.L.3
-
115
-
-
0037079306
-
Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia
-
Thunberg U, Tobin G, Johnson A, etal. Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia. Lancet. 2002;360(9349):1935-1939.
-
(2002)
Lancet.
, vol.360
, Issue.9349
, pp. 1935-1939
-
-
Thunberg, U.1
Tobin, G.2
Johnson, A.3
-
116
-
-
79955579562
-
P2X(7) receptor activation enhances SK3 channels-and cystein cathepsin-dependent cancer cells invasiveness
-
Jelassi B, Chantome A, Alcaraz-Perez F, etal. P2X(7) receptor activation enhances SK3 channels-and cystein cathepsin-dependent cancer cells invasiveness. Oncogene. 2011;30(18):2108-2122.
-
(2011)
Oncogene.
, vol.30
, Issue.18
, pp. 2108-2122
-
-
Jelassi, B.1
Chantome, A.2
Alcaraz-Perez, F.3
-
117
-
-
0033004707
-
Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors
-
Soto F, Lambrecht G, Nickel P, Stuhmer W, Busch AE. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology. 1999;38(1):141-149.
-
(1999)
Neuropharmacology.
, vol.38
, Issue.1
, pp. 141-149
-
-
Soto, F.1
Lambrecht, G.2
Nickel, P.3
Stuhmer, W.4
Busch, A.E.5
-
118
-
-
0343158251
-
Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors
-
Klapperstuck M, Buttner C, Nickel P, Schmalzing G, Lambrecht G, Markwardt F. Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors. Eur J Pharmacol. 2000;387(3):245-252.
-
(2000)
Eur J Pharmacol.
, vol.387
, Issue.3
, pp. 245-252
-
-
Klapperstuck, M.1
Buttner, C.2
Nickel, P.3
Schmalzing, G.4
Lambrecht, G.5
Markwardt, F.6
-
119
-
-
0033841633
-
The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor
-
Rettinger J, Schmalzing G, Damer S, Muller G, Nickel P, Lambrecht G. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor. Neuropharmacology. 2000;39(11):2044-2053.
-
(2000)
Neuropharmacology.
, vol.39
, Issue.11
, pp. 2044-2053
-
-
Rettinger, J.1
Schmalzing, G.2
Damer, S.3
Muller, G.4
Nickel, P.5
Lambrecht, G.6
-
120
-
-
0034876923
-
NF449: A subnanomolar potency antagonist at recombinant rat P2X1 receptors
-
Braun K, Rettinger J, Ganso M, etal. NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2001;364(3):285-290.
-
(2001)
Naunyn Schmiedebergs Arch Pharmacol.
, vol.364
, Issue.3
, pp. 285-290
-
-
Braun, K.1
Rettinger, J.2
Ganso, M.3
-
121
-
-
1842557492
-
Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist
-
Kassack MU, Braun K, Ganso M, etal. Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur J Med Chem. 2004;39(4):345-357.
-
(2004)
Eur J Med Chem.
, vol.39
, Issue.4
, pp. 345-357
-
-
Kassack, M.U.1
Braun, K.2
Ganso, M.3
-
122
-
-
13844294341
-
Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
-
Rettinger J, Braun K, Hochmann H, etal. Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist. Neuropharmacology. 2005;48(3):461-468.
-
(2005)
Neuropharmacology.
, vol.48
, Issue.3
, pp. 461-468
-
-
Rettinger, J.1
Braun, K.2
Hochmann, H.3
-
123
-
-
0032585938
-
Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors
-
King BF, Liu M, Pintor J, Gualix J, Miras-Portugal MT, Burnstock G. Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors. Br J Pharmacol. 1999;128(5):981-988.
-
(1999)
Br J Pharmacol.
, vol.128
, Issue.5
, pp. 981-988
-
-
King, B.F.1
Liu, M.2
Pintor, J.3
Gualix, J.4
Miras-Portugal, M.T.5
Burnstock, G.6
-
124
-
-
0033913716
-
Diinosine pentaphosphate: An antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones
-
Dunn PM, Liu M, Zhong Y, King BF, Burnstock G. Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X(3) and P2X(2/3) receptors and between two P2X receptors in rat sensory neurones. Br J Pharmacol. 2000;130(6):1378-1384.
-
(2000)
Br J Pharmacol.
, vol.130
, Issue.6
, pp. 1378-1384
-
-
Dunn, P.M.1
Liu, M.2
Zhong, Y.3
King, B.F.4
Burnstock, G.5
-
125
-
-
25644446860
-
The P2X3 antagonist P1, P5-di[inosine-5′] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons
-
Ford KK, Matchett M, Krause JE, Yu W. The P2X3 antagonist P1, P5-di[inosine-5′] pentaphosphate binds to the desensitized state of the receptor in rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 2005;315(1):405-413.
-
(2005)
J Pharmacol Exp Ther.
, vol.315
, Issue.1
, pp. 405-413
-
-
Ford, K.K.1
Matchett, M.2
Krause, J.E.3
Yu, W.4
-
126
-
-
0031866948
-
Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors
-
Virginio C, Robertson G, Surprenant A, North RA. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998;53(6):969-973.
-
(1998)
Mol Pharmacol.
, vol.53
, Issue.6
, pp. 969-973
-
-
Virginio, C.1
Robertson, G.2
Surprenant, A.3
North, R.A.4
-
127
-
-
0033664106
-
Competitive antagonism of recombinant P2X(2/3) receptors by 2′, 3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP)
-
Burgard EC, Niforatos W, van Biesen T, etal. Competitive antagonism of recombinant P2X(2/3) receptors by 2′, 3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP). Mol Pharmacol. 2000;58(6):1502-1510.
-
(2000)
Mol Pharmacol.
, vol.58
, Issue.6
, pp. 1502-1510
-
-
Burgard, E.C.1
Niforatos, W.2
van Biesen, T.3
-
128
-
-
0141507009
-
2′, 3′-O-(2,4,6, trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor
-
Neelands TR, Burgard EC, Uchic ME, etal. 2′, 3′-O-(2,4,6, trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor. Br J Pharmacol. 2003;140(1):202-210.
-
(2003)
Br J Pharmacol.
, vol.140
, Issue.1
, pp. 202-210
-
-
Neelands, T.R.1
Burgard, E.C.2
Uchic, M.E.3
-
129
-
-
0034601136
-
Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles
-
Surprenant A, Schneider DA, Wilson HL, Galligan JJ, North RA. Functional properties of heteromeric P2X(1/5) receptors expressed in HEK cells and excitatory junction potentials in guinea-pig submucosal arterioles. J Auton Nerv Syst. 2000;81(1-3):249-263.
-
(2000)
J Auton Nerv Syst.
, vol.81
, Issue.1-3
, pp. 249-263
-
-
Surprenant, A.1
Schneider, D.A.2
Wilson, H.L.3
Galligan, J.J.4
North, R.A.5
-
130
-
-
0030977216
-
The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes
-
Gargett CE, Wiley JS. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol. 1997;120(8):1483-1490.
-
(1997)
Br J Pharmacol.
, vol.120
, Issue.8
, pp. 1483-1490
-
-
Gargett, C.E.1
Wiley, J.S.2
-
131
-
-
0031595744
-
Isoquinolines as antagonists of the P2X7 nucleotide receptor: High selectivity for the human versus rat receptor homologues
-
Humphreys BD, Virginio C, Surprenant A, Rice J, Dubyak GR. Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues. Mol Pharmacol. 1998;54(1):22-32.
-
(1998)
Mol Pharmacol.
, vol.54
, Issue.1
, pp. 22-32
-
-
Humphreys, B.D.1
Virginio, C.2
Surprenant, A.3
Rice, J.4
Dubyak, G.R.5
-
132
-
-
0242585424
-
Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor
-
Baraldi PG, del Carmen Nunez M, Morelli A, Falzoni S, Di Virgilio F, Romagnoli R. Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J Med Chem. 2003;46(8):1318-1329.
-
(2003)
J Med Chem.
, vol.46
, Issue.8
, pp. 1318-1329
-
-
Baraldi, P.G.1
del Carmen Nunez, M.2
Morelli, A.3
Falzoni, S.4
Di Virgilio, F.5
Romagnoli, R.6
-
133
-
-
38149132392
-
Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor
-
Lee GE, Joshi BV, Chen W, etal. Synthesis and structure-activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor. Bioorg Med Chem Lett. 2008;18(2):571-575.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.2
, pp. 571-575
-
-
Lee, G.E.1
Joshi, B.V.2
Chen, W.3
-
134
-
-
34547609022
-
From tyrosine to glycine: Synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor
-
Romagnoli R, Baraldi PG, Carrion MD, etal. From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor. J Med Chem. 2007;50(15):3706-3715.
-
(2007)
J Med Chem.
, vol.50
, Issue.15
, pp. 3706-3715
-
-
Romagnoli, R.1
Baraldi, P.G.2
Carrion, M.D.3
-
135
-
-
0033932598
-
Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors
-
Jiang LH, Mackenzie AB, North RA, Surprenant A. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol. 2000;58(1):82-88.
-
(2000)
Mol Pharmacol.
, vol.58
, Issue.1
, pp. 82-88
-
-
Jiang, L.H.1
McKenzie, A.B.2
North, R.A.3
Surprenant, A.4
-
136
-
-
20444383141
-
Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist
-
Jaime-Figueroa S, Greenhouse R, Padilla F, Dillon MP, Gever JR, Ford AP. Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorg Med Chem Lett. 2005;15(13):3292-3295.
-
(2005)
Bioorg Med Chem Lett.
, vol.15
, Issue.13
, pp. 3292-3295
-
-
Jaime-Figueroa, S.1
Greenhouse, R.2
Padilla, F.3
Dillon, M.P.4
Gever, J.R.5
Ford, A.P.6
-
137
-
-
32544436125
-
Purinoceptors as therapeutic targets for lower urinary tract dysfunction
-
Ford AP, Gever JR, Nunn PA, etal. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006;147 Suppl 2:S132-S143.
-
(2006)
Br J Pharmacol.
, vol.147
, Issue.SUPPL. 2
-
-
Ford, A.P.1
Gever, J.R.2
Nunn, P.A.3
-
138
-
-
0037168683
-
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
-
Jarvis MF, Burgard EC, McGaraughty S, etal. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A. 2002;99(26):17179-17184.
-
(2002)
Proc Natl Acad Sci U S A.
, vol.99
, Issue.26
, pp. 17179-17184
-
-
Jarvis, M.F.1
Burgard, E.C.2
McGaraughty, S.3
-
139
-
-
61349100301
-
Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain
-
Carter DS, Alam M, Cai H, etal. Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009;19(6):1628-1631.
-
(2009)
Bioorg Med Chem Lett.
, vol.19
, Issue.6
, pp. 1628-1631
-
-
Carter, D.S.1
Alam, M.2
Cai, H.3
-
140
-
-
61349092411
-
Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain
-
Jahangir A, Alam M, Carter DS, etal. Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009;19(6):1632-1635.
-
(2009)
Bioorg Med Chem Lett.
, vol.19
, Issue.6
, pp. 1632-1635
-
-
Jahangir, A.1
Alam, M.2
Carter, D.S.3
-
141
-
-
77956389019
-
Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats
-
Kaan TK, Yip PK, Patel S, etal. Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain. 2010;133(9):2549-2564.
-
(2010)
Brain.
, vol.133
, Issue.9
, pp. 2549-2564
-
-
Kaan, T.K.1
Yip, P.K.2
Patel, S.3
-
142
-
-
74349119720
-
Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist
-
Brotherton-Pleiss CE, Dillon MP, Ford AP, etal. Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett. 2010;20(3):1031-1036.
-
(2010)
Bioorg Med Chem Lett.
, vol.20
, Issue.3
, pp. 1031-1036
-
-
Brotherton-Pleiss, C.E.1
Dillon, M.P.2
Ford, A.P.3
-
143
-
-
33745142545
-
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists
-
Nelson DW, Gregg RJ, Kort ME, etal. Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. J Med Chem. 2006;49(12):3659-3666.
-
(2006)
J Med Chem.
, vol.49
, Issue.12
, pp. 3659-3666
-
-
Nelson, D.W.1
Gregg, R.J.2
Kort, M.E.3
-
144
-
-
34250314400
-
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists
-
Carroll WA, Kalvin DM, Perez Medrano A, etal. Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists. Bioorg Med Chem Lett. 2007;17(14):4044-4048.
-
(2007)
Bioorg Med Chem Lett.
, vol.17
, Issue.14
, pp. 4044-4048
-
-
Carroll, W.A.1
Kalvin, D.M.2
Perez Medrano, A.3
-
145
-
-
40749094413
-
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists
-
Florjancic AS, Peddi S, Perez-Medrano A, etal. Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists. Bioorg Med Chem Lett. 2008;18(6):2089-2092.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.6
, pp. 2089-2092
-
-
Florjancic, A.S.1
Peddi, S.2
Perez-Medrano, A.3
-
146
-
-
34249099764
-
P2X7-related modulation of pathological nociception in rats
-
McGaraughty S, Chu KL, Namovic MT, etal. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007;146(4):1817-1828.
-
(2007)
Neuroscience.
, vol.146
, Issue.4
, pp. 1817-1828
-
-
McGaraughty, S.1
Chu, K.L.2
Namovic, M.T.3
-
147
-
-
67849099111
-
The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice
-
Honore P, Donnelly-Roberts D, Namovic M, etal. The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav Brain Res. 2009;204(1):77-81.
-
(2009)
Behav Brain Res.
, vol.204
, Issue.1
, pp. 77-81
-
-
Honore, P.1
Donnelly-Roberts, D.2
Namovic, M.3
-
148
-
-
66249113481
-
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain
-
Perez-Medrano A, Donnelly-Roberts DL, Honore P, etal. Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain. J Med Chem. 2009;52(10):3366-3376.
-
(2009)
J Med Chem.
, vol.52
, Issue.10
, pp. 3366-3376
-
-
Perez-Medrano, A.1
Donnelly-Roberts, D.L.2
Honore, P.3
-
149
-
-
40749128845
-
Synthesis and in vitro activity of N′-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists
-
Morytko MJ, Betschmann P, Woller K, etal. Synthesis and in vitro activity of N′-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists. Bioorg Med Chem Lett. 2008;18(6):2093-2096.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.6
, pp. 2093-2096
-
-
Morytko, M.J.1
Betschmann, P.2
Woller, K.3
-
150
-
-
33751165071
-
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
-
Honore P, Donnelly-Roberts D, Namovic MT, etal. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther. 2006;319(3):1376-1385.
-
(2006)
J Pharmacol Exp Ther.
, vol.319
, Issue.3
, pp. 1376-1385
-
-
Honore, P.1
Donnelly-Roberts, D.2
Namovic, M.T.3
-
151
-
-
58049118595
-
[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors
-
Donnelly-Roberts DL, Namovic MT, Surber B, etal. [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors. Neuropharmacology. 2009;56(1):223-229.
-
(2009)
Neuropharmacology.
, vol.56
, Issue.1
, pp. 223-229
-
-
Donnelly-Roberts, D.L.1
Namovic, M.T.2
Surber, B.3
-
153
-
-
33845189595
-
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373
-
Stokes L, Jiang LH, Alcaraz L, etal. Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. Br J Pharmacol. 2006;149(7):880-887.
-
(2006)
Br J Pharmacol.
, vol.149
, Issue.7
, pp. 880-887
-
-
Stokes, L.1
Jiang, L.H.2
Alcaraz, L.3
-
154
-
-
10744232557
-
Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists
-
Baxter A, Bent J, Bowers K, etal. Hit-to-Lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists. Bioorg Med Chem Lett. 2003;13(22):4047-4050.
-
(2003)
Bioorg Med Chem Lett.
, vol.13
, Issue.22
, pp. 4047-4050
-
-
Baxter, A.1
Bent, J.2
Bowers, K.3
-
155
-
-
37849008468
-
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors
-
Furber M, Alcaraz L, Bent JE, etal. Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. J Med Chem. 2007;50(24):5882-5885.
-
(2007)
J Med Chem.
, vol.50
, Issue.24
, pp. 5882-5885
-
-
Furber, M.1
Alcaraz, L.2
Bent, J.E.3
-
156
-
-
39449124756
-
Negative and positive allosteric modulators of the P2X(7) receptor
-
Michel AD, Chambers LJ, Walter DS. Negative and positive allosteric modulators of the P2X(7) receptor. Br J Pharmacol. 2008;153(4):737-750.
-
(2008)
Br J Pharmacol.
, vol.153
, Issue.4
, pp. 737-750
-
-
Michel, A.D.1
Chambers, L.J.2
Walter, D.S.3
-
157
-
-
79957813413
-
Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535
-
Duplantier AJ, Dombroski MA, Subramanyam C, etal. Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535. Bioorg Med Chem Lett. 2011;21(12):3708-3711.
-
(2011)
Bioorg Med Chem Lett.
, vol.21
, Issue.12
, pp. 3708-3711
-
-
Duplantier, A.J.1
Dombroski, M.A.2
Subramanyam, C.3
-
158
-
-
84856274262
-
P2X receptor antagonists for pain management: Examination of binding and physicochemical properties
-
Gum RJ, Wakefield B, Jarvis MF. P2X receptor antagonists for pain management: examination of binding and physicochemical properties. Purinergic Signal. 2012;8(Suppl 1):41-56.
-
(2012)
Purinergic Signal.
, vol.8
, Issue.SUPPL. 1
, pp. 41-56
-
-
Gum, R.J.1
Wakefield, B.2
Jarvis, M.F.3
-
159
-
-
0347949526
-
Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
-
McGaraughty S, Wismer CT, Zhu CZ, etal. Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br J Pharmacol. 2003;140(8):1381-1388.
-
(2003)
Br J Pharmacol.
, vol.140
, Issue.8
, pp. 1381-1388
-
-
McGaraughty, S.1
Wismer, C.T.2
Zhu, C.Z.3
-
160
-
-
77954038361
-
AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
-
Gever JR, Soto R, Henningsen RA, etal. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010;160(6):1387-1398.
-
(2010)
Br J Pharmacol.
, vol.160
, Issue.6
, pp. 1387-1398
-
-
Gever, J.R.1
Soto, R.2
Henningsen, R.A.3
-
161
-
-
84865661641
-
Role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibers
-
Weigand LA, Ford AP, Undem BJ. Role for ATP in bronchoconstriction-induced activation of guinea pig vagal intrapulmonary C-fibers. J Physiol. 2012;S90(Pt16):4109-4120.
-
(2012)
J Physiol.
, vol.S90
, Issue.PART 16
, pp. 4109-4120
-
-
Weigand, L.A.1
Ford, A.P.2
Undem, B.J.3
-
162
-
-
77949783979
-
Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord
-
Kaan TK, Yip PK, Grist J, etal. Endogenous purinergic control of bladder activity via presynaptic P2X3 and P2X2/3 receptors in the spinal cord. J Neurosci. 2010;30(12):4503-4507.
-
(2010)
J Neurosci.
, vol.30
, Issue.12
, pp. 4503-4507
-
-
Kaan, T.K.1
Yip, P.K.2
Grist, J.3
-
163
-
-
74949123761
-
P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide
-
Clark AK, Staniland AA, Marchand F, Kaan TK, McMahon SB, Malcangio M. P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci. 2010;30(2):573-582.
-
(2010)
J Neurosci.
, vol.30
, Issue.2
, pp. 573-582
-
-
Clark, A.K.1
Staniland, A.A.2
Marchand, F.3
Kaan, T.K.4
McMahon, S.B.5
Malcangio, M.6
-
164
-
-
68149157440
-
Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
-
Peng W, Cotrina ML, Han X, etal. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2009;106(30):12489-12493.
-
(2009)
Proc Natl Acad Sci U S A.
, vol.106
, Issue.30
, pp. 12489-12493
-
-
Peng, W.1
Cotrina, M.L.2
Han, X.3
-
165
-
-
66249138835
-
Antagonists of the P2X(7) receptor. From lead identification to drug development
-
Guile SD, Alcaraz L, Birkinshaw TN, etal. Antagonists of the P2X(7) receptor. From lead identification to drug development. J Med Chem.2009;52(10):3123-3141.
-
(2009)
J Med Chem.
, vol.52
, Issue.10
, pp. 3123-3141
-
-
Guile, S.D.1
Alcaraz, L.2
Birkinshaw, T.N.3
-
166
-
-
84868447348
-
Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
-
[Epub ahead of print]
-
Keystone EC, Wang MM, Layton M, Hollis S, McInnes IB. Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine. Ann Rheum Dis. 2011. [Epub ahead of print].
-
(2011)
Ann Rheum Dis.
-
-
Keystone, E.C.1
Wang, M.M.2
Layton, M.3
Hollis, S.4
McInnes, I.B.5
-
167
-
-
84859456520
-
Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate
-
Stock TC, Bloom BJ, Wei N, etal. Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012;39(4):720-727.
-
(2012)
J Rheumatol.
, vol.39
, Issue.4
, pp. 720-727
-
-
Stock, T.C.1
Bloom, B.J.2
Wei, N.3
-
168
-
-
84856533787
-
A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury
-
Marcillo A, Frydel B, Bramlett HM, Dietrich WD. A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury. Exp Neurol. 2012;233(2):687-692.
-
(2012)
Exp Neurol.
, vol.233
, Issue.2
, pp. 687-692
-
-
Marcillo, A.1
Frydel, B.2
Bramlett, H.M.3
Dietrich, W.D.4
-
169
-
-
0346690401
-
Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior
-
Inscho EW, Cook AK, Imig JD, Vial C, Evans RJ. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest. 2003;112(12):1895-1905.
-
(2003)
J Clin Invest.
, vol.112
, Issue.12
, pp. 1895-1905
-
-
Inscho, E.W.1
Cook, A.K.2
Imig, J.D.3
Vial, C.4
Evans, R.J.5
-
170
-
-
0042422021
-
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
-
Hechler B, Lenain N, Marchese P, etal. A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med. 2003;198(4):661-667.
-
(2003)
J Exp Med.
, vol.198
, Issue.4
, pp. 661-667
-
-
Hechler, B.1
Lenain, N.2
Marchese, P.3
-
171
-
-
70149083748
-
P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation
-
Lecut C, Frederix K, Johnson DM, etal. P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation. J Immunol. 2009;183(4):2801-2809.
-
(2009)
J Immunol.
, vol.183
, Issue.4
, pp. 2801-2809
-
-
Lecut, C.1
Frederix, K.2
Johnson, D.M.3
-
172
-
-
0242558890
-
P2X2subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine
-
Ren J, Bian X, DeVries M, etal. P2X2subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol. 2003;552(Pt 3):809-821.
-
(2003)
J Physiol.
, vol.552
, Issue.PART 3
, pp. 809-821
-
-
Ren, J.1
Bian, X.2
DeVries, M.3
-
173
-
-
34548687226
-
Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor
-
Ryten M, Koshi R, Knight GE, etal. Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor. Neuroscience. 2007;148(3):700-711.
-
(2007)
Neuroscience.
, vol.148
, Issue.3
, pp. 700-711
-
-
Ryten, M.1
Koshi, R.2
Knight, G.E.3
-
174
-
-
80053034884
-
Knocking out P2X receptors reduces transmitter secretion in taste buds
-
Huang YA, Stone LM, Pereira E, etal. Knocking out P2X receptors reduces transmitter secretion in taste buds. J Neurosci. 2011;31(38):13654-13661.
-
(2011)
J Neurosci.
, vol.31
, Issue.38
, pp. 13654-13661
-
-
Huang, Y.A.1
Stone, L.M.2
Pereira, E.3
-
175
-
-
84858858878
-
P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis
-
Custer EE, Knott TK, Cuadra AE, Ortiz-Miranda S, Lemos JR. P2X purinergic receptor knockout mice reveal endogenous ATP modulation of both vasopressin and oxytocin release from the intact neurohypophysis. J Neuroendocrinol. 2012;24(4):674-680.
-
(2012)
J Neuroendocrinol.
, vol.24
, Issue.4
, pp. 674-680
-
-
Custer, E.E.1
Knott, T.K.2
Cuadra, A.E.3
Ortiz-Miranda, S.4
Lemos, J.R.5
-
176
-
-
80052181424
-
ATP-activated P2X2 current in mouse spermatozoa
-
Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. Proc Natl Acad Sci U S A. 2011;108(34):14342-14347.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, Issue.34
, pp. 14342-14347
-
-
Navarro, B.1
Miki, K.2
Clapham, D.E.3
-
177
-
-
0035413364
-
P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
-
Vlaskovska M, Kasakov L, Rong W, etal. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci. 2001;21(15):5670-5677.
-
(2001)
J Neurosci.
, vol.21
, Issue.15
, pp. 5670-5677
-
-
Vlaskovska, M.1
Kasakov, L.2
Rong, W.3
-
178
-
-
0041854182
-
Peristalsis is impaired in the small intestine of mice lacking the P2X3subunit
-
Bian X, Ren J, DeVries M, etal. Peristalsis is impaired in the small intestine of mice lacking the P2X3subunit. J Physiol. 2003;551(Pt 1):309-322.
-
(2003)
J Physiol.
, vol.551
, Issue.PART 1
, pp. 309-322
-
-
Bian, X.1
Ren, J.2
DeVries, M.3
-
179
-
-
0346218117
-
Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia
-
Rong W, Gourine AV, Cockayne DA, etal. Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci. 2003;23(36):11315-11321.
-
(2003)
J Neurosci.
, vol.23
, Issue.36
, pp. 11315-11321
-
-
Rong, W.1
Gourine, A.V.2
Cockayne, D.A.3
-
180
-
-
20444484395
-
Enhanced thermal avoidance in mice lacking the ATP receptor P2X3
-
Shimizu I, Iida T, Guan Y, etal. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain. 2005;116(1-2):96-108.
-
(2005)
Pain.
, vol.116
, Issue.1-2
, pp. 96-108
-
-
Shimizu, I.1
Iida, T.2
Guan, Y.3
-
181
-
-
33750925171
-
Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit
-
Wang Y, Mackes J, Chan S, etal. Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit. J Neurochem. 2006;99(5):1425-1434.
-
(2006)
J Neurochem.
, vol.99
, Issue.5
, pp. 1425-1434
-
-
Wang, Y.1
Mackes, J.2
Chan, S.3
-
182
-
-
0037634326
-
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
-
Ke HZ, Qi H, Weidema AF, etal. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol. 2003;17(7):1356-1367.
-
(2003)
Mol Endocrinol.
, vol.17
, Issue.7
, pp. 1356-1367
-
-
Ke, H.Z.1
Qi, H.2
Weidema, A.F.3
-
183
-
-
30044443068
-
The P2X7 nucleotide receptor mediates skeletal mechanotransduction
-
Li J, Liu D, Ke HZ, Duncan RL, Turner CH. The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem. 2005;280(52):42952-42959.
-
(2005)
J Biol Chem.
, vol.280
, Issue.52
, pp. 42952-42959
-
-
Li, J.1
Liu, D.2
Ke, H.Z.3
Duncan, R.L.4
Turner, C.H.5
-
184
-
-
3242673859
-
Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts
-
Korcok J, Raimundo LN, Ke HZ, Sims SM, Dixon SJ. Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts. J Bone Miner Res. 2004;19(4):642-651.
-
(2004)
J Bone Miner Res.
, vol.19
, Issue.4
, pp. 642-651
-
-
Korcok, J.1
Raimundo, L.N.2
Ke, H.Z.3
Sims, S.M.4
Dixon, S.J.5
-
185
-
-
34047243995
-
P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid
-
Panupinthu N, Zhao L, Possmayer F, Ke HZ, Sims SM, Dixon SJ. P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid. J Biol Chem. 2007;282(5):3403-3412.
-
(2007)
J Biol Chem.
, vol.282
, Issue.5
, pp. 3403-3412
-
-
Panupinthu, N.1
Zhao, L.2
Possmayer, F.3
Ke, H.Z.4
Sims, S.M.5
Dixon, S.J.6
-
186
-
-
13544258083
-
P2X7 receptor-dependent and-independent T cell death is induced by nicotinamide adenine dinucleotide
-
Kawamura H, Aswad F, Minagawa M, etal. P2X7 receptor-dependent and-independent T cell death is induced by nicotinamide adenine dinucleotide. J Immunol. 2005;174(4):1971-1979.
-
(2005)
J Immunol.
, vol.174
, Issue.4
, pp. 1971-1979
-
-
Kawamura, H.1
Aswad, F.2
Minagawa, M.3
-
187
-
-
32544448639
-
P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling
-
Suadicani SO, Brosnan CF, Scemes E. P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci. 2006;26(5):1378-1385.
-
(2006)
J Neurosci.
, vol.26
, Issue.5
, pp. 1378-1385
-
-
Suadicani, S.O.1
Brosnan, C.F.2
Scemes, E.3
-
188
-
-
32044454242
-
P2X7 receptors regulate NKT cells in autoimmune hepatitis
-
Kawamura H, Aswad F, Minagawa M, Govindarajan S, Dennert G. P2X7 receptors regulate NKT cells in autoimmune hepatitis. J Immunol. 2006;176(4):2152-2160.
-
(2006)
J Immunol.
, vol.176
, Issue.4
, pp. 2152-2160
-
-
Kawamura, H.1
Aswad, F.2
Minagawa, M.3
Govindarajan, S.4
Dennert, G.5
-
189
-
-
64149094083
-
Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland
-
Nakamoto T, Brown DA, Catalan MA, Gonzalez-Begne M, Romanenko VG, Melvin JE. Purinergic P2X7 receptors mediate ATP-induced saliva secretion by the mouse submandibular gland. J Biol Chem. 2009;284(8):4815-4822.
-
(2009)
J Biol Chem.
, vol.284
, Issue.8
, pp. 4815-4822
-
-
Nakamoto, T.1
Brown, D.A.2
Catalan, M.A.3
Gonzalez-Begne, M.4
Romanenko, V.G.5
Melvin, J.E.6
-
190
-
-
77956750583
-
Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands
-
Novak I, Jans IM, Wohlfahrt L. Effect of P2X(7) receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands. J Physiol. 2010;588(Pt 18):3615-3627.
-
(2010)
J Physiol.
, vol.588
, Issue.PART 18
, pp. 3615-3627
-
-
Novak, I.1
Jans, I.M.2
Wohlfahrt, L.3
-
191
-
-
79953228814
-
P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet
-
Inscho EW, Cook AK, Clarke A, Zhang S, Guan Z. P2X1 receptor-mediated vasoconstriction of afferent arterioles in angiotensin II-infused hypertensive rats fed a high-salt diet. Hypertension. 2011;57(4):780-787.
-
(2011)
Hypertension.
, vol.57
, Issue.4
, pp. 780-787
-
-
Inscho, E.W.1
Cook, A.K.2
Clarke, A.3
Zhang, S.4
Guan, Z.5
-
192
-
-
45749129759
-
Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats
-
Ito K, Iwami A, Katsura H, Ikeda M. Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2008;377(4-6):483-490.
-
(2008)
Naunyn Schmiedebergs Arch Pharmacol.
, vol.377
, Issue.4-6
, pp. 483-490
-
-
Ito, K.1
Iwami, A.2
Katsura, H.3
Ikeda, M.4
-
193
-
-
0035884935
-
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion
-
Fairbairn IP, Stober CB, Kumararatne DS, Lammas DA. ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol. 2001;167(6):3300-3307.
-
(2001)
J Immunol.
, vol.167
, Issue.6
, pp. 3300-3307
-
-
Fairbairn, I.P.1
Stober, C.B.2
Kumararatne, D.S.3
Lammas, D.A.4
-
194
-
-
33644871635
-
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages
-
Shemon AN, Sluyter R, Fernando SL, etal. A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. J Biol Chem. 2006;281(4):2079-2086.
-
(2006)
J Biol Chem.
, vol.281
, Issue.4
, pp. 2079-2086
-
-
Shemon, A.N.1
Sluyter, R.2
Fernando, S.L.3
-
195
-
-
33847052870
-
A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis
-
Fernando SL, Saunders BM, Sluyter R, etal. A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis. Am J Respir Crit Care Med. 2007;175(4):360-366.
-
(2007)
Am J Respir Crit Care Med.
, vol.175
, Issue.4
, pp. 360-366
-
-
Fernando, S.L.1
Saunders, B.M.2
Sluyter, R.3
-
196
-
-
33750201396
-
The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice
-
Goncalves RG, Gabrich L, Rosario A Jr, etal. The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Kidney Int. 2006;70(9):1599-1606.
-
(2006)
Kidney Int.
, vol.70
, Issue.9
, pp. 1599-1606
-
-
Goncalves, R.G.1
Gabrich, L.2
Rosario Jr., A.3
-
197
-
-
67649383228
-
Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration
-
Diaz-Hernandez M, Diez-Zaera M, Sanchez-Nogueiro J, etal. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration. FASEB J. 2009;23(6):1893-1906.
-
(2009)
FASEB J.
, vol.23
, Issue.6
, pp. 1893-1906
-
-
Diaz-Hernandez, M.1
Diez-Zaera, M.2
Sanchez-Nogueiro, J.3
-
198
-
-
0038143359
-
P2X7mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease
-
Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R. P2X7mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem. 2003;278(15):13309-13317.
-
(2003)
J Biol Chem.
, vol.278
, Issue.15
, pp. 13309-13317
-
-
Parvathenani, L.K.1
Tertyshnikova, S.2
Greco, C.R.3
Roberts, S.B.4
Robertson, B.5
Posmantur, R.6
-
199
-
-
33750601018
-
Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus
-
McLarnon JG, Ryu JK, Walker DG, Choi HB. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. J Neuropathol Exp Neurol. 2006;65(11):1090-1097.
-
(2006)
J Neuropathol Exp Neurol.
, vol.65
, Issue.11
, pp. 1090-1097
-
-
McLarnon, J.G.1
Ryu, J.K.2
Walker, D.G.3
Choi, H.B.4
-
200
-
-
33747190855
-
P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro
-
Skaper SD, Facci L, Culbert AA, etal. P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro. Glia. 2006;54(3):234-242.
-
(2006)
Glia.
, vol.54
, Issue.3
, pp. 234-242
-
-
Skaper, S.D.1
Facci, L.2
Culbert, A.A.3
-
201
-
-
64249169414
-
Activation of microglia by amyloid {beta} requires P2X7 receptor expression
-
Sanz JM, Chiozzi P, Ferrari D, etal. Activation of microglia by amyloid {beta} requires P2X7 receptor expression. J Immunol. 2009;182(7):4378-4385.
-
(2009)
J Immunol.
, vol.182
, Issue.7
, pp. 4378-4385
-
-
Sanz, J.M.1
Chiozzi, P.2
Ferrari, D.3
-
202
-
-
79251641533
-
Microglial P2X(7) receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9mouse model of Alzheimer's disease
-
Lee HG, Won SM, Gwag BJ, Lee YB. Microglial P2X(7) receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9mouse model of Alzheimer's disease. Exp Mol Med. 2011;43(1):7-14.
-
(2011)
Exp Mol Med.
, vol.43
, Issue.1
, pp. 7-14
-
-
Lee, H.G.1
Won, S.M.2
Gwag, B.J.3
Lee, Y.B.4
-
203
-
-
67449087580
-
P2X7 deficiency attenuates renal injury in experimental glomerulonephritis
-
Taylor SR, Turner CM, Elliott JI, etal. P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol. 2009;20(6):1275-1281.
-
(2009)
J Am Soc Nephrol.
, vol.20
, Issue.6
, pp. 1275-1281
-
-
Taylor, S.R.1
Turner, C.M.2
Elliott, J.I.3
-
204
-
-
78649993400
-
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
-
Wilhelm K, Ganesan J, Muller T, etal. Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med. 2010;16(12):1434-1438.
-
(2010)
Nat Med.
, vol.16
, Issue.12
, pp. 1434-1438
-
-
Wilhelm, K.1
Ganesan, J.2
Muller, T.3
-
205
-
-
77953503071
-
Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in rats
-
Zhou D, Chen ML, Zhang YQ, Zhao ZQ. Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in rats. J Neurosci. 2010;30(23):8042-8047.
-
(2010)
J Neurosci.
, vol.30
, Issue.23
, pp. 8042-8047
-
-
Zhou, D.1
Chen, M.L.2
Zhang, Y.Q.3
Zhao, Z.Q.4
-
206
-
-
77953198913
-
Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: Implications for amyotrophic lateral sclerosis
-
Gandelman M, Peluffo H, Beckman JS, Cassina P, Barbeito L. Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis. J Neuroinflammation. 2010;7:33.
-
(2010)
J Neuroinflammation.
, vol.7
, pp. 33
-
-
Gandelman, M.1
Peluffo, H.2
Beckman, J.S.3
Cassina, P.4
Barbeito, L.5
-
207
-
-
79955491175
-
The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice
-
Kim JE, Kang TC. The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice. J Clin Invest. 2011;121(5):2037-2047.
-
(2011)
J Clin Invest.
, vol.121
, Issue.5
, pp. 2037-2047
-
-
Kim, J.E.1
Kang, T.C.2
-
208
-
-
80051636256
-
P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome
-
Keating C, Pelegrin P, Martinez CM, Grundy D. P2X7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome. J Immunol. 2011;187(3):1467-1474.
-
(2011)
J Immunol.
, vol.187
, Issue.3
, pp. 1467-1474
-
-
Keating, C.1
Pelegrin, P.2
Martinez, C.M.3
Grundy, D.4
-
209
-
-
82955173738
-
The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice
-
Martins JP, Silva RB, Coutinho-Silva R, etal. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012;165(1):183-196.
-
(2012)
Br J Pharmacol.
, vol.165
, Issue.1
, pp. 183-196
-
-
Martins, J.P.1
Silva, R.B.2
Coutinho-Silva, R.3
-
210
-
-
33745047597
-
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder
-
Barden N, Harvey M, Gagne B, etal. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2006;141B(4):374-382.
-
(2006)
Am J Med Genet B Neuropsychiatr Genet.
, vol.141 B
, Issue.4
, pp. 374-382
-
-
Barden, N.1
Harvey, M.2
Gagne, B.3
-
211
-
-
33747873833
-
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder
-
Lucae S, Salyakina D, Barden N, etal. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum Mol Genet. 2006;15(16):2438-2445.
-
(2006)
Hum Mol Genet.
, vol.15
, Issue.16
, pp. 2438-2445
-
-
Lucae, S.1
Salyakina, D.2
Barden, N.3
-
212
-
-
61449251630
-
Association between depression and the Gln460Arg polymorphism of P2RX7gene: A dimensional approach
-
Hejjas K, Szekely A, Domotor E, etal. Association between depression and the Gln460Arg polymorphism of P2RX7gene: a dimensional approach. Am J Med Genet B Neuropsychiatr Genet. 2009;150B(2):295-299.
-
(2009)
Am J Med Genet B Neuropsychiatr Genet.
, vol.150 B
, Issue.2
, pp. 295-299
-
-
Hejjas, K.1
Szekely, A.2
Domotor, E.3
-
213
-
-
66249146391
-
Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar-and unipolar-affective disorders
-
McQuillin A, Bass NJ, Choudhury K, etal. Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar-and unipolar-affective disorders. Mol Psychiatry. 2009;14(6):614-620.
-
(2009)
Mol Psychiatry.
, vol.14
, Issue.6
, pp. 614-620
-
-
McQuillin, A.1
Bass, N.J.2
Choudhury, K.3
-
214
-
-
84861472676
-
A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events
-
Gidlof O, Smith JG, Melander O, etal. A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events. PLoS One. 2012;7(5):e37491.
-
(2012)
PLoS One.
, vol.7
, Issue.5
-
-
Gidlof, O.1
Smith, J.G.2
Melander, O.3
-
215
-
-
0029088454
-
Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors)
-
Evans RJ, Lewis C, Buell G, Valera S, North RA, Surprenant A. Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors). Mol Pharmacol. 1995;48(2):178-183.
-
(1995)
Mol Pharmacol.
, vol.48
, Issue.2
, pp. 178-183
-
-
Evans, R.J.1
Lewis, C.2
Buell, G.3
Valera, S.4
North, R.A.5
Surprenant, A.6
-
216
-
-
27444436716
-
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency
-
Ullmann H, Meis S, Hongwiset D, etal. Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005;48(22):7040-7048.
-
(2005)
J Med Chem.
, vol.48
, Issue.22
, pp. 7040-7048
-
-
Ullmann, H.1
Meis, S.2
Hongwiset, D.3
-
218
-
-
38849143976
-
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue
-
Fonfria E, Clay WC, Levy DS, etal. Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue. Br J Pharmacol. 2008;153(3):544-556.
-
(2008)
Br J Pharmacol.
, vol.153
, Issue.3
, pp. 544-556
-
-
Fonfria, E.1
Clay, W.C.2
Levy, D.S.3
-
219
-
-
0038022869
-
NF449, a novel picomolar potency antagonist at human P2X1 receptors
-
Hulsmann M, Nickel P, Kassack M, Schmalzing G, Lambrecht G, Markwardt F. NF449, a novel picomolar potency antagonist at human P2X1 receptors. Eur J Pharmacol. 2003;470(1-2):1-7.
-
(2003)
Eur J Pharmacol.
, vol.470
, Issue.1-2
, pp. 1-7
-
-
Hulsmann, M.1
Nickel, P.2
Kassack, M.3
Schmalzing, G.4
Lambrecht, G.5
Markwardt, F.6
-
220
-
-
33745146902
-
The suramin analog 4,4′,4″,4″′-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: Subtype selectivity is determined by location of sulfonic acid groups
-
Hausmann R, Rettinger J, Gerevich Z, etal. The suramin analog 4,4′,4″,4″′-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol Pharmacol. 2006;69(6):2058-2067.
-
(2006)
Mol Pharmacol.
, vol.69
, Issue.6
, pp. 2058-2067
-
-
Hausmann, R.1
Rettinger, J.2
Gerevich, Z.3
-
221
-
-
34548494816
-
Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist
-
Jung KY, Moon HD, Lee GE, Lim HH, Park CS, Kim YC. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007;50(18):4543-4547.
-
(2007)
J Med Chem.
, vol.50
, Issue.18
, pp. 4543-4547
-
-
Jung, K.Y.1
Moon, H.D.2
Lee, G.E.3
Lim, H.H.4
Park, C.S.5
Kim, Y.C.6
-
222
-
-
38749115790
-
Painful purinergic receptors
-
Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF. Painful purinergic receptors. J Pharmacol Exp Ther. 2008;324(2):409-415.
-
(2008)
J Pharmacol Exp Ther.
, vol.324
, Issue.2
, pp. 409-415
-
-
Donnelly-Roberts, D.1
McGaraughty, S.2
Shieh, C.C.3
Honore, P.4
Jarvis, M.F.5
-
223
-
-
70350543348
-
Cloning and pharmacological characterization of the dog P2X7 receptor
-
Roman S, Cusdin FS, Fonfria E, etal. Cloning and pharmacological characterization of the dog P2X7 receptor. Br J Pharmacol. 2009;158(6):1513-1526.
-
(2009)
Br J Pharmacol.
, vol.158
, Issue.6
, pp. 1513-1526
-
-
Roman, S.1
Cusdin, F.S.2
Fonfria, E.3
-
224
-
-
80052216594
-
Pharmacological properties of the rhesus macaque monkey P2X7 receptor
-
Bradley HJ, Browne LE, Yang W, Jiang LH. Pharmacological properties of the rhesus macaque monkey P2X7 receptor. Br J Pharmacol. 2011;164(2b):743-754.
-
(2011)
Br J Pharmacol.
, vol.164
, Issue.2 B
, pp. 743-754
-
-
Bradley, H.J.1
Browne, L.E.2
Yang, W.3
Jiang, L.H.4
-
225
-
-
34247646953
-
Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding
-
Michel AD, Chambers LJ, Clay WC, Condreay JP, Walter DS, Chessell IP. Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol. 2007;151(1):103-114.
-
(2007)
Br J Pharmacol.
, vol.151
, Issue.1
, pp. 103-114
-
-
Michel, A.D.1
Chambers, L.J.2
Clay, W.C.3
Condreay, J.P.4
Walter, D.S.5
Chessell, I.P.6
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