P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

Journal of Physiology

Volumn 567, Issue 2, 2005, Pages 621-639

  Cockayne, Debra A ^a   Dunn, Philip M ^b   Zhong, Yu ^a   Rong, Weifang ^c   Hamilton, Sara G ^d   Knight, Gillian E ^b   Ruan, Huai Zhen ^b   Ma, Bei ^b   Yip, Ping ^d   Nunn, Philip ^a   McMahon, Stephen B ^d   Burnstock, Geoffrey ^b   Ford, Anthony P D W ^a  

^a ROCHE BIOSCIENCE   (United States)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; FORMALDEHYDE; PURINE P2X2 RECEPTOR; PURINE P2X3 RECEPTOR; PROTEIN SUBUNIT; PURINE P2 RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER DISTENSION; CELIAC GANGLION; CONTROLLED STUDY; FEMALE; KNOCKOUT MOUSE; MALE; MICTURITION REFLEX; MOUSE; MOUSE MUTANT; NERVE CONDUCTION; NOCICEPTION; NODOSE GANGLION; NONHUMAN; PAIN; PATCH CLAMP; PELVIC NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SPINAL GANGLION; SUPERIOR CERVICAL GANGLION; SYMPATHETIC NERVE CELL; WILD TYPE; ANIMAL; BLADDER; CHEMISTRY; GENETICS; INNERVATION; MECHANOTRANSDUCTION; METABOLISM; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; REFLEX; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; NEURONS, AFFERENT; PAIN; PROTEIN SUBUNITS; RECEPTORS, PURINERGIC P2; REFLEX; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY BLADDER;

EID: 24944564718     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.088435     Document Type: Article

References (55)

1. 3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci 22, 8139-8147.
2. Bardoni R, Goldstein PA, Lee CJ, Gu JG & MacDermott AB (1997). ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. J Neurosci 17, 5297-5304.
3. Bertrand PP & Bornstein JC (2002). ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. J Neurosci 22, 4767-4775.
4. 3 subunit. J Physiol 551, 309-322.
5. Bland-Ward PA & Humphrey PPA (1997). Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol 122, 365-371.
6. Burgard EC, Niforatos W, Van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA & Jarvis MF (1999). P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol l82, 1590-1598.
7. Burnstock G (2000). P2X receptors in sensory neurons. Br J Anaesth 84, 476-488.
8. Burnstock G (2001). Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22, 182-188.
9. Burnstock G (2003). Purinergic receptors in the nervous system. In Current Topics in Membranes, vol. 54, ed. Schwiebert EM, pp. 307-368. Academic Press, San Diego.
10. 1 receptors revealed using knockout mice. Mol Pharmacol 65, 139-148.
11. 3-deficient mice. Nature 407, 1011-1015.
12. Dmitrieva N, Shelton D, Rice AS & McMahon SB (1997). The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78, 449-459.
13. Dorn G, Patel S, Wotherspoon G, Hemmings-Mieszczak M, Barclay J, Natt FJC, Martin P, Bevan S, Fox A, Ganju P, Wishart W & Hall J (2004). siRNA relieves chronic neuropathic pain. Nucleic Acids Res 32, e49.
14. + channels by gallamine and a novel bis-quaternary quinolinium cyclophane, UCL 1530. Br J Pharmacol 117, 35-42.
15. Dunn PM, Zhong Y & Burnstock G (2001). P2X receptors in peripheral neurons. Prog Neurobiol 65, 107-134.
16. Ferguson DR, Kennedy I & Burton TJ (1997). ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol 505, 503-511.
17. Gerevich Z & Illes P (2005). P2Y receptors and pain transmission. Purinergic Signal 1, 3-10.
18. Gu JG & MacDermott AB (1997). Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389, 749-753.
19. Habler HL, Janig W & Koltzenburg M (1990). Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol 425, 545-562.
20. 3 antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain 99, 11-19.
21. 3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics. Pain 96, 99-105.
22. Hugel S & Schlichter R (2000). Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20, 2121-2130.
23. Inoue K, Tsuda M & Koizumi S (2003). ATP induced three types of pain behaviors, including allodynia. Drug Dev Res 59, 56-63.
24. Janig W & Morrison JF (1986). Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception. Prog Brain Res 67, 87-114.
25. 3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets 7, 513-522.
26. 2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc Natl Acad Sci U S A 99, 17179-17184.
27. 3 allosteric modulator, cibacron blue. Br J Pharmacol 132, 259-269.
28. Khakh BS, Humphrey PP & Surprenant A (1995). Electrophysiological properties of P2X-purinoceptors in rat superior cervical, nodose and guinea-pig coeliac neurones. J Physiol 484, 385-395.
29. 1 receptors. Br J Pharmacol 128, 981-988.
30. Kirkup AJ, Booth CE, Chessell IP, Humphrey PPA & Grundy D (1999). Excitatory effect of P2X receptor activation on mesenteric afferent nerves in the anaesthetised rat. J Physiol 520, 551-563.
31. Knight GE, Bodin P, De Groat WC & Burnstock G (2002). ATP is released from guinea pig ureter epithelium on distension. Am J Physiol Renal Physiol 282, F281-288.
32. 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br J Pharmacol 140, 1381-1388.
33. Nakatsuka T & Gu JG (2001). ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 21, 6522-6531.
34. Nakatsuka T, Tsuzuki K, Ling JX, Sonobe H & Gu JG (2003). Distinct roles of P2X receptors in modulating glutamate release at different primary sensory synapses in rat spinal cord. J Neurophysiol 89, 3243-3252.
35. North RA (2002). Molecular physiology of P2X receptors. Physiol Rev 82, 1013-1067.
36. Pandita RK & Andersson K-E (2004). Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats. J Urol 168, 1230-1234.
37. 3-receptors present in neurones of the rat dorsal root ganglia. Br J Pharmacol 124, 176-180.
38. Rong W, Spyer KM & Burnstock G (2002). Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol 541, 591-600.
39. 4 receptors in dorsal root, nodose and trigeminal ganglia of the rat. Histochem Cell Biol 120, 415-426.
40. Silva AJ, Simpson EM, Takahashi JS, Lipp HP, Nakanishi S, Wehner JM, Giese KP, Tully T, Abel T & Chapman PF (1997). Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19, 755-759.
41. 3 receptors. Nature 407, 1015-1017.
42. Sun Y & Chai TC (2002). Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis. BJU Int 90, 381-385.
43. Thomas S, Virginio C, North RA & Surprenant A (1998). The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. J Physiol 509, 411-417.
44. 2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci 20, 90RC.
45. Tsuda M, Ueno S & Inoue K (1999a). Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. Br J Pharmacol 128, 1497-1504.
46. Tsuda M, Ueno S & Inoue K (1999b). In vivo pathway of thermal hyperalgesia by intrathecal administration of α, β-methylene ATP in mouse spinal cord: Involvement of the glutamate-NMDA receptor system. Br J Pharmacol 127, 449-456.
47. 3 receptors in neuropathic pain in a mouse model of chronic constriction injury. Drug Dev Res 59, 104-111.
48. 2/3 receptors. Mol Pharmacol 53, 969-973.
49. 3 knockout mice reveal a major sensory role for urothelially released ATP. J Neurosci 21, 5670-5677.
50. 2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats. Eur J Pharmacol 504, 45-53.
51. Wynn G, Rong W, Xiang Z & Burnstock G (2003). Purinergic mechanisms contribute to mechanosensory transduction in the rat colorectum. Gastroenterology 125, 1398-1409.
52. Zhong Y, Banning AS, Cockayne DA, Ford APDW, Burnstock G & McMahon SB (2003). Bladder and cutaneous sensory neurons of the rat express different functional P2X receptors. Neuroscience 120, 667-675.
53. 3-deficient mice. Eur J Neurosci 14, 1784-1792.
54. Zhong Y, Dunn PM & Burnstock G (2000). Pharmacological comparison of P2X receptors on rat coeliac, mouse coeliac and mouse pelvic ganglion neurons. Neuropharmacology 39, 172-180.
55. Zhong Y, Dunn PM, Xiang Z, Bo X & Burnstock G (1998). Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br J Pharmacol 125, 771-781.