Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize

Journal of Biological Chemistry

Volumn 280, Issue 11, 2005, Pages 10759-10765

  Barrera, Nelson P ^a   Ormond, Susan J ^a   Henderson, Robert M ^a   Murrell Lagnado, Ruth D ^a   Edwardson, J Michael ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ANTIBODIES; ATOMIC FORCE MICROSCOPY; IMAGING TECHNIQUES; MOLECULAR DYNAMICS; POSITIVE IONS;

ADDUCTS; CROSS-LINKING; DIRECT IMAGING; RECEPTORS; TRIMERS;

OLIGOMERS;

HISTIDINE; PURINE P2X2 RECEPTOR; PURINE P2X6 RECEPTOR;

ARTICLE; ATOMIC FORCE MICROSCOPY; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; GEOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOLECULAR MODEL; OLIGOMERIZATION; PRIORITY JOURNAL;

ANIMALS; CELL LINE; DETERGENTS; DIMERIZATION; EPITOPES; HISTIDINE; HUMANS; IMMUNOBLOTTING; MICROSCOPY, ATOMIC FORCE; MODELS, BIOLOGICAL; NORMAL DISTRIBUTION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, PURINERGIC P2; TRANSFECTION;

EID: 15444372454     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412265200     Document Type: Article

References (25)

1. Khakh, B. S. (2001) Nat. Rev. Neurosci. 2, 165-174
2. North, R. A. (2002) Physiol. Rev. 82, 1013-1067
3. Bean, B. P. (1990) J. Neurosci. 10, 1-10
4. Ding, S., and Sachs, F. (1999) J. Gen. Physiol. 113, 695-720
5. Stoop, R., Thomas, S., Rassendren, F., Kawashima, E., Buell, G., Surprenant, A., and North, A. R. (1999) Mol. Pharmacol. 56, 973-981
6. Nicke, A., Bäumert, H. G., Rettinger, J., Eichele, A., Lambrecht, G., Mutschler, E., and Schmalzing, G. (1998) EMBO J. 17, 3016-3028
7. Aschrafi, A., Sadtler, S., Niculescu, C., Rettinger, J., and Schmalzing, G. (2004) J. Mol. Biol. 342, 333-343
8. Kim, M., Yoo, O. J., and Choe, S. (1997) Biochem. Biophys. Res. Commun. 240, 618-622
9. Neish, C. S., Martin, I. L., Davies, M., Henderson, R. M., and Edwardson, J. M. (2003) Nanotechnology 14, 864-872
10. Schneider, S. W., Lärmer, J., Henderson, R. M., and Oberleithner, H. (1998) Pfluegers Arch. Eur. J. Physiol. 435, 362-367
11. Durchschlag, H., and Zipper, P. (1997) J. Appl. Crystallogr. 30, 803-807
12. Grant, E. H. (1957) Phys. Med. Biol. 2, 17-28
13. Torres, G. E., Egan, T. M., and Voigt, M. M. (1998) FEBS Lett. 425, 19-23
14. Jiang, L.-H., Kim, M., Spelta, V, Bo, X., Surprenant, A., and North, R. A. (2003) J. Neurosci. 23, 8903-8910
15. Lärmer, J., Schneider, S. W., Danker, T., Schwab, A., and Oberleithner, H. (1997) Pfluegers Arch. Eur. J. Physiol. 434, 254-260
16. Neish, C. S., Martin, I. L., Henderson, R. M., and Edwardson, J. M. (2002) Brit. J. Pharmacol. 135, 1943-1950
17. Bobanovic, L. K., Royle, S. J., and Murrell-Lagnado, R. D. (2002) J. Neurosci. 22, 4814-4824
18. Ellis, D. J., Dryden, D. T. F., Berge, T., Edwardson, J. M., and Henderson, R. M. (1999) Nat. Struct. Biol. 6, 15-17
19. Berge, T., Ellis, D. J., Dryden, D. T. F., Edwardson, J. M., and Henderson, R. M. (2000) Biophys. J. 79, 479-484
20. Saslowsky, D. E., Lawrence, J., Ren, X., Brown, D. A., Henderson, R. M., and Edwardson, J. M. (2002) J. Biol. Chem. 277, 26966-26970
21. McKernan, R. M., and Whiting, P. J. (1996) Trends. Neurosci. 19, 139-143
22. Farrar, S. J., Whiting, P. J., Bonnert, T. P., and McKernan, R. M. (1999) J. Biol. Chem. 274, 10100-10104
23. Chaumont, S., Jiang, L.-H., Penna, A., North, R. A., and Rassendren, F. (2004) J. Biol. Chem. 279, 29628-29638
24. Jones, C. A., Vial, C., Sellers, L. A., Humphrey, P. P. A., Evans, R. J., and Chessell, I. P. (2004) Mol. Pharmacol. 65, 979-985
25. Torres, G. E., Egan, T. M., and Voigt, M. M. (1999) J. Biol. Chem. 274, 6653-6659